BRPI0912159B8 - copolímero compreendendo um primeiro bloco que compreende uma unidade hidrofílica em ph fisiológico e um segundo bloco que compreende grupos hidrofóbicos, e uso do dito copolímero para liberação intracelular de um polinucleotídeo - Google Patents

copolímero compreendendo um primeiro bloco que compreende uma unidade hidrofílica em ph fisiológico e um segundo bloco que compreende grupos hidrofóbicos, e uso do dito copolímero para liberação intracelular de um polinucleotídeo

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Publication number
BRPI0912159B8
BRPI0912159B8 BRPI0912159A BRPI0912159A BRPI0912159B8 BR PI0912159 B8 BRPI0912159 B8 BR PI0912159B8 BR PI0912159 A BRPI0912159 A BR PI0912159A BR PI0912159 A BRPI0912159 A BR PI0912159A BR PI0912159 B8 BRPI0912159 B8 BR PI0912159B8
Authority
BR
Brazil
Prior art keywords
block
copolymer
physiological
copolymers
hydrophobic groups
Prior art date
Application number
BRPI0912159A
Other languages
English (en)
Inventor
S Hoffman Allan
Gall Anna
J Convertine Anthony
L Duvall Craig
Benoit Danielle
S Stayton Patrick
Johnson Paul
Original Assignee
Phaserx Inc
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Phaserx Inc, Univ Washington filed Critical Phaserx Inc
Publication of BRPI0912159A2 publication Critical patent/BRPI0912159A2/pt
Publication of BRPI0912159B1 publication Critical patent/BRPI0912159B1/pt
Publication of BRPI0912159B8 publication Critical patent/BRPI0912159B8/pt

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    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
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    • C08F299/00—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
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Abstract

copolímero de dibloco e usos dos mesmos descritos aqui são copolímeros, e métodos de preparar e utilizar tais copolímeros. tais copolímero têm pelo menos dois blocos: um primeiro bloco que tem pelo menos uma unidade que é hidrofílica em ph fisiológico, e um segundo bloco que tem grupos hidrofóbicos. este segundo bloco também tem pelo menos uma unidade com um grupo que é aniônico em cerca de ph fisiológico. os copolímeros descritos são disruptivos de uma membrana celular, incluindo uma membrana extracelular, uma membrana intracelular, uma vesícula, uma organela, um endossoma, um lipossoma, ou uma célula de eritrócito. preferivelmente, em certos exemplos, o copolímero rompe a membrana e entra no ambiente intracelular. em exemplos específicos, o copolímero é endossomolítico.
BRPI0912159A 2008-05-13 2009-05-13 copolímero compreendendo um primeiro bloco que compreende uma unidade hidrofílica em ph fisiológico e um segundo bloco que compreende grupos hidrofóbicos, e uso do dito copolímero para liberação intracelular de um polinucleotídeo BRPI0912159B8 (pt)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US5291408P 2008-05-13 2008-05-13
US5290808P 2008-05-13 2008-05-13
US9129408P 2008-08-22 2008-08-22
US11204808P 2008-11-06 2008-11-06
US11205408P 2008-11-06 2008-11-06
US12076908P 2008-12-08 2008-12-08
US14077908P 2008-12-24 2008-12-24
US14077408P 2008-12-24 2008-12-24
US17137709P 2009-04-21 2009-04-21
PCT/US2009/043847 WO2009140427A2 (en) 2008-05-13 2009-05-13 Diblock copolymers and polynucleotide complexes thereof for delivery into cells

Publications (3)

Publication Number Publication Date
BRPI0912159A2 BRPI0912159A2 (pt) 2015-10-13
BRPI0912159B1 BRPI0912159B1 (pt) 2019-11-05
BRPI0912159B8 true BRPI0912159B8 (pt) 2021-05-25

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ID=41319323

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Application Number Title Priority Date Filing Date
BRPI0912159A BRPI0912159B8 (pt) 2008-05-13 2009-05-13 copolímero compreendendo um primeiro bloco que compreende uma unidade hidrofílica em ph fisiológico e um segundo bloco que compreende grupos hidrofóbicos, e uso do dito copolímero para liberação intracelular de um polinucleotídeo

Country Status (13)

Country Link
US (3) US9476063B2 (pt)
EP (2) EP2281011B1 (pt)
JP (2) JP5911723B2 (pt)
KR (1) KR101661636B1 (pt)
CN (2) CN103342789B (pt)
AU (1) AU2009246327B8 (pt)
BR (1) BRPI0912159B8 (pt)
CA (3) CA3065577C (pt)
ES (1) ES2404131T3 (pt)
IL (1) IL209238A (pt)
MX (1) MX2010012238A (pt)
WO (1) WO2009140427A2 (pt)
ZA (1) ZA201008729B (pt)

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