BRPI0912412A2 - compostos de pirazina fundidos úteis para o tratamento de doenças degenerativas e inflamatórias. - Google Patents

compostos de pirazina fundidos úteis para o tratamento de doenças degenerativas e inflamatórias.

Info

Publication number: BRPI0912412A2
Authority: BR; Brazil
Prior art keywords: degenerative; treatment; inflammatory diseases; compounds useful; pyrazine compounds
Prior art date: 2008-05-07

Application number

BRPI0912412A

Other languages

English (en)

Inventor

Grégory Louis Joseph Bar

Hervé Van De Poel

Mark Stuart Chambers

Martin James Inglis Andrews

Original Assignee

Galapagos Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-05-07

Filing date

2009-05-06

Publication date

2016-07-26

2009-05-06 Application filed by Galapagos Nv filed Critical Galapagos Nv

2016-07-26 Publication of BRPI0912412A2 publication Critical patent/BRPI0912412A2/pt

Links

230000003412 degenerative effect Effects 0.000 title 1
208000027866 inflammatory disease Diseases 0.000 title 1
208000015122 neurodegenerative disease Diseases 0.000 title 1
150000003216 pyrazines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BRPI0912412A 2008-05-07 2009-05-06 compostos de pirazina fundidos úteis para o tratamento de doenças degenerativas e inflamatórias. BRPI0912412A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US12683308P	2008-05-07	2008-05-07
US14582709P	2009-01-20	2009-01-20
PCT/EP2009/055500 WO2009135885A1 (en)	2008-05-07	2009-05-06	Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases

Publications (1)

Publication Number	Publication Date
BRPI0912412A2 true BRPI0912412A2 (pt)	2016-07-26

Family

ID=40935606

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0912412A BRPI0912412A2 (pt)	2008-05-07	2009-05-06	compostos de pirazina fundidos úteis para o tratamento de doenças degenerativas e inflamatórias.

Country Status (20)

Country	Link
US (1)	US8012983B2 (pt)
EP (1)	EP2307426A1 (pt)
JP (1)	JP2011519897A (pt)
KR (1)	KR20110028445A (pt)
CN (1)	CN102036997A (pt)
AR (1)	AR071619A1 (pt)
AU (1)	AU2009245731A1 (pt)
BR (1)	BRPI0912412A2 (pt)
CA (1)	CA2723745A1 (pt)
CL (1)	CL2009001064A1 (pt)
CO (1)	CO6321159A2 (pt)
CR (1)	CR11823A (pt)
EA (1)	EA201071275A1 (pt)
IL (1)	IL209104A0 (pt)
MX (1)	MX2010011994A (pt)
PE (1)	PE20091880A1 (pt)
TW (1)	TW201002716A (pt)
UY (1)	UY31813A (pt)
WO (1)	WO2009135885A1 (pt)
ZA (1)	ZA201008759B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW201120043A (en) *	2009-11-05	2011-06-16	Galapagos Nv	Fused pyrazine compounds as their salts, useful for the treatment of degenerative and inflammatory diseases
EP3010922B1 (en) *	2013-06-19	2017-03-15	Galapagos NV	Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
EP3137454A1 (en)	2014-04-28	2017-03-08	Pfizer Inc.	Heteroaromatic compounds and their use as dopamine d1 ligands
MX388576B (es)	2016-06-07	2025-03-20	Jacobio Pharmaceuticals Co Ltd	Derivados heterociclicos novedosos utiles como inhibidores de shp2.
EA202190196A1 (ru)	2017-03-23	2021-08-31	Джакобио Фармасьютикалс Ко., Лтд.	Новые гетероциклические производные, применимые в качестве ингибиторов shp2
CN108379583B (zh)	2018-03-27	2021-08-17	北京大学	一种肿瘤转移药物治疗的靶标及其应用
US20210393623A1 (en)	2018-09-26	2021-12-23	Jacobio Pharmaceuticals Co., Ltd.	Novel Heterocyclic Derivatives Useful as SHP2 Inhibitors
CN113967214A (zh) *	2021-11-30	2022-01-25	广东药科大学	一种咪唑并吡嗪环丙烷甲酰胺类化合物的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6413776B1 (en)	1998-06-12	2002-07-02	Galapagos Geonomics N.V.	High throughput screening of gene function using adenoviral libraries for functional genomics applications
US20020132823A1 (en)	2001-01-17	2002-09-19	Jiahuai Han	Assay method
US7186832B2 (en)	2003-02-20	2007-03-06	Sugen Inc.	Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
US7893058B2 (en)	2006-05-15	2011-02-22	Janssen Pharmaceutica Nv	Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
PT2029602E (pt) *	2006-05-31	2010-07-08	Galapagos Nv	Compostos de triazolopirazina uteis para o tratamento de doenãas degenerativas e inflamatërias
WO2008138843A1 (en)	2007-05-10	2008-11-20	Galapagos N.V.	Imidazopyridines and triazolopyrimidines useful for the treatment of joint degenerative & inflammatory diseases
US8148369B2 (en) *	2007-05-10	2012-04-03	Janssen Pharmaceutica Nv	Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases

2009
- 2009-05-04 CL CL2009001064A patent/CL2009001064A1/es unknown
- 2009-05-04 AR ARP090101598A patent/AR071619A1/es unknown
- 2009-05-06 BR BRPI0912412A patent/BRPI0912412A2/pt not_active IP Right Cessation
- 2009-05-06 EA EA201071275A patent/EA201071275A1/ru unknown
- 2009-05-06 PE PE2009000625A patent/PE20091880A1/es not_active Application Discontinuation
- 2009-05-06 JP JP2011507918A patent/JP2011519897A/ja active Pending
- 2009-05-06 EP EP09742103A patent/EP2307426A1/en not_active Withdrawn
- 2009-05-06 KR KR1020107027298A patent/KR20110028445A/ko not_active Withdrawn
- 2009-05-06 CA CA2723745A patent/CA2723745A1/en not_active Abandoned
- 2009-05-06 AU AU2009245731A patent/AU2009245731A1/en not_active Abandoned
- 2009-05-06 WO PCT/EP2009/055500 patent/WO2009135885A1/en not_active Ceased
- 2009-05-06 US US12/436,219 patent/US8012983B2/en not_active Expired - Fee Related
- 2009-05-06 CN CN2009801163126A patent/CN102036997A/zh active Pending
- 2009-05-06 MX MX2010011994A patent/MX2010011994A/es not_active Application Discontinuation
- 2009-05-07 UY UY0001031813A patent/UY31813A/es unknown
- 2009-05-07 TW TW098115200A patent/TW201002716A/zh unknown
2010
- 2010-11-04 IL IL209104A patent/IL209104A0/en unknown
- 2010-12-03 CR CR11823A patent/CR11823A/es not_active Application Discontinuation
- 2010-12-03 CO CO10152830A patent/CO6321159A2/es not_active Application Discontinuation
- 2010-12-06 ZA ZA2010/08759A patent/ZA201008759B/en unknown

Also Published As

Publication number	Publication date
EP2307426A1 (en)	2011-04-13
AU2009245731A1 (en)	2009-11-12
JP2011519897A (ja)	2011-07-14
PE20091880A1 (es)	2009-12-28
US8012983B2 (en)	2011-09-06
CO6321159A2 (es)	2011-09-20
CN102036997A (zh)	2011-04-27
EA201071275A1 (ru)	2011-06-30
TW201002716A (en)	2010-01-16
CA2723745A1 (en)	2009-11-12
CR11823A (es)	2011-03-16
WO2009135885A1 (en)	2009-11-12
MX2010011994A (es)	2010-11-30
US20090286798A1 (en)	2009-11-19
IL209104A0 (en)	2011-01-31
UY31813A (es)	2010-01-05
AR071619A1 (es)	2010-06-30
CL2009001064A1 (es)	2009-10-09
ZA201008759B (en)	2011-08-31
KR20110028445A (ko)	2011-03-18

Legal Events

Date	Code	Title	Description
2016-09-13	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 4A, 5A, 6A E 7A ANUIDADES.
2017-01-10	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.
2021-06-01	B350	Update of information on the portal [chapter 15.35 patent gazette]

Publication	Publication Date	Title
BRPI1015569A2 (pt)	2016-08-16	compostos úteis para o tratamento de doenças degenerativas e inflamatórias.
BRPI0916862A2 (pt)	2016-02-10	compostos úteis para o tratamento de doenças degenerativas e inflamatórias
CY2019006I1 (el)	2020-05-29	Βελτιωμενα nanobodies τμ για τη θεραπεια διαταραχων που μεσολαβουνται απο συσσωματωματα
BRPI1014759A2 (pt)	2016-04-19	composto útil para o tratamento de doenças degenerativas e inflamatórias
BRPI0816784A2 (pt)	2015-03-24	Fatores neuro-endócrinos para o tratamento de doenças degenerativas
BRPI0716844A2 (pt)	2013-10-22	Inidores de quinase úteis para o tratamento de doenças proliferativas
BR112012001666A2 (pt)	2019-09-24	composições de proteína rsv f e métodos para fazer as mesmas
DK2504005T3 (da)	2014-01-13	Anvendelse af 1,3-diphenylprop-2-en-1-on-derivater til behandling af lever-sygdomme
BRPI0921321A2 (pt)	2018-10-16	métodos para o tratamento de indwcções e tumores
CR11019A (es)	2009-10-20	3-imidazolil-indoles para el tratamiento de enfermedades proliferativas
DK1874781T3 (da)	2009-11-02	Dihydrothienopyrimidiner til behandling af inflammatoriske sygdomme
BRPI0918527A2 (pt)	2015-12-01	compostos para o tratamento de disturbios do cns
BRPI0812221A2 (pt)	2014-12-16	Ácidos benzoilamino-indan-2-carboxílicos substituídos e compostos relacionados.
BRPI0911577A2 (pt)	2016-01-05	derivados espiro-indol para o tratamento de doenças parasíticas.
BRPI0912412A2 (pt)	2016-07-26	compostos de pirazina fundidos úteis para o tratamento de doenças degenerativas e inflamatórias.
BRPI1009783A2 (pt)	2016-03-08	compostos para o tratamento de distúrbios metabólicos.
BRPI0816712A2 (pt)	2016-11-08	terapia de intervalo para o tratamento de tinnitus
BRPI0914410A2 (pt)	2016-08-16	composição de polidesoxirribonucleotídeo injetável para o tratamento de doenças osteoarticulares.
BR112012004836A2 (pt)	2019-09-24	pirazinilpiridinas úteis para o tratamento de doenças proliferativas
BRPI0912687A2 (pt)	2016-01-26	uso de bactéria probiótica para o tratamento de hiperhomocisteinaemia
BRPI0818170A2 (pt)	2017-05-16	5-cianotienopiridinas para o tratamento de tumores.
DK2117565T3 (da)	2012-11-19	Anvendelse af chitosaner til behandlingen af negleinflammatoriske sygdomme
BRPI0818719A2 (pt)	2015-05-05	Composição para o tratamento de doença articular
BRPI0915130A2 (pt)	2019-09-24	derivado de ácido 7h-indolo{2,1-a]{2]-benzapina-10-carboxílico para o tratamento de hepatite c
BRPI0912679A2 (pt)	2016-01-26	composição farmacêutica para o tratamento de fibromialgia