BRPI0913901A2 - micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato - Google Patents

micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato

Info

Publication number
BRPI0913901A2
BRPI0913901A2 BRPI0913901A BRPI0913901A BRPI0913901A2 BR PI0913901 A2 BRPI0913901 A2 BR PI0913901A2 BR PI0913901 A BRPI0913901 A BR PI0913901A BR PI0913901 A BRPI0913901 A BR PI0913901A BR PI0913901 A2 BRPI0913901 A2 BR PI0913901A2
Authority
BR
Brazil
Prior art keywords
malate
biosynthesis
fumarate
microorganisms
acrylate
Prior art date
Application number
BRPI0913901A
Other languages
English (en)
Inventor
Anthony P Burgard
Mark J Burk
Priti Pharkya
Original Assignee
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Publication of BRPI0913901A2 publication Critical patent/BRPI0913901A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44Polycarboxylic acids
    • C12P7/46Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BRPI0913901A 2008-06-17 2009-06-17 micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato BRPI0913901A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7334808P 2008-06-17 2008-06-17
US7712708P 2008-06-30 2008-06-30
US8862808P 2008-08-13 2008-08-13
PCT/US2009/047715 WO2009155382A1 (en) 2008-06-17 2009-06-17 Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate

Publications (1)

Publication Number Publication Date
BRPI0913901A2 true BRPI0913901A2 (pt) 2016-12-13

Family

ID=41434434

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0913901A BRPI0913901A2 (pt) 2008-06-17 2009-06-17 micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato

Country Status (5)

Country Link
US (4) US8129154B2 (pt)
EP (1) EP2304039B1 (pt)
BR (1) BRPI0913901A2 (pt)
CA (1) CA2725549A1 (pt)
WO (1) WO2009155382A1 (pt)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673601B2 (en) * 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
WO2009094485A1 (en) 2008-01-22 2009-07-30 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
EP3450550A1 (en) * 2008-03-05 2019-03-06 Genomatica, Inc. Primary alcohol producing organisms
NO2265709T3 (pt) 2008-03-27 2018-04-07
AU2009242615A1 (en) * 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
BRPI0913901A2 (pt) 2008-06-17 2016-12-13 Genomatica Inc micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato
US20100021978A1 (en) * 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
US20100184173A1 (en) * 2008-11-14 2010-07-22 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
JP2012511928A (ja) * 2008-12-16 2012-05-31 ゲノマチカ, インク. 合成ガス及び他の炭素源の有用な製品への変換のための微生物及び方法
CA2754470A1 (en) * 2009-03-13 2010-09-16 Mascoma Corporation Mesophilic and thermophilic organisms modified to produce acrylate, and methods of use thereof
AU2010242789B2 (en) * 2009-04-30 2016-03-10 Genomatica, Inc. Organisms for the production of 1,3-butanediol
BRPI1013505A2 (pt) 2009-04-30 2018-02-14 Genomatica Inc organismos para a produção de isopropanol, n-butanol, e isobutanol
KR20200038334A (ko) 2009-05-07 2020-04-10 게노마티카 인코포레이티드 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법
WO2010132845A1 (en) * 2009-05-15 2010-11-18 Genomatica, Inc. Organisms for the production of cyclohexanone
US8420375B2 (en) * 2009-06-10 2013-04-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol
EP3190174A1 (en) 2009-08-05 2017-07-12 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
BR112012004594A2 (pt) 2009-09-01 2016-06-21 Novozymes Inc célula hospedeira fúngica filamentosa, e, método para produzir um ácido dicarboxílico
SG179048A1 (en) 2009-09-09 2012-04-27 Genomatica Inc Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
CN102762735B (zh) 2009-10-13 2016-08-03 基因组股份公司 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法
EP2491125A4 (en) 2009-10-23 2014-04-23 Genomatica Inc MICRO-ORGANISMS FOR THE MANUFACTURE OF ANILINE
SG181607A1 (en) 2009-12-10 2012-07-30 Genomatica Inc Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
PH12012501526A1 (en) 2010-01-29 2018-03-21 Genomatica Inc Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
WO2011100601A1 (en) 2010-02-11 2011-08-18 Metabolix, Inc. Process for gamma-butyrolactone production
US8637286B2 (en) * 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
EP2566969B1 (en) 2010-05-05 2019-09-04 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
WO2011153317A1 (en) 2010-06-04 2011-12-08 Novozymes, Inc. C4 dicarboxylic acid production in filamentous fungi
EP2582716A1 (en) 2010-06-21 2013-04-24 Novozymes, Inc. Aspergillus aculeatus derived polypeptides having c4-dicarboxylic acid transporter activity and polynucleotides encoding same
IN2013CN00459A (pt) 2010-06-21 2015-07-03 Novozymes Inc
CN103025877A (zh) 2010-07-26 2013-04-03 基因组股份公司 用于生物合成芳族化合物、2,4-戊二烯酸和1,3-丁二烯的微生物和方法
US9187772B2 (en) 2010-09-01 2015-11-17 University Of Florida Research Foundation, Inc. L-malate production by metabolically engineered escherichia coli
CN103502429B (zh) 2010-10-28 2018-07-17 道达尔研究技术弗吕股份有限公司 使用红曲霉来生产聚乳酸的方法
WO2012103263A2 (en) * 2011-01-25 2012-08-02 Finley Kenneth R Compositions and methods for malate and fumarate production
US20130309736A1 (en) * 2011-01-25 2013-11-21 Cargill, Incorporated Compositions and methods for malate and fumarate production
CA2825525A1 (en) 2011-01-25 2012-08-02 Jeanette M. HURYTA Compositions and methods for succinate production
WO2012118848A1 (en) 2011-02-28 2012-09-07 Novozymes, Inc. Microorganism for c4-dicarboxylic acid production
WO2013188546A2 (en) * 2012-06-15 2013-12-19 Invista Technologies S.À.R.L. Methods for biosynthesizing 1,3 butadiene
BR112013032516A2 (pt) 2011-06-17 2017-03-01 Invista Tech Sarl método de biosintetizar butadieno e método para produzir butadieno
US9422578B2 (en) 2011-06-17 2016-08-23 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
CN103917649A (zh) 2011-08-19 2014-07-09 诺维信股份有限公司 用于生产c4-二羧酸的重组微生物
IN2014CN01258A (pt) * 2011-08-19 2015-04-24 Genomatica Inc
CN102321683B (zh) * 2011-09-30 2014-05-28 常茂生物化学工程股份有限公司 采用发酵法制备富马酸发酵液及富马酸发酵液分离提取纯品富马酸的方法
CN104321434A (zh) * 2011-12-02 2015-01-28 英威达技术有限责任公司 生物合成1,3丁二烯的方法
CN104350034B (zh) 2012-06-08 2018-07-31 Cj 第一制糖株式会社 可再生丙烯酸生产和自其制备的产物
MY172692A (en) 2012-07-13 2019-12-10 Calysta Inc Biorefinery system, methods and compositions thereof
US9850507B2 (en) 2012-07-25 2017-12-26 Cargill, Incorporated Yeast cells having reductive TCA pathway from pyruvate to succinate and overexpressing an exogenous NAD(P)+ transhydrogenase enzyme
KR101974221B1 (ko) * 2012-08-24 2019-04-30 성균관대학교산학협력단 유기산 생산을 위한 재조합 미생물 및 이를 이용한 유기산 제조방법
CN104822824A (zh) 2012-10-15 2015-08-05 凯利斯塔公司 用于烃的生物氧化的遗传工程改造的微生物
US9777295B2 (en) 2012-11-28 2017-10-03 Invista North America S.A.R.L. Methods for biosynthesis of isobutene
WO2014152434A2 (en) 2013-03-15 2014-09-25 Genomatica, Inc. Microorganisms and methods for producing butadiene and related compounds by formate assimilation
US10294496B2 (en) 2013-07-19 2019-05-21 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
WO2015021059A1 (en) 2013-08-05 2015-02-12 INVISTA North America S.á r.l. Methods for biosynthesis of isobutene
WO2015021045A2 (en) 2013-08-05 2015-02-12 INVISTA North America S.á r.l. Methods for biosynthesis of isoprene
CN103627721B (zh) * 2013-10-22 2015-08-05 浙江工业大学 G6PDH基因在提高黑根霉对甾体C11α-羟基化能力中的应用及菌株
US10808262B2 (en) 2013-12-03 2020-10-20 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis
EP3744830B1 (en) 2013-12-27 2023-11-22 Genomatica, Inc. Methods and organisms with increased carbon flux efficiencies
KR102208963B1 (ko) * 2014-05-14 2021-01-28 삼성전자주식회사 신규한 아크릴산 생성 경로를 갖는 미생물 및 이를 이용한 아크릴산 생산 방법
US9920339B2 (en) 2014-06-16 2018-03-20 Invista North America S.A.R.L. Methods, reagents and cells for biosynthesizing compounds
JP6620373B2 (ja) * 2014-06-30 2019-12-18 Jmtcエンザイム株式会社 形質転換体およびその製造方法、ならびに炭素数4のジカルボン酸の製造方法
CN107208118A (zh) 2014-09-18 2017-09-26 基因组股份公司 具有提高的能源效率的非天然微生物
JP7025932B2 (ja) * 2016-02-04 2022-02-25 花王株式会社 変異リゾプス属菌
JP6944748B2 (ja) * 2016-06-29 2021-10-06 花王株式会社 C4ジカルボン酸の製造方法
CN106222122A (zh) * 2016-07-20 2016-12-14 江南大学 大肠杆菌工程菌及其催化马来酸合成富马酸的方法
WO2019006255A1 (en) 2017-06-30 2019-01-03 Invista North America S.A.R.L. METHODS, MATERIALS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS AND DERIVATIVES
US11162115B2 (en) 2017-06-30 2021-11-02 Inv Nylon Chemicals Americas, Llc Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
CN110951660B (zh) * 2019-12-19 2021-12-03 江南大学 一株固定co2产苹果酸的大肠杆菌工程菌的构建及应用
CN112195117B (zh) * 2020-09-18 2022-05-03 安徽瑞邦生物科技有限公司 一株大肠杆菌及其在生物催化生产低副产物烟酰胺中的应用
EP4086912B1 (en) * 2021-05-06 2024-07-10 Tata Consultancy Services Limited A method and a system for profiling of a metagenome sample
WO2023049786A2 (en) * 2021-09-24 2023-03-30 Nitto Denko Corporation Yeast cells with improved tolerance to acrylic acid
WO2023049789A2 (en) * 2021-09-24 2023-03-30 Nitto Denko Corporation Yeast cells with reduced propensity to degrade acrylic acid
CN113846024B (zh) * 2021-12-01 2022-03-29 南京昊禾生物科技有限公司 一种降低l-苹果酸发酵过程中副产物富马酸的方法、菌种及应用
CN116103213B (zh) * 2023-01-31 2025-11-04 江南大学 一种代谢工程改造大肠杆菌生产富马酸的方法

Family Cites Families (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3513209A (en) 1968-08-19 1970-05-19 Du Pont Method of making 1,4-cyclohexadiene
US4076948A (en) 1968-10-10 1978-02-28 El Paso Products Company Process for treatment of adipic acid mother liquor
GB1230276A (pt) 1968-12-09 1971-04-28
US3965182A (en) 1969-10-02 1976-06-22 Ethyl Corporation Preparation of aniline from phenol and ammonia
JPS4831084B1 (pt) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
JPS5543759B2 (pt) 1972-06-28 1980-11-07
DE2455617C3 (de) 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
US4190495A (en) 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
US4344002A (en) 1978-02-22 1982-08-10 Supertex, Inc. Detection circuit and structure therefor
US4301077A (en) 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
JPS60114197A (ja) 1983-11-25 1985-06-20 Agency Of Ind Science & Technol 微生物によるジカルボン酸の製造法
US4871667A (en) 1984-11-26 1989-10-03 Agency Of Industrial Science & Technology Process for preparing muconic acid
US4652685A (en) 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
EP0249773B1 (en) 1986-06-11 1992-12-16 Michigan Biotechnology Institute A process for the production of succinic acid by anaerobic fermentation
US5168055A (en) 1986-06-11 1992-12-01 Rathin Datta Fermentation and purification process for succinic acid
US5143834A (en) 1986-06-11 1992-09-01 Glassner David A Process for the production and purification of succinic acid
US5182199A (en) 1987-05-27 1993-01-26 Hartley Brian S Thermophilic ethanol production in a two-stage closed system
DE68923805T2 (de) 1988-04-27 1995-12-07 Daicel Chem Verfahren zur herstellung von optisch aktivem 1,3-butanediol.
JP3043063B2 (ja) 1989-04-27 2000-05-22 バイオコントロール システムズ インコーポレイテッド 微生物のための沈澱テスト
US5192673A (en) 1990-04-30 1993-03-09 Michigan Biotechnology Institute Mutant strain of C. acetobutylicum and process for making butanol
US5079143A (en) * 1990-05-02 1992-01-07 The Upjohn Company Method of indentifying compounds useful as antiparasitic drugs
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
US5416020A (en) 1992-09-29 1995-05-16 Bio-Technical Resources Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
US6136577A (en) 1992-10-30 2000-10-24 Bioengineering Resources, Inc. Biological production of ethanol from waste gases with Clostridium ljungdahlii
FR2702492B1 (fr) 1993-03-12 1995-05-24 Rhone Poulenc Chimie Procédé de production par fermentation d'acide itaconique.
US5487987A (en) 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5700934A (en) 1995-03-01 1997-12-23 Dsm N.V. Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors
US5478952A (en) 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
FR2736927B1 (fr) 1995-07-18 1997-10-17 Rhone Poulenc Fibres & Polymer Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes
US5573931A (en) 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
US5869301A (en) 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5770435A (en) 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
WO1997032012A1 (en) 1996-02-27 1997-09-04 Michigan State University Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39e secondary-alcohol dehydrogenase and enzyme biochemical characterization
US5958745A (en) 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
DE69638265D1 (de) 1996-07-01 2010-11-11 Emmaus Foundation Inc BIOLOGISCHE HESTELLUNG VON ESSIGSäURE AUS ABGASEN
KR100459818B1 (ko) 1996-09-02 2004-12-03 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 ε-카프로락탐의 제조방법
EP0977865A1 (en) 1997-02-13 2000-02-09 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
KR100516986B1 (ko) 1997-02-19 2005-09-26 코닌클리즈케 디에스엠 엔.브이. 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법
US6274790B1 (en) 1997-04-14 2001-08-14 The University Of British Columbia Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis
KR19990013007A (ko) 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ss373(kctc 8818p)과 이를 이용한숙신산의 생산방법
ATE356137T1 (de) * 1997-08-04 2007-03-15 Millennium Pharm Inc Neue moleküle aus der familie der tango-77- ähnlichen proteine und ihre verewendungen.
JPH11103863A (ja) 1997-10-08 1999-04-20 Nippon Shokubai Co Ltd マレイン酸異性化酵素遺伝子
US6280986B1 (en) 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
US20030087381A1 (en) 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
EP2194122B1 (en) 1998-04-13 2015-12-02 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
US6432686B1 (en) 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US6444784B1 (en) 1998-05-29 2002-09-03 Exxonmobil Research & Engineering Company Wax crystal modifiers (LAW657)
DE19856136C2 (de) 1998-12-04 2002-10-24 Pasteur Institut Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension
EP1147229A2 (en) 1999-02-02 2001-10-24 Bernhard O. Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
US6365376B1 (en) 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
EP1159435A1 (en) 1999-03-05 2001-12-05 Monsanto Technology LLC Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
WO2000071738A1 (en) * 1999-05-21 2000-11-30 Cargill Dow Llc Methods and materials for the synthesis of organic products
US6852517B1 (en) 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6660857B2 (en) 2000-02-03 2003-12-09 Dsm N.V. Process for the preparation of ε-caprolactam
WO2002008438A2 (en) 2000-07-25 2002-01-31 Bioengineering Resources, Inc. Methods for increasing the production of ethanol from microbial fermentation
US7233567B1 (en) * 2000-09-22 2007-06-19 Nortel Networks Limited Apparatus and method for supporting multiple traffic redundancy mechanisms
CA2429039A1 (en) 2000-11-20 2002-05-30 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
JP2004521619A (ja) * 2000-11-22 2004-07-22 カージル ダウ ポリマーズ エルエルシー 有機生成物の合成のための方法及び材料
CN1358841A (zh) 2000-12-11 2002-07-17 云南省微生物研究所 云南链霉菌
CN1491282A (zh) 2000-12-28 2004-04-21 丰田自动车株式会社 异戊二烯醇的制备方法
US7711490B2 (en) 2001-01-10 2010-05-04 The Penn State Research Foundation Method and system for modeling cellular metabolism
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
WO2002070730A2 (en) 2001-03-01 2002-09-12 The Regents Of The University Of California Models and methods for determining systemic properties of regulated reaction networks
US6743610B2 (en) 2001-03-30 2004-06-01 The University Of Chicago Method to produce succinic acid from raw hydrolysates
CA2356540A1 (en) 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
WO2003040690A2 (en) 2001-11-02 2003-05-15 Rice University Recycling system for manipulation of intracellular nadh availability
EP1575881B1 (en) 2002-01-18 2009-05-27 Novozymes A/S Alanine 2,3- aminomutase
WO2003066863A1 (fr) 2002-02-06 2003-08-14 Showa Denko K.K. Gene reductase d'un compose carbonyle alpha-substitue-alpha, beta-insature
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
WO2003082214A2 (en) 2002-03-29 2003-10-09 Genomatica, Inc. Human metabolic models and methods
WO2003095651A1 (fr) 2002-05-10 2003-11-20 Kyowa Hakko Kogyo Co., Ltd. Procede de production d'acide mevalonique
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
JP4418793B2 (ja) 2002-07-10 2010-02-24 ザ ペン ステート リサーチ ファウンデーション 遺伝子ノックアウト戦略を決定する方法
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
WO2004007688A2 (en) 2002-07-15 2004-01-22 Kosan Biosciences, Inc. Metabolic pathways for starter units in polyketide biosynthesis
ES2356526T3 (es) 2002-10-04 2011-04-08 E.I. Du Pont De Nemours And Company Procedimiento para la producción biológica de 1,3-propanodiol con elevado rendimiento.
US7734420B2 (en) 2002-10-15 2010-06-08 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
US20040152159A1 (en) 2002-11-06 2004-08-05 Causey Thomas B. Materials and methods for the efficient production of acetate and other products
JP4275666B2 (ja) 2003-02-24 2009-06-10 財団法人地球環境産業技術研究機構 微生物による高効率水素製造方法
WO2004092344A2 (en) * 2003-04-14 2004-10-28 E. I. Du Pont De Nemours And Company A method for preparing para-hydroxystyrene by biocatalytic decarboxylation of para-hydroxycinnamic acid in a biphasic reaction medium
US7927859B2 (en) 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
CN1852978A (zh) 2003-09-17 2006-10-25 三菱化学株式会社 制备无-氨基有机酸的方法
US7244610B2 (en) 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
FR2864967B1 (fr) 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
US7491520B2 (en) 2004-01-19 2009-02-17 Dsm Ip Assets B.V. Biochemical synthesis of 6-amino caproic acid
US7262046B2 (en) 2004-08-09 2007-08-28 Rice University Aerobic succinate production in bacteria
CN101044245B (zh) 2004-08-27 2012-05-02 莱斯大学 具有增加的琥珀酸产量的突变大肠杆菌菌株
EP1790721A4 (en) 2004-09-09 2008-12-10 Res Inst Innovative Tech Earth DNA FRAGMENT WITH PROMOTER FUNCTION
CN101023178A (zh) 2004-09-17 2007-08-22 莱斯大学 高琥珀酸产出细菌
WO2006069174A2 (en) 2004-12-22 2006-06-29 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
JP2006204255A (ja) 2005-01-31 2006-08-10 Canon Inc アセチル−CoAアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法
DK1760156T3 (da) * 2005-08-10 2013-03-18 Univ Florida Materialer og fremgangsmåder til effektiv mælkesyrefremstilling
KR100679638B1 (ko) 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 d 또는 e를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
KR100676160B1 (ko) * 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
WO2007030830A2 (en) * 2005-09-09 2007-03-15 Genomatica, Inc. Methods and organisms for the growth-coupled production of succinate
WO2007050671A2 (en) 2005-10-26 2007-05-03 E. I. Du Pont De Nemours And Company Fermentive production of four carbon alcohols
US7334808B2 (en) 2005-11-18 2008-02-26 Fatzinger Edward C Tow device
US8962298B2 (en) 2006-05-02 2015-02-24 Butamax Advanced Biofuels Llc Recombinant host cell comprising a diol dehydratase
US7712708B2 (en) 2006-06-05 2010-05-11 Illinios Tool Works Inc. Fastener clip
WO2008013996A2 (en) * 2006-07-27 2008-01-31 Gevo Inc. Engineered microorganisms for increasing product yield in biotransformations, related methods and systems
US8673601B2 (en) 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
PL2137315T3 (pl) 2007-03-16 2015-02-27 Genomatica Inc Kompozycje i sposoby do biosyntezy 1,4-butanodiolu i jego prekursorów
US20080293125A1 (en) 2007-04-18 2008-11-27 Gevo, Inc. Engineered microorganisms for producing isopropanol
US20080274522A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of 2-butanone
EP2017344A1 (en) 2007-07-20 2009-01-21 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Production of itaconic acid
US8285554B2 (en) * 2007-07-27 2012-10-09 Dsp Group Limited Method and system for dynamic aliasing suppression
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
BRPI0814995A2 (pt) 2007-08-10 2015-02-03 Genomatica Inc Métodos para a síntese de olefinas e derivados
WO2009049274A2 (en) 2007-10-12 2009-04-16 The Regents Of The University Of California Microorganism engineered to produce isopropanol
WO2009094485A1 (en) 2008-01-22 2009-07-30 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
WO2009103026A1 (en) 2008-02-15 2009-08-20 Gevo, Inc. Engineered microorganisms for producing isopropanol
EP3450550A1 (en) 2008-03-05 2019-03-06 Genomatica, Inc. Primary alcohol producing organisms
NO2265709T3 (pt) 2008-03-27 2018-04-07
AU2009242615A1 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
BRPI0913901A2 (pt) 2008-06-17 2016-12-13 Genomatica Inc micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato
US20100021978A1 (en) 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
EP2334800B1 (en) 2008-09-10 2018-12-26 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
US8354563B2 (en) 2008-10-16 2013-01-15 Maverick Biofuels, Inc. Methods and apparatus for synthesis of alcohols from syngas
US20100184173A1 (en) 2008-11-14 2010-07-22 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
JP2012511928A (ja) 2008-12-16 2012-05-31 ゲノマチカ, インク. 合成ガス及び他の炭素源の有用な製品への変換のための微生物及び方法
BRPI1013505A2 (pt) 2009-04-30 2018-02-14 Genomatica Inc organismos para a produção de isopropanol, n-butanol, e isobutanol
AU2010242789B2 (en) 2009-04-30 2016-03-10 Genomatica, Inc. Organisms for the production of 1,3-butanediol
KR20200038334A (ko) 2009-05-07 2020-04-10 게노마티카 인코포레이티드 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법
WO2010132845A1 (en) 2009-05-15 2010-11-18 Genomatica, Inc. Organisms for the production of cyclohexanone
MY187676A (en) 2009-06-04 2021-10-08 Genomatica Inc Microorganisms for the production of 1,4-butanediol and related methods
VN29235A1 (pt) 2009-06-04 2012-03-26
US8420375B2 (en) 2009-06-10 2013-04-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol
SG179048A1 (en) 2009-09-09 2012-04-27 Genomatica Inc Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
CN102762735B (zh) 2009-10-13 2016-08-03 基因组股份公司 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法
EP2491125A4 (en) 2009-10-23 2014-04-23 Genomatica Inc MICRO-ORGANISMS FOR THE MANUFACTURE OF ANILINE
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
SG181607A1 (en) 2009-12-10 2012-07-30 Genomatica Inc Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol
PH12012501526A1 (en) 2010-01-29 2018-03-21 Genomatica Inc Microorganisms and methods for the biosynthesis of p-toluate and terephthalate
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US20110312049A1 (en) 2010-04-13 2011-12-22 Osterhout Robin E Microorganisms and methods for the production of ethylene glycol
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
EP2566969B1 (en) 2010-05-05 2019-09-04 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
CN103025877A (zh) 2010-07-26 2013-04-03 基因组股份公司 用于生物合成芳族化合物、2,4-戊二烯酸和1,3-丁二烯的微生物和方法
WO2012082978A1 (en) 2010-12-17 2012-06-21 Genomatica, Inc. Microorganisms and methods for the production of 1.4- cyclohexanedimethanol
EP2670852A4 (en) 2011-02-02 2017-04-26 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
JP5742362B2 (ja) 2011-03-28 2015-07-01 富士通株式会社 退避処理装置

Also Published As

Publication number Publication date
EP2304039B1 (en) 2019-08-21
EP2304039A1 (en) 2011-04-06
US20180363012A1 (en) 2018-12-20
WO2009155382A1 (en) 2009-12-23
US9689006B2 (en) 2017-06-27
US11525149B2 (en) 2022-12-13
US9062330B2 (en) 2015-06-23
US20100009419A1 (en) 2010-01-14
US8129154B2 (en) 2012-03-06
CA2725549A1 (en) 2009-12-23
US20160017382A1 (en) 2016-01-21
US20120237990A1 (en) 2012-09-20
EP2304039A4 (en) 2012-11-07

Similar Documents

Publication Publication Date Title
BRPI0913901A2 (pt) micro-organismos e métodos para a biossíntese de fumarato, malato e acrilato
BRPI0806898A2 (pt) Inibidores de mek
EP2236375A4 (en) Driving supporting device, driving supporting method, and driving supporting program
IL179344A0 (en) Tracking method
ZA201101849B (en) Information presenting device
GB0822937D0 (en) Microorganism
BRPI0911077A2 (pt) método para tratamento de biomassa
GB0820262D0 (en) Microorganisms
EP2381415A4 (en) Person-judging device, method, and program
EP2249503A4 (en) DECODING DEVICE, DECODING METHOD AND PROGRAM THEREFOR
EP2230910A4 (en) PRE-SURGICAL TREATMENT
BRPI0717826A2 (pt) Métodos para produzir um l-aminoácido, e para produzir um alquil-éster inferior de alfa-l-aspartil-l-fenil-alanina
EP2374521A4 (en) METHOD AND DEVICE FOR GAS LIQUID REPLACEMENT
ZA201008214B (en) 5-lipoxygenase-activating protein inhibitor
EP2352438A4 (en) SEAM DEVICE
GB0821049D0 (en) Tracking device,system and method
GB0812318D0 (en) Microorganism
EP2345713A4 (en) CONCENTRATED CULTURE SOLUTION AND USE METHOD THEREOF
AP2011005623A0 (en) Phosphodiestarase inhibitors.
EP2322966A4 (en) MICROSCOPE AND ITS CONTROL METHOD
GB2464301B (en) A tracking device and method of operation
EP2291754A4 (en) Media foundation source reader
GB0817429D0 (en) Enzyme inhibitors
GB0600228D0 (en) Inactivation method
TWI368170B (en) Interruption-based concurrent profiling method

Legal Events

Date Code Title Description
B15I Others concerning applications: loss of priority

Free format text: PERDA DAS PRIORIDADES US 61/073,348 DE 17/06/2008, US 61/077,127 DE 30/06/2008 E US 61/088,628 DE 13/08/2008 REIVINDICADAS NO PCT/US2009/047715 POR NAO CUMPRIMENTO DA EXIGENCIA PUBLICADA NA RPI 2389 DE 18/10/2016 DE MANEIRA SATISFATORIA. O DIREITO DE PRIORIDADE NAO PODE SER EXTRAPOLADO DE UM PEDIDO PARA OUTRO, DESTA FORMA, A CESSAO ENVIADA PARA O PEDIDO DE PATENTE US 12/486,724 DE 17/06/2009, MESMO ESTE REIVINDICANDO AS PRIORIDADES SOLICITADAS NO PEDIDO, NAO PODE SER CONSIDERADA VALIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]