BRPI0914305B8 - compostos de piridazina carboxamida substituída como compostos inibidores da quinase, uso dos compostos e uso de uma composição compreendendo os compostos - Google Patents

compostos de piridazina carboxamida substituída como compostos inibidores da quinase, uso dos compostos e uso de uma composição compreendendo os compostos

Info

Publication number
BRPI0914305B8
BRPI0914305B8 BRPI0914305A BRPI0914305A BRPI0914305B8 BR PI0914305 B8 BRPI0914305 B8 BR PI0914305B8 BR PI0914305 A BRPI0914305 A BR PI0914305A BR PI0914305 A BRPI0914305 A BR PI0914305A BR PI0914305 B8 BRPI0914305 B8 BR PI0914305B8
Authority
BR
Brazil
Prior art keywords
compounds
kinase inhibitor
composition
substituted carboxamide
pyridazine
Prior art date
Application number
BRPI0914305A
Other languages
English (en)
Inventor
Liang Congxin
Li Zhigang
Original Assignee
Xcovery Holding Co Llc
Xcovery Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xcovery Holding Co Llc, Xcovery Holdings Inc filed Critical Xcovery Holding Co Llc
Publication of BRPI0914305A2 publication Critical patent/BRPI0914305A2/pt
Publication of BRPI0914305B1 publication Critical patent/BRPI0914305B1/pt
Publication of BRPI0914305B8 publication Critical patent/BRPI0914305B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

compostos de piridazina carboxamida substituída como compostos inibidores da quinase os derivados de piridazina têm propriedades de droga inesperadas como inibidores da proteína quinase e são úteis no tratamento de distúrbios relacionados a atividades anormais da proteína quinase, tais como câncer.
BRPI0914305A 2008-06-19 2009-06-18 compostos de piridazina carboxamida substituída como compostos inibidores da quinase, uso dos compostos e uso de uma composição compreendendo os compostos BRPI0914305B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13250508P 2008-06-19 2008-06-19
US61/132,505 2008-06-19
PCT/US2009/003654 WO2009154769A1 (en) 2008-06-19 2009-06-18 Substituted pyridazine carboxamide compounds as kinase inhibitor compounds

Publications (3)

Publication Number Publication Date
BRPI0914305A2 BRPI0914305A2 (pt) 2015-08-11
BRPI0914305B1 BRPI0914305B1 (pt) 2021-05-11
BRPI0914305B8 true BRPI0914305B8 (pt) 2021-05-25

Family

ID=41434356

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0914305A BRPI0914305B8 (pt) 2008-06-19 2009-06-18 compostos de piridazina carboxamida substituída como compostos inibidores da quinase, uso dos compostos e uso de uma composição compreendendo os compostos

Country Status (15)

Country Link
US (3) US8697866B2 (pt)
EP (2) EP2303018B1 (pt)
JP (1) JP5670325B2 (pt)
KR (1) KR101691640B1 (pt)
CN (1) CN102098917B (pt)
AU (1) AU2009260810B2 (pt)
BR (1) BRPI0914305B8 (pt)
CA (1) CA2728408C (pt)
ES (2) ES2551899T3 (pt)
IL (1) IL210099A (pt)
MX (1) MX2010014171A (pt)
NZ (1) NZ590542A (pt)
PL (1) PL2303018T3 (pt)
RU (1) RU2526618C2 (pt)
WO (1) WO2009154769A1 (pt)

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KR101691640B1 (ko) * 2008-06-19 2016-12-30 엑스커버리 홀딩 컴퍼니 엘엘씨 키나아제 억제제 화합물로서의 치환된 피리다진 카르복사마이드 화합물
WO2011117286A1 (en) * 2010-03-23 2011-09-29 Basf Se Pyridazine compounds for controlling invertebrate pests
EA025030B1 (ru) * 2010-10-08 2016-11-30 Икскавери Холдинг Кампани, Ллс Соединение {5-[(1r)-1-(2,6-дихлор-3-фторфенил)этокси]-6-аминопиридазин-3-ил}-n-(1-метил-6-оксо-1,6-дигидропиридин-3-ил)карбоксамид в качестве киназного ингибитора
EP2625176B1 (en) 2010-10-08 2016-08-17 Xcovery Holding Company LLC Substitututed 6-amino-pyridazin-3-yl-carboxamide compounds as protein kinase modulators
WO2014048939A1 (en) 2012-09-26 2014-04-03 F. Hoffmann-La Roche Ag Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
CN102952091A (zh) * 2012-10-19 2013-03-06 盛世泰科生物医药技术(苏州)有限公司 一种4-氨基异恶唑盐酸盐的合成方法
RU2550346C2 (ru) * 2013-09-26 2015-05-10 Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
TWI646094B (zh) * 2016-06-01 2019-01-01 大陸商貝達藥業股份有限公司 Crystal form of inhibitory protein kinase active compound and application thereof
JP2021532181A (ja) * 2018-07-24 2021-11-25 エピザイム，インク． Ｓｍａｒｃａ２アンタゴニストとして有用なピリジン−２−オン化合物
WO2020128020A2 (de) * 2018-12-21 2020-06-25 Saltigo Gmbh Verfahren zur herstellung von 2-alkoxy-4-amino-5-methyl-pyridinen und/oder von 2-alkoxy-4-alkylamino-5-methyl-pyridinen
CN112457268A (zh) * 2020-12-11 2021-03-09 平江县吉成科技有限责任公司 一种温和的4-氨基异恶唑盐酸盐的合成方法
CN116082110B (zh) * 2023-01-09 2024-04-12 北京肿瘤医院(北京大学肿瘤医院) 一种11c标记靶向间变性淋巴瘤激酶alk突变分子探针及应用

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Also Published As

Publication number Publication date
AU2009260810B2 (en) 2015-09-17
US20160176900A1 (en) 2016-06-23
CN102098917B (zh) 2016-03-16
KR101691640B1 (ko) 2016-12-30
BRPI0914305B1 (pt) 2021-05-11
BRPI0914305A2 (pt) 2015-08-11
RU2526618C2 (ru) 2014-08-27
JP5670325B2 (ja) 2015-02-18
IL210099A (en) 2015-11-30
IL210099A0 (en) 2011-02-28
WO2009154769A1 (en) 2009-12-23
KR20110044974A (ko) 2011-05-03
US8697866B2 (en) 2014-04-15
EP2303018A4 (en) 2012-06-20
NZ590542A (en) 2012-12-21
RU2011139352A (ru) 2013-04-10
EP3061752B1 (en) 2018-02-21
ES2551899T3 (es) 2015-11-24
EP2303018B1 (en) 2015-10-14
US9296724B2 (en) 2016-03-29
CA2728408C (en) 2017-12-05
CN102098917A (zh) 2011-06-15
PL2303018T3 (pl) 2016-06-30
ES2670665T3 (es) 2018-05-31
US20140221376A1 (en) 2014-08-07
EP3061752A1 (en) 2016-08-31
JP2011524905A (ja) 2011-09-08
EP2303018A1 (en) 2011-04-06
US20110160209A1 (en) 2011-06-30
MX2010014171A (es) 2011-07-04
CA2728408A1 (en) 2009-12-23
AU2009260810A1 (en) 2009-12-23

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25F Entry of change of name and/or headquarter and transfer of application, patent and certif. of addition of invention: change of name on requirement

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