BRPI0914305A2 - Compostos de piridazina carboxamida substituída como compostos inibidores da quinase - Google Patents
Compostos de piridazina carboxamida substituída como compostos inibidores da quinaseInfo
- Publication number
- BRPI0914305A2 BRPI0914305A2 BRPI0914305-0A BRPI0914305A BRPI0914305A2 BR PI0914305 A2 BRPI0914305 A2 BR PI0914305A2 BR PI0914305 A BRPI0914305 A BR PI0914305A BR PI0914305 A2 BRPI0914305 A2 BR PI0914305A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- kinase inhibitor
- substituted carboxamide
- carboxamide pyridazine
- inhibitor compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13250508P | 2008-06-19 | 2008-06-19 | |
| US61/132,505 | 2008-06-19 | ||
| PCT/US2009/003654 WO2009154769A1 (en) | 2008-06-19 | 2009-06-18 | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0914305A2 true BRPI0914305A2 (pt) | 2015-08-11 |
| BRPI0914305B1 BRPI0914305B1 (pt) | 2021-05-11 |
| BRPI0914305B8 BRPI0914305B8 (pt) | 2021-05-25 |
Family
ID=41434356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0914305A BRPI0914305B8 (pt) | 2008-06-19 | 2009-06-18 | compostos de piridazina carboxamida substituída como compostos inibidores da quinase, uso dos compostos e uso de uma composição compreendendo os compostos |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8697866B2 (pt) |
| EP (2) | EP3061752B1 (pt) |
| JP (1) | JP5670325B2 (pt) |
| KR (1) | KR101691640B1 (pt) |
| CN (1) | CN102098917B (pt) |
| AU (1) | AU2009260810B2 (pt) |
| BR (1) | BRPI0914305B8 (pt) |
| CA (1) | CA2728408C (pt) |
| ES (2) | ES2551899T3 (pt) |
| IL (1) | IL210099A (pt) |
| MX (1) | MX2010014171A (pt) |
| NZ (1) | NZ590542A (pt) |
| PL (1) | PL2303018T3 (pt) |
| RU (1) | RU2526618C2 (pt) |
| WO (1) | WO2009154769A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5670325B2 (ja) * | 2008-06-19 | 2015-02-18 | エックスカバリー ホールディング カンパニー エルエルシー | キナーゼ阻害化合物としての置換されたピリダジンカルボキサミド化合物 |
| WO2011117286A1 (en) * | 2010-03-23 | 2011-09-29 | Basf Se | Pyridazine compounds for controlling invertebrate pests |
| CA2813580C (en) * | 2010-10-08 | 2017-12-05 | Xcovery Holding Company, Llc | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds |
| PL2625176T3 (pl) * | 2010-10-08 | 2017-08-31 | Xcovery Holding Company Llc | Podstawione związki 6-amino-pirydazyn-3-ylo-karboksyamidu jako modulatory kinazy białkowej |
| AU2013322736A1 (en) * | 2012-09-26 | 2015-02-26 | F. Hoffmann-La Roche Ag | Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use |
| CN102952091A (zh) * | 2012-10-19 | 2013-03-06 | 盛世泰科生物医药技术(苏州)有限公司 | 一种4-氨基异恶唑盐酸盐的合成方法 |
| RU2550346C2 (ru) * | 2013-09-26 | 2015-05-10 | Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" | Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний |
| TWI646094B (zh) * | 2016-06-01 | 2019-01-01 | 大陸商貝達藥業股份有限公司 | Crystal form of inhibitory protein kinase active compound and application thereof |
| MA53377A (fr) * | 2018-07-24 | 2021-06-02 | Epizyme Inc | Composés de pyridin-2-one utiles en tant qu'antagonistes de smarca2 |
| CN113242853B (zh) * | 2018-12-21 | 2025-06-24 | 赛拓有限责任公司 | 用于制备2-烷氧基-4-氨基-5-甲基-吡啶和/或2-烷氧基-4-烷基氨基-5-甲基-吡啶的方法 |
| CN112457268A (zh) * | 2020-12-11 | 2021-03-09 | 平江县吉成科技有限责任公司 | 一种温和的4-氨基异恶唑盐酸盐的合成方法 |
| CN116082110B (zh) * | 2023-01-09 | 2024-04-12 | 北京肿瘤医院(北京大学肿瘤医院) | 一种11c标记靶向间变性淋巴瘤激酶alk突变分子探针及应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4369172A (en) | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| DE3583799D1 (de) | 1985-01-11 | 1991-09-19 | Abbott Lab Ltd | Feste zubereitung mit langsamer freisetzung. |
| JP2773959B2 (ja) | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| UA73092C2 (uk) | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
| DE69924735T2 (de) | 1998-07-28 | 2006-01-19 | Tanabe Seiyaku Co., Ltd. | Zur wirkstoffabgabe an zielorten im darm fähige zubereitung |
| US6461631B1 (en) | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| UA76492C2 (en) * | 2001-09-21 | 2006-08-15 | Lilly Co Eli | Muscarinic agonists, a pharmaceutical composition on their basis |
| US6800663B2 (en) | 2002-10-18 | 2004-10-05 | Alkermes Controlled Therapeutics Inc. Ii, | Crosslinked hydrogel copolymers |
| DK1603570T5 (da) * | 2003-02-26 | 2013-12-09 | Sugen Inc | Aminoheteroarylforbindelser som proteinkinaseinhibitorer |
| CN1905873A (zh) * | 2003-11-19 | 2007-01-31 | 阵列生物制药公司 | Mek的杂环抑制剂及其使用方法 |
| EP1786777A1 (en) | 2004-08-26 | 2007-05-23 | Pfizer, Inc. | Aminoheteroaryl compounds as protein tyrosine kinase inhibitors |
| ES2355923T3 (es) | 2004-08-26 | 2011-04-01 | Pfizer, Inc. | Compuestos de aminoheteroarilo sustituidos con pirazol como inhibidores de proteina quinasa. |
| MX2007003377A (es) * | 2004-09-23 | 2007-05-10 | Pfizer Prod Inc | Agonistas del receptor de trombopoyetina. |
| KR20070094754A (ko) * | 2004-12-01 | 2007-09-21 | 데브젠 엔브이 | 이온 채널, 특히 Ｋｖ 패밀리로부터의 이온 채널과상호작용하는 5-카복사미도 치환된 티아졸 유도체 |
| US7601355B2 (en) * | 2005-06-01 | 2009-10-13 | Northwestern University | Compositions and methods for altering immune function |
| US7745477B2 (en) * | 2006-02-07 | 2010-06-29 | Hoffman-La Roche Inc. | Heteroaryl and benzyl amide compounds |
| US7772233B2 (en) * | 2006-04-19 | 2010-08-10 | Merck Serono, S.A. | Arylamino N-heteroaryl compounds as MEK inhibitors |
| JP2010516680A (ja) | 2007-01-19 | 2010-05-20 | エックスカバリー，インコーポレイテッド | キナーゼ阻害薬化合物 |
| TW200918521A (en) * | 2007-08-31 | 2009-05-01 | Astrazeneca Ab | Heterocyclic amides and methods of use thereof |
| JP5670325B2 (ja) * | 2008-06-19 | 2015-02-18 | エックスカバリー ホールディング カンパニー エルエルシー | キナーゼ阻害化合物としての置換されたピリダジンカルボキサミド化合物 |
| EP2427458B1 (en) * | 2009-05-05 | 2014-05-07 | F.Hoffmann-La Roche Ag | Isoxazole-pyridazine derivatives |
| US8669254B2 (en) * | 2010-12-15 | 2014-03-11 | Hoffman-La Roche Inc. | Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents |
-
2009
- 2009-06-18 JP JP2011514617A patent/JP5670325B2/ja active Active
- 2009-06-18 PL PL09767082T patent/PL2303018T3/pl unknown
- 2009-06-18 RU RU2011139352/04A patent/RU2526618C2/ru active
- 2009-06-18 ES ES09767082.2T patent/ES2551899T3/es active Active
- 2009-06-18 US US12/997,980 patent/US8697866B2/en active Active
- 2009-06-18 CA CA2728408A patent/CA2728408C/en active Active
- 2009-06-18 EP EP15189299.9A patent/EP3061752B1/en active Active
- 2009-06-18 BR BRPI0914305A patent/BRPI0914305B8/pt active IP Right Grant
- 2009-06-18 KR KR1020117001272A patent/KR101691640B1/ko active Active
- 2009-06-18 MX MX2010014171A patent/MX2010014171A/es active IP Right Grant
- 2009-06-18 WO PCT/US2009/003654 patent/WO2009154769A1/en not_active Ceased
- 2009-06-18 CN CN200980128355.6A patent/CN102098917B/zh active Active
- 2009-06-18 ES ES15189299.9T patent/ES2670665T3/es active Active
- 2009-06-18 NZ NZ590542A patent/NZ590542A/xx unknown
- 2009-06-18 AU AU2009260810A patent/AU2009260810B2/en active Active
- 2009-06-18 EP EP09767082.2A patent/EP2303018B1/en active Active
-
2010
- 2010-12-19 IL IL210099A patent/IL210099A/en active IP Right Grant
-
2014
- 2014-04-09 US US14/249,245 patent/US9296724B2/en active Active
-
2016
- 2016-02-29 US US15/056,182 patent/US20160176900A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2728408C (en) | 2017-12-05 |
| US20110160209A1 (en) | 2011-06-30 |
| NZ590542A (en) | 2012-12-21 |
| PL2303018T3 (pl) | 2016-06-30 |
| IL210099A0 (en) | 2011-02-28 |
| US9296724B2 (en) | 2016-03-29 |
| EP2303018A1 (en) | 2011-04-06 |
| EP2303018B1 (en) | 2015-10-14 |
| AU2009260810B2 (en) | 2015-09-17 |
| EP3061752A1 (en) | 2016-08-31 |
| EP3061752B1 (en) | 2018-02-21 |
| CN102098917B (zh) | 2016-03-16 |
| BRPI0914305B1 (pt) | 2021-05-11 |
| BRPI0914305B8 (pt) | 2021-05-25 |
| ES2670665T3 (es) | 2018-05-31 |
| WO2009154769A1 (en) | 2009-12-23 |
| ES2551899T3 (es) | 2015-11-24 |
| RU2526618C2 (ru) | 2014-08-27 |
| JP5670325B2 (ja) | 2015-02-18 |
| RU2011139352A (ru) | 2013-04-10 |
| MX2010014171A (es) | 2011-07-04 |
| EP2303018A4 (en) | 2012-06-20 |
| JP2011524905A (ja) | 2011-09-08 |
| KR20110044974A (ko) | 2011-05-03 |
| AU2009260810A1 (en) | 2009-12-23 |
| CN102098917A (zh) | 2011-06-15 |
| US20160176900A1 (en) | 2016-06-23 |
| CA2728408A1 (en) | 2009-12-23 |
| US8697866B2 (en) | 2014-04-15 |
| IL210099A (en) | 2015-11-30 |
| US20140221376A1 (en) | 2014-08-07 |
| KR101691640B1 (ko) | 2016-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B25F | Entry of change of name and/or headquarter and transfer of application, patent and certif. of addition of invention: change of name on requirement |
Owner name: XCOVERY HOLDING COMPANY LLC (US) Free format text: A FIM DE ATENDER A(S) ALTERACAO(OES) DE NOME REQUERIDA(S) ATRAVES DA PETICAO NO870200054923 DE 04/05/2020, E NECESSARIO:1. ESCLARECER A DIVERGENCIA QUE HA ENTRE O ENDERECO APRESENTADO NA PETICAO SUPRA E OENDERECO DA TITULAR, CONFORME PETICAO 020100118583 DE 20/12/2010;2. APRESENTAR GRU REFERENTE AO CUMPRIMENTO DA PRESENTE EXIGENCIA. |
|
| B25D | Requested change of name of applicant approved |
Owner name: XCOVERY HOLDINGS, INC. (US) |
|
| B25G | Requested change of headquarter approved |
Owner name: XCOVERY HOLDINGS, INC. (US) |
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