BRPI0915084A2 - composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto, métodos para a profilaxia ou tratamento de um estado de doença ou uma condição e de câncer - Google Patents
composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto, métodos para a profilaxia ou tratamento de um estado de doença ou uma condição e de câncerInfo
- Publication number
- BRPI0915084A2 BRPI0915084A2 BRPI0915084A BRPI0915084A BRPI0915084A2 BR PI0915084 A2 BRPI0915084 A2 BR PI0915084A2 BR PI0915084 A BRPI0915084 A BR PI0915084A BR PI0915084 A BRPI0915084 A BR PI0915084A BR PI0915084 A2 BRPI0915084 A2 BR PI0915084A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- prophylaxis
- cancer
- preparing
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6118408P | 2008-06-13 | 2008-06-13 | |
| GB0810902.7 | 2008-06-13 | ||
| US61/061,184 | 2008-06-13 | ||
| GBGB0810902.7A GB0810902D0 (en) | 2008-06-13 | 2008-06-13 | New compounds |
| PCT/EP2009/057318 WO2009150240A1 (en) | 2008-06-13 | 2009-06-12 | Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0915084A2 true BRPI0915084A2 (pt) | 2015-10-27 |
| BRPI0915084B1 BRPI0915084B1 (pt) | 2020-02-11 |
| BRPI0915084B8 BRPI0915084B8 (pt) | 2021-05-25 |
Family
ID=39672279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0915084A BRPI0915084B8 (pt) | 2008-06-13 | 2009-06-12 | composto, e, composição farmacêutica |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8796244B2 (pt) |
| EP (1) | EP2300465B1 (pt) |
| JP (1) | JP5596023B2 (pt) |
| KR (1) | KR101745730B1 (pt) |
| CN (1) | CN102137859B (pt) |
| AU (1) | AU2009256584B2 (pt) |
| BR (1) | BRPI0915084B8 (pt) |
| CA (1) | CA2727062A1 (pt) |
| DK (1) | DK2300465T3 (pt) |
| ES (1) | ES2735979T3 (pt) |
| GB (1) | GB0810902D0 (pt) |
| HR (1) | HRP20191027T1 (pt) |
| HU (1) | HUE045300T2 (pt) |
| IL (1) | IL209864A (pt) |
| LT (1) | LT2300465T (pt) |
| MX (1) | MX2010013743A (pt) |
| NZ (1) | NZ589781A (pt) |
| RU (1) | RU2518089C2 (pt) |
| SI (1) | SI2300465T1 (pt) |
| WO (1) | WO2009150240A1 (pt) |
| ZA (1) | ZA201008961B (pt) |
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| HRP20150642T1 (hr) | 2006-12-22 | 2015-08-14 | Astex Therapeutics Limited | BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a |
| US8513276B2 (en) | 2006-12-22 | 2013-08-20 | Astex Therapeutics Limited | Imidazo[1,2-a]pyridine compounds for use in treating cancer |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| JP2012521354A (ja) * | 2009-03-20 | 2012-09-13 | アムジエン・インコーポレーテツド | Ｐｉ３キナーゼの阻害薬 |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) * | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| WO2011104731A1 (en) * | 2010-02-26 | 2011-09-01 | Decode Genetics Ehf | Genetic variants as markers for use in urinary bladder cancer risk assessment, diagnosis, prognosis and treatment |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| EP2727920B1 (en) | 2011-07-29 | 2016-11-02 | FUJIFILM Corporation | 1,5-naphthyridine derivative or salt thereof |
| UA111382C2 (uk) | 2011-10-10 | 2016-04-25 | Оріон Корпорейшн | Інгібітори протеїнкінази |
| CN103214481B (zh) * | 2012-01-21 | 2016-08-03 | 中国科学院上海药物研究所 | 新型咪唑并[1,2-a]吡啶类化合物、其制备方法、包含此类化合物的药物组合物及其用途 |
| RS58514B1 (sr) | 2012-06-13 | 2019-04-30 | Incyte Holdings Corp | Supstituisana triciklična jedinjenja kao inhibitori fgfr |
| CN102786543B (zh) * | 2012-07-24 | 2016-04-27 | 上海瑞博化学有限公司 | 咪唑并[1，2-a]吡啶-6-硼酸频哪醇酯及其衍生物的制备方法 |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US8729263B2 (en) | 2012-08-13 | 2014-05-20 | Novartis Ag | 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions |
| JP6430383B2 (ja) * | 2012-09-28 | 2018-11-28 | ヴァンダービルト ユニバーシティーＶａｎｄｅｒｂｉｌｔ Ｕｎｉｖｅｒｓｉｔｙ | 選択的ｂｍｐ阻害剤としての縮合複素環化合物 |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| SG11201504622PA (en) | 2012-12-20 | 2015-07-30 | Inception 2 Inc | Triazolone compounds and uses thereof |
| CN103923078A (zh) * | 2013-01-15 | 2014-07-16 | 华东理工大学 | 3,4-二取代(1H-吡唑[3,4-b]吡啶)类化合物及其用途 |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| MX2015011438A (es) | 2013-03-13 | 2016-02-03 | Hoffmann La Roche | Procedimiento para preparar compuestos benzoxazepina. |
| PH12015502383B1 (en) | 2013-04-19 | 2023-02-03 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| KR20210130843A (ko) | 2013-07-31 | 2021-11-01 | 노파르티스 아게 | 1,4-이치환된 피리다진 유사체 및 smn-결핍-관련 상태를 치료하기 위한 그의 용도 |
| US9556126B2 (en) | 2013-12-20 | 2017-01-31 | Signal Pharmaceuticals, Llc | Substituted diaminopyrimidyl compounds, compositions thereof, and methods of treatment therewith |
| BR122022015241B1 (pt) | 2013-12-20 | 2023-09-26 | Astex Therapeutics Limited | Compostos heterocíclicos bicíclicos intermediários para a preparação de um composto de fórmula (i) |
| KR102344105B1 (ko) | 2014-08-18 | 2021-12-29 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 모노시클릭 피리딘 유도체의 염 및 이의 결정 |
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| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| TWI712601B (zh) | 2015-02-20 | 2020-12-11 | 美商英塞特公司 | 作為fgfr抑制劑之雙環雜環 |
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| US11773106B2 (en) | 2015-10-16 | 2023-10-03 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
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| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| CN108367000A (zh) | 2015-12-17 | 2018-08-03 | 卫材R&D管理有限公司 | 用于乳腺癌的治疗剂 |
| US20190218214A1 (en) * | 2016-09-14 | 2019-07-18 | Vanderbilt University | Inhibition of BMP Signaling Compounds, Compositions and Uses Thereof |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| CN109776401A (zh) * | 2017-11-14 | 2019-05-21 | 成都博腾药业有限公司 | 一种制备6-氯-5-三氟甲基-2-氨基吡啶的方法 |
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| WO2019178383A1 (en) | 2018-03-14 | 2019-09-19 | Vanderbilt University | Inhibition of bmp signaling, compounds, compositions and uses thereof |
| US11219619B2 (en) | 2018-03-28 | 2022-01-11 | Eisai R&D Management Co., Ltd. | Therapeutic agent for hepatocellular carcinoma |
| HRP20241288T1 (hr) | 2018-05-04 | 2024-12-06 | Incyte Corporation | Čvrsti oblici fgfr inhibitora i postupci za njihovu proizvodnju |
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| CN112851677A (zh) * | 2019-11-26 | 2021-05-28 | 中国科学院大连化学物理研究所 | 一种咪唑并吡啶或嘧啶衍生物的合成方法 |
| JP7832891B2 (ja) | 2019-12-04 | 2026-03-18 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤の誘導体 |
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2008
- 2008-06-13 GB GBGB0810902.7A patent/GB0810902D0/en not_active Ceased
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2009
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- 2009-06-12 CA CA2727062A patent/CA2727062A1/en not_active Abandoned
- 2009-06-12 NZ NZ589781A patent/NZ589781A/xx not_active IP Right Cessation
- 2009-06-12 US US12/997,754 patent/US8796244B2/en active Active
- 2009-06-12 HU HUE09761801A patent/HUE045300T2/hu unknown
- 2009-06-12 KR KR1020117000791A patent/KR101745730B1/ko not_active Expired - Fee Related
- 2009-06-12 MX MX2010013743A patent/MX2010013743A/es active IP Right Grant
- 2009-06-12 HR HRP20191027 patent/HRP20191027T1/hr unknown
- 2009-06-12 AU AU2009256584A patent/AU2009256584B2/en not_active Ceased
- 2009-06-12 LT LTEP09761801.1T patent/LT2300465T/lt unknown
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- 2009-06-12 RU RU2011100786/04A patent/RU2518089C2/ru active
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- 2009-06-12 EP EP09761801.1A patent/EP2300465B1/en active Active
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2010
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Also Published As
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|---|---|
| DK2300465T3 (da) | 2019-06-24 |
| KR101745730B1 (ko) | 2017-06-12 |
| US20120208791A1 (en) | 2012-08-16 |
| EP2300465A1 (en) | 2011-03-30 |
| US8796244B2 (en) | 2014-08-05 |
| ES2735979T3 (es) | 2019-12-23 |
| BRPI0915084B8 (pt) | 2021-05-25 |
| CN102137859A (zh) | 2011-07-27 |
| KR20110017000A (ko) | 2011-02-18 |
| BRPI0915084B1 (pt) | 2020-02-11 |
| IL209864A (en) | 2015-10-29 |
| HUE045300T2 (hu) | 2019-12-30 |
| JP5596023B2 (ja) | 2014-09-24 |
| ZA201008961B (en) | 2015-05-27 |
| WO2009150240A1 (en) | 2009-12-17 |
| IL209864A0 (en) | 2011-02-28 |
| HRP20191027T1 (hr) | 2019-11-29 |
| RU2518089C2 (ru) | 2014-06-10 |
| CN102137859B (zh) | 2015-07-01 |
| NZ589781A (en) | 2013-02-22 |
| GB0810902D0 (en) | 2008-07-23 |
| JP2011522866A (ja) | 2011-08-04 |
| EP2300465B1 (en) | 2019-04-17 |
| LT2300465T (lt) | 2019-06-25 |
| SI2300465T1 (sl) | 2019-08-30 |
| CA2727062A1 (en) | 2009-12-17 |
| AU2009256584A1 (en) | 2009-12-17 |
| MX2010013743A (es) | 2011-02-15 |
| RU2011100786A (ru) | 2012-07-20 |
| AU2009256584B2 (en) | 2014-06-12 |
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