BRPI0915336A2 - composto capaz de inibir a atividade de uma pad, composição, e, uso de um composto - Google Patents

composto capaz de inibir a atividade de uma pad, composição, e, uso de um composto

Info

Publication number
BRPI0915336A2
BRPI0915336A2 BRPI0915336A BRPI0915336A BRPI0915336A2 BR PI0915336 A2 BRPI0915336 A2 BR PI0915336A2 BR PI0915336 A BRPI0915336 A BR PI0915336A BR PI0915336 A BRPI0915336 A BR PI0915336A BR PI0915336 A2 BRPI0915336 A2 BR PI0915336A2
Authority
BR
Brazil
Prior art keywords
compound
inhibiting
pad
activity
composition
Prior art date
Application number
BRPI0915336A
Other languages
English (en)
Inventor
Petrus Johannes Theodorus Rutjes Floris
Josef Maria Pruijn Gerardus
Wouter Drijfhout Jan
Maria Hendrik Raats Jozef
Hendrix Blaauw Richard
Original Assignee
Academisch Ziekenhuis Leiden
Chiralix B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academisch Ziekenhuis Leiden, Chiralix B V filed Critical Academisch Ziekenhuis Leiden
Publication of BRPI0915336A2 publication Critical patent/BRPI0915336A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Rehabilitation Therapy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BRPI0915336A 2008-06-16 2009-06-15 composto capaz de inibir a atividade de uma pad, composição, e, uso de um composto BRPI0915336A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6175408P 2008-06-16 2008-06-16
EP08158330 2008-06-16
PCT/NL2009/050340 WO2010005293A1 (en) 2008-06-16 2009-06-15 Peptidylarginine deiminase (pad) inhibitors

Publications (1)

Publication Number Publication Date
BRPI0915336A2 true BRPI0915336A2 (pt) 2017-06-27

Family

ID=39800635

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915336A BRPI0915336A2 (pt) 2008-06-16 2009-06-15 composto capaz de inibir a atividade de uma pad, composição, e, uso de um composto

Country Status (11)

Country Link
US (1) US8404647B2 (pt)
EP (1) EP2288616B1 (pt)
JP (1) JP2011524170A (pt)
KR (1) KR20110063731A (pt)
CN (1) CN102105486A (pt)
AU (1) AU2009270003A1 (pt)
BR (1) BRPI0915336A2 (pt)
CA (1) CA2728351A1 (pt)
ES (1) ES2400013T3 (pt)
RU (1) RU2011101391A (pt)
WO (1) WO2010005293A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012026309A1 (ja) * 2010-08-23 2012-03-01 公立大学法人横浜市立大学 抗ｐａｄ４抗体医薬の創成
JP6135046B2 (ja) * 2012-04-20 2017-05-31 株式会社島津製作所 糖ペプチドの質量分析法
US20150376294A1 (en) 2012-12-03 2015-12-31 Rigshospitalet Anti-pad2 antibodies and treatment of autoimmune diseases
WO2016118476A1 (en) 2015-01-20 2016-07-28 The Children's Medical Center Corporation Anti-net compounds for treating and preventing fibrosis and for facilitating wound healing
WO2016155745A1 (en) 2015-03-27 2016-10-06 Rigshospitalet Cross-reactive anti-pad antibodies
WO2019008408A1 (en) 2017-07-07 2019-01-10 INSERM (Institut National de la Santé et de la Recherche Médicale) METHODS FOR DETERMINING WHETHER A PATIENT SUFFERING FROM MYELOPROLIFERATIVE NEOPLASM IS AT RISK OF THROMBOSIS
JPWO2019131769A1 (ja) * 2017-12-26 2021-02-12 公立大学法人名古屋市立大学 新規抗ｐａｄ４抗体
US12448358B2 (en) * 2019-07-03 2025-10-21 University Of Massachusetts Inhibitors of protein arginine deiminase 1 and methods of preparation and use thereof
CN111733151B (zh) * 2020-07-13 2021-11-12 山东新创生物科技有限公司 一种基于padi4作为肿瘤标志物制得的抗原、抗体及应用
CN118001407B (zh) * 2024-04-02 2024-06-21 北京大学人民医院 Pad2在制备治疗缺血缺氧性恶性心律失常药物中的应用
WO2026020127A2 (en) * 2024-07-19 2026-01-22 Bristol-Myers Squibb Company Methods of assessing citrullination and activity of pad2 modulators

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053069A2 (en) * 1997-05-20 1998-11-26 Human Genome Sciences, Inc. Gdnf receptors
DE19740310A1 (de) * 1997-09-13 1999-04-01 Octapharma Ag Peptid mit Affinität zu Gerinnungsfaktor VIII
US6284735B1 (en) * 1998-04-28 2001-09-04 Lion Bioscience Ag HP-3228 and related peptides to treat sexual dysfunction
CA2391356A1 (en) * 1999-12-21 2001-06-28 Innogenetics N.V. Peptides designed for the diagnosis and treatment of rheumatoid arthritis
ATE489462T1 (de) * 2002-04-25 2010-12-15 Toagosei Co Ltd Antimikrobielles polypeptid und nutzung davon
CA2421321A1 (en) * 2003-03-07 2004-09-07 London Health Sciences Centre Research Inc. Peptides associated with hla-dr mhc class ii molecule and involved in rheumatoid arthritis
US20050159334A1 (en) * 2004-01-16 2005-07-21 Gluck Oscar S. Method for treating rheumatoid arthritis by inhibiting peptidylarginine deiminase
CA2555199A1 (en) * 2004-02-04 2005-08-18 Yokohama City University Peptidylarginine deiminase 4 inhibitor
WO2007076302A2 (en) * 2005-12-20 2007-07-05 Boehringer Ingelheim International Gmbh High throughput assay for modulators of peptidylarginine deiminase activity

Also Published As

Publication number Publication date
ES2400013T3 (es) 2013-04-05
US8404647B2 (en) 2013-03-26
CA2728351A1 (en) 2010-01-14
AU2009270003A1 (en) 2010-01-14
JP2011524170A (ja) 2011-09-01
WO2010005293A1 (en) 2010-01-14
US20110142868A1 (en) 2011-06-16
EP2288616B1 (en) 2012-11-21
KR20110063731A (ko) 2011-06-14
CN102105486A (zh) 2011-06-22
RU2011101391A (ru) 2012-08-10
EP2288616A1 (en) 2011-03-02

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A, 7A E 8A ANUIDADES.

B25G Requested change of headquarter approved

Owner name: CHIRALIX B.V. (NL) , ACADEMISCH ZIEKENHUIS LEIDEN

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]