BRPI1008906A2 - composto, composição farmacêutica, e, uso de um composto. - Google Patents

composto, composição farmacêutica, e, uso de um composto.

Info

Publication number: BRPI1008906A2
Authority: BR; Brazil
Prior art keywords: compound; pharmaceutical composition; pharmaceutical; composition
Prior art date: 2009-02-24

Application number

BRPI1008906A

Other languages

English (en)

Inventor

Carl Berthelette

Joey Methot

John Colucci

Karine Villeneuve

Michael Boyd

Original Assignee

Merck Canada Inc

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-02-24

Filing date

2010-02-19

Publication date

2016-03-15

2010-02-19 Application filed by Merck Canada Inc, Merck Sharp & Dohme filed Critical Merck Canada Inc

2016-03-15 Publication of BRPI1008906A2 publication Critical patent/BRPI1008906A2/pt

2019-10-15 Publication of BRPI1008906B1 publication Critical patent/BRPI1008906B1/pt

Links

150000001875 compounds Chemical class 0.000 title 2
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Ophthalmology & Optometry (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Otolaryngology (AREA)
Anesthesiology (AREA)
Oncology (AREA)
Hematology (AREA)
Transplantation (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI1008906-3A 2009-02-24 2010-02-19 Composto, composição farmacêutica, e, uso de um composto BRPI1008906B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US15496809P	2009-02-24	2009-02-24
US61/154968		2009-02-24
PCT/US2010/024713 WO2010099039A1 (en)	2009-02-24	2010-02-19	Indole derivatives as crth2 receptor antagonists

Publications (2)

Publication Number	Publication Date
BRPI1008906A2 true BRPI1008906A2 (pt)	2016-03-15
BRPI1008906B1 BRPI1008906B1 (pt)	2019-10-15

Family

ID=42046150

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1008906-3A BRPI1008906B1 (pt)	2009-02-24	2010-02-19	Composto, composição farmacêutica, e, uso de um composto

Country Status (36)

Country	Link
US (2)	US8394819B2 (pt)
EP (2)	EP2492267B1 (pt)
JP (1)	JP4989786B1 (pt)
KR (2)	KR101276530B1 (pt)
CN (1)	CN102333771B (pt)
AR (1)	AR075597A1 (pt)
AU (1)	AU2010218209B2 (pt)
BR (1)	BRPI1008906B1 (pt)
CA (1)	CA2752981C (pt)
CL (1)	CL2011002056A1 (pt)
CO (1)	CO6410295A2 (pt)
CR (1)	CR20110455A (pt)
DK (1)	DK2401269T3 (pt)
DO (1)	DOP2011000271A (pt)
EA (1)	EA021076B1 (pt)
EC (1)	ECSP11011288A (pt)
ES (2)	ES2450594T3 (pt)
HN (1)	HN2011002272A (pt)
HR (1)	HRP20140384T1 (pt)
IL (1)	IL214342A0 (pt)
MA (1)	MA33134B1 (pt)
MX (1)	MX2011008869A (pt)
MY (1)	MY152062A (pt)
NI (1)	NI201100162A (pt)
NZ (1)	NZ594767A (pt)
PE (1)	PE20120056A1 (pt)
PL (1)	PL2401269T3 (pt)
PT (1)	PT2401269E (pt)
RS (1)	RS53268B (pt)
SG (1)	SG173775A1 (pt)
SI (1)	SI2401269T1 (pt)
TN (1)	TN2011000382A1 (pt)
TW (2)	TWI444381B (pt)
UA (1)	UA105039C2 (pt)
WO (1)	WO2010099039A1 (pt)
ZA (1)	ZA201105767B (pt)

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BR112013015397A2 (pt)	2010-12-23	2016-09-20	Merck Sharp & Dohme	composto, composição farmacêutica, e, uso de um composto
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US11524964B2 (en)	2015-10-16	2022-12-13	Abbvie Inc.	Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en)	2015-10-16	2022-06-21	Abbvie Inc.	Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
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US20120004233A1 (en)	2009-01-26	2012-01-05	Amira Pharmaceuticals, Inc	Tricyclic compounds as antagonists of prostaglandin d2 receptors

2010
- 2010-02-19 MA MA34181A patent/MA33134B1/fr unknown
- 2010-02-19 HR HRP20140384AT patent/HRP20140384T1/hr unknown
- 2010-02-19 SG SG2011059912A patent/SG173775A1/en unknown
- 2010-02-19 ES ES10705068.4T patent/ES2450594T3/es active Active
- 2010-02-19 PE PE2011001523A patent/PE20120056A1/es not_active Application Discontinuation
- 2010-02-19 DK DK10705068.4T patent/DK2401269T3/da active
- 2010-02-19 ES ES12168410.4T patent/ES2529420T3/es active Active
- 2010-02-19 JP JP2011550331A patent/JP4989786B1/ja not_active Expired - Fee Related
- 2010-02-19 KR KR1020137005315A patent/KR101276530B1/ko not_active Expired - Fee Related
- 2010-02-19 NZ NZ594767A patent/NZ594767A/xx not_active IP Right Cessation
- 2010-02-19 PT PT107050684T patent/PT2401269E/pt unknown
- 2010-02-19 US US12/708,924 patent/US8394819B2/en active Active
- 2010-02-19 RS RS20140213A patent/RS53268B/sr unknown
- 2010-02-19 KR KR1020117019538A patent/KR101275980B1/ko not_active Expired - Fee Related
- 2010-02-19 BR BRPI1008906-3A patent/BRPI1008906B1/pt not_active IP Right Cessation
- 2010-02-19 AU AU2010218209A patent/AU2010218209B2/en not_active Ceased
- 2010-02-19 UA UAA201111313A patent/UA105039C2/uk unknown
- 2010-02-19 MY MYPI2011003785 patent/MY152062A/en unknown
- 2010-02-19 EP EP12168410.4A patent/EP2492267B1/en active Active
- 2010-02-19 EA EA201171081A patent/EA021076B1/ru not_active IP Right Cessation
- 2010-02-19 SI SI201030527T patent/SI2401269T1/sl unknown
- 2010-02-19 CN CN201080010563.9A patent/CN102333771B/zh not_active Expired - Fee Related
- 2010-02-19 EP EP10705068.4A patent/EP2401269B1/en active Active
- 2010-02-19 WO PCT/US2010/024713 patent/WO2010099039A1/en not_active Ceased
- 2010-02-19 CA CA2752981A patent/CA2752981C/en not_active Expired - Fee Related
- 2010-02-19 MX MX2011008869A patent/MX2011008869A/es active IP Right Grant
- 2010-02-19 PL PL10705068T patent/PL2401269T3/pl unknown
- 2010-02-23 TW TW102128348A patent/TWI444381B/zh not_active IP Right Cessation
- 2010-02-23 TW TW099105206A patent/TWI454474B/zh not_active IP Right Cessation
- 2010-02-24 AR ARP100100535A patent/AR075597A1/es not_active Application Discontinuation
2011
- 2011-07-28 IL IL214342A patent/IL214342A0/en unknown
- 2011-08-03 TN TN2011000382A patent/TN2011000382A1/fr unknown
- 2011-08-05 ZA ZA2011/05767A patent/ZA201105767B/en unknown
- 2011-08-23 NI NI201100162A patent/NI201100162A/es unknown
- 2011-08-23 CL CL2011002056A patent/CL2011002056A1/es unknown
- 2011-08-23 HN HN2011002272A patent/HN2011002272A/es unknown
- 2011-08-24 DO DO2011000271A patent/DOP2011000271A/es unknown
- 2011-08-24 EC EC2011011288A patent/ECSP11011288A/es unknown
- 2011-08-24 CR CR20110455A patent/CR20110455A/es unknown
- 2011-08-30 CO CO11111105A patent/CO6410295A2/es not_active Application Discontinuation
2013
- 2013-02-07 US US13/762,050 patent/US9023864B2/en active Active

Also Published As

Publication number	Publication date
EP2401269A1 (en)	2012-01-04
CA2752981A1 (en)	2010-09-02
CA2752981C (en)	2013-11-12
ECSP11011288A (es)	2011-10-31
ES2450594T3 (es)	2014-03-25
US8394819B2 (en)	2013-03-12
SG173775A1 (en)	2011-09-29
BRPI1008906B1 (pt)	2019-10-15
KR101276530B1 (ko)	2013-06-18
JP4989786B1 (ja)	2012-08-01
PL2401269T3 (pl)	2014-07-31
PT2401269E (pt)	2014-03-11
HN2011002272A (es)	2014-02-24
JP2012517484A (ja)	2012-08-02
AU2010218209B2 (en)	2012-12-13
AU2010218209A1 (en)	2011-08-25
MX2011008869A (es)	2011-12-16
TW201402573A (zh)	2014-01-16
SI2401269T1 (sl)	2014-04-30
TW201035096A (en)	2010-10-01
TWI444381B (zh)	2014-07-11
CN102333771B (zh)	2014-03-19
US20100234415A1 (en)	2010-09-16
HRP20140384T1 (en)	2014-05-23
UA105039C2 (uk)	2014-04-10
KR20130028156A (ko)	2013-03-18
US20130150398A1 (en)	2013-06-13
NZ594767A (en)	2013-05-31
EP2492267B1 (en)	2014-11-26
KR20110107395A (ko)	2011-09-30
DOP2011000271A (es)	2011-10-15
RS53268B (sr)	2014-08-29
EA201171081A1 (ru)	2012-02-28
ES2529420T3 (es)	2015-02-19
IL214342A0 (en)	2011-09-27
HK1160465A1 (en)	2012-08-17
WO2010099039A1 (en)	2010-09-02
CL2011002056A1 (es)	2012-04-09
TWI454474B (zh)	2014-10-01
NI201100162A (es)	2012-02-01
PE20120056A1 (es)	2012-02-05
MY152062A (en)	2014-08-15
US9023864B2 (en)	2015-05-05
EP2492267A1 (en)	2012-08-29
DK2401269T3 (da)	2014-04-28
ZA201105767B (en)	2012-04-25
CO6410295A2 (es)	2012-03-30
EA021076B1 (ru)	2015-03-31
CR20110455A (es)	2012-01-10
CN102333771A (zh)	2012-01-25
EP2401269B1 (en)	2014-01-29
TN2011000382A1 (en)	2013-03-27
AR075597A1 (es)	2011-04-20
KR101275980B1 (ko)	2013-06-17
MA33134B1 (fr)	2012-03-01

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2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
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