BRPI0915387B8 - agente para a regeneração da membrana timpânica ou canal auditivo externo e uso de uma esponja de gelatina que carrega o fator de crescimento fibroblástico básico e uma cola de fibrina - Google Patents

agente para a regeneração da membrana timpânica ou canal auditivo externo e uso de uma esponja de gelatina que carrega o fator de crescimento fibroblástico básico e uma cola de fibrina

Info

Publication number
BRPI0915387B8
BRPI0915387B8 BRPI0915387A BRPI0915387A BRPI0915387B8 BR PI0915387 B8 BRPI0915387 B8 BR PI0915387B8 BR PI0915387 A BRPI0915387 A BR PI0915387A BR PI0915387 A BRPI0915387 A BR PI0915387A BR PI0915387 B8 BRPI0915387 B8 BR PI0915387B8
Authority
BR
Brazil
Prior art keywords
regeneration
ear canal
tympanic membrane
agent
gelatin sponge
Prior art date
Application number
BRPI0915387A
Other languages
English (en)
Inventor
Kanemaru Shin-Ichi
Original Assignee
Kaken Pharma Co Ltd
Nobelpharma Co Ltd
Shin Ichi Kanemaru
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharma Co Ltd, Nobelpharma Co Ltd, Shin Ichi Kanemaru filed Critical Kaken Pharma Co Ltd
Publication of BRPI0915387A2 publication Critical patent/BRPI0915387A2/pt
Publication of BRPI0915387B1 publication Critical patent/BRPI0915387B1/pt
Publication of BRPI0915387B8 publication Critical patent/BRPI0915387B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • A61F11/20—Ear surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/14—Materials or treatment for tissue regeneration for ear reconstruction or ear implants, e.g. implantable hearing aids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers & Plastics (AREA)
  • Prostheses (AREA)

Abstract

agente para a regeneração da membrana timpânica ou canal auditivo externo. a presente invenção refere-se a um agente de regeneração da membrana timpânica ou canal auditivo que compreende uma combinação de uma esponja de gelatina que carrega o fator de crescimento fibroblástico básico (bfgf) e um material de cobertura. o material de cobertura é utilizado não apenas para fixar a esponja de gelatina na parte afetada, mas também para o propósito de prevenir a secagem e infecções para proporcionar um ambiente de cultura que é favorável à regeneração do tecido isolado a partir da parte externa. para promover a regeneração do tecido, a margem do defeito da membrana timpânica ou canal auditivo é preferivelmente renovada antecipadamente.
BRPI0915387A 2008-06-26 2009-06-26 agente para a regeneração da membrana timpânica ou canal auditivo externo e uso de uma esponja de gelatina que carrega o fator de crescimento fibroblástico básico e uma cola de fibrina BRPI0915387B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2008167744 2008-06-26
JP2008-167744 2008-06-26
PCT/JP2009/061767 WO2009157558A1 (ja) 2008-06-26 2009-06-26 鼓膜または外耳道再生剤

Publications (3)

Publication Number Publication Date
BRPI0915387A2 BRPI0915387A2 (pt) 2016-10-11
BRPI0915387B1 BRPI0915387B1 (pt) 2019-09-24
BRPI0915387B8 true BRPI0915387B8 (pt) 2021-05-25

Family

ID=41444618

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0915387A BRPI0915387B8 (pt) 2008-06-26 2009-06-26 agente para a regeneração da membrana timpânica ou canal auditivo externo e uso de uma esponja de gelatina que carrega o fator de crescimento fibroblástico básico e uma cola de fibrina

Country Status (12)

Country Link
US (3) US9161904B2 (pt)
EP (1) EP2353547B1 (pt)
JP (1) JP5398712B2 (pt)
KR (1) KR101604150B1 (pt)
CN (2) CN105381506A (pt)
AU (1) AU2009263249B2 (pt)
BR (1) BRPI0915387B8 (pt)
CA (1) CA2729093C (pt)
ES (1) ES2671068T3 (pt)
MX (1) MX2010014077A (pt)
RU (1) RU2544367C2 (pt)
WO (1) WO2009157558A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201892619A1 (ru) 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
JP6240596B2 (ja) * 2011-07-11 2017-11-29 イアー サイエンス インスティテュート オーストラリア 鼓膜修復のためのデバイス
CN104812419B (zh) 2012-06-28 2017-06-09 图兰恩教育基金管理人 选择性可聚合组合物及其活体内使用方法
PT2996709T (pt) 2013-05-15 2020-07-14 Univ Leland Stanford Junior Modulação da atividade do fator de crescimento epidérmico de ligação à heparina para cicatrização da membrana timpânica
CN111921076B (zh) * 2015-10-01 2023-05-23 耐贝医药株式会社 鼓膜修复剂制造夹具及鼓膜修复剂制造容器
CN106693064B (zh) * 2016-12-07 2020-07-28 同济大学 一种用于上颌窦底提升的复合材料以及制备方法
CN107349471A (zh) * 2017-06-16 2017-11-17 卓阮医疗科技（苏州）有限公司 一种载药缓释的复合组织修复材料及其制备方法
JP2022043368A (ja) * 2018-12-26 2022-03-16 国立大学法人京都大学 感音難聴治療用組成物
WO2020243478A1 (en) * 2019-05-29 2020-12-03 Massachusetts Eye And Ear Infirmary Fibroblast growth factor 2 (fgf2) for treatment of human sensorineural hearing loss
CN110302425A (zh) * 2019-06-20 2019-10-08 温州医科大学附属第一医院 混合水凝胶生物材料的制备方法及其应用
JPWO2021112254A1 (pt) * 2019-12-06 2021-06-10
RU2763980C1 (ru) * 2021-06-04 2022-01-12 федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се Способ закрытия стойких перфораций барабанной перепонки
WO2023015341A1 (en) * 2021-08-09 2023-02-16 The University Of Western Australia Compositions and methods for wound healing
CN117717650A (zh) * 2022-09-09 2024-03-19 辽宁何氏医学院 一种壳聚糖/明胶球结膜修复生物海绵及其制备方法和应用
EP4788385A1 (en) * 2023-10-05 2026-08-12 Royal College of Surgeons in Ireland A layered implant and system to repair a perforation in a tympanic membrane
CN118718095B (zh) * 2024-09-04 2024-11-29 诺一迈尔(山东)医学科技有限公司 一种声传导生物鼓膜修复材料及其制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2358385A1 (fr) 1976-07-12 1978-02-10 Nihon Nohyaku Co Ltd Derives de l'anilide benzoique et fongicides contenant ces derives
JPS539739A (en) 1976-07-12 1978-01-28 Nippon Nohyaku Co Ltd #-trifluoromethyl-##-isoproxybenzoic acid anilide, its preparation and its use
EP0248819B2 (en) 1985-09-12 2000-08-30 Scios Inc. Recombinant fibroblast growth factors
JP2770926B2 (ja) 1985-12-17 1998-07-02 サイナーゲン インコーポレーテッド 毛管内皮細胞プロテアーゼ合成、ｄｎａ合成および遊走を促進することの出来るヒト胎盤血管形成誘導因子
JP2504468B2 (ja) 1987-06-26 1996-06-05 株式会社東芝 エレベ―タの制御装置
IL88133A0 (en) 1987-10-26 1989-06-30 Lilly Co Eli N-phenylalkylbenzamide fungicides
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
JPH10337302A (ja) * 1997-06-06 1998-12-22 Unitika Ltd 鼓膜欠損閉鎖促進材及びその製造方法
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
AU6597300A (en) 1999-08-19 2001-03-19 Ishihara Sangyo Kaisha Ltd. Agents for controlling animal diseases caused by endoparasites
AU1591701A (en) * 1999-11-12 2001-06-06 Fibrogen, Inc. Recombinant gelatins
US20030229333A1 (en) 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
EP1438942A1 (en) * 2003-01-17 2004-07-21 Schering Oy An otorhinological drug delivery device
CN1552465A (zh) * 2003-06-05 2004-12-08 胡庆柳 纤维蛋白止血贴
WO2006007417A2 (en) 2004-06-16 2006-01-19 The New York Eye & Ear Infirmary Repair of tympanic membrane perforation
WO2006062871A2 (en) 2004-12-08 2006-06-15 Pervasis Therapeutics, Inc. Materials and methods for minimally-invasive administration of a cell-containing flowable composition
RU2277423C1 (ru) 2005-04-07 2006-06-10 Андрей Валентинович Васильев Способ коррекции структурно-функциональных изменений соединительной ткани
AU2005331924A1 (en) 2005-05-12 2006-11-23 Angiotech International Ag Compositions and methods for treating diverticular disease
AU2006265601A1 (en) 2005-06-30 2007-01-11 Anthrogenesis Corporation Repair of tympanic membrane using placenta derived collagen biofabric
JP5008284B2 (ja) * 2005-09-09 2012-08-22 グンゼ株式会社 組織再生用基材
JP4599563B2 (ja) 2005-11-04 2010-12-15 国立大学法人 岡山大学 外耳道再建用成形品及びその製造方法
ES2549409T3 (es) 2005-11-22 2015-10-27 Bayer Intellectual Property Gmbh Nuevos derivados de N-(1-metil-2-feniletil)benzamida
TWI435863B (zh) 2006-03-20 2014-05-01 Nihon Nohyaku Co Ltd Ｎ-２-（雜）芳基乙基甲醯胺衍生物及含該衍生物之蟲害防治劑
EP2041090A1 (en) 2006-07-06 2009-04-01 Bayer CropScience SA N- (4-pyridin-2-ylbutyl) benzamide derivatives and their use as fungicides
WO2008003746A1 (en) 2006-07-06 2008-01-10 Bayer Cropscience Sa N-(4-pyridin-2-ylbutyl) carboxamide derivatives, their process of preparation and their use as fungicides
JP5205274B2 (ja) 2006-11-22 2013-06-05 日本農薬株式会社 新規なピラゾール誘導体、有害生物防除剤及びその使用方法
JP5481716B2 (ja) 2006-12-13 2014-04-23 独立行政法人農業・食品産業技術総合研究機構 サイクロデキストランの製造方法およびサイクロデキストラン合成酵素の製造方法
CL2008000512A1 (es) 2007-02-22 2008-08-29 Bayer Cropscience Sa Compuestos derivados de n-(3-fenilpropil)carboxamida; procedimiento de preparacion de dichos compuestos; composicion fungicida; y metodo para combatir de forma preventiva o curativa los hongos fitopatogenos de cultivos.
US20100063155A1 (en) 2007-02-22 2010-03-11 Pierre-Yves Coqueron N-(3-phenylpropyl)benzamide derivatives
ES2574821T3 (es) 2007-04-12 2016-06-22 Nihon Nohyaku Co., Ltd. Composición de agente nematicida y método de uso de la misma
EP2181097A1 (en) 2007-07-26 2010-05-05 Syngeta Participations AG Novel microbiocides
GB0807140D0 (en) 2008-04-18 2008-05-21 Syngenta Participations Ag Novel microbiocides
GB0904658D0 (en) 2009-03-18 2009-04-29 Syngenta Crop Protection Ag Novel microbiocides
JP2012087116A (ja) 2010-09-21 2012-05-10 Ishihara Sangyo Kaisha Ltd ベンズアミド誘導体又はその塩、それらを含有する殺虫剤、殺ダニ剤、殺線虫剤又は殺土壌害虫剤
CA2828060C (en) 2011-03-02 2018-11-06 The University Of Tokyo Endoparasite control agent

Also Published As

Publication number Publication date
KR101604150B1 (ko) 2016-03-16
RU2011102755A (ru) 2012-08-10
AU2009263249B2 (en) 2015-03-19
RU2544367C2 (ru) 2015-03-20
EP2353547A1 (en) 2011-08-10
US10117969B2 (en) 2018-11-06
BRPI0915387B1 (pt) 2019-09-24
CA2729093A1 (en) 2009-12-30
CA2729093C (en) 2018-04-10
EP2353547A4 (en) 2013-11-06
KR20110021994A (ko) 2011-03-04
BRPI0915387A2 (pt) 2016-10-11
CN105381506A (zh) 2016-03-09
US20190038811A1 (en) 2019-02-07
US20160067383A1 (en) 2016-03-10
ES2671068T3 (es) 2018-06-04
US9161904B2 (en) 2015-10-20
AU2009263249A1 (en) 2009-12-30
US20110110987A1 (en) 2011-05-12
WO2009157558A1 (ja) 2009-12-30
EP2353547B1 (en) 2018-01-17
MX2010014077A (es) 2011-04-05
US10357595B2 (en) 2019-07-23
JP5398712B2 (ja) 2014-01-29
CN102131478A (zh) 2011-07-20
JPWO2009157558A1 (ja) 2011-12-15

Similar Documents

Publication Publication Date Title
CL2008001756A1 (es) Agente de arn de interferencia (iarn); composicion farmaceutica que lo comprende; y su uso para tratar procesos patologicos mediados al menos en parte por la expresion del canal de sodio epitelial alfa (alfa-enac)
CR9942A (es) Inhibidores de proteina activadora de la 5-lipoxigenasa (flap)
EA200901308A1 (ru) Ингибиторы белка, активирующего 5-липоксигеназу (flap)
BRPI0921830A8 (pt) Composição para tratamento bucal compreendendo sílica fundida
MX2008011085A (es) Composiciones antimicrobianas y metodos para sellar cateteres.
BRPI0610108B8 (pt) compostos promotores de apoptose e composição que compreende os ditos compostos
BR112013032472A2 (pt) produto autoadesivo para tratar ferimento
CO2020010303A2 (es) Conjugados de il-15, y sus usos
CL2009000349A1 (es) Compuestos derivados de 4,5-dihidro-oxazol-2-ilamina; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de la enfermedad de alzheimer.
NO20085243L (no) Farmasoytisk sammensetning til behandling av virusinfeksjoner og/eller tumorsykdommer gjennom inhibering av proteinfolding og Proteinnedbryting
EA200801164A3 (ru) Ингибиторы протеина, активирующего 5-липоксигеназу (flap)
BR0114927A (pt) Composição de gel farmacêutica substancialmente não aquosa para aplicação na pele, e, uso da composição
CO6210786A2 (es) Implemento de cuidado oral que alberga un agente de cuidado oral
EP1899451A4 (en) METHOD AND COMPOSITIONS FOR REGULATING THE DEVELOPMENT OF BIOFILMS
NO20081042L (no) PPAR aktive forbindelser
CL2008003593A1 (es) Compuestos derivados de isoxazolo-piridazina; procedimiento de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de trastornos cognitivos como el alzheimer
MX2020003095A (es) Arni variante.
BRPI0710483A8 (pt) composições e kits úteis para o tratamento de doenças respiratórias
BR112012020661A2 (pt) artigo para cuidados pessoais flexível
BRPI0621277B8 (pt) aplicador de tampão
CL2011003327A1 (es) Composicion farmaceutica que comprende finafloxacina y un agente antiinflamatorio; uso en el tratamiento de infecciones oftalmicas, oticas o nasales.
BR112017001952A2 (pt) conjunto de curativo para ferimentos
NO20092073L (no) Modulatorer av C3A-reseptor, og fremgangsmater for anvendelse derav
UY38426A (es) Uso de recambio plasmático de bajo volumen para el tratamiento de la enfermedad de alzheimer en etapas temprana y moderada
BRPI0507982A (pt) sistema e método para fornecer tratamento a um corpo

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: NOBELPHARMA CO., LTD. (JP)

B25B Requested transfer of rights rejected

Owner name: NOBELPHARMA CO., LTD. (JP)

B25B Requested transfer of rights rejected

Owner name: NOBELPHARMA CO., LTD. (JP)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/06/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF