BRPI0915513A2 - derivados de ácido fenóxi-cromano carboxílico 6-substituído - Google Patents

derivados de ácido fenóxi-cromano carboxílico 6-substituído

Info

Publication number: BRPI0915513A2
Authority: BR; Brazil
Prior art keywords: carboxylic acid; acid derivatives; substituted phenoxy; chroman carboxylic; chroman
Prior art date: 2008-06-25

Application number

BRPI0915513A

Other languages

English (en)

Inventor

Adam Cook

Christopher P Corrette

Christopher T Clark

Ganghyeok Kim

George A Doherty

Kevin W Hunt

Laurence E Burgess

Robert Kirk Delisle

Todd Romoff

Original Assignee

Array Biopharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-06-25

Filing date

2009-06-24

Publication date

2016-01-26

2009-06-24 Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc

2016-01-26 Publication of BRPI0915513A2 publication Critical patent/BRPI0915513A2/pt

2019-11-19 Publication of BRPI0915513B1 publication Critical patent/BRPI0915513B1/pt

2021-05-25 Publication of BRPI0915513B8 publication Critical patent/BRPI0915513B8/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyrane Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

BRPI0915513A 2008-06-25 2009-06-24 compostos derivados de ácido fenóxi-cromano carboxílico 6-substituído, composições farmacêuticas compreendendo os referidos compostos, uso dos mesmos, e processo para a preparação destes BRPI0915513B8 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7561508P	2008-06-25	2008-06-25
PCT/US2009/048499 WO2009158426A1 (en)	2008-06-25	2009-06-24	6-substituted phenoxychroman carboxylic acid derivatives

Publications (3)

Publication Number	Publication Date
BRPI0915513A2 true BRPI0915513A2 (pt)	2016-01-26
BRPI0915513B1 BRPI0915513B1 (pt)	2019-11-19
BRPI0915513B8 BRPI0915513B8 (pt)	2021-05-25

Family

ID=40996727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0915513A BRPI0915513B8 (pt)	2008-06-25	2009-06-24	compostos derivados de ácido fenóxi-cromano carboxílico 6-substituído, composições farmacêuticas compreendendo os referidos compostos, uso dos mesmos, e processo para a preparação destes

Country Status (32)

Country	Link
US (4)	US8569522B2 (pt)
EP (3)	EP3144303B1 (pt)
JP (2)	JP5753780B2 (pt)
KR (1)	KR101728175B1 (pt)
CN (2)	CN102131794B (pt)
AR (1)	AR072301A1 (pt)
AU (1)	AU2009262274B2 (pt)
BR (1)	BRPI0915513B8 (pt)
CA (1)	CA2729217C (pt)
CL (1)	CL2010001528A1 (pt)
CO (1)	CO6362002A2 (pt)
CR (1)	CR20110037A (pt)
CY (1)	CY1115650T1 (pt)
DK (1)	DK2307397T3 (pt)
ES (2)	ES2582161T3 (pt)
HR (1)	HRP20140988T1 (pt)
IL (2)	IL210198A (pt)
MX (1)	MX2011000173A (pt)
MY (2)	MY161425A (pt)
NZ (1)	NZ590437A (pt)
PH (1)	PH12014500079B1 (pt)
PL (1)	PL2307397T3 (pt)
PT (1)	PT2307397E (pt)
RS (1)	RS53665B1 (pt)
RU (1)	RU2507200C2 (pt)
SG (2)	SG2014013544A (pt)
SI (1)	SI2307397T1 (pt)
TW (2)	TWI476186B (pt)
UA (1)	UA104867C2 (pt)
UY (1)	UY31938A (pt)
WO (1)	WO2009158426A1 (pt)
ZA (1)	ZA201100604B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RS53665B1 (sr)	2008-06-25	2015-04-30	Array Biopharma Inc.	Derivati 6-supstituisane fenoksihroman karboksilne kiseline
EP2379535B1 (en) *	2008-12-22	2016-06-15	Array Biopharma Inc.	7-phenoxychroman carboxylic acid derivatives
EP2457900A1 (en)	2010-11-25	2012-05-30	Almirall, S.A.	New pyrazole derivatives having CRTh2 antagonistic behaviour
TWI654180B (zh)	2012-06-29	2019-03-21	美商艾佛艾姆希公司	殺真菌之雜環羧醯胺
TW201507722A (zh) *	2013-04-30	2015-03-01	Bayer Cropscience Ag	做為殺線蟲劑及殺體內寄生蟲劑的ｎ－（２－鹵素－２－苯乙基）－羧醯胺類
WO2015126750A1 (en)	2014-02-19	2015-08-27	Array Biopharma Inc.	BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO TREATMENT WITH A CRTh2 INHIBITOR
CN111057003A (zh) *	2019-12-06	2020-04-24	广安凯特制药有限公司	一种立他司特中间体5,7-二氯-1,2,3,4-四氢异喹啉的合成方法
SE2151519A1 (en) *	2021-12-10	2023-06-11	Amidea Sweden Ab	2-(2,5-dimethoxyphenyl)ethanamine and uses thereof
CN114181039A (zh) *	2021-12-23	2022-03-15	凯美克(上海)医药科技有限公司	一种4,4-二苯基-3-丁烯-1-醇的合成方法
TW202515529A (zh) *	2023-08-29	2025-04-16	韓商Ｊｗ製藥公司	用於治療異位性皮膚炎之雜環衍生物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5059609A (en)	1987-10-19	1991-10-22	Pfizer Inc.	Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
US5006550A (en) *	1989-12-29	1991-04-09	Allergan, Inc.	Chroman esters of phenols and benzoic acids having retinoid-like activity
US5952326A (en)	1997-12-10	1999-09-14	Pfizer Inc.	Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases
DE19850131A1 (de) *	1998-10-30	2000-05-04	Merck Patent Gmbh	Chromenon- und Chromanonderivate
WO2000071538A2 (en)	1999-05-21	2000-11-30	Pfizer Products Inc.	1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
CN1474803B (zh) *	2000-09-14	2012-11-21	田边三菱制药株式会社	酰胺衍生物及其制备药物的用途
WO2003029239A1 (en) *	2001-10-04	2003-04-10	Wyeth	Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
AU2003297398B2 (en) *	2002-12-20	2009-09-24	Amgen Inc.	Asthma and allergic inflammation modulators
JP2008531558A (ja) *	2005-02-25	2008-08-14	イーライリリーアンドカンパニー	新規なリポオキシゲナーゼ阻害剤
GB0611781D0 (en)	2006-06-14	2006-07-26	Argenta Discovery Ltd	2-Oxo-2H-Chromene Compounds
AU2007286829B2 (en) *	2006-08-21	2013-05-02	Array Biopharma, Inc.	4-substituted phenoxyphenylacetic acid derivatives
US8039484B2 (en) *	2006-10-31	2011-10-18	Merck Sharp & Dohme Corp.	Antidiabetic bicyclic compounds
US7960567B2 (en) *	2007-05-02	2011-06-14	Amgen Inc.	Compounds and methods useful for treating asthma and allergic inflammation
WO2009061730A2 (en)	2007-11-05	2009-05-14	Array Biopharma Inc.	4-heteroaryl-substituted phenoxyphenylacetic acid
RS53665B1 (sr)	2008-06-25	2015-04-30	Array Biopharma Inc.	Derivati 6-supstituisane fenoksihroman karboksilne kiseline
EP2379535B1 (en) *	2008-12-22	2016-06-15	Array Biopharma Inc.	7-phenoxychroman carboxylic acid derivatives

2009
- 2009-06-24 RS RS20140627A patent/RS53665B1/sr unknown
- 2009-06-24 ES ES13195749.0T patent/ES2582161T3/es active Active
- 2009-06-24 AR ARP090102331A patent/AR072301A1/es active IP Right Grant
- 2009-06-24 MY MYPI2010006174A patent/MY161425A/en unknown
- 2009-06-24 SG SG2014013544A patent/SG2014013544A/en unknown
- 2009-06-24 UA UAA201100801A patent/UA104867C2/uk unknown
- 2009-06-24 KR KR1020117001795A patent/KR101728175B1/ko not_active Expired - Fee Related
- 2009-06-24 WO PCT/US2009/048499 patent/WO2009158426A1/en not_active Ceased
- 2009-06-24 DK DK09770959.6T patent/DK2307397T3/da active
- 2009-06-24 NZ NZ590437A patent/NZ590437A/en not_active IP Right Cessation
- 2009-06-24 SG SG2014013528A patent/SG2014013528A/en unknown
- 2009-06-24 EP EP16170994.4A patent/EP3144303B1/en active Active
- 2009-06-24 PT PT97709596T patent/PT2307397E/pt unknown
- 2009-06-24 BR BRPI0915513A patent/BRPI0915513B8/pt not_active IP Right Cessation
- 2009-06-24 ES ES09770959.6T patent/ES2524314T3/es active Active
- 2009-06-24 MY MYPI2014001094A patent/MY185134A/en unknown
- 2009-06-24 SI SI200931031T patent/SI2307397T1/sl unknown
- 2009-06-24 MX MX2011000173A patent/MX2011000173A/es active IP Right Grant
- 2009-06-24 CA CA2729217A patent/CA2729217C/en not_active Expired - Fee Related
- 2009-06-24 JP JP2011516614A patent/JP5753780B2/ja not_active Expired - Fee Related
- 2009-06-24 CN CN2009801332711A patent/CN102131794B/zh not_active Expired - Fee Related
- 2009-06-24 PL PL09770959T patent/PL2307397T3/pl unknown
- 2009-06-24 EP EP13195749.0A patent/EP2826774B1/en active Active
- 2009-06-24 EP EP09770959.6A patent/EP2307397B1/en active Active
- 2009-06-24 RU RU2011102595/04A patent/RU2507200C2/ru active
- 2009-06-24 UY UY0001031938A patent/UY31938A/es not_active Application Discontinuation
- 2009-06-24 US US13/001,201 patent/US8569522B2/en not_active Expired - Fee Related
- 2009-06-24 HR HRP20140988AT patent/HRP20140988T1/hr unknown
- 2009-06-24 AU AU2009262274A patent/AU2009262274B2/en not_active Ceased
- 2009-06-24 CN CN201310354758.0A patent/CN103450138B/zh not_active Expired - Fee Related
- 2009-06-25 TW TW103112407A patent/TWI476186B/zh not_active IP Right Cessation
- 2009-06-25 TW TW098121432A patent/TWI436990B/zh not_active IP Right Cessation
2010
- 2010-12-23 IL IL210198A patent/IL210198A/en active IP Right Grant
- 2010-12-23 CL CL2010001528A patent/CL2010001528A1/es unknown
2011
- 2011-01-21 CR CR20110037A patent/CR20110037A/es unknown
- 2011-01-24 ZA ZA2011/00604A patent/ZA201100604B/en unknown
- 2011-01-28 CO CO11010027A patent/CO6362002A2/es active IP Right Grant
2013
- 2013-08-29 US US14/013,898 patent/US8716498B2/en not_active Expired - Fee Related
2014
- 2014-01-08 PH PH12014500079A patent/PH12014500079B1/en unknown
- 2014-03-27 JP JP2014065161A patent/JP2014122241A/ja not_active Withdrawn
- 2014-03-31 US US14/231,356 patent/US9096567B2/en not_active Expired - Fee Related
- 2014-10-21 CY CY20141100859T patent/CY1115650T1/el unknown
2015
- 2015-05-04 US US14/702,947 patent/US9556139B2/en not_active Expired - Fee Related
- 2015-09-21 IL IL241754A patent/IL241754A/en active IP Right Grant

Also Published As

Publication number	Publication date
PL2307397T3 (pl)	2015-02-27
RU2011102595A (ru)	2012-07-27
KR101728175B1 (ko)	2017-04-18
IL210198A0 (en)	2011-03-31
ZA201100604B (en)	2015-08-26
PH12014500079A1 (en)	2015-02-09
UY31938A (es)	2011-01-31
CY1115650T1 (el)	2017-01-04
CL2010001528A1 (es)	2011-07-01
PH12014500079B1 (en)	2015-02-09
EP2826774B1 (en)	2016-05-25
KR20110027798A (ko)	2011-03-16
SG2014013528A (en)	2014-07-30
EP2307397A1 (en)	2011-04-13
HRP20140988T1 (hr)	2014-12-05
EP3144303B1 (en)	2018-09-26
US20110105463A1 (en)	2011-05-05
RS53665B1 (sr)	2015-04-30
MY185134A (en)	2021-04-30
EP2307397B1 (en)	2014-08-20
MY161425A (en)	2017-04-14
ES2524314T3 (es)	2014-12-05
AU2009262274A1 (en)	2009-12-30
US20150232442A1 (en)	2015-08-20
CN102131794A (zh)	2011-07-20
JP2014122241A (ja)	2014-07-03
TWI476186B (zh)	2015-03-11
US9096567B2 (en)	2015-08-04
CA2729217C (en)	2016-09-06
US8569522B2 (en)	2013-10-29
US20140221342A1 (en)	2014-08-07
UA104867C2 (uk)	2014-03-25
SI2307397T1 (sl)	2014-11-28
TW201022222A (en)	2010-06-16
CR20110037A (es)	2011-03-14
US20140005418A1 (en)	2014-01-02
TW201427965A (zh)	2014-07-16
TWI436990B (zh)	2014-05-11
CN103450138B (zh)	2015-04-08
CN102131794B (zh)	2013-09-25
RU2507200C2 (ru)	2014-02-20
PT2307397E (pt)	2014-10-29
IL241754A (en)	2017-02-28
AU2009262274B2 (en)	2013-08-01
CN103450138A (zh)	2013-12-18
JP5753780B2 (ja)	2015-07-22
IL210198A (en)	2015-10-29
EP2826774A1 (en)	2015-01-21
MX2011000173A (es)	2011-06-20
BRPI0915513B1 (pt)	2019-11-19
CA2729217A1 (en)	2009-12-30
AR072301A1 (es)	2010-08-18
SG2014013544A (en)	2014-07-30
NZ590437A (en)	2012-07-27
DK2307397T3 (da)	2014-11-03
HK1155735A1 (en)	2012-05-25
JP2011526290A (ja)	2011-10-06
ES2582161T3 (es)	2016-09-09
CO6362002A2 (es)	2012-01-20
BRPI0915513B8 (pt)	2021-05-25
EP3144303A1 (en)	2017-03-22
IL241754A0 (en)	2015-11-30
US8716498B2 (en)	2014-05-06
WO2009158426A1 (en)	2009-12-30
US9556139B2 (en)	2017-01-31

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-03-26	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]	Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI
2019-06-04	B06T	Formal requirements before examination [chapter 6.20 patent gazette]
2019-09-10	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-11-19	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/11/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 19/11/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/06/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2022-04-19	B21F	Lapse acc. art. 78, item iv - on non-payment of the annual fees in time	Free format text: REFERENTE A 13A ANUIDADE.
2022-08-09	B24J	Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)	Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2676 DE 19-04-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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BRPI0913368A2 (pt)	2015-11-24	compostos de ácido carboxílico
BRPI1013937A2 (pt)	2016-08-09	compostos de ácido carboxílico
BRPI0909527A2 (pt)	2019-09-24	derivados substituídos de 4-aminociclohexano
BRPI0914544A2 (pt)	2015-12-15	derivados de pirimidona substituídos
BRPI0909317A2 (pt)	2017-04-11	imidazoquinolinas substituídas
ECSP12011999A (es)	2012-07-31	Derivados benzamida sustituidos
BRPI1013246A2 (pt)	2016-04-05	derivados de benzofuralina
BR112012002828A2 (pt)	2015-10-13	derivados de 5-fluorpirimidinona
BRPI0812411A2 (pt)	2014-12-02	Amidas de ácido pirazol carboxílico úteis como microbicidas
EP2281080A4 (en)	2012-10-10	POLYLACTIC ACID FIBERS
DK2308877T3 (da)	2014-04-22	Imidazopyridin-2-on-derivater
EP2376493A4 (en)	2012-05-30	DIHYDROPYRIMIDOPYRIMIDINDERIVAT
BRPI0915064A2 (pt)	2015-10-27	derivados de qunoxalinadiona
BR112012000763A2 (pt)	2018-03-13	derivados de piridin-4-ila
BRPI0913832A2 (pt)	2015-10-20	derivados de pirrolopiridinilpirimidin-2-ilamina
BRPI0914301A2 (pt)	2015-10-13	derivados de pirimidin-4-ona substituída
BRPI0915513A2 (pt)	2016-01-26	derivados de ácido fenóxi-cromano carboxílico 6-substituído
BRPI1013844A2 (pt)	2016-04-12	derivados de piridina-isoxazol
EP2336132A4 (en)	2012-03-21	MORPHOLINPURINDERIVAT
BRPI0920496A2 (pt)	2019-09-24	derivados substituídos de pirimidina etriazina
DK2275414T3 (da)	2015-06-22	Cyclopentylacrylamidderivat
ATE545635T1 (de)	2012-03-15	Substituierte n-oxidpyrazinderivate
BRPI1014454A2 (pt)	2016-04-05	derivados de isoxazol-pirazol
BRPI0906357A2 (pt)	2015-07-07	Derivados de oxazepinopirimidona arilamida substituídos