BRPI0918443A2 - uso de uma agonista receptor de ang-(1-7) em lesão pulmonar aguda - Google Patents

uso de uma agonista receptor de ang-(1-7) em lesão pulmonar aguda

Info

Publication number: BRPI0918443A2
Authority: BR; Brazil
Prior art keywords: ang; receptor agonist; lung injury; acute lung; acute
Prior art date: 2008-09-12

Application number

BRPI0918443A

Other languages

English (en)

Inventor

Thomas Walther

Wolfgang Kuebler

Original Assignee

Charite Universitätsmedizin Berlin

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-09-12

Filing date

2009-09-11

Publication date

2015-11-24

2009-09-11 Application filed by Charite Universitätsmedizin Berlin filed Critical Charite Universitätsmedizin Berlin

2009-09-11 Priority to BR122013002187A priority Critical patent/BR122013002187A2/pt

2015-11-24 Publication of BRPI0918443A2 publication Critical patent/BRPI0918443A2/pt

Links

PVHLMTREZMEJCG-GDTLVBQBSA-N Ile(5)-angiotensin II (1-7) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 PVHLMTREZMEJCG-GDTLVBQBSA-N 0.000 title 1
206010069351 acute lung injury Diseases 0.000 title 1
239000000018 receptor agonist Substances 0.000 title 1
229940044601 receptor agonist Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/085—Angiotensins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Addiction (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BRPI0918443A 2008-09-12 2009-09-11 uso de uma agonista receptor de ang-(1-7) em lesão pulmonar aguda BRPI0918443A2 (pt)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
BR122013002187A BR122013002187A2 (pt)	2008-09-12	2009-09-11	peptídeo e composição farmacêutica compreendendo o mesmo

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08016142A EP2163259B1 (en)	2008-09-12	2008-09-12	Use of an Ang-(1-7) receptor agonist in acute lung injury
PCT/EP2009/006619 WO2010028845A2 (en)	2008-09-12	2009-09-11	Use of an ang-(1-7) receptor agonist in acute lung injury

Publications (1)

Publication Number	Publication Date
BRPI0918443A2 true BRPI0918443A2 (pt)	2015-11-24

Family

ID=40430691

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BR122013002187A BR122013002187A2 (pt)	2008-09-12	2009-09-11	peptídeo e composição farmacêutica compreendendo o mesmo
BRPI0918443A BRPI0918443A2 (pt)	2008-09-12	2009-09-11	uso de uma agonista receptor de ang-(1-7) em lesão pulmonar aguda

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BR122013002187A BR122013002187A2 (pt)	2008-09-12	2009-09-11	peptídeo e composição farmacêutica compreendendo o mesmo

Country Status (9)

Country	Link
US (4)	US20110281805A1 (pt)
EP (2)	EP2163259B1 (pt)
JP (2)	JP2012502071A (pt)
KR (1)	KR20110074978A (pt)
CN (2)	CN103263661A (pt)
BR (2)	BR122013002187A2 (pt)
CA (1)	CA2736922C (pt)
ES (1)	ES2393455T3 (pt)
WO (1)	WO2010028845A2 (pt)

Families Citing this family (23)

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ES2393455T3 (es) *	2008-09-12	2012-12-21	Charité-Universitátsmedizin Berlin (Charité)	Uso de un agonista del receptor Ang-(1-7) en lesiones pulmonares agudas
JP2015504870A (ja) *	2011-12-16	2015-02-16	タリックスファーマシューティカルズリミテッド	線維症を処置するためのアンジオテンシン
CN102532265A (zh) *	2011-12-29	2012-07-04	中国人民解放军第四军医大学	一种短肽、其异构体及其应用
US20130210726A1 (en) *	2012-02-10	2013-08-15	Tarix Pharmaceuticals Ltd.	Compositions and methods for treatment of peripheral vascular disease
US8557958B1 (en)	2012-06-18	2013-10-15	Tarix Pharmaceuticals Ltd.	Compositions and methods for treatment of diabetes
CA2884792A1 (en) *	2012-09-17	2014-03-20	Tarix Pharmaceuticals Ltd.	Oral formulations of angiotensin
US8633158B1 (en) *	2012-10-02	2014-01-21	Tarix Pharmaceuticals Ltd.	Angiotensin in treating brain conditions
CN105636645A (zh) *	2013-04-19	2016-06-01	爱荷华大学研究基金会	在肌萎缩症中的血管紧张素
JP2016520592A (ja) *	2013-05-24	2016-07-14	タリックスファーマシューティカルズリミテッド	マルファン症候群および関連障害の処置におけるアンジオテンシンペプチド
WO2015054005A1 (en) *	2013-10-11	2015-04-16	Tarix Pharmaceuticals Ltd.	Compositions and methods for treatment of bdnf-related conditions
US9333233B2 (en)	2014-02-25	2016-05-10	Tarix Pharmaceuticals Ltd.	Methods and compositions for the delayed treatment of stroke
RU2016152088A (ru) *	2014-07-17	2018-08-21	Юниверсити Оф Саузерн Калифорния	Способы, соединения и композиции для лечения заболеваний опорно-двигательного аппарата
CN106535920B (zh)	2014-07-21	2020-10-30	代表亚利桑那大学的亚利桑那校董会	Ang-(1-7)衍生物寡肽及其使用和生产方法
US10183055B2 (en) *	2014-07-21	2019-01-22	Arizona Board Of Regents On Behalf Of The University Of Arizona	Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
JP7010698B2 (ja) *	2015-04-08	2022-01-26	コーニンクレッカフィリップスエヌヴェ	急性呼吸促迫症候群（ａｒｄｓ）のリスクスコアによって導かれる換気治療推薦のためのツール
WO2018129511A2 (en) *	2017-01-09	2018-07-12	Arizona Board Of Regents On Behalf Of The University Of Arizona	Ang-(1-7) and derivative oligopeptides for the treatment of traumatic brain injury and other cognitive impairments
US20200188473A1 (en) *	2017-05-02	2020-06-18	Beth Israel Deaconess Medical Center, Inc.	Combination therapy for cancer
CN112316107B (zh) *	2019-07-17	2023-01-06	首都医科大学附属北京妇产医院	血管紧张素(1-7)在胰腺疾病中的应用
WO2021183863A1 (en) *	2020-03-13	2021-09-16	Constant Therapeutics Llc	Methods and compositions for treatment of coronavirus infection
WO2022094025A1 (en) *	2020-10-30	2022-05-05	Gere Dizerega	Angiotensin-1-7 for the treatment of covid-19
US12343331B2 (en)	2021-01-28	2025-07-01	Capacity Bio, Inc.	Methods and agents that stimulate mitochondrial turnover for treating disease
EP4085921A1 (en)	2021-05-04	2022-11-09	CU-Pharmaceuticals UG	Angiotensin-(1-7) in the treatment of sars-cov related diseases
CN117147877A (zh) *	2023-08-30	2023-12-01	重庆医科大学附属儿童医院	Ang1-7作为生物标志物在预测、诊断儿童脓毒症中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6110895A (en) *	1996-12-16	2000-08-29	University Of Southern California	Method of promoting healing in skin grafts
YU78601A (sh)	1999-05-05	2005-07-19	Aventis Pharma Deutschland Gmbh.	1-(p-tienilbenzil)-imidazoli kao agonisti angiotenzin-(1-7)- receptora, postupak za njihovu proizvodnju, njihova primena i farmaceutski preparati koji ih sadrže
AU2003217783A1 (en) *	2002-02-27	2003-09-09	Wake Forest University	Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
US20050119180A1 (en) *	2002-03-28	2005-06-02	Roks Antonius J.M.	Use of angiotensin 1-7 for enhancing cardiac function
EP1723962A1 (en) *	2005-05-19	2006-11-22	IMBA-Institut für Molekulare Biotechnologie GmbH	Use of inhibitors of the renin-angiotensin system for the treatment of lung injuries
BRPI0503122A (pt)	2005-05-30	2007-05-02	Univ Minas Gerais	composições farmacêuticas do peptìdeo angiotensina-(1-7) [ang-(1-7)] e seus análogos, agonistas e antagonistas usando as ciclodextrinas, seus derivados, e o polìmeros biodegradáveis e/ou dos produtos derivados para uso no controle das funções do sistema reprodutivo
BRPI0502497A (pt)	2005-06-28	2007-02-06	Univ Minas Gerais	uso de agonistas e antagonistas do receptor acoplado a proteìna g, mas, como moduladores de atividade apoptótica para o estudo, a prevenção e o tratamento de doenças
BRPI0602366B1 (pt)	2006-04-26	2017-12-12	Universidade Federal De Minas Gerais	Use of agonists of the receptor coupled to protein g, but, in the treatment of metabolic syndrome, its components and their complications
WO2008130217A1 (en) *	2006-08-08	2008-10-30	Applied Nanosystems B.V.	Cyclic angiotensin analogs
ES2393455T3 (es) *	2008-09-12	2012-12-21	Charité-Universitátsmedizin Berlin (Charité)	Uso de un agonista del receptor Ang-(1-7) en lesiones pulmonares agudas

2008
- 2008-09-12 ES ES08016142T patent/ES2393455T3/es active Active
- 2008-09-12 EP EP08016142A patent/EP2163259B1/en not_active Not-in-force
2009
- 2009-09-11 WO PCT/EP2009/006619 patent/WO2010028845A2/en not_active Ceased
- 2009-09-11 CN CN2013101168734A patent/CN103263661A/zh active Pending
- 2009-09-11 BR BR122013002187A patent/BR122013002187A2/pt not_active IP Right Cessation
- 2009-09-11 BR BRPI0918443A patent/BRPI0918443A2/pt not_active IP Right Cessation
- 2009-09-11 KR KR1020117008209A patent/KR20110074978A/ko not_active Ceased
- 2009-09-11 CN CN200980135629.4A patent/CN102164614B/zh not_active Expired - Fee Related
- 2009-09-11 US US13/063,685 patent/US20110281805A1/en not_active Abandoned
- 2009-09-11 JP JP2011526411A patent/JP2012502071A/ja active Pending
- 2009-09-11 EP EP09778494A patent/EP2341938A2/en not_active Ceased
- 2009-09-11 CA CA2736922A patent/CA2736922C/en not_active Expired - Fee Related
2012
- 2012-08-21 US US13/590,894 patent/US8383772B2/en not_active Expired - Fee Related
2013
- 2013-06-28 US US13/931,168 patent/US20140073760A1/en not_active Abandoned
- 2013-12-13 JP JP2013257932A patent/JP5881122B2/ja not_active Expired - Fee Related
2015
- 2015-06-25 US US14/750,500 patent/US20160051621A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP5881122B2 (ja)	2016-03-09
CA2736922C (en)	2014-08-19
US20120321701A1 (en)	2012-12-20
CA2736922A1 (en)	2010-03-18
WO2010028845A3 (en)	2010-06-10
CN102164614A (zh)	2011-08-24
JP2012502071A (ja)	2012-01-26
CN102164614B (zh)	2014-03-26
KR20110074978A (ko)	2011-07-05
WO2010028845A2 (en)	2010-03-18
US8383772B2 (en)	2013-02-26
HK1161100A1 (en)	2012-08-24
BR122013002187A2 (pt)	2016-04-05
EP2163259A1 (en)	2010-03-17
EP2163259B1 (en)	2012-06-13
CN103263661A (zh)	2013-08-28
US20110281805A1 (en)	2011-11-17
US20160051621A1 (en)	2016-02-25
ES2393455T3 (es)	2012-12-21
US20140073760A1 (en)	2014-03-13
JP2014074048A (ja)	2014-04-24
EP2341938A2 (en)	2011-07-13

Legal Events

Date	Code	Title	Description
2017-07-18	B08F	Application fees: application dismissed [chapter 8.6 patent gazette]
2017-11-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

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