BRPI0918460A2 - dispositivo de espectrômetro de massa - cromatografia líquida, emissor para um fluxo nanoescala, método para fabricar uma coluna de cromatografia líquida, para identificar um epítopo, e para produzir uma composição que compreende um epítodo, uso do dispositivo, epítopo, e, uso de um epítopo. - Google Patents

dispositivo de espectrômetro de massa - cromatografia líquida, emissor para um fluxo nanoescala, método para fabricar uma coluna de cromatografia líquida, para identificar um epítopo, e para produzir uma composição que compreende um epítodo, uso do dispositivo, epítopo, e, uso de um epítopo.

Info

Publication number
BRPI0918460A2
BRPI0918460A2 BRPI0918460A BRPI0918460A BRPI0918460A2 BR PI0918460 A2 BRPI0918460 A2 BR PI0918460A2 BR PI0918460 A BRPI0918460 A BR PI0918460A BR PI0918460 A BRPI0918460 A BR PI0918460A BR PI0918460 A2 BRPI0918460 A2 BR PI0918460A2
Authority
BR
Brazil
Prior art keywords
epitope
liquid chromatography
fabricating
identifying
producing
Prior art date
Application number
BRPI0918460A
Other languages
English (en)
Inventor
Adrianus Petrus Josephus Maria De Jong
Cécile Antoinette Carola Maria Van Els
Ernst Christiaan Soethout
Hugo Derk Meiring
Original Assignee
Nederlanden Staat
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlanden Staat filed Critical Nederlanden Staat
Publication of BRPI0918460A2 publication Critical patent/BRPI0918460A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6034—Construction of the column joining multiple columns
    • G01N30/6039—Construction of the column joining multiple columns in series
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
    • G01N2030/562—Packing methods or coating methods packing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods
    • G01N2030/562—Packing methods or coating methods packing
    • G01N2030/565—Packing methods or coating methods packing slurry packing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
BRPI0918460A 2008-09-09 2009-09-09 dispositivo de espectrômetro de massa - cromatografia líquida, emissor para um fluxo nanoescala, método para fabricar uma coluna de cromatografia líquida, para identificar um epítopo, e para produzir uma composição que compreende um epítodo, uso do dispositivo, epítopo, e, uso de um epítopo. BRPI0918460A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08163987 2008-09-09
PCT/NL2009/050539 WO2010030178A1 (en) 2008-09-09 2009-09-09 Lcms technology and its uses

Publications (1)

Publication Number Publication Date
BRPI0918460A2 true BRPI0918460A2 (pt) 2015-11-24

Family

ID=40627150

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0918460A BRPI0918460A2 (pt) 2008-09-09 2009-09-09 dispositivo de espectrômetro de massa - cromatografia líquida, emissor para um fluxo nanoescala, método para fabricar uma coluna de cromatografia líquida, para identificar um epítopo, e para produzir uma composição que compreende um epítodo, uso do dispositivo, epítopo, e, uso de um epítopo.

Country Status (14)

Country Link
US (1) US20110186731A1 (pt)
EP (1) EP2324347A1 (pt)
JP (1) JP2012502296A (pt)
KR (1) KR20110084182A (pt)
CN (1) CN102216768A (pt)
AU (1) AU2009292304A1 (pt)
BR (1) BRPI0918460A2 (pt)
CA (1) CA2736479A1 (pt)
IL (1) IL211657A0 (pt)
MX (1) MX2011002567A (pt)
NZ (1) NZ591617A (pt)
RU (1) RU2011113852A (pt)
WO (1) WO2010030178A1 (pt)
ZA (1) ZA201101824B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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US9504936B2 (en) * 2010-04-05 2016-11-29 Purdue Research Foundation Method of packing chromatographic columns
CN102621259B (zh) * 2011-03-24 2014-08-20 苏州汇通色谱分离纯化有限公司 毛细抛物线形高效毛细液相色谱制备柱
CN102565246A (zh) * 2011-11-23 2012-07-11 福建中烟工业有限责任公司 一种用于提高气相色谱中心切割技术性能的阀转换方法
HK1205138A1 (en) 2012-07-27 2015-12-11 Institut National De La Santé Et De La Recherche Médicale (Inserm) Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
WO2016098757A1 (ja) * 2014-12-15 2016-06-23 積水メディカル株式会社 アミノ酸またはアシルカルニチンの検出方法
CN105218671A (zh) * 2015-09-29 2016-01-06 李艳华 一种传染病病原体全人源化抗体的制备方法
GB201701986D0 (en) 2017-02-07 2017-03-22 Thermo Fisher Scient (Bremen) Gmbh n
WO2020240510A1 (en) * 2019-05-31 2020-12-03 Dh Technologies Development Pte. Ltd. Electrospray probe
US12209989B2 (en) * 2019-09-30 2025-01-28 Dh Technologies Development Pte. Ltd. Sampling probe with internal sampling for use in mass spectrometry systems and methods
CN110828284A (zh) * 2019-11-18 2020-02-21 深圳至秦仪器有限公司 一种自吸式毛细管电喷雾离子源
WO2021140178A1 (en) * 2020-01-10 2021-07-15 F. Hoffmann-La Roche Ag Calibration of mass spectrometry systems
CN114464521B (zh) * 2022-02-17 2024-04-19 河北医科大学 一种毛细管针及其制备方法
CN115356425A (zh) * 2022-07-27 2022-11-18 上海奥浦迈生物科技股份有限公司 一种应用于培养基上清蛋白定量的nanoHPLC-Titer系统
GB2641573A (en) * 2024-06-07 2025-12-10 Thermo Fisher Scient Bremen Gmbh Liquid separation mass spectrometer system

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US5679255A (en) * 1992-06-22 1997-10-21 The Dow Chemical Company Microcolumns for chromatography and method for making same
US5389221A (en) * 1993-03-09 1995-02-14 The University Of North Carolina At Chapel Hill Two dimensional separation system
US5788166A (en) * 1996-08-27 1998-08-04 Cornell Research Foundation, Inc. Electrospray ionization source and method of using the same
WO1999034810A1 (en) * 1998-01-12 1999-07-15 Her Majesty In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada A process for the isolation, recovery and purification of non-polar extractives
NL1016034C2 (nl) * 2000-08-03 2002-02-08 Tno Werkwijze en systeem voor het identificeren en kwantificeren van chemische componenten van een te onderzoeken mengsel van materialen.
AU4338502A (en) * 2000-10-23 2002-06-24 Genetics Inst Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures
US6395183B1 (en) * 2001-01-24 2002-05-28 New Objectives, Inc. Method for packing capillary columns with particulate materials
US6989129B2 (en) * 2001-04-05 2006-01-24 The President And Fellows Of Harvard College Automated capillary liquid chromatography small volume analysis system
US7976779B2 (en) * 2002-06-26 2011-07-12 California Institute Of Technology Integrated LC-ESI on a chip
JP2004101477A (ja) * 2002-09-12 2004-04-02 Yoshio Yamauchi ２次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置
US6909091B2 (en) * 2003-05-30 2005-06-21 Nanosep Ab Separation and analysis of sample components
US7087895B1 (en) * 2003-06-07 2006-08-08 Musc Foundation For Research Development Electrospray ionization using pointed fibers
US7015466B2 (en) * 2003-07-24 2006-03-21 Purdue Research Foundation Electrosonic spray ionization method and device for the atmospheric ionization of molecules
JP4613002B2 (ja) * 2003-10-29 2011-01-12 株式会社日立ハイテクノロジーズ エレクトロスプレイ用カラム一体型チップの製造方法
US20060060769A1 (en) * 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US7763848B2 (en) * 2005-01-18 2010-07-27 Phoenix S&T, Inc. Apparatus and method for controlling an electrostatically induced liquid spray
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US7758754B2 (en) * 2007-01-09 2010-07-20 Membrane Technology And Research, Inc Pervaporation process and assembly
GB2459604B (en) * 2007-02-26 2011-07-06 Wisconsin Alumni Res Found Surface plasmon resonance compatible carbon thin films

Also Published As

Publication number Publication date
ZA201101824B (en) 2011-11-30
NZ591617A (en) 2012-11-30
CN102216768A (zh) 2011-10-12
EP2324347A1 (en) 2011-05-25
AU2009292304A2 (en) 2011-05-12
WO2010030178A1 (en) 2010-03-18
CA2736479A1 (en) 2010-03-18
IL211657A0 (en) 2011-05-31
US20110186731A1 (en) 2011-08-04
MX2011002567A (es) 2011-09-27
RU2011113852A (ru) 2012-10-20
AU2009292304A1 (en) 2010-03-18
JP2012502296A (ja) 2012-01-26
KR20110084182A (ko) 2011-07-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2370 DE 07-06-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.