BRPI0815360A2 - Composto derivado de 4-pirimidinossulfamida, composição farmacêutica que o contem, uso e processo para pa preparação do composto - Google Patents

Composto derivado de 4-pirimidinossulfamida, composição farmacêutica que o contem, uso e processo para pa preparação do composto

Info

Publication number: BRPI0815360A2
Authority: BR; Brazil
Prior art keywords: pyrimidinosulfamide; pharmaceutical composition; composition containing; derivative compound; pair preparation
Prior art date: 2007-08-17

Application number

BRPI0815360-4A2A

Other languages

English (en)

Inventor

Martin Bolli

Christoph Boss

Alexander Treiber

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-17

Filing date

2008-08-15

Publication date

2015-02-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40140023&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0815360(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-08-15 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2015-02-10 Publication of BRPI0815360A2 publication Critical patent/BRPI0815360A2/pt

2017-12-26 Publication of BRPI0815360A8 publication Critical patent/BRPI0815360A8/pt

2018-12-04 Publication of BRPI0815360B1 publication Critical patent/BRPI0815360B1/pt

2021-05-25 Publication of BRPI0815360B8 publication Critical patent/BRPI0815360B8/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Transplantation (AREA)

BRPI0815360A 2007-08-17 2008-08-15 composto derivado de 4-pirimidinossulfamida, composição farmacêutica que o contem, uso e processo para a preparação do composto BRPI0815360B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IB2007053292		2007-08-17
IB2008052571		2008-06-26
PCT/IB2008/053282 WO2009024906A1 (en)	2007-08-17	2008-08-15	4-pyrimidinesulfamide derivative

Publications (4)

Publication Number	Publication Date
BRPI0815360A2 true BRPI0815360A2 (pt)	2015-02-10
BRPI0815360A8 BRPI0815360A8 (pt)	2017-12-26
BRPI0815360B1 BRPI0815360B1 (pt)	2018-12-04
BRPI0815360B8 BRPI0815360B8 (pt)	2021-05-25

Family

ID=40140023

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0815360A BRPI0815360B8 (pt)	2007-08-17	2008-08-15	composto derivado de 4-pirimidinossulfamida, composição farmacêutica que o contem, uso e processo para a preparação do composto

Country Status (31)

Country	Link
US (1)	US8324232B2 (pt)
EP (1)	EP2190837B1 (pt)
JP (1)	JP5323075B2 (pt)
KR (1)	KR101528946B1 (pt)
CN (1)	CN101772494B (pt)
AR (1)	AR070018A1 (pt)
AU (1)	AU2008290234B2 (pt)
BR (1)	BRPI0815360B8 (pt)
CA (1)	CA2695511C (pt)
CY (2)	CY1113255T1 (pt)
DK (1)	DK2190837T3 (pt)
ES (1)	ES2394584T3 (pt)
FI (1)	FIC20240041I1 (pt)
FR (1)	FR24C1047I2 (pt)
HR (1)	HRP20120878T1 (pt)
HU (1)	HUS2400041I1 (pt)
IL (1)	IL203936A (pt)
LT (1)	LTC2190837I2 (pt)
MA (1)	MA31702B1 (pt)
MX (1)	MX2010001837A (pt)
MY (1)	MY152281A (pt)
NL (1)	NL301304I2 (pt)
NO (1)	NO2024053I1 (pt)
NZ (1)	NZ583990A (pt)
PL (1)	PL2190837T3 (pt)
PT (1)	PT2190837E (pt)
RU (1)	RU2485116C2 (pt)
SI (1)	SI2190837T1 (pt)
TW (1)	TWI411437B (pt)
WO (1)	WO2009024906A1 (pt)
ZA (1)	ZA201001872B (pt)

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FI3658140T3 (fi) *	2017-02-27	2025-08-12	Idorsia Pharmaceuticals Ltd	Aprositentaanin yhdistelmiä muiden vaikuttavien ainesosien kanssa resistentin verenpainetaudin hoitamiseksi
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CN108997223B (zh) *	2018-08-09	2020-06-30	浙江先锋科技股份有限公司	5-(4-溴苯基)-4，6-二氯嘧啶的制备方法
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JP2025519101A (ja)	2022-05-22	2025-06-24	イドルシア・ファーマシューティカルズ・リミテッド	高血圧の治療のための４－ピリミジンスルファミド誘導体の使用
WO2023227721A1 (en)	2022-05-25	2023-11-30	Idorsia Pharmaceuticals Ltd	Crystalline forms of sodium (5-(4-bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)(sulfamoyl)amide
CN119330888B (zh) *	2024-10-25	2025-11-28	上海药坦药物研究开发有限公司	一种阿普昔腾坦的制备方法
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CN119528820B (zh) *	2024-11-29	2025-10-10	浙江国邦药业有限公司	一种阿普昔腾坦的合成方法
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AR062501A1 (es)	2006-08-29	2008-11-12	Actelion Pharmaceuticals Ltd	Composiciones terapeuticas
PL2254570T3 (pl)	2008-02-20	2014-05-30	Actelion Pharmaceuticals Ltd	Połączenie zawierające paklitaksel do leczenia raka jajnika
JP5764061B2 (ja)	2008-08-13	2015-08-12	アクテリオンファーマシューティカルズリミテッドＡｃｔｅｌｉｏｎＰｈａｒｍａｃｅｕｔｉｃａｌｓＬｔｄ	マシテンタン含有治療用組成物

2008
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- 2008-08-15 WO PCT/IB2008/053282 patent/WO2009024906A1/en not_active Ceased
- 2008-08-15 KR KR1020107004945A patent/KR101528946B1/ko active Active
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2010
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2012
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2024
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Also Published As

Publication number	Publication date
CN101772494B (zh)	2013-05-15
RU2485116C2 (ru)	2013-06-20
CY1113255T1 (el)	2016-04-13
AU2008290234B2 (en)	2013-11-21
KR101528946B1 (ko)	2015-06-15
FR24C1047I2 (fr)	2025-10-10
FR24C1047I1 (fr)	2025-01-10
BRPI0815360B8 (pt)	2021-05-25
US20120142716A1 (en)	2012-06-07
BRPI0815360A8 (pt)	2017-12-26
NO2024053I1 (no)	2024-12-03
ZA201001872B (en)	2011-05-25
HK1144196A1 (en)	2011-02-02
IL203936A (en)	2016-03-31
HRP20120878T1 (hr)	2012-11-30
MX2010001837A (es)	2010-03-10
SI2190837T1 (sl)	2012-11-30
JP2010536742A (ja)	2010-12-02
ES2394584T3 (es)	2013-02-04
LTPA2024534I1 (pt)	2024-12-27
CY2024031I1 (el)	2026-02-25
JP5323075B2 (ja)	2013-10-23
MY152281A (en)	2014-09-15
NZ583990A (en)	2012-06-29
TW200927122A (en)	2009-07-01
CN101772494A (zh)	2010-07-07
CA2695511C (en)	2015-11-03
HUS2400041I1 (hu)	2024-12-28
FIC20240041I1 (fi)	2024-12-02
EP2190837B1 (en)	2012-08-15
RU2010109543A (ru)	2011-09-27
CA2695511A1 (en)	2009-02-26
CY2024031I2 (el)	2026-02-25
TWI411437B (zh)	2013-10-11
KR20100052517A (ko)	2010-05-19
EP2190837A1 (en)	2010-06-02
US8324232B2 (en)	2012-12-04
LTC2190837I2 (pt)	2026-04-27
AU2008290234A1 (en)	2009-02-26
MA31702B1 (fr)	2010-09-01
PT2190837E (pt)	2012-10-31
DK2190837T3 (da)	2012-10-08
AR070018A1 (es)	2010-03-10
NL301304I2 (nl)	2024-12-19
WO2009024906A1 (en)	2009-02-26
PL2190837T3 (pl)	2013-01-31
BRPI0815360B1 (pt)	2018-12-04

Legal Events

Date	Code	Title	Description
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2017-12-26	B25A	Requested transfer of rights approved	Owner name: IDORSIA PHARMACEUTICALS LTD (CH)
2018-01-23	B25L	Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled	Owner name: ACTELION PHARMACEUTICALS LTD (CH)
2018-01-30	B25C	Requirement related to requested transfer of rights	Owner name: ACTELION PHARMACEUTICALS LTD (CH)
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-02	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-05-02	B25A	Requested transfer of rights approved	Owner name: IDORSIA PHARMACEUTICALS LTD (CH)
2018-07-03	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2018-11-06	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2018-12-04	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/12/2018, OBSERVADAS AS CONDICOES LEGAIS.
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/08/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

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