BRPI0815360A2 - Composto derivado de 4-pirimidinossulfamida, composição farmacêutica que o contem, uso e processo para pa preparação do composto - Google Patents

Composto derivado de 4-pirimidinossulfamida, composição farmacêutica que o contem, uso e processo para pa preparação do composto

Info

Publication number: BRPI0815360A2
Authority: BR; Brazil
Prior art keywords: pyrimidinosulfamide; pharmaceutical composition; composition containing; derivative compound; pair preparation
Prior art date: 2007-08-17

Application number

BRPI0815360-4A2A

Other languages

English (en)

Inventor

Martin Bolli

Christoph Boss

Alexander Treiber

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-17

Filing date

2008-08-15

Publication date

2015-02-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40140023&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0815360(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-08-15 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2015-02-10 Publication of BRPI0815360A2 publication Critical patent/BRPI0815360A2/pt

2017-12-26 Publication of BRPI0815360A8 publication Critical patent/BRPI0815360A8/pt

2018-12-04 Publication of BRPI0815360B1 publication Critical patent/BRPI0815360B1/pt

2021-05-25 Publication of BRPI0815360B8 publication Critical patent/BRPI0815360B8/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Physical Education & Sports Medicine (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)

BRPI0815360A 2007-08-17 2008-08-15 composto derivado de 4-pirimidinossulfamida, composição farmacêutica que o contem, uso e processo para a preparação do composto BRPI0815360B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IB2007053292		2007-08-17
IB2008052571		2008-06-26
PCT/IB2008/053282 WO2009024906A1 (en)	2007-08-17	2008-08-15	4-pyrimidinesulfamide derivative

Publications (4)

Publication Number	Publication Date
BRPI0815360A2 true BRPI0815360A2 (pt)	2015-02-10
BRPI0815360A8 BRPI0815360A8 (pt)	2017-12-26
BRPI0815360B1 BRPI0815360B1 (pt)	2018-12-04
BRPI0815360B8 BRPI0815360B8 (pt)	2021-05-25

Family

ID=40140023

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0815360A BRPI0815360B8 (pt)	2007-08-17	2008-08-15	composto derivado de 4-pirimidinossulfamida, composição farmacêutica que o contem, uso e processo para a preparação do composto

Country Status (31)

Country	Link
US (1)	US8324232B2 (pt)
EP (1)	EP2190837B1 (pt)
JP (1)	JP5323075B2 (pt)
KR (1)	KR101528946B1 (pt)
CN (1)	CN101772494B (pt)
AR (1)	AR070018A1 (pt)
AU (1)	AU2008290234B2 (pt)
BR (1)	BRPI0815360B8 (pt)
CA (1)	CA2695511C (pt)
CY (2)	CY1113255T1 (pt)
DK (1)	DK2190837T3 (pt)
ES (1)	ES2394584T3 (pt)
FI (1)	FIC20240041I1 (pt)
FR (1)	FR24C1047I2 (pt)
HR (1)	HRP20120878T1 (pt)
HU (1)	HUS2400041I1 (pt)
IL (1)	IL203936A (pt)
LT (1)	LTC2190837I2 (pt)
MA (1)	MA31702B1 (pt)
MX (1)	MX2010001837A (pt)
MY (1)	MY152281A (pt)
NL (1)	NL301304I2 (pt)
NO (1)	NO2024053I1 (pt)
NZ (1)	NZ583990A (pt)
PL (1)	PL2190837T3 (pt)
PT (1)	PT2190837E (pt)
RU (1)	RU2485116C2 (pt)
SI (1)	SI2190837T1 (pt)
TW (1)	TWI411437B (pt)
WO (1)	WO2009024906A1 (pt)
ZA (1)	ZA201001872B (pt)

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EP2907811A1 (en) *	2014-02-14	2015-08-19	Actelion Pharmaceuticals Ltd.	Process for manufacturing pyrimidine sulfamide derivatives
US10669264B2 (en) *	2015-11-30	2020-06-02	Laurus Labs Limited	Process for the preparation of macitentan
WO2017191565A1 (en) *	2016-05-04	2017-11-09	Shilpa Medicare Limited	Process for preparation of macitentan
UA126122C2 (uk) *	2017-02-27	2022-08-17	Ідорсія Фармасьютікалз Лтд	Комбінації похідної 4-піримідинсульфаміду з активними інгредієнтами для лікування захворювань, пов'язаних з ендотеліном
LT3716979T (lt) *	2017-11-30	2025-07-10	Idorsia Pharmaceuticals Ltd	4-pirimidinsulfamido darinio derinys su sglt-2 inhibitoriumi, skirtas su endotelinu susijusių ligų gydymui
CN108997223B (zh) *	2018-08-09	2020-06-30	浙江先锋科技股份有限公司	5-(4-溴苯基)-4，6-二氯嘧啶的制备方法
EP3897646B1 (en)	2018-12-21	2024-05-22	Actelion Pharmaceuticals Ltd	Macitentan for the treatment of pulmonary arterial hypertension
TW202042818A (zh)	2019-01-25	2020-12-01	瑞士商艾克泰聯製藥有限公司	用於治療慢性血栓性肺高血壓之醫藥組成物
CN114630668B (zh) *	2019-11-07	2024-02-27	苏州科睿思制药有限公司	一种Aprocitentan晶型及其制备方法和用途
WO2021237004A1 (en)	2020-05-21	2021-11-25	Teva Pharmaceuticals International Gmbh	Solid state forms of aprocitentan and process for preparation thereof
CN114644595A (zh) *	2020-12-19	2022-06-21	普济生物科技（台州）有限公司	阿普昔腾坦的无定型态、其药物组合物和用途
WO2023111797A1 (en) *	2021-12-17	2023-06-22	Janssen Biotech, Inc.	Pyrimidine sulfamide derivatives and process for manufacturing them
CN119255805A (zh)	2022-05-22	2025-01-03	爱杜西亚药品有限公司	用于治疗高血压的阿普昔腾坦
WO2023227721A1 (en)	2022-05-25	2023-11-30	Idorsia Pharmaceuticals Ltd	Crystalline forms of sodium (5-(4-bromophenyl)-6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)pyrimidin-4-yl)(sulfamoyl)amide
CN119330888B (zh) *	2024-10-25	2025-11-28	上海药坦药物研究开发有限公司	一种阿普昔腾坦的制备方法
CN119504609A (zh) *	2024-11-27	2025-02-25	成都启晟合研医药科技有限公司	一种阿普昔腾坦的中间体化合物、阿普昔腾坦及其制备方法
CN119528820B (zh) *	2024-11-29	2025-10-10	浙江国邦药业有限公司	一种阿普昔腾坦的合成方法
CN119528821B (zh) *	2024-11-29	2025-10-10	浙江国邦药业有限公司	一种阿普昔腾坦的制备方法

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KR20030041577A (ko)	2001-11-20	2003-05-27	디디에스텍주식회사	난용성 약물과 치환된 시클로덱스트린을 함유하는고체분산체 및 이를 함유하는 약제학적 조성물
CN1326569C (zh)	2002-02-26	2007-07-18	阿斯特拉曾尼卡有限公司	含有水溶性纤维素衍生物的iressa药物制剂
NZ540937A (en) *	2002-12-02	2008-06-30	Actelion Pharmaceuticals Ltd	Pyrimidine-sulfamides and their use as endothelian receptor antagonist
HRP20050675A2 (en)	2003-02-25	2005-10-31	Eli Lilly And Company	Crystalline non-solavated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride
ES2393117T3 (es) *	2005-09-12	2012-12-18	Actelion Pharmaceuticals Ltd.	Composición farmacéutica estable que comprende una pirimidina-sulfamida
AR062501A1 (es)	2006-08-29	2008-11-12	Actelion Pharmaceuticals Ltd	Composiciones terapeuticas
MX2010008994A (es)	2008-02-20	2010-09-07	Actelion Pharmaceuticals Ltd	Combinacion que comprende paclitaxel para el tratamiento del cancer de ovario.
MX350011B (es)	2008-08-13	2017-08-22	Actelion Pharmaceuticals Ltd	Composiciones terapeuticas que contienen macitentan.

2008
- 2008-02-07 MX MX2010001837A patent/MX2010001837A/es active IP Right Grant
- 2008-08-14 AR ARP080103552A patent/AR070018A1/es not_active Application Discontinuation
- 2008-08-15 PT PT08807330T patent/PT2190837E/pt unknown
- 2008-08-15 PL PL08807330T patent/PL2190837T3/pl unknown
- 2008-08-15 KR KR1020107004945A patent/KR101528946B1/ko active Active
- 2008-08-15 MY MYPI20100680 patent/MY152281A/en unknown
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Also Published As

Publication number	Publication date
AU2008290234A1 (en)	2009-02-26
CY2024031I2 (el)	2026-02-25
MY152281A (en)	2014-09-15
SI2190837T1 (sl)	2012-11-30
CA2695511C (en)	2015-11-03
ZA201001872B (en)	2011-05-25
TW200927122A (en)	2009-07-01
LTC2190837I2 (pt)	2026-04-27
CY2024031I1 (el)	2026-02-25
PL2190837T3 (pl)	2013-01-31
EP2190837B1 (en)	2012-08-15
CN101772494A (zh)	2010-07-07
KR101528946B1 (ko)	2015-06-15
NZ583990A (en)	2012-06-29
NL301304I2 (nl)	2024-12-19
HK1144196A1 (en)	2011-02-02
CY1113255T1 (el)	2016-04-13
FR24C1047I2 (fr)	2025-10-10
PT2190837E (pt)	2012-10-31
WO2009024906A1 (en)	2009-02-26
ES2394584T3 (es)	2013-02-04
TWI411437B (zh)	2013-10-11
MX2010001837A (es)	2010-03-10
AR070018A1 (es)	2010-03-10
AU2008290234B2 (en)	2013-11-21
EP2190837A1 (en)	2010-06-02
US20120142716A1 (en)	2012-06-07
RU2010109543A (ru)	2011-09-27
DK2190837T3 (da)	2012-10-08
HUS2400041I1 (hu)	2024-12-28
US8324232B2 (en)	2012-12-04
IL203936A (en)	2016-03-31
CN101772494B (zh)	2013-05-15
NO2024053I1 (no)	2024-12-03
LTPA2024534I1 (pt)	2024-12-27
MA31702B1 (fr)	2010-09-01
FR24C1047I1 (fr)	2025-01-10
JP2010536742A (ja)	2010-12-02
RU2485116C2 (ru)	2013-06-20
KR20100052517A (ko)	2010-05-19
BRPI0815360A8 (pt)	2017-12-26
JP5323075B2 (ja)	2013-10-23
HRP20120878T1 (hr)	2012-11-30
BRPI0815360B1 (pt)	2018-12-04
FIC20240041I1 (fi)	2024-12-02
BRPI0815360B8 (pt)	2021-05-25
CA2695511A1 (en)	2009-02-26

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2017-12-26	B25A	Requested transfer of rights approved	Owner name: IDORSIA PHARMACEUTICALS LTD (CH)
2018-01-23	B25L	Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled	Owner name: ACTELION PHARMACEUTICALS LTD (CH)
2018-01-30	B25C	Requirement related to requested transfer of rights	Owner name: ACTELION PHARMACEUTICALS LTD (CH)
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-05-02	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-05-02	B25A	Requested transfer of rights approved	Owner name: IDORSIA PHARMACEUTICALS LTD (CH)
2018-07-03	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2018-11-06	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2018-12-04	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/12/2018, OBSERVADAS AS CONDICOES LEGAIS.
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/08/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

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