BRPI0918653A2 - combinação de inibidor de ns3 protese de hcv com interferon e ribavirina. - Google Patents
combinação de inibidor de ns3 protese de hcv com interferon e ribavirina.Info
- Publication number
- BRPI0918653A2 BRPI0918653A2 BRPI0918653A BRPI0918653A BRPI0918653A2 BR PI0918653 A2 BRPI0918653 A2 BR PI0918653A2 BR PI0918653 A BRPI0918653 A BR PI0918653A BR PI0918653 A BRPI0918653 A BR PI0918653A BR PI0918653 A2 BRPI0918653 A2 BR PI0918653A2
- Authority
- BR
- Brazil
- Prior art keywords
- ribavirin
- hcv
- prosthesis
- interferon
- inhibitor combination
- Prior art date
Links
- 102000014150 Interferons Human genes 0.000 title 1
- 108010050904 Interferons Proteins 0.000 title 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229940079322 interferon Drugs 0.000 title 1
- 229960000329 ribavirin Drugs 0.000 title 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9775308P | 2008-09-17 | 2008-09-17 | |
| US10903308P | 2008-10-28 | 2008-10-28 | |
| US17193509P | 2009-04-23 | 2009-04-23 | |
| PCT/US2009/056771 WO2010033443A1 (en) | 2008-09-17 | 2009-09-14 | Combination of hcv ns3 protease inhibitor with interferon and ribavirin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0918653A2 true BRPI0918653A2 (pt) | 2015-12-01 |
Family
ID=41571875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0918653A BRPI0918653A2 (pt) | 2008-09-17 | 2009-09-14 | combinação de inibidor de ns3 protese de hcv com interferon e ribavirina. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8399484B2 (pt) |
| EP (1) | EP2337583A1 (pt) |
| JP (1) | JP5539363B2 (pt) |
| KR (1) | KR20110054003A (pt) |
| CN (1) | CN102159245B (pt) |
| AR (1) | AR073516A1 (pt) |
| AU (1) | AU2009293493B2 (pt) |
| BR (1) | BRPI0918653A2 (pt) |
| CA (1) | CA2737376A1 (pt) |
| CL (1) | CL2011000571A1 (pt) |
| CO (1) | CO6351753A2 (pt) |
| EA (1) | EA019965B1 (pt) |
| EC (1) | ECSP11010877A (pt) |
| IL (1) | IL210152A0 (pt) |
| MA (1) | MA32634B1 (pt) |
| MX (1) | MX2011002602A (pt) |
| MY (1) | MY152824A (pt) |
| NZ (1) | NZ591030A (pt) |
| PE (1) | PE20110343A1 (pt) |
| TW (1) | TWI454263B (pt) |
| UA (1) | UA103496C2 (pt) |
| UY (1) | UY32124A (pt) |
| WO (1) | WO2010033443A1 (pt) |
| ZA (1) | ZA201009151B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| AU2009293493B2 (en) | 2008-09-17 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Combination of HCV NS3 protease inhibitor with interferon and ribavirin |
| AR075584A1 (es) * | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| CN105001302A (zh) * | 2009-09-28 | 2015-10-28 | 英特穆恩公司 | C型肝炎病毒复制的环肽抑制剂 |
| KR20120106942A (ko) * | 2009-10-30 | 2012-09-27 | 베링거 인겔하임 인터내셔날 게엠베하 | Bi201335, 인터페론 알파 및 리바비린을 포함하는 hcv 병용 치료요법을 위한 투여 용법 |
| WO2012041771A1 (en) * | 2010-09-30 | 2012-04-05 | Boehringer Ingelheim International Gmbh | Combination therapy for treating hcv infection |
| KR20140003521A (ko) | 2010-12-30 | 2014-01-09 | 이난타 파마슈티칼스, 인코포레이티드 | 페난트리딘 매크로사이클릭 c형 간염 세린 프로테아제 억제제 |
| CN103534256B (zh) | 2010-12-30 | 2016-08-10 | 益安药业 | 大环丙型肝炎丝氨酸蛋白酶抑制剂 |
| SG191923A1 (en) * | 2011-01-10 | 2013-08-30 | Proteus Digital Health Inc | System, method, and article to prompt behavior change |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| CN104023726A (zh) | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如,与abt-072或abt-333) |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| DE112012003510T5 (de) | 2011-10-21 | 2015-03-19 | Abbvie Inc. | Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon |
| JP2015509980A (ja) * | 2012-03-14 | 2015-04-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Hcv−hiv同時感染患者集団のhcv感染症を治療するための併用療法 |
| US20140242029A1 (en) * | 2013-02-27 | 2014-08-28 | Boehringer Ingelheim International Gmbh | Combination therapy for treating hcv infection in an hcv-hiv coinfected patient population |
| WO2013147749A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient subgenotype populations |
| WO2013147750A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
| WO2013143581A1 (en) | 2012-03-28 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Combination therapy for treating hcv infection in specific patient subgenotype sub-population |
| WO2014138374A1 (en) | 2013-03-08 | 2014-09-12 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
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| CN1835765A (zh) | 2003-08-13 | 2006-09-20 | 霍华德·J·史密斯及同仁控股有限公司 | 治疗病毒感染的方法 |
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| WO2008070358A2 (en) * | 2006-11-16 | 2008-06-12 | Phenomix Corporation | N-cyclopropyl-hydroxyproline-based tripeptidic hepatitis c serine protease inhibitors containing an isoindole, pyrrolopyridine, pyrrolopyrimidine or pyrrolopyrazine heterocycle in the side chain |
| NZ582096A (en) | 2007-06-29 | 2012-05-25 | Gilead Sciences Inc | Antiviral compounds that inhibit hepatitis c virus (hcv) |
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| RU2490272C2 (ru) | 2008-02-04 | 2013-08-20 | Айденикс Фармасьютикалз, Инк. | Макроциклические ингибиторы серинпротеазы |
| AU2009293494B2 (en) | 2008-09-16 | 2014-04-24 | Boehringer Ingelheim International Gmbh | Crystalline forms of a 2-thiazolyl- 4-quinolinyl-oxy derivative, a potent HCV inhibitor |
| AU2009293493B2 (en) | 2008-09-17 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Combination of HCV NS3 protease inhibitor with interferon and ribavirin |
| TW201023858A (en) | 2008-09-18 | 2010-07-01 | Ortho Mcneil Janssen Pharm | Synergistic combinations of a macrocyclic inhibitor of HCV and a nucleoside |
| PE20120322A1 (es) | 2009-07-07 | 2012-04-14 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende faldaprevir o una sal del mismo en un vehiculo auto-emulsionante |
| KR20120106942A (ko) | 2009-10-30 | 2012-09-27 | 베링거 인겔하임 인터내셔날 게엠베하 | Bi201335, 인터페론 알파 및 리바비린을 포함하는 hcv 병용 치료요법을 위한 투여 용법 |
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| WO2012041771A1 (en) | 2010-09-30 | 2012-04-05 | Boehringer Ingelheim International Gmbh | Combination therapy for treating hcv infection |
-
2009
- 2009-09-14 AU AU2009293493A patent/AU2009293493B2/en not_active Ceased
- 2009-09-14 BR BRPI0918653A patent/BRPI0918653A2/pt not_active IP Right Cessation
- 2009-09-14 PE PE2011000635A patent/PE20110343A1/es not_active Application Discontinuation
- 2009-09-14 EP EP09792492A patent/EP2337583A1/en not_active Withdrawn
- 2009-09-14 NZ NZ591030A patent/NZ591030A/xx not_active IP Right Cessation
- 2009-09-14 CA CA2737376A patent/CA2737376A1/en not_active Abandoned
- 2009-09-14 MX MX2011002602A patent/MX2011002602A/es active IP Right Grant
- 2009-09-14 WO PCT/US2009/056771 patent/WO2010033443A1/en not_active Ceased
- 2009-09-14 KR KR1020117005679A patent/KR20110054003A/ko not_active Ceased
- 2009-09-14 UA UAA201104531A patent/UA103496C2/uk unknown
- 2009-09-14 MY MYPI20111139 patent/MY152824A/en unknown
- 2009-09-14 CN CN2009801362929A patent/CN102159245B/zh not_active Expired - Fee Related
- 2009-09-14 EA EA201100506A patent/EA019965B1/ru not_active IP Right Cessation
- 2009-09-14 JP JP2011527889A patent/JP5539363B2/ja not_active Expired - Fee Related
- 2009-09-16 TW TW098131293A patent/TWI454263B/zh not_active IP Right Cessation
- 2009-09-16 UY UY0001032124A patent/UY32124A/es not_active Application Discontinuation
- 2009-09-16 AR ARP090103556A patent/AR073516A1/es unknown
- 2009-09-16 US US12/560,752 patent/US8399484B2/en active Active
-
2010
- 2010-12-20 ZA ZA2010/09151A patent/ZA201009151B/en unknown
- 2010-12-21 IL IL210152A patent/IL210152A0/en unknown
-
2011
- 2011-03-09 EC EC2011010877A patent/ECSP11010877A/es unknown
- 2011-03-14 MA MA33700A patent/MA32634B1/fr unknown
- 2011-03-16 CO CO11032826A patent/CO6351753A2/es not_active Application Discontinuation
- 2011-03-17 CL CL2011000571A patent/CL2011000571A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102159245B (zh) | 2013-07-24 |
| TWI454263B (zh) | 2014-10-01 |
| CA2737376A1 (en) | 2010-03-25 |
| ZA201009151B (en) | 2011-09-28 |
| TW201016218A (en) | 2010-05-01 |
| EA019965B1 (ru) | 2014-07-30 |
| US20100068182A1 (en) | 2010-03-18 |
| MX2011002602A (es) | 2011-04-07 |
| NZ591030A (en) | 2012-10-26 |
| JP5539363B2 (ja) | 2014-07-02 |
| CL2011000571A1 (es) | 2011-07-29 |
| MY152824A (en) | 2014-11-28 |
| PE20110343A1 (es) | 2011-06-25 |
| WO2010033443A1 (en) | 2010-03-25 |
| MA32634B1 (fr) | 2011-09-01 |
| AU2009293493B2 (en) | 2014-09-18 |
| IL210152A0 (en) | 2011-03-31 |
| CN102159245A (zh) | 2011-08-17 |
| CO6351753A2 (es) | 2011-12-20 |
| JP2012502999A (ja) | 2012-02-02 |
| AR073516A1 (es) | 2010-11-10 |
| EP2337583A1 (en) | 2011-06-29 |
| ECSP11010877A (es) | 2011-04-29 |
| US8399484B2 (en) | 2013-03-19 |
| UY32124A (es) | 2010-04-30 |
| EA201100506A1 (ru) | 2011-10-31 |
| UA103496C2 (uk) | 2013-10-25 |
| KR20110054003A (ko) | 2011-05-24 |
| HK1156865A1 (en) | 2012-06-22 |
| AU2009293493A1 (en) | 2010-03-25 |
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