BRPI0918673A2 - criogéis de copolímeros de álcool vinílico, copolímeros de álcool vinílico e métodos e produtos dos mesmos - Google Patents

criogéis de copolímeros de álcool vinílico, copolímeros de álcool vinílico e métodos e produtos dos mesmos

Info

Publication number
BRPI0918673A2
BRPI0918673A2 BRPI0918673A BRPI0918673A BRPI0918673A2 BR PI0918673 A2 BRPI0918673 A2 BR PI0918673A2 BR PI0918673 A BRPI0918673 A BR PI0918673A BR PI0918673 A BRPI0918673 A BR PI0918673A BR PI0918673 A2 BRPI0918673 A2 BR PI0918673A2
Authority
BR
Brazil
Prior art keywords
vinyl alcohol
alcohol copolymers
cryovels
products
methods
Prior art date
Application number
BRPI0918673A
Other languages
English (en)
Portuguese (pt)
Inventor
Albert Mihranyan
Maria Strömme
Original Assignee
Albert Mihranyan
Maria Strömme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert Mihranyan, Maria Strömme filed Critical Albert Mihranyan
Publication of BRPI0918673A2 publication Critical patent/BRPI0918673A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F216/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F216/02—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F216/04—Acyclic compounds
    • C08F216/06—Polyvinyl alcohol ; Vinyl alcohol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F218/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid
    • C08F218/02—Esters of monocarboxylic acids
    • C08F218/04—Vinyl esters
    • C08F218/08—Vinyl acetate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/12—Hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04—Acids; Metal salts or ammonium salts thereof
    • C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Manufacturing & Machinery (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polymerisation Methods In General (AREA)
BRPI0918673A 2008-09-15 2009-09-14 criogéis de copolímeros de álcool vinílico, copolímeros de álcool vinílico e métodos e produtos dos mesmos BRPI0918673A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9697608P 2008-09-15 2008-09-15
PCT/IB2009/054012 WO2010029517A1 (en) 2008-09-15 2009-09-14 Vinyl alcohol co-polymer cryogels, vinyl alcohol co-polymers, and methods and products thereof

Publications (1)

Publication Number Publication Date
BRPI0918673A2 true BRPI0918673A2 (pt) 2015-12-01

Family

ID=41226623

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0918673A BRPI0918673A2 (pt) 2008-09-15 2009-09-14 criogéis de copolímeros de álcool vinílico, copolímeros de álcool vinílico e métodos e produtos dos mesmos

Country Status (13)

Country Link
US (1) US8975309B2 (2)
EP (1) EP2331587A1 (2)
JP (1) JP5694167B2 (2)
KR (1) KR20110069093A (2)
CN (1) CN102149735A (2)
AU (1) AU2009290442A1 (2)
BR (1) BRPI0918673A2 (2)
CA (1) CA2736833A1 (2)
EA (1) EA018466B1 (2)
IL (1) IL211383A0 (2)
MX (1) MX2011002746A (2)
NZ (1) NZ591708A (2)
WO (1) WO2010029517A1 (2)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120160254A1 (en) * 2009-03-16 2012-06-28 Protista Biotechnology Ab Cryotropic hydrogels and their use as filters
EP2440321B1 (en) 2009-06-11 2017-11-22 Case Western Reserve University Low density hydrophobic material and method of making the same
US8608991B2 (en) 2009-06-11 2013-12-17 Case Western Reserve University Porous material having controlled voids and method of making the same
EP2701745B1 (en) * 2011-04-28 2018-07-11 President and Fellows of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
JP5705056B2 (ja) * 2011-07-28 2015-04-22 日本合成化学工業株式会社 ポリビニルアルコール系重合体粒子の製造方法
WO2014022749A1 (en) * 2012-08-02 2014-02-06 President And Fellows Of Harvard College Porous electrolytic polymer cryogels for enhanced electrical collapsibility
RU2543895C2 (ru) * 2013-05-17 2015-03-10 Общество С Ограниченной Ответственностью "Научно-Производственный Центр "Амфион" Гидрогелевый материал на основе сшиваемого поливинилового спирта
US10939677B2 (en) * 2013-06-12 2021-03-09 Nanyang Technological University Antibacterial cryogel and porous hydrogel, their preparation method, and their use for disinfecting water
CN105859945B (zh) * 2016-03-24 2018-06-15 合众（佛山）化工有限公司 一种改性聚乙烯醇共聚物交联型陶瓷坯体增强剂的制备方法
RU2729025C1 (ru) * 2019-07-19 2020-08-03 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр травматологии и ортопедии имени Н.Н. Приорова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТО им. Н.Н. Приорова" Минздрава России) Способ хирургического лечения гнойно-воспалительных процессов костных и мягкотканых структур опорно-двигательной системы пациента с использованием мягких спейсеров, импрегнированных антибактериальными средствами
CN112825981B (zh) * 2020-12-31 2023-05-09 内江师范学院 芦荟皮饲料用功能添加剂、制备方法及应用
CN114014969B (zh) * 2021-11-15 2023-08-11 上海华峰新材料研发科技有限公司 一种水溶性聚合物及其制备方法和应用
CN114426681B (zh) * 2021-12-24 2023-11-10 东华大学 一种稠杂环类还原物-聚丙烯酰胺粘附水凝胶的制备方法
WO2025154722A1 (en) * 2024-01-16 2025-07-24 Kuraray Co., Ltd. Polyvinyl alcohol copolymer and particulate water-soluble diverting agent formed therefrom
CN119979127A (zh) * 2025-02-26 2025-05-13 上海第二工业大学 一种冷链运输用高焓值相变凝胶材料及其制备方法
CN121554813A (zh) * 2026-01-22 2026-02-24 浙江省肿瘤医院 一种用于术后腹腔组织积液引流的高强可变形多孔水凝胶

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB835651A (en) 1957-03-15 1960-05-25 Shawinigan Chem Ltd Stable vinyl acetate-acrylamide copolymer emulsions and water-resistant films therefrom
JPS5227455A (en) * 1975-07-24 1977-03-01 Sumitomo Chem Co Ltd Process for preparing a high polymer material having water absorption properties
CA1181915A (en) * 1981-02-05 1985-02-05 Nippon Oil Co., Ltd. Process for preparing a hydrogel
JPS57130543A (en) * 1981-02-05 1982-08-13 Nippon Oil Co Ltd Preparation of gel
US4326980A (en) 1981-02-23 1982-04-27 Betz Laboratories, Inc. Acrylic copolymer composition inhibits scale formation and disperses oil in aqueous systems
US5981826A (en) * 1997-05-05 1999-11-09 Georgia Tech Research Corporation Poly(vinyl alcohol) cryogel
JP4132467B2 (ja) 1999-09-14 2008-08-13 株式会社クラレ ビニルアルコール系重合体の製法
US20030153708A1 (en) 2002-01-11 2003-08-14 Caneba Gerald Tablada Free radical retrograde precipitation copolymers and process for making same
CN100415821C (zh) * 2003-04-15 2008-09-03 英诺格尔股份公司 聚乙烯醇凝胶
RU2252945C1 (ru) 2003-10-30 2005-05-27 Институт элементоорганических соединений им. А.Н. Несмеянова РАН (ИНЭОС РАН) Полимерная композиция для получения криогеля поливинилового спирта
CN1320931C (zh) * 2004-05-14 2007-06-13 中国科学院长春应用化学研究所 含药物、壳聚糖的聚乙烯醇水凝胶敷料及其制备方法
KR101429774B1 (ko) * 2005-05-09 2014-10-02 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법
CA2641582A1 (en) 2006-02-09 2007-08-16 Gerard T. Caneba Multifunctional multipolymeric surfactants for oil and bitumen recovery and other applications

Also Published As

Publication number Publication date
CN102149735A (zh) 2011-08-10
EA018466B1 (ru) 2013-08-30
KR20110069093A (ko) 2011-06-22
EA201100494A1 (ru) 2011-10-31
IL211383A0 (en) 2011-04-28
MX2011002746A (es) 2011-05-30
NZ591708A (en) 2013-07-26
WO2010029517A1 (en) 2010-03-18
US20110230567A1 (en) 2011-09-22
AU2009290442A1 (en) 2010-03-18
US8975309B2 (en) 2015-03-10
CA2736833A1 (en) 2010-03-18
EP2331587A1 (en) 2011-06-15
JP5694167B2 (ja) 2015-04-01
JP2012503036A (ja) 2012-02-02

Similar Documents

Publication Publication Date Title
BRPI0918673A2 (pt) criogéis de copolímeros de álcool vinílico, copolímeros de álcool vinílico e métodos e produtos dos mesmos
PT2963031T (pt) Pró-fármacos de tetrahidrocanabinol, composições compreendendo pró-fármacos de tetrahidrocanabinol e métodos de utilização dos mesmos
BRPI0916588A2 (pt) cobertor, produtos correlacionados e métodos de produção dos mesmos
BRPI0912198A2 (pt) anticorpos anti-fn14 e usos dos mesmos
BRPI0920927A2 (pt) derivados de azaquinolinona e usos dos mesmos
BRPI0914682A2 (pt) compostos de heteroarila e usos dos mesmos
BRPI1011404A2 (pt) mutantes e usos dos mesmos
BRPI1009455A2 (pt) anticorpos anti-c40 e usos dos mesmos
BRPI0914891A2 (pt) agonistas de aril gpr119 e usos dos mesmos
BRPI0911004A2 (pt) Artigo antimicrobiano, líquido de tratamento e métodos de preparação dos mesmos
BRPI1014997A2 (pt) compostos heteroarila e usos dos mesmos
LT2740732T (lt) Mtor kinazės inhibitoriai, skirti onkologinėms indikacijoms ir ligoms, susijusioms su mtor/p13k/akt keliais
BRPI0818477A2 (pt) Dc-sign, icam-3 e lsectin porcinos e usos dos mesmos
BRPI0819909A2 (pt) anticorpos antimesotelina e usos dos mesmos
BRPI0822337A2 (pt) Folatos, composições e usos dos mesmos
PT2616087T (pt) Fagos antibacterianos, péptidos fágicos e métodos de utilização dos mesmos
BRPI0922050A2 (pt) proteção de processamento multi-espacial e controle de volume dinâmico
PT2424896E (pt) Anticorpos anti-ceacam1 e métodos de utilização dos mesmos
BRPI0922807A2 (pt) imonuglobulinas de domínio variável duplo e usos dos mesmos
BRPI0912480A2 (pt) compostos de monoalquiltina de alta pureza e usos dos mesmos
BRPI0922483A2 (pt) agonista de receptor gpr120 e usos dos mesmos
BRPI0908906A2 (pt) compostos heterocíclicos e usos dos mesmos
BRPI1013943A2 (pt) Composto cetais e usos dos mesmos.
BRPI0810471A2 (pt) Produtos de glicoproteína definidos e métodos relacionados
BRPI0909469A2 (pt) compostos de oximetileno de arila e usos dos mesmos

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.