BRPI0918955A2 - preparação sólida, e, método para estabilizar um composto, e para melhorar a dissoulução de um composto - Google Patents

preparação sólida, e, método para estabilizar um composto, e para melhorar a dissoulução de um composto

Info

Publication number: BRPI0918955A2
Authority: BR; Brazil
Prior art keywords: compound; dissoulution; stabilizing; improving; solid preparation
Prior art date: 2008-09-25

Application number

BRPI0918955A

Other languages

English (en)

Inventor

Junya Nomura

Kazuhiro Hirata

Yutaka Tanoue

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-09-25

Filing date

2009-09-25

Publication date

2015-12-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42059801&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0918955(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-09-25 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2015-12-01 Publication of BRPI0918955A2 publication Critical patent/BRPI0918955A2/pt

Links

Classifications

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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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BRPI0918955A 2008-09-25 2009-09-25 preparação sólida, e, método para estabilizar um composto, e para melhorar a dissoulução de um composto BRPI0918955A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10010808P	2008-09-25	2008-09-25
PCT/JP2009/066690 WO2010035806A1 (ja)	2008-09-25	2009-09-25	固形医薬組成物

Publications (1)

Publication Number	Publication Date
BRPI0918955A2 true BRPI0918955A2 (pt)	2015-12-01

Family

ID=42059801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0918955A BRPI0918955A2 (pt)	2008-09-25	2009-09-25	preparação sólida, e, método para estabilizar um composto, e para melhorar a dissoulução de um composto

Country Status (25)

Country	Link
US (1)	US9173849B2 (pt)
EP (1)	EP2332535A4 (pt)
JP (1)	JP5570426B2 (pt)
KR (1)	KR20110063557A (pt)
CN (2)	CN102223884B (pt)
AR (1)	AR073380A1 (pt)
AU (1)	AU2009297522A1 (pt)
BR (1)	BRPI0918955A2 (pt)
CA (1)	CA2738147C (pt)
CL (1)	CL2011000625A1 (pt)
CO (1)	CO6361934A2 (pt)
CR (1)	CR20110209A (pt)
EA (1)	EA201170483A1 (pt)
EC (1)	ECSP11011001A (pt)
GE (1)	GEP20146063B (pt)
IL (1)	IL211886A0 (pt)
MA (1)	MA32721B1 (pt)
MX (1)	MX2011003261A (pt)
NZ (1)	NZ592225A (pt)
PE (1)	PE20110844A1 (pt)
TW (1)	TW201014850A (pt)
UA (1)	UA102271C2 (pt)
UY (1)	UY32126A (pt)
WO (1)	WO2010035806A1 (pt)
ZA (1)	ZA201102715B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG175794A1 (en) *	2009-04-30	2011-12-29	Takeda Pharmaceutical	Solid preparation
KR101792299B1 (ko)	2010-03-19	2017-10-31	다이이찌 산쿄 가부시키가이샤	항응고제의 용출 개선 방법
TR201004754A1 (tr) *	2010-06-11	2012-01-23	Sanovel �La� San. Ve T�C. A.�.	Yeni Farmasötik Kombinasyonlar
TWI578988B (zh) *	2011-08-10	2017-04-21	第一三共股份有限公司	含二胺衍生物之醫藥組成物
ES2903149T3 (es) *	2012-05-14	2022-03-31	Shionogi & Co	Preparación que contiene derivado de 7-carbamoilmorfinano 6,7-insaturado
CN103768071B (zh) *	2012-10-23	2016-08-17	中国医药工业研究总院	一种治疗糖尿病的口服制剂
US20160331689A1 (en) *	2015-05-12	2016-11-17	SE Tylose USA, Inc.	Aqueous enteric coating composition
JP7101464B2 (ja) *	2017-09-28	2022-07-15	エルメッド株式会社	アジルサルタン又はその塩及びアムロジピン又はその塩含有錠剤の品質向上方法、並びにアジルサルタン又はその塩及びアムロジピン又はその塩含有錠剤及びその製造方法
JP7206872B2 (ja) *	2018-12-07	2023-01-18	ニプロ株式会社	アジルサルタン及びアムロジピンを含有する医薬組成物及びその製造方法
CN114404375B (zh) *	2022-01-21	2023-06-27	武汉九珑人福药业有限责任公司	一种叶酸固体制剂及其原料组合物、制备方法和应用
TW202432121A (zh) *	2022-11-24	2024-08-16	大陸商上海雲晟研新生物科技有限公司	包含美阿沙坦鉀與鈣通道阻滯劑的藥物組合物、及其製備方法及用途

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5703110A (en) *	1990-04-27	1997-12-30	Takeda Chemical Industries, Ltd.	Benzimidazole derivatives, their production and use
US5656650A (en) *	1990-12-14	1997-08-12	Smithkline Beecham Corp.	Angiotensin II receptor blocking compositions
KR100222252B1 (ko)	1990-12-14	1999-10-01	스튜어트 알. 수터	안지오텐신 ii 수용체 차단 조성물
IL102183A (en) *	1991-06-27	1999-11-30	Takeda Chemical Industries Ltd	Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
CA2125251C (en)	1993-06-07	2005-04-26	Yoshiyuki Inada	A pharmaceutical composition for angiotensin ii-mediated diseases
US5721263A (en) *	1993-06-07	1998-02-24	Takeda Chemical Industries, Ltd.	Pharmaceutical composition for angiotensin II-mediated diseases
WO1997010224A1 (en)	1995-09-13	1997-03-20	Takeda Chemical Industries, Ltd.	Benzoxazepine compounds, their production and use as lipid lowering agents
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR035016A1 (es)	1999-08-25	2004-04-14	Takeda Chemical Industries Ltd	Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
US6459014B1 (en) *	1999-11-15	2002-10-01	Paragon Trade Brands, Inc.	Absorbent article which maintains prolonged natural skin pH
JP2001294524A (ja)	2000-04-12	2001-10-23	Taisho Pharmaceut Co Ltd	アセトアミノフェン配合内服固形製剤
US20030187023A1 (en)	2000-07-17	2003-10-02	Keiji Kubo	Sulfone derivatives, process for their production and use thereof
CA2456034A1 (en)	2001-08-03	2003-02-20	Takeda Chemical Industries, Ltd.	Sustained-release medicines
EP1438027A1 (en) *	2001-10-25	2004-07-21	DepoMed, Inc.	Methods of treatment using a gastric retained losartan dosage
PL376733A1 (pl)	2002-11-01	2006-01-09	Takeda Pharmaceutical Company Limited	Środek do zapobiegania lub leczenia neuropatii
AU2003277576A1 (en)	2002-11-08	2004-06-07	Takeda Pharmaceutical Company Limited	Receptor function controlling agent
WO2004048363A1 (ja)	2002-11-22	2004-06-10	Takeda Pharmaceutical Company Limited	イミダゾール誘導体、その製造法および用途
US20040170687A1 (en) *	2003-02-27	2004-09-02	Integrity Pharmaceutical Corporation	Compositions with improved stability and methods of formulation thereof
US20060177506A1 (en) *	2003-03-17	2006-08-10	Shigeo Yanai	Release control compositions
EP1630152A4 (en)	2003-05-30	2009-09-23	Takeda Pharmaceutical	CONDENSED CYCLIC COMPOUND
CA2536111A1 (en) *	2003-07-24	2005-02-03	Wockhardt Limited	Oral compositions for treatment of diseases
EP1506967B1 (en) *	2003-08-13	2007-11-21	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
EP1669352A4 (en)	2003-09-30	2008-12-17	Takeda Pharmaceutical	THIAZOLINE DERIVATIVE AND ITS USE
EP1695961A4 (en)	2003-12-17	2007-10-24	Takeda Pharmaceutical	UREA DERIVATIVE, METHOD FOR THE PRODUCTION AND THEIR USE
AU2004309271A1 (en)	2003-12-25	2005-07-14	Takeda Pharmaceutical Company Limited	3-(4-benzyloxyphenyl)propanoic acid derivatives
US7585880B2 (en)	2003-12-26	2009-09-08	Takeda Pharmaceutical Company Limited	Phenylpropanoic acid derivatives
US7157584B2 (en)	2004-02-25	2007-01-02	Takeda Pharmaceutical Company Limited	Benzimidazole derivative and use thereof
EP1726580A4 (en)	2004-03-15	2008-02-13	Takeda Pharmaceutical	AMINOPHNYLPROPANO ACID DERIVATIVE
EP1731505B1 (en)	2004-03-30	2015-01-14	Takeda Pharmaceutical Company Limited	Alkoxyphenylpropanoic acid derivatives
TWI396686B (zh)	2004-05-21	2013-05-21	Takeda Pharmaceutical	環狀醯胺衍生物、以及其製品和用法
DK1863801T3 (da) *	2005-03-30	2010-11-15	Takeda Pharmaceutical	Benzimidazolderivat og anvendelse deraf
EP2308839B1 (en)	2005-04-20	2017-03-01	Takeda Pharmaceutical Company Limited	Fused heterocyclic compounds
PL1897558T3 (pl) *	2005-06-09	2014-01-31	Norgine Bv	Stały preparat 2-heksadecyloksy-6-metylo-4H-3,1-benzoksazyn-4-onu
TWI405580B (zh) *	2005-06-27	2013-08-21	Sankyo Co	含有血管收縮素ｉｉ接受器拮抗劑及鈣通道阻斷劑之醫藥調配物
JP5110697B2 (ja) *	2005-06-27	2012-12-26	第一三共株式会社	固形製剤
DE102005031577A1 (de) *	2005-07-06	2007-01-11	Bayer Healthcare Ag	Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten
JPWO2007013694A1 (ja)	2005-07-29	2009-02-12	武田薬品工業株式会社	フェノキシアルカン酸化合物
JP5084503B2 (ja)	2005-07-29	2012-11-28	武田薬品工業株式会社	シクロプロパンカルボン酸化合物
CA2617969A1 (en)	2005-08-10	2007-02-15	Takeda Pharmaceutical Company Limited	Therapeutic agent for diabetes
JP2007063225A (ja)	2005-09-01	2007-03-15	Takeda Chem Ind Ltd	イミダゾピリジン化合物
NZ569661A (en)	2005-12-28	2011-06-30	Takeda Pharmaceutical	Therapeutic agent for diabetes
CA2642988C (en) *	2006-02-27	2015-10-27	Takeda Pharmaceutical Company Limited	Pharmaceutical product comprising a benzimidazole in combination with a desiccant
ES2379661T3 (es)	2006-06-27	2012-04-30	Takeda Pharmaceutical Company Limited	Compuestos cíclicos condensados
JP5306818B2 (ja)	2006-10-18	2013-10-02	武田薬品工業株式会社	縮合複素環化合物
US8410087B2 (en)	2006-10-19	2013-04-02	Takeda Pharmaceutical Company Limited	Indole compound
EP2128138A1 (en)	2007-01-29	2009-12-02	Takeda Pharmaceutical Company Limited	Pyrazole compound
RS51592B (sr)	2007-02-01	2011-08-31	Takeda Pharmaceutical Company Limited	Čvrsti preparat koji sadrži alogliptin i pioglitazon
CA2677736A1 (en)	2007-02-09	2008-08-21	Takeda Pharmaceutical Company Limited	Fused ring compounds as partial agonists of ppar-gamma
WO2008123536A1 (en)	2007-03-28	2008-10-16	Takeda Pharmaceutical Company Limited	Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a ph control agent
JPWO2008136428A1 (ja)	2007-04-27	2010-07-29	武田薬品工業株式会社	含窒素５員複素環化合物
WO2008156757A1 (en)	2007-06-19	2008-12-24	Takeda Pharmaceutical Company Limited	Indazole compounds for activating glucokinase
AR067557A1 (es) *	2007-07-19	2009-10-14	Takeda Pharmaceutical	Preparacion solida y metodo de preparacion
JP5635491B2 (ja)	2008-07-31	2014-12-03	武田薬品工業株式会社	固形医薬組成物

2009
- 2009-09-16 TW TW098131167A patent/TW201014850A/zh unknown
- 2009-09-16 UY UY0001032126A patent/UY32126A/es not_active Application Discontinuation
- 2009-09-16 AR ARP090103548A patent/AR073380A1/es not_active Application Discontinuation
- 2009-09-25 MX MX2011003261A patent/MX2011003261A/es unknown
- 2009-09-25 KR KR1020117009104A patent/KR20110063557A/ko not_active Withdrawn
- 2009-09-25 PE PE2011000787A patent/PE20110844A1/es not_active Application Discontinuation
- 2009-09-25 US US12/998,167 patent/US9173849B2/en not_active Expired - Fee Related
- 2009-09-25 BR BRPI0918955A patent/BRPI0918955A2/pt not_active IP Right Cessation
- 2009-09-25 CN CN200980146684.3A patent/CN102223884B/zh not_active Expired - Fee Related
- 2009-09-25 NZ NZ592225A patent/NZ592225A/en not_active IP Right Cessation
- 2009-09-25 CN CN201410471654.2A patent/CN104306975A/zh active Pending
- 2009-09-25 AU AU2009297522A patent/AU2009297522A1/en not_active Abandoned
- 2009-09-25 EA EA201170483A patent/EA201170483A1/ru unknown
- 2009-09-25 JP JP2010530880A patent/JP5570426B2/ja not_active Expired - Fee Related
- 2009-09-25 EP EP09816220.9A patent/EP2332535A4/en not_active Withdrawn
- 2009-09-25 GE GEAP200912204A patent/GEP20146063B/en unknown
- 2009-09-25 CA CA2738147A patent/CA2738147C/en not_active Expired - Fee Related
- 2009-09-25 WO PCT/JP2009/066690 patent/WO2010035806A1/ja not_active Ceased
- 2009-09-25 UA UAA201105161A patent/UA102271C2/ru unknown
2011
- 2011-03-23 IL IL211886A patent/IL211886A0/en unknown
- 2011-03-24 CL CL2011000625A patent/CL2011000625A1/es unknown
- 2011-04-12 ZA ZA2011/02715A patent/ZA201102715B/en unknown
- 2011-04-20 MA MA33782A patent/MA32721B1/fr unknown
- 2011-04-25 CO CO11050084A patent/CO6361934A2/es not_active Application Discontinuation
- 2011-04-25 CR CR20110209A patent/CR20110209A/es unknown
- 2011-04-25 EC EC2011011001A patent/ECSP11011001A/es unknown

Also Published As

Publication number	Publication date
US9173849B2 (en)	2015-11-03
UY32126A (es)	2010-04-30
UA102271C2 (en)	2013-06-25
EP2332535A1 (en)	2011-06-15
CL2011000625A1 (es)	2011-07-08
TW201014850A (en)	2010-04-16
US20110229567A1 (en)	2011-09-22
EA201170483A1 (ru)	2011-10-31
WO2010035806A1 (ja)	2010-04-01
CA2738147C (en)	2016-10-11
JPWO2010035806A1 (ja)	2012-02-23
MA32721B1 (fr)	2011-10-02
CO6361934A2 (es)	2012-01-20
GEP20146063B (en)	2014-03-25
PE20110844A1 (es)	2011-12-05
MX2011003261A (es)	2011-04-21
CN102223884A (zh)	2011-10-19
ZA201102715B (en)	2012-07-25
IL211886A0 (en)	2011-06-30
NZ592225A (en)	2012-06-29
ECSP11011001A (es)	2011-05-31
CA2738147A1 (en)	2010-04-01
CN104306975A (zh)	2015-01-28
EP2332535A4 (en)	2013-11-27
JP5570426B2 (ja)	2014-08-13
AR073380A1 (es)	2010-11-03
CN102223884B (zh)	2015-05-06
AU2009297522A1 (en)	2010-04-01
CR20110209A (es)	2011-05-27
KR20110063557A (ko)	2011-06-10

Legal Events

Date	Code	Title	Description
2016-06-07	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 6A ANUIDADE.
2016-09-27	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2370 DE 07-06-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI0918955A2 (pt)	2015-12-01	preparação sólida, e, método para estabilizar um composto, e para melhorar a dissoulução de um composto
BRPI0906906A2 (pt)	2015-07-21	Método para preparar um composto e composto
BRPI0909691A2 (pt)	2015-08-04	Composto, método para preparar um composto, e, composição farmacêutica
BRPI0919937A2 (pt)	2016-02-16	composto, e, método para melhorar a atividade de adjuvante de uma imidazoquinolina
BRPI0917196A2 (pt)	2015-11-10	método para a preparação de um complexo, e, forma cristalina de um composto.
BR112012000623A2 (pt)	2016-02-10	composição de emulsão estabilizada, método, e, método para preparar uma composição de emulsão estabilizada
BRPI0911254A2 (pt)	2015-10-06	processo para a preparação de um composto
BRPI1010937A2 (pt)	2019-09-24	composto, uso de um composto, e, método para tratar câncer
BRPI0912384A2 (pt)	2015-10-13	composição, e, método para preparar uma composição
BRPI0906098A2 (pt)	2015-06-30	Método de preparação de um composto
BRPI1010775A2 (pt)	2016-03-22	composição, método para preparar uma composição, e, uso de uma composição.
BRPI0914040A2 (pt)	2015-11-03	composição de catalisador e método para transaminar um composto reagente
BRPI0914038A2 (pt)	2015-11-03	composição de catalisador e método para transaminar um composto reagente
BRPI1010933A2 (pt)	2016-04-05	processo para a preparação de um pó, e, composto
BRPI0909198A2 (pt)	2019-09-24	composto antifolato, composto, método para preparar um composto antifolato, composição farmacêutica, método para tratar
BRPI0815550A2 (pt)	2015-02-18	Método para estabilizar fenilefrina
BR112012001998A2 (pt)	2017-01-31	solução oftálmica, uso de um composto, e, método para preparação de uma solução oftálmica.
BRPI0908252A2 (pt)	2015-07-21	Processo para preparar um composto, e, uso de um composto
BRPI1012978A2 (pt)	2016-03-29	composição tópica, método para preparar a mesma, e, uso de um composto
BRPI0911897A2 (pt)	2015-07-28	Processo para a preparação de compostos, e, composto
BRPI1014691A2 (pt)	2015-08-25	Composto, e, processo para a preparação de um composto.
BR112014010479A2 (pt)	2017-04-25	composto, método para preparar um composto, método para a preparação de icotinib a partir de um composto e método para a preparação de cloridrato de icotinib a partir de um composto
BRPI0919410A2 (pt)	2015-12-15	método para produção de um composto oxidado
BR112012004173A2 (pt)	2017-05-30	"composto, composição, método para preparar uma composição, e, uso de um composto"
BR112013009590A2 (pt)	2016-07-19	composto, composição fungicida e método