BRPI0918955A2 - preparação sólida, e, método para estabilizar um composto, e para melhorar a dissoulução de um composto - Google Patents

preparação sólida, e, método para estabilizar um composto, e para melhorar a dissoulução de um composto

Info

Publication number: BRPI0918955A2
Authority: BR; Brazil
Prior art keywords: compound; dissoulution; stabilizing; improving; solid preparation
Prior art date: 2008-09-25

Application number

BRPI0918955A

Other languages

English (en)

Inventor

Junya Nomura

Kazuhiro Hirata

Yutaka Tanoue

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-09-25

Filing date

2009-09-25

Publication date

2015-12-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42059801&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0918955(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-09-25 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2015-12-01 Publication of BRPI0918955A2 publication Critical patent/BRPI0918955A2/pt

Links

Classifications

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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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BRPI0918955A 2008-09-25 2009-09-25 preparação sólida, e, método para estabilizar um composto, e para melhorar a dissoulução de um composto BRPI0918955A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US10010808P	2008-09-25	2008-09-25
PCT/JP2009/066690 WO2010035806A1 (ja)	2008-09-25	2009-09-25	固形医薬組成物

Publications (1)

Publication Number	Publication Date
BRPI0918955A2 true BRPI0918955A2 (pt)	2015-12-01

Family

ID=42059801

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0918955A BRPI0918955A2 (pt)	2008-09-25	2009-09-25	preparação sólida, e, método para estabilizar um composto, e para melhorar a dissoulução de um composto

Country Status (25)

Country	Link
US (1)	US9173849B2 (pt)
EP (1)	EP2332535A4 (pt)
JP (1)	JP5570426B2 (pt)
KR (1)	KR20110063557A (pt)
CN (2)	CN102223884B (pt)
AR (1)	AR073380A1 (pt)
AU (1)	AU2009297522A1 (pt)
BR (1)	BRPI0918955A2 (pt)
CA (1)	CA2738147C (pt)
CL (1)	CL2011000625A1 (pt)
CO (1)	CO6361934A2 (pt)
CR (1)	CR20110209A (pt)
EA (1)	EA201170483A1 (pt)
EC (1)	ECSP11011001A (pt)
GE (1)	GEP20146063B (pt)
IL (1)	IL211886A0 (pt)
MA (1)	MA32721B1 (pt)
MX (1)	MX2011003261A (pt)
NZ (1)	NZ592225A (pt)
PE (1)	PE20110844A1 (pt)
TW (1)	TW201014850A (pt)
UA (1)	UA102271C2 (pt)
UY (1)	UY32126A (pt)
WO (1)	WO2010035806A1 (pt)
ZA (1)	ZA201102715B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2010242308A1 (en) *	2009-04-30	2011-12-01	Takeda Pharmaceutical Company Limited	Solid preparation
BR112012023654B1 (pt)	2010-03-19	2022-04-12	Daiichi Sankyo Company, Limited	Método para produzir grânulos contendo agente anticoagulante e método para produzir uma composição farmacêutica contendo o dito agente
TR201004754A1 (tr) *	2010-06-11	2012-01-23	Sanovel �La� San. Ve T�C. A.�.	Yeni Farmasötik Kombinasyonlar
EP2742941B1 (en) *	2011-08-10	2018-04-18	Daiichi Sankyo Company, Limited	Pharmaceutical composition containing diamine derivative
JP5818219B2 (ja) *	2012-05-14	2015-11-18	塩野義製薬株式会社	６，７−不飽和−７−カルバモイルモルヒナン誘導体含有製剤
CN103768071B (zh) *	2012-10-23	2016-08-17	中国医药工业研究总院	一种治疗糖尿病的口服制剂
US20160331689A1 (en) *	2015-05-12	2016-11-17	SE Tylose USA, Inc.	Aqueous enteric coating composition
JP7101464B2 (ja) *	2017-09-28	2022-07-15	エルメッド株式会社	アジルサルタン又はその塩及びアムロジピン又はその塩含有錠剤の品質向上方法、並びにアジルサルタン又はその塩及びアムロジピン又はその塩含有錠剤及びその製造方法
JP7206872B2 (ja) *	2018-12-07	2023-01-18	ニプロ株式会社	アジルサルタン及びアムロジピンを含有する医薬組成物及びその製造方法
CN114404375B (zh) *	2022-01-21	2023-06-27	武汉九珑人福药业有限责任公司	一种叶酸固体制剂及其原料组合物、制备方法和应用
US20260191830A1 (en) *	2022-11-24	2026-07-09	Shanghai Aurora Biotechnology Co., Ltd.	Pharmaceutical composition comprising azilsartan medoxomil potassium and calcium channel blocker, method for preparing same, and use thereof

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5703110A (en)	1990-04-27	1997-12-30	Takeda Chemical Industries, Ltd.	Benzimidazole derivatives, their production and use
EP0565634B1 (en)	1990-12-14	1999-03-17	Smithkline Beecham Corporation	Angiotensin ii receptor blocking compositions
US5656650A (en)	1990-12-14	1997-08-12	Smithkline Beecham Corp.	Angiotensin II receptor blocking compositions
IL102183A (en)	1991-06-27	1999-11-30	Takeda Chemical Industries Ltd	Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
US5721263A (en) *	1993-06-07	1998-02-24	Takeda Chemical Industries, Ltd.	Pharmaceutical composition for angiotensin II-mediated diseases
CA2125251C (en)	1993-06-07	2005-04-26	Yoshiyuki Inada	A pharmaceutical composition for angiotensin ii-mediated diseases
CN1072649C (zh)	1995-09-13	2001-10-10	武田药品工业株式会社	苯并氧杂吖庚因化合物,其生产方法和用途
US6638937B2 (en)	1998-07-06	2003-10-28	Bristol-Myers Squibb Co.	Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR035016A1 (es)	1999-08-25	2004-04-14	Takeda Chemical Industries Ltd	Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima.
US6459014B1 (en) *	1999-11-15	2002-10-01	Paragon Trade Brands, Inc.	Absorbent article which maintains prolonged natural skin pH
JP2001294524A (ja)	2000-04-12	2001-10-23	Taisho Pharmaceut Co Ltd	アセトアミノフェン配合内服固形製剤
EP1302462A4 (en)	2000-07-17	2007-07-18	Takeda Pharmaceutical	SULFONATE DERIVATIVES, PROCESS FOR PRODUCTION AND USE THEREOF
EP1413315A4 (en)	2001-08-03	2006-08-16	Takeda Pharmaceutical	DRUGS WITH CONTINUOUS RELEASE
JP2005508358A (ja)	2001-10-25	2005-03-31	デポメド・インコーポレイテッド	胃滞留型ロサルタン投与量を用いる治療方法
BR0315815A (pt)	2002-11-01	2005-09-13	Takeda Pharmaceutical	Agentes para prevenir ou tratar neuropatia, para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor, neuroprotetor e farmacêutico, composto, métodos para prevenir ou tratar neuropatia e para promover a produção ou a secreção de um fator neurotrópico, para melhorar a dor para proteger um nervo em um mamìfero e para produzir um composto e uso de um composto
AU2003277576A1 (en)	2002-11-08	2004-06-07	Takeda Pharmaceutical Company Limited	Receptor function controlling agent
US20070004736A1 (en)	2002-11-22	2007-01-04	Keiji Kubo	Imidazole derivative, process for producing the same, and use
US20040170687A1 (en)	2003-02-27	2004-09-02	Integrity Pharmaceutical Corporation	Compositions with improved stability and methods of formulation thereof
WO2004082679A1 (ja) *	2003-03-17	2004-09-30	Takeda Pharmaceutical Company Limited	放出制御組成物
US7820837B2 (en)	2003-05-30	2010-10-26	Takeda Pharmaceutical Company Limited	Condensed ring compound
DE60331236D1 (de)	2003-07-24	2010-03-25	Eswaran Krishnan Iyer	Orale zusammensetzungen zur behandlung von diabetes
MXPA06001601A (es)	2003-08-13	2006-08-25	Takeda Pharmaceutical	Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa.
EP1669352A4 (en)	2003-09-30	2008-12-17	Takeda Pharmaceutical	THIAZOLINE DERIVATIVE AND ITS USE
WO2005058823A1 (ja)	2003-12-17	2005-06-30	Takeda Pharmaceutical Company Limited	ウレア誘導体、その製造法及び用途
US7456218B2 (en)	2003-12-25	2008-11-25	Takeda Pharmaceutical Company Limited	3-(4-benzyloxyphenyl) propanoic acid derivatives
WO2005063725A1 (ja)	2003-12-26	2005-07-14	Takeda Pharmaceutical Company Limited	フェニルプロパン酸誘導体
US7157584B2 (en)	2004-02-25	2007-01-02	Takeda Pharmaceutical Company Limited	Benzimidazole derivative and use thereof
WO2005087710A1 (ja)	2004-03-15	2005-09-22	Takeda Pharmaceutical Company Limited	アミノフェニルプロパン酸誘導体
JP4859665B2 (ja)	2004-03-30	2012-01-25	武田薬品工業株式会社	アルコキシフェニルプロパン酸誘導体
TWI396686B (zh)	2004-05-21	2013-05-21	Takeda Pharmaceutical	環狀醯胺衍生物、以及其製品和用法
AR055755A1 (es)	2005-03-30	2007-09-05	Takeda Pharmaceutical	Derivado de bencimidazol, procesos de obtencion, composiciones farmaceuticas y usos.
US8957070B2 (en)	2005-04-20	2015-02-17	Takeda Pharmaceutical Company Limited	Glucokinase activator compounds, methods of activating glucokinase and methods of treating diabetes and obesity
JP5044398B2 (ja) *	2005-06-09	2012-10-10	武田薬品工業株式会社	固形製剤
WO2007001066A1 (en) *	2005-06-27	2007-01-04	Daiichi Sankyo Company, Limited	Pharmaceutical preparation containing an angiotensin ii receptor antagonist and a calcium channel blocker
JP5110697B2 (ja) *	2005-06-27	2012-12-26	第一三共株式会社	固形製剤
DE102005031577A1 (de) *	2005-07-06	2007-01-11	Bayer Healthcare Ag	Pharmazeutische Darreichungsformen enthaltend eine Wirkstoffkombination von Nifedipin und/oder Nisoldipin und einem Angiotensin-II Antagonisten
EP1916234B1 (en)	2005-07-29	2014-11-12	Takeda Pharmaceutical Company Limited	Cyclopropanecarboxylic acid compound
US20090054435A1 (en)	2005-07-29	2009-02-26	Hiroshi Imoto	Phenoxyalkanoic Acid Compound
JP4094660B1 (ja)	2005-08-10	2008-06-04	武田薬品工業株式会社	糖尿病治療剤
JP2007063225A (ja)	2005-09-01	2007-03-15	Takeda Chem Ind Ltd	イミダゾピリジン化合物
KR20080081354A (ko)	2005-12-28	2008-09-09	다케다 야쿠힌 고교 가부시키가이샤	당뇨병 치료제
WO2007097451A1 (ja) *	2006-02-27	2007-08-30	Takeda Pharmaceutical Company Limited	医薬パッケージ
AU2007265966B2 (en)	2006-06-27	2012-05-17	Takeda Pharmaceutical Company Limited	Fused cyclic compounds
EP2298772A1 (en)	2006-10-18	2011-03-23	Takeda Pharmaceutical Company Limited	Fused heterocyclic compounds
CN101573357B (zh)	2006-10-19	2013-01-23	武田药品工业株式会社	吲哚化合物
WO2008093639A1 (ja)	2007-01-29	2008-08-07	Takeda Pharmaceutical Company Limited	ピラゾール化合物
TW201350143A (zh)	2007-02-01	2013-12-16	Takeda Pharmaceutical	固體型製劑
AU2008215490A1 (en)	2007-02-09	2008-08-21	Takeda Pharmaceutical Company Limited	Fused ring compounds as partial agonists of PPAR-gamma
TWI415634B (zh) *	2007-03-28	2013-11-21	Takeda Pharmaceutical	固態醫藥組成物
JPWO2008136428A1 (ja)	2007-04-27	2010-07-29	武田薬品工業株式会社	含窒素５員複素環化合物
EP2157859A4 (en)	2007-06-19	2011-01-12	Takeda Pharmaceutical	INDAZOL COMPOUNDS FOR THE ACTIVATION OF GLUCCOKINASE
AR067557A1 (es)	2007-07-19	2009-10-14	Takeda Pharmaceutical	Preparacion solida y metodo de preparacion
US9169238B2 (en)	2008-07-31	2015-10-27	Takeda Pharmaceutical Company Limited	Solid pharmaceutical composition

2009
- 2009-09-16 TW TW098131167A patent/TW201014850A/zh unknown
- 2009-09-16 UY UY0001032126A patent/UY32126A/es not_active Application Discontinuation
- 2009-09-16 AR ARP090103548A patent/AR073380A1/es not_active Application Discontinuation
- 2009-09-25 WO PCT/JP2009/066690 patent/WO2010035806A1/ja not_active Ceased
- 2009-09-25 BR BRPI0918955A patent/BRPI0918955A2/pt not_active IP Right Cessation
- 2009-09-25 EP EP09816220.9A patent/EP2332535A4/en not_active Withdrawn
- 2009-09-25 NZ NZ592225A patent/NZ592225A/en not_active IP Right Cessation
- 2009-09-25 PE PE2011000787A patent/PE20110844A1/es not_active Application Discontinuation
- 2009-09-25 MX MX2011003261A patent/MX2011003261A/es unknown
- 2009-09-25 UA UAA201105161A patent/UA102271C2/ru unknown
- 2009-09-25 AU AU2009297522A patent/AU2009297522A1/en not_active Abandoned
- 2009-09-25 KR KR1020117009104A patent/KR20110063557A/ko not_active Withdrawn
- 2009-09-25 JP JP2010530880A patent/JP5570426B2/ja not_active Expired - Fee Related
- 2009-09-25 CN CN200980146684.3A patent/CN102223884B/zh not_active Expired - Fee Related
- 2009-09-25 US US12/998,167 patent/US9173849B2/en not_active Expired - Fee Related
- 2009-09-25 CN CN201410471654.2A patent/CN104306975A/zh active Pending
- 2009-09-25 CA CA2738147A patent/CA2738147C/en not_active Expired - Fee Related
- 2009-09-25 EA EA201170483A patent/EA201170483A1/ru unknown
- 2009-09-25 GE GEAP200912204A patent/GEP20146063B/en unknown
2011
- 2011-03-23 IL IL211886A patent/IL211886A0/en unknown
- 2011-03-24 CL CL2011000625A patent/CL2011000625A1/es unknown
- 2011-04-12 ZA ZA2011/02715A patent/ZA201102715B/en unknown
- 2011-04-20 MA MA33782A patent/MA32721B1/fr unknown
- 2011-04-25 EC EC2011011001A patent/ECSP11011001A/es unknown
- 2011-04-25 CR CR20110209A patent/CR20110209A/es unknown
- 2011-04-25 CO CO11050084A patent/CO6361934A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
CO6361934A2 (es)	2012-01-20
ECSP11011001A (es)	2011-05-31
KR20110063557A (ko)	2011-06-10
NZ592225A (en)	2012-06-29
CN102223884A (zh)	2011-10-19
UA102271C2 (en)	2013-06-25
GEP20146063B (en)	2014-03-25
WO2010035806A1 (ja)	2010-04-01
CN102223884B (zh)	2015-05-06
ZA201102715B (en)	2012-07-25
MX2011003261A (es)	2011-04-21
UY32126A (es)	2010-04-30
JPWO2010035806A1 (ja)	2012-02-23
US20110229567A1 (en)	2011-09-22
EP2332535A4 (en)	2013-11-27
CR20110209A (es)	2011-05-27
IL211886A0 (en)	2011-06-30
PE20110844A1 (es)	2011-12-05
AU2009297522A1 (en)	2010-04-01
EP2332535A1 (en)	2011-06-15
AR073380A1 (es)	2010-11-03
CA2738147C (en)	2016-10-11
CL2011000625A1 (es)	2011-07-08
MA32721B1 (fr)	2011-10-02
TW201014850A (en)	2010-04-16
US9173849B2 (en)	2015-11-03
CA2738147A1 (en)	2010-04-01
JP5570426B2 (ja)	2014-08-13
EA201170483A1 (ru)	2011-10-31
CN104306975A (zh)	2015-01-28

Legal Events

Date	Code	Title	Description
2016-06-07	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 6A ANUIDADE.
2016-09-27	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2370 DE 07-06-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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