BRPI0919020B8 - uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris - Google Patents
uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectorisInfo
- Publication number
- BRPI0919020B8 BRPI0919020B8 BRPI0919020A BRPI0919020A BRPI0919020B8 BR PI0919020 B8 BRPI0919020 B8 BR PI0919020B8 BR PI0919020 A BRPI0919020 A BR PI0919020A BR PI0919020 A BRPI0919020 A BR PI0919020A BR PI0919020 B8 BRPI0919020 B8 BR PI0919020B8
- Authority
- BR
- Brazil
- Prior art keywords
- treat
- ischemia
- angina pectoris
- lineage cells
- monocyte lineage
- Prior art date
Links
- 206010002383 Angina Pectoris Diseases 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 208000028867 ischemia Diseases 0.000 title 1
- 210000001616 monocyte Anatomy 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/17—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0645—Macrophages, e.g. Kuepfer cells in the liver; Monocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris. a presente invenção refere-se a composições e métodos para o tratamento de doenças e condições isquêmicas, particularmente isquemia do miocárdio, do snc/cérebro e de membros. mais particularmente, a presente invenção estabelece métodos de tratamento de doenças mediante administração de monócitos obtidos de sangue, incluindo sangue de cordão umbilical, sangue periférico ou medula óssea, a um indivíduo que precisa de tratamento, em que a formulação específica é administrada para o indivíduo, em um tempo especificamente determinado para proporcionar a eficácia terapêutica. em uma modalidade, as células são para injeção no miocárdio isquêmico para o tratamento de angina.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9672708P | 2008-09-12 | 2008-09-12 | |
| US61/096,727 | 2008-09-12 | ||
| US17380709P | 2009-04-29 | 2009-04-29 | |
| US61/173,807 | 2009-04-29 | ||
| PCT/US2009/056867 WO2010031006A1 (en) | 2008-09-12 | 2009-09-14 | Ischemic tissue cell therapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0919020A8 BRPI0919020A8 (pt) | 2018-05-29 |
| BRPI0919020B1 BRPI0919020B1 (pt) | 2021-03-23 |
| BRPI0919020B8 true BRPI0919020B8 (pt) | 2021-05-25 |
Family
ID=42005531
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0919020D BRPI0919020A2 (pt) | 2008-09-12 | 2009-09-14 | Uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris |
| BRPI0919020A BRPI0919020B8 (pt) | 2008-09-12 | 2009-09-14 | uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0919020D BRPI0919020A2 (pt) | 2008-09-12 | 2009-09-14 | Uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8784802B2 (pt) |
| EP (1) | EP2331679B1 (pt) |
| JP (4) | JP6105846B2 (pt) |
| CN (2) | CN102186970A (pt) |
| BR (2) | BRPI0919020A2 (pt) |
| CA (1) | CA2737193A1 (pt) |
| HK (1) | HK1248125A1 (pt) |
| RU (1) | RU2535966C2 (pt) |
| WO (1) | WO2010031006A1 (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130078224A1 (en) | 2010-03-30 | 2013-03-28 | Life Sciences Research Partners Vzw | Induction/monitoring of arteriogenesis using sdf1 and pdgfb or inhibition of phd2 |
| EP2412724A1 (en) * | 2010-07-29 | 2012-02-01 | Centre National de la Recherche Scientifique (C.N.R.S) | Regulation of Glypican 4 activity to modulate the fate of stem cells and uses thereof |
| CN101940594B (zh) * | 2010-08-27 | 2013-12-04 | 上海士腾生物技术有限公司 | 用于治疗缺血性心血管疾病的制剂及其制备方法 |
| US20130142762A1 (en) | 2011-11-07 | 2013-06-06 | Hina W. Chaudhry | Methods of cardiac repair |
| ITPD20120318A1 (it) * | 2012-10-29 | 2014-04-30 | Alvaro Bido | Liquido refrigerante |
| FR3026744B1 (fr) | 2014-10-06 | 2024-04-19 | Hopitaux Paris Assist Publique | Methode de generation de progeniteurs de cellules t |
| US20160287638A1 (en) * | 2015-04-02 | 2016-10-06 | Stemedica Cell Technologies, Inc. | Ischemic tolerant cells and cellular factors in the treatment of peripheral artery disease |
| WO2016172309A2 (en) * | 2015-04-21 | 2016-10-27 | The Regents Of The University Of California | System and method for monitoring and treating arrhythmia and cardiac function via the intrinsic cardiac nervous system |
| JP6903866B2 (ja) * | 2016-01-27 | 2021-07-14 | 国立大学法人 熊本大学 | 血液由来単球の増殖誘導方法 |
| MX2019002288A (es) * | 2016-08-26 | 2019-09-18 | Rexgenero Biosciences S L | Suspensión celular para usarse en el tratamiento de la arteriopatía periférica de las extremidades inferiores. |
| ES2931530T3 (es) | 2017-02-13 | 2022-12-30 | Hopitaux Paris Assist Publique | Método para generar progenitores de células T |
| EP3615064A4 (en) * | 2017-04-25 | 2021-02-24 | Abraham J and Phyllis Katz Cord Blood Foundation | ENRICHED CELL COMPOSITIONS AND THERAPEUTIC USES |
| RU2661048C1 (ru) * | 2017-12-28 | 2018-07-11 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ лечения больных острым инфарктом миокарда с поздней госпитализацией |
| WO2021029436A1 (ja) * | 2019-08-09 | 2021-02-18 | 公益財団法人神戸医療産業都市推進機構 | 血管内皮細胞活性化物質のスクリーニング方法 |
| RU2725860C1 (ru) * | 2019-12-26 | 2020-07-06 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский университет "Московский институт электронной техники" | Тканеинженерная конструкция для регенерации сердечной ткани |
| CN115996708A (zh) * | 2020-06-30 | 2023-04-21 | 国立大学法人高知大学 | 含有脐带血单个核细胞培养上清的脑神经损伤治疗剂 |
| US12385011B2 (en) * | 2020-12-30 | 2025-08-12 | Creative Medical Technologies, Inc. | Treatment of heart failure and/or post infarct pathological remodeling by ex vivo reprogrammed immune cells |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| GB9310557D0 (en) | 1993-05-21 | 1993-07-07 | Smithkline Beecham Plc | Novel process and apparatus |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US5800812A (en) * | 1995-09-15 | 1998-09-01 | Yeda Research And Development Co. Ltd. | Methods of use of mononuclear phagocytes to promote axonal regeneration |
| US6267955B1 (en) * | 1995-09-15 | 2001-07-31 | Yeda Research And Development Co. Ltd. | Mononuclear phagocytes and their use to promote axonal regeneration |
| DE69837491T2 (de) | 1997-07-03 | 2008-01-17 | Osiris Therapeutics, Inc. | Menschliche mesenchymale stammzellen aus peripherem blut |
| US20020034501A1 (en) * | 2000-05-18 | 2002-03-21 | Robert Pawliuk | Methods and compositions for promoting angiogenesis using monocytes |
| JP2002069001A (ja) * | 2000-08-29 | 2002-03-08 | Asahi Kasei Corp | 樹状細胞を主成分とする細胞ワクチン |
| JP2002171965A (ja) * | 2000-12-04 | 2002-06-18 | Kansai Tlo Kk | 骨髄単核球細胞の分離、濃縮方法及び血管再生剤 |
| US20050202098A1 (en) | 2001-01-31 | 2005-09-15 | Tolaren | Disease therapy using dying or dead cells |
| MXPA04004813A (es) * | 2001-11-21 | 2004-08-11 | Yeda Res & Dev | Procedimientos para la produccion de leucocitos fagociticos mononucleares humanos. |
| CA2493122C (en) * | 2002-07-25 | 2012-11-27 | The Scripps Research Institute | Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith |
| US9969977B2 (en) | 2002-09-20 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| FI20060154A7 (fi) * | 2003-08-18 | 2006-05-11 | Btg Int Ltd | Neurogeneratiivisten tilojen hoito |
| JP2006050976A (ja) * | 2004-08-12 | 2006-02-23 | Asahi Kasei Medical Co Ltd | 細胞回収方法 |
| CN1754574A (zh) * | 2004-09-27 | 2006-04-05 | 深圳市中兴扬帆生物工程有限公司 | 使用免疫细胞治疗血液缺损症和骨髓抑制 |
| BRPI0516992A8 (pt) * | 2004-10-22 | 2018-04-03 | Univ South Florida | Método de potencializar modulação imune e inflamatória para célula e terapia de droga |
| US20070231306A1 (en) * | 2005-02-24 | 2007-10-04 | The Scripps Research Institute | Isolated myeloid-like cell populations and methods of treatment therewith |
| JP4949230B2 (ja) * | 2005-03-03 | 2012-06-06 | 株式会社カネカ | 細胞調製方法および装置 |
| US20060210543A1 (en) * | 2005-03-21 | 2006-09-21 | Jonathan Leor | Method of treating infarcted myocardium |
| EP1951864B1 (en) * | 2005-11-07 | 2014-05-07 | Amorcyte, Inc. | Compositions and methods of vascular injury repair |
| US7833789B2 (en) * | 2006-08-01 | 2010-11-16 | Fondazione Centro San Raffaele Del Monte Tabor | Monocyte cell |
| US20080206196A1 (en) * | 2007-02-26 | 2008-08-28 | Calvin Cao | Differentiation of cord blood into neural like cells, and method to treat neurological condition patients |
-
2009
- 2009-09-14 EP EP09813763.1A patent/EP2331679B1/en not_active Not-in-force
- 2009-09-14 CN CN200980139421XA patent/CN102186970A/zh active Pending
- 2009-09-14 BR BRPI0919020D patent/BRPI0919020A2/pt unknown
- 2009-09-14 CN CN201710060312.5A patent/CN107595889A/zh active Pending
- 2009-09-14 CA CA2737193A patent/CA2737193A1/en not_active Abandoned
- 2009-09-14 JP JP2011527030A patent/JP6105846B2/ja not_active Expired - Fee Related
- 2009-09-14 RU RU2011113869/10A patent/RU2535966C2/ru not_active IP Right Cessation
- 2009-09-14 BR BRPI0919020A patent/BRPI0919020B8/pt active IP Right Grant
- 2009-09-14 WO PCT/US2009/056867 patent/WO2010031006A1/en not_active Ceased
- 2009-09-14 US US13/063,456 patent/US8784802B2/en active Active
-
2014
- 2014-02-17 JP JP2014027268A patent/JP2014088443A/ja not_active Withdrawn
- 2014-07-21 US US14/336,621 patent/US10335434B2/en active Active
-
2016
- 2016-04-11 JP JP2016078709A patent/JP2016128521A/ja active Pending
-
2017
- 2017-09-08 JP JP2017173071A patent/JP2017214426A/ja not_active Withdrawn
-
2018
- 2018-06-14 HK HK18107708.8A patent/HK1248125A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010031006A1 (en) | 2010-03-18 |
| CN107595889A (zh) | 2018-01-19 |
| US20140369983A1 (en) | 2014-12-18 |
| JP2012502114A (ja) | 2012-01-26 |
| US10335434B2 (en) | 2019-07-02 |
| US8784802B2 (en) | 2014-07-22 |
| BRPI0919020A2 (pt) | 2017-08-22 |
| JP6105846B2 (ja) | 2017-03-29 |
| JP2017214426A (ja) | 2017-12-07 |
| CN102186970A (zh) | 2011-09-14 |
| EP2331679A4 (en) | 2012-12-26 |
| EP2331679A1 (en) | 2011-06-15 |
| CA2737193A1 (en) | 2010-03-18 |
| JP2014088443A (ja) | 2014-05-15 |
| US20110274674A1 (en) | 2011-11-10 |
| RU2011113869A (ru) | 2012-10-20 |
| EP2331679B1 (en) | 2017-04-19 |
| RU2535966C2 (ru) | 2014-12-20 |
| JP2016128521A (ja) | 2016-07-14 |
| HK1248125A1 (zh) | 2018-10-12 |
| BRPI0919020A8 (pt) | 2018-05-29 |
| BRPI0919020B1 (pt) | 2021-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0919020B8 (pt) | uso de células de linhagem monocitária enriquecidas para tratar isquemia e para tratar angina pectoris | |
| BR112016014481A2 (pt) | tratamento de câncer utilizando combinações de inibidores de erk e raf | |
| BR112015006828A8 (pt) | composto, ou um sal farmaceuticamente aceitável do mesmo; composição farmacêutica; uso do composto; e método para modular a atividade de uma proteína ire1 | |
| BR112014000240A2 (pt) | derivados de benzilamina como inibidores de calicreína plasmática | |
| AR044007A1 (es) | Metodos para el tratamiento de la enfermedad de parkinson | |
| BR112012031163A2 (pt) | métodos de terapia combinada para tratamento de doenças proliferativas | |
| AR067903A1 (es) | Metodo para tratar la depresion mediada por estres | |
| BR112012018500A2 (pt) | alguns inibidores de quinurenina-3-monooxigenase, composições farmacêuticas e métodos de uso destas | |
| BR112014010291A2 (pt) | composições de lipossoma combinacionais para terapia de câncer | |
| MX385305B (es) | Composiciones de ribósido de nicotinamida para uso tópico en el tratamiento de afecciones de la piel. | |
| SV2011003901A (es) | Compuestos de arilo con sustituyentes heterocíclicos como inhibidores de hif | |
| BR112012023421A2 (pt) | composição farmacêutica para tratamento de aumento de pressão intraocular | |
| BR112016013734A2 (pt) | Composto, composição farmacêutica, kit, e uso de um composto | |
| CO7101246A2 (es) | Compuesto de carbamato y preparación y uso de los mismos | |
| BR112013027119A2 (pt) | novos conjugados ligante-droga (adcs) e uso dos mesmos | |
| BR112012023021A2 (pt) | compostos de indazol e seus usos | |
| CU20070203A7 (es) | Composición farmacéutica que comprende una difenilurea sustituida con omega-carboxiarilo para el tratamiento del cáncer | |
| CY1116344T1 (el) | Κυτταρα προερχομενα απο ιστο ομφαλιου λωρου για την θεραπεια νευροπαθητικου πονου και σπαστικοτητας | |
| WO2015157559A3 (en) | 10',11'-modified saxitoxins useful for the treatment of pain | |
| EA201290139A1 (ru) | Модуляторы кальциевого канала, активируемого высвобождением кальция, представляющие собой производные пиразола, и способы лечения немелкоклеточного рака легких | |
| EP4124346A3 (en) | Compositions and methods for treating diseases | |
| BR112014003071A2 (pt) | tratamento de doença vascular periférica com o uso de células derivadas do tecido do cordão umbilical | |
| BR112013020586A2 (pt) | Uso de células derivadas de tecido do cordão umbilical | |
| CL2023002549A1 (es) | Ciertos compuestos de pladienolida y métodos de uso (divisional). | |
| BR112013007423A2 (pt) | terapia combinada no que diz respeito ao tratamento da infecção por hcv |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: CRYOPRAXIS CRIOBIOLOGIA LTDA (BR/RJ) , UNIVERSITY |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/03/2021, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 14/09/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |