BRPI0919199B8 - suspensão farmacêutica submicrométrica aquosa oftálmica, e seu método de formação - Google Patents

suspensão farmacêutica submicrométrica aquosa oftálmica, e seu método de formação

Info

Publication number
BRPI0919199B8
BRPI0919199B8 BRPI0919199A BRPI0919199A BRPI0919199B8 BR PI0919199 B8 BRPI0919199 B8 BR PI0919199B8 BR PI0919199 A BRPI0919199 A BR PI0919199A BR PI0919199 A BRPI0919199 A BR PI0919199A BR PI0919199 B8 BRPI0919199 B8 BR PI0919199B8
Authority
BR
Brazil
Prior art keywords
suspension
submicrometric
formation
preparing
submicron
Prior art date
Application number
BRPI0919199A
Other languages
English (en)
Inventor
Asgharian Bahram
J Castillo Ernesto
A Chowhan Masood
Original Assignee
Alcon Res Ltd
Alcon Res Llc
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41353867&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0919199(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Res Ltd, Alcon Res Llc, Novartis Ag filed Critical Alcon Res Ltd
Publication of BRPI0919199A2 publication Critical patent/BRPI0919199A2/pt
Publication of BRPI0919199B1 publication Critical patent/BRPI0919199B1/pt
Publication of BRPI0919199B8 publication Critical patent/BRPI0919199B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

suspensões farmacêuticas submicrométricas estabilizadas e métodos para preparar as mesmas. a presente invenção refere-se a uma suspensão farmacêutica submicrométrica e a um método para preparar a suspensão submicrométrica. a suspensão submicrométrica é útil para administração de agente terapêutico relativamente hidrofóbico e/ou de baixa solubilidade. a suspensão submicrométrica e o método para preparar a suspensão submicrométrica empregam tipicamente um material polimérico que ajuda na prevenção da agregação do agente terapêutico.
BRPI0919199A 2008-09-19 2009-09-16 suspensão farmacêutica submicrométrica aquosa oftálmica, e seu método de formação BRPI0919199B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9828008P 2008-09-19 2008-09-19
US61/098,280 2008-09-19
PCT/US2009/057065 WO2010033528A1 (en) 2008-09-19 2009-09-16 Stabilized pharmaceutical sub-micron suspensions and methods of forming same

Publications (3)

Publication Number Publication Date
BRPI0919199A2 BRPI0919199A2 (pt) 2015-12-15
BRPI0919199B1 BRPI0919199B1 (pt) 2020-10-27
BRPI0919199B8 true BRPI0919199B8 (pt) 2021-05-25

Family

ID=41353867

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919199A BRPI0919199B8 (pt) 2008-09-19 2009-09-16 suspensão farmacêutica submicrométrica aquosa oftálmica, e seu método de formação

Country Status (26)

Country Link
US (3) US20100076045A1 (pt)
EP (2) EP2425815B1 (pt)
JP (3) JP5739809B2 (pt)
KR (1) KR101682924B1 (pt)
CN (2) CN102176898A (pt)
AR (2) AR073597A1 (pt)
AU (1) AU2009293400B2 (pt)
BR (1) BRPI0919199B8 (pt)
CA (1) CA2736106C (pt)
CL (1) CL2009001856A1 (pt)
CY (1) CY1119740T1 (pt)
DK (1) DK2425815T3 (pt)
ES (2) ES2592503T3 (pt)
HR (1) HRP20180050T1 (pt)
HU (1) HUE037933T2 (pt)
LT (1) LT2425815T (pt)
MX (1) MX348204B (pt)
NO (1) NO2425815T3 (pt)
PL (2) PL2425815T3 (pt)
PT (2) PT2425815T (pt)
RU (1) RU2521258C2 (pt)
SI (1) SI2425815T1 (pt)
TW (1) TWI580441B (pt)
UY (1) UY32095A (pt)
WO (1) WO2010033528A1 (pt)
ZA (1) ZA201101398B (pt)

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Also Published As

Publication number Publication date
US20100076045A1 (en) 2010-03-25
WO2010033528A1 (en) 2010-03-25
US20170216228A1 (en) 2017-08-03
CN102176898A (zh) 2011-09-07
ZA201101398B (en) 2012-04-25
ES2592503T3 (es) 2016-11-30
ES2657455T3 (es) 2018-03-05
UY32095A (es) 2010-01-29
CN104688682A (zh) 2015-06-10
BRPI0919199A2 (pt) 2015-12-15
HUE037933T2 (hu) 2018-09-28
AR073597A1 (es) 2010-11-17
JP5739809B2 (ja) 2015-06-24
EP2425815A1 (en) 2012-03-07
CL2009001856A1 (es) 2010-12-31
EP2425815B1 (en) 2017-10-25
SI2425815T1 (en) 2018-02-28
EP2328551B1 (en) 2016-06-15
BRPI0919199B1 (pt) 2020-10-27
KR20110054055A (ko) 2011-05-24
RU2521258C2 (ru) 2014-06-27
CA2736106C (en) 2016-08-16
TW201014612A (en) 2010-04-16
AR124648A2 (es) 2023-04-19
HRP20180050T1 (hr) 2018-02-09
AU2009293400A1 (en) 2010-03-25
JP2015052020A (ja) 2015-03-19
LT2425815T (lt) 2018-01-25
JP2012503003A (ja) 2012-02-02
TWI580441B (zh) 2017-05-01
CA2736106A1 (en) 2010-03-25
MX348204B (es) 2017-05-30
NO2425815T3 (pt) 2018-03-24
DK2425815T3 (da) 2018-01-29
EP2328551A1 (en) 2011-06-08
MX2011002494A (es) 2011-04-07
RU2011115211A (ru) 2012-10-27
HK1152258A1 (zh) 2012-02-24
JP2017043637A (ja) 2017-03-02
AU2009293400B2 (en) 2015-05-07
PL2425815T3 (pl) 2018-03-30
PT2328551T (pt) 2016-09-22
PT2425815T (pt) 2018-01-31
PL2328551T3 (pl) 2017-04-28
US20140294970A1 (en) 2014-10-02
CY1119740T1 (el) 2018-09-05
KR101682924B1 (ko) 2016-12-06

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