BRPI0919282A2 - composto, composição farmacêutica, inibidor de ikkb, método para inibir ikkb, métodos para prevenir e/ou tratar uma doença ou sintoma associado com nf-kb, uma doença ou sintoma associado com ikkb, e uma doença ou sintoma associado com reação inflamatória aguda ou crônica em mamíferos - Google Patents
composto, composição farmacêutica, inibidor de ikkb, método para inibir ikkb, métodos para prevenir e/ou tratar uma doença ou sintoma associado com nf-kb, uma doença ou sintoma associado com ikkb, e uma doença ou sintoma associado com reação inflamatória aguda ou crônica em mamíferosInfo
- Publication number
- BRPI0919282A2 BRPI0919282A2 BRPI0919282A BRPI0919282A BRPI0919282A2 BR PI0919282 A2 BRPI0919282 A2 BR PI0919282A2 BR PI0919282 A BRPI0919282 A BR PI0919282A BR PI0919282 A BRPI0919282 A BR PI0919282A BR PI0919282 A2 BRPI0919282 A2 BR PI0919282A2
- Authority
- BR
- Brazil
- Prior art keywords
- disease
- ikkb
- symptom associated
- mammals
- chronic
- Prior art date
Links
- 101150057269 IKBKB gene Proteins 0.000 title 3
- 201000010099 disease Diseases 0.000 title 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 3
- 208000024891 symptom Diseases 0.000 title 3
- 206010061218 Inflammation Diseases 0.000 title 1
- 241000124008 Mammalia Species 0.000 title 1
- 230000001154 acute effect Effects 0.000 title 1
- 230000001684 chronic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10208608P | 2008-10-02 | 2008-10-02 | |
| PCT/JP2009/005072 WO2010038465A1 (ja) | 2008-10-02 | 2009-10-01 | ８位置換イソキノリン誘導体及びその用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0919282A2 true BRPI0919282A2 (pt) | 2017-03-28 |
Family
ID=42073244
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0919282A BRPI0919282A2 (pt) | 2008-10-02 | 2009-10-01 | composto, composição farmacêutica, inibidor de ikkb, método para inibir ikkb, métodos para prevenir e/ou tratar uma doença ou sintoma associado com nf-kb, uma doença ou sintoma associado com ikkb, e uma doença ou sintoma associado com reação inflamatória aguda ou crônica em mamíferos |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8299055B2 (pt) |
| EP (1) | EP2366699B1 (pt) |
| JP (1) | JP5312466B2 (pt) |
| KR (1) | KR101323448B1 (pt) |
| CN (1) | CN102171204B (pt) |
| AU (1) | AU2009298981B2 (pt) |
| BR (1) | BRPI0919282A2 (pt) |
| CA (1) | CA2738563C (pt) |
| ES (1) | ES2431368T3 (pt) |
| PL (1) | PL2366699T3 (pt) |
| RU (1) | RU2504544C2 (pt) |
| WO (1) | WO2010038465A1 (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2003131A4 (en) * | 2006-04-04 | 2009-12-16 | Taisho Pharmaceutical Co Ltd | AMINOPYRROLIDINE COMPOUND |
| EP3395184B1 (en) | 2011-01-28 | 2025-03-26 | Tate & Lyle Solutions USA LLC | Stevia blends containing rebaudioside b |
| GB201217700D0 (en) | 2012-08-01 | 2012-11-14 | Tate & Lyle Ingredients | Sweetener compositions containing rebaudioside B |
| US9565840B2 (en) | 2012-11-01 | 2017-02-14 | Kyoto University | Fibrotic non-human animal, and use thereof |
| EP3204379B1 (en) | 2014-10-10 | 2019-03-06 | Genentech, Inc. | Pyrrolidine amide compounds as histone demethylase inhibitors |
| AR112682A1 (es) | 2017-08-17 | 2019-11-27 | Syngenta Participations Ag | Compuestos herbicidas |
| AR114422A1 (es) | 2018-03-30 | 2020-09-02 | Syngenta Participations Ag | Compuestos herbicidas |
| GB201818348D0 (en) | 2018-11-12 | 2018-12-26 | Syngenta Participations Ag | Herbicidal compounds |
| GB201818349D0 (en) | 2018-11-12 | 2018-12-26 | Syngenta Participations Ag | Herbicidal compounds |
| GB201901617D0 (en) | 2019-02-06 | 2019-03-27 | Syngenta Crop Protection Ag | Herbicidal compounds |
| AR117990A1 (es) | 2019-02-06 | 2021-09-08 | Syngenta Crop Protection Ag | Compuestos herbicidas |
| WO2020161138A1 (en) | 2019-02-07 | 2020-08-13 | Syngenta Crop Protection Ag | Pyridazinium compounds for use in controlling unwanted plant growth |
| GB201901760D0 (en) | 2019-02-08 | 2019-03-27 | Syngenta Crop Protection Ag | Herbicidal compounds |
| GB201901866D0 (en) | 2019-02-11 | 2019-04-03 | Syngenta Crop Protection Ag | Pre-harvest desiccation method |
| GB201902064D0 (en) | 2019-02-14 | 2019-04-03 | Syngenta Crop Protection Ag | Herbicidal compounds |
| GB201902013D0 (en) | 2019-02-14 | 2019-04-03 | Syngenta Crop Protection Ag | Herbicidal compounds |
| GB201902107D0 (en) | 2019-02-15 | 2019-04-03 | Syngenta Crop Protection Ag | Herbicidal compounds |
| CN113453554B (zh) | 2019-02-15 | 2023-09-05 | 先正达农作物保护股份公司 | 除草组合物 |
| JP2022520645A (ja) | 2019-02-15 | 2022-03-31 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 除草組成物 |
| CN113453553A (zh) | 2019-02-15 | 2021-09-28 | 先正达农作物保护股份公司 | 除草组合物 |
| WO2020164924A1 (en) | 2019-02-15 | 2020-08-20 | Syngenta Crop Protection Ag | Herbicidal compositions |
| CA3128409A1 (en) | 2019-02-15 | 2020-08-20 | Syngenta Crop Protection Ag | Herbicidal compositions |
| GB201902383D0 (en) | 2019-02-21 | 2019-04-10 | Syngenta Crop Protection Ag | Herbicidal compounds |
| GB201903000D0 (en) | 2019-03-06 | 2019-04-17 | Syngenta Crop Protection Ag | Herbicidal compounds |
| ES3025089T3 (en) | 2019-11-06 | 2025-06-06 | Yuhan Corp | Pyrrolidine and piperidine compounds |
| JP2023068213A (ja) * | 2020-03-31 | 2023-05-17 | 慶應義塾 | 炎症性腸疾患処置剤、及び、アミド化合物又はその塩 |
| WO2021201126A1 (ja) * | 2020-03-31 | 2021-10-07 | 富士フイルム株式会社 | アミド化合物又はその塩、医薬組成物、及び、ヒストン脱アセチル化酵素阻害剤 |
| TWI783480B (zh) * | 2020-05-27 | 2022-11-11 | 美商美國禮來大藥廠 | 用於抑制cdk7之化合物 |
| TW202317532A (zh) | 2021-07-15 | 2023-05-01 | 大陸商四川海思科製藥有限公司 | Aak1抑制劑及其用途 |
| US20250066294A1 (en) | 2021-12-27 | 2025-02-27 | Fundación Centro De Investigación Cooperativa De Energías Alternativas Cic Energigune Fundazioa | Method for preparing ionic compounds |
| CN118489172A (zh) | 2021-12-27 | 2024-08-13 | 可替代能源Cic研究合作中心基金会 | 包含离子化合物的固体聚合物电解质及其用途 |
| CN117551057A (zh) * | 2023-03-24 | 2024-02-13 | 浙江海正药业股份有限公司 | 苯并环类衍生物及其制备方法和用途 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9322828D0 (en) * | 1993-11-05 | 1993-12-22 | Sandoz Ltd | Organic compounds |
| JPH1087491A (ja) * | 1996-07-26 | 1998-04-07 | Asahi Chem Ind Co Ltd | 転写調節因子阻害剤 |
| HUP0102492A2 (hu) | 1998-06-19 | 2001-11-28 | Smithkline Beecham Corp. | Amino-indanon származékok alkalmazása NF-kB transzkripciós faktor inhibitor hatású gyógyszerkészítmények előállítására |
| DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
| AU2002211827B2 (en) | 2000-10-03 | 2006-12-14 | Bristol-Myers Squibb Company | Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same |
| EP1328272A1 (en) | 2000-10-12 | 2003-07-23 | SmithKline Beecham Corporation | Nf-kappa-b inhibitors |
| DE60133758T2 (de) * | 2000-10-26 | 2009-07-02 | Amgen Inc., Thousand Oaks | Antiphlogistische mittel |
| JP2002193938A (ja) | 2000-12-01 | 2002-07-10 | Bayer Ag | ４−アリールピリジン誘導体 |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| JP2004529088A (ja) | 2001-02-01 | 2004-09-24 | ブリストル−マイヤーズ スクイブ カンパニー | ＩｋＢキナーゼ（ＩＫＫ）のインヒビターを用いる炎症性および免疫疾患の処置法 |
| SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| ES2315430T3 (es) | 2001-10-04 | 2009-04-01 | Smithkline Beecham Corporation | Inhibidores de nf-kb. |
| AU2002365426A1 (en) | 2001-10-12 | 2003-09-02 | Barnes-Jewish Hospital | Methods for screening osteogenic compounds |
| US20040006118A1 (en) | 2001-10-12 | 2004-01-08 | Callahan James F | Nf-kb inhibitors |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| WO2003103658A1 (ja) | 2002-06-05 | 2003-12-18 | 株式会社医薬分子設計研究所 | 免疫関連プロテインキナーゼ阻害剤 |
| DE60312997T2 (de) | 2002-06-06 | 2007-12-13 | Smithkline Beecham Corp. | Nf-kb-inhibitoren |
| US7094789B2 (en) | 2002-07-22 | 2006-08-22 | Asahi Kasei Pharma Corporation | 5-substituted isoquinoline derivatives |
| CA2493230A1 (en) | 2002-07-22 | 2004-01-29 | Asahi Kasei Pharma Corporation | 5-substituted isoquinoline derivative |
| BRPI0408704A (pt) | 2003-03-24 | 2006-03-07 | Hoffmann La Roche | benzil-piridazinonas como inibidores de transcriptase reversa |
| AU2004230952A1 (en) | 2003-04-09 | 2004-10-28 | Millenium Pharmaceuticals, Inc. | Beta-carbolines useful for treating inflammatory disease |
| GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
| TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
| MX2008000017A (es) | 2005-06-28 | 2008-03-26 | Sanofi Aventis | Derivados de isoquinolina como inhibidores de rho-cinasa. |
-
2009
- 2009-10-01 BR BRPI0919282A patent/BRPI0919282A2/pt not_active Application Discontinuation
- 2009-10-01 ES ES09817505T patent/ES2431368T3/es active Active
- 2009-10-01 CA CA2738563A patent/CA2738563C/en not_active Expired - Fee Related
- 2009-10-01 US US12/571,601 patent/US8299055B2/en not_active Expired - Fee Related
- 2009-10-01 WO PCT/JP2009/005072 patent/WO2010038465A1/ja not_active Ceased
- 2009-10-01 RU RU2011112393/04A patent/RU2504544C2/ru not_active IP Right Cessation
- 2009-10-01 CN CN200980138589.9A patent/CN102171204B/zh not_active Expired - Fee Related
- 2009-10-01 JP JP2010531755A patent/JP5312466B2/ja not_active Expired - Fee Related
- 2009-10-01 PL PL09817505T patent/PL2366699T3/pl unknown
- 2009-10-01 AU AU2009298981A patent/AU2009298981B2/en not_active Ceased
- 2009-10-01 EP EP09817505.2A patent/EP2366699B1/en not_active Not-in-force
- 2009-10-01 KR KR1020117007358A patent/KR101323448B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011112393A (ru) | 2012-11-10 |
| ES2431368T3 (es) | 2013-11-26 |
| KR101323448B1 (ko) | 2013-11-27 |
| CN102171204A (zh) | 2011-08-31 |
| EP2366699A4 (en) | 2012-03-14 |
| JPWO2010038465A1 (ja) | 2012-03-01 |
| PL2366699T3 (pl) | 2013-12-31 |
| RU2504544C2 (ru) | 2014-01-20 |
| AU2009298981A1 (en) | 2010-04-08 |
| CA2738563A1 (en) | 2010-04-08 |
| AU2009298981B2 (en) | 2012-09-27 |
| US8299055B2 (en) | 2012-10-30 |
| KR20110048583A (ko) | 2011-05-11 |
| EP2366699B1 (en) | 2013-08-07 |
| CA2738563C (en) | 2014-02-11 |
| JP5312466B2 (ja) | 2013-10-09 |
| CN102171204B (zh) | 2014-08-20 |
| WO2010038465A1 (ja) | 2010-04-08 |
| EP2366699A1 (en) | 2011-09-21 |
| US20100261701A1 (en) | 2010-10-14 |
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