BRPI0919629A8 - Método para preparação da (3s,4s)-4-(r-2-(benziloxi) tridecil) - 3 - hexil -2- oxetanona e novos intermediários utilizados - Google Patents

Método para preparação da (3s,4s)-4-(r-2-(benziloxi) tridecil) - 3 - hexil -2- oxetanona e novos intermediários utilizados

Info

Publication number
BRPI0919629A8
BRPI0919629A8 BRPI0919629A BRPI0919629A BRPI0919629A8 BR PI0919629 A8 BRPI0919629 A8 BR PI0919629A8 BR PI0919629 A BRPI0919629 A BR PI0919629A BR PI0919629 A BRPI0919629 A BR PI0919629A BR PI0919629 A8 BRPI0919629 A8 BR PI0919629A8
Authority
BR
Brazil
Prior art keywords
hexyl
oxetanone
tridecyl
benzyloxy
preparation
Prior art date
Application number
BRPI0919629A
Other languages
English (en)
Inventor
Min Yun Sang
Jin Hong Dong
Ki Yang Weon
Ho Yoo Jae
Sook Kim Ji
Sub Lee Moon
Kyong Kim Han
Jung Lim Eun
Ho Moon Young
Chang Young-Kil
Sun Lee Gwan
Original Assignee
Hanmi Holdings Co Ltd
Hanmi Science Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Holdings Co Ltd, Hanmi Science Co Ltd filed Critical Hanmi Holdings Co Ltd
Publication of BRPI0919629A2 publication Critical patent/BRPI0919629A2/pt
Publication of BRPI0919629A8 publication Critical patent/BRPI0919629A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

MÉTODO PARA PREPARAÇÃO DA (3S,4S)-4((R)-2-(BENZILOXI) TRIDECIL)-3-HEXIL-2-OXETANONA E NOVOS INTERMEDIÁRIOS UTILIZADOS. A presente invenção está relacionada a um método de alto rendimento para preparação de (3S,4S)-4-(((R)-2-(benziloxi)tridecil)-3-hexil-2-oxetanona altamente pura, utilizando um sal metálico do ácido (2S,3S,5R)-2-hexil-3,5-diidroxiexadecanóico como um intermediário.
BRPI0919629A 2008-11-04 2009-10-30 Método para preparação da (3s,4s)-4-(r-2-(benziloxi) tridecil) - 3 - hexil -2- oxetanona e novos intermediários utilizados BRPI0919629A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080108991A KR101126084B1 (ko) 2008-11-04 2008-11-04 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
PCT/KR2009/006338 WO2010053275A2 (en) 2008-11-04 2009-10-30 Method for preparing (3s,4s)-4-((r)-2-(benzyloxy)tridecyl)-3-hexyl-2-oxetanone and novel intermediate used therefor

Publications (2)

Publication Number Publication Date
BRPI0919629A2 BRPI0919629A2 (pt) 2015-08-18
BRPI0919629A8 true BRPI0919629A8 (pt) 2016-06-07

Family

ID=42153375

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919629A BRPI0919629A8 (pt) 2008-11-04 2009-10-30 Método para preparação da (3s,4s)-4-(r-2-(benziloxi) tridecil) - 3 - hexil -2- oxetanona e novos intermediários utilizados

Country Status (14)

Country Link
US (1) US8637700B2 (pt)
EP (1) EP2376469B1 (pt)
JP (1) JP5301676B2 (pt)
KR (1) KR101126084B1 (pt)
CN (1) CN102177149A (pt)
AU (1) AU2009311846B2 (pt)
BR (1) BRPI0919629A8 (pt)
CA (1) CA2741690C (pt)
ES (1) ES2467677T3 (pt)
IL (1) IL212632A (pt)
MX (1) MX2011004657A (pt)
NZ (1) NZ591735A (pt)
TW (1) TWI383974B (pt)
WO (1) WO2010053275A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010084502A1 (en) * 2009-01-22 2010-07-29 Biocon Limited A crystalline form of orlistat and a process thereof
CN112625009A (zh) * 2020-12-18 2021-04-09 植恩生物技术股份有限公司 一种奥利司他关键中间体的精制方法
CN114702383B (zh) * 2022-03-24 2024-03-15 中山万汉制药有限公司 一种苄氧基取代的脂肪酸衍生物及其制备方法与用途
CN115403464A (zh) * 2022-08-01 2022-11-29 湖南迪诺制药股份有限公司 奥利司他中间体、其制备方法及奥利司他合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3918364A1 (de) * 1989-06-06 1990-12-13 Hoechst Ag 3-desmethyl-2-methyl-mevalonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
CA2035972C (en) * 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
US6545165B1 (en) * 2000-02-04 2003-04-08 Roche Colorado Corporation Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
US6392061B1 (en) * 2000-10-16 2002-05-21 Zpro Chemical, Inc. Process for making (2S, 3S, 5S) oxetanone derivatives
US6734177B2 (en) * 2001-04-17 2004-05-11 Novartis Ag Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors
CA2450617A1 (en) * 2001-06-13 2002-12-19 Ranbaxy Laboratories Limited Methyl analogs of simvastatin as novel hmg-coa reductase inhibitors
JPWO2004065346A1 (ja) 2003-01-21 2006-05-18 住友化学株式会社 （−）−テトラヒドロリプスタチンおよびその中間体の製造方法

Also Published As

Publication number Publication date
TWI383974B (zh) 2013-02-01
MX2011004657A (es) 2011-05-30
KR101126084B1 (ko) 2012-03-29
RU2011122677A (ru) 2012-12-20
JP2012507506A (ja) 2012-03-29
AU2009311846B2 (en) 2011-11-10
BRPI0919629A2 (pt) 2015-08-18
WO2010053275A2 (en) 2010-05-14
ES2467677T3 (es) 2014-06-12
EP2376469B1 (en) 2014-04-30
EP2376469A2 (en) 2011-10-19
JP5301676B2 (ja) 2013-09-25
KR20100049941A (ko) 2010-05-13
EP2376469A4 (en) 2012-05-02
WO2010053275A3 (en) 2010-08-19
CA2741690C (en) 2013-11-19
AU2009311846A1 (en) 2011-06-30
CA2741690A1 (en) 2010-05-14
IL212632A (en) 2014-12-31
US8637700B2 (en) 2014-01-28
TW201024273A (en) 2010-07-01
IL212632A0 (en) 2011-07-31
CN102177149A (zh) 2011-09-07
NZ591735A (en) 2012-03-30
US20110178330A1 (en) 2011-07-21

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B25D Requested change of name of applicant approved

Owner name: HANMI SCIENCE CO., LTD. (KR)

B25G Requested change of headquarter approved

Owner name: HANMI SCIENCE CO., LTD. (KR)

B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements