BRPI0919629A2 - Método para preparação da (3s,4s)-4-(r-2-(benziloxi) tridecil) - 3 - hexil -2- oxetanona e novos intermediários utilizados - Google Patents

Método para preparação da (3s,4s)-4-(r-2-(benziloxi) tridecil) - 3 - hexil -2- oxetanona e novos intermediários utilizados

Info

Publication number: BRPI0919629A2
Authority: BR; Brazil
Prior art keywords: oxetanone; tridecyl; benzyloxy; hexyl; preparation
Prior art date: 2008-11-04

Application number

BRPI0919629-3A

Other languages

English (en)

Inventor

Sang Min Yun

Dong Jin Hong

Weon Ki Yang

Jae Ho Yoo

Ji Sook Kim

Moon Sub Lee

Han Kyong Kim

Eun Jung Lim

Young Ho Moon

Young-Kil Chang

Gwan Sun Lee

Original Assignee

Hanmi Holdings Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-11-04

Filing date

2009-10-30

Publication date

2015-08-18

2009-10-30 Application filed by Hanmi Holdings Co Ltd filed Critical Hanmi Holdings Co Ltd

2015-08-18 Publication of BRPI0919629A2 publication Critical patent/BRPI0919629A2/pt

2016-06-07 Publication of BRPI0919629A8 publication Critical patent/BRPI0919629A8/pt

Links

GAMXMSBSPXGAGZ-PKTNWEFCSA-N (3s,4s)-3-hexyl-4-[(2r)-2-phenylmethoxytridecyl]oxetan-2-one Chemical compound C([C@@H](CCCCCCCCCCC)OCC=1C=CC=CC=1)[C@@H]1OC(=O)[C@H]1CCCCCC GAMXMSBSPXGAGZ-PKTNWEFCSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Epoxy Compounds (AREA)

BRPI0919629A 2008-11-04 2009-10-30 Método para preparação da (3s,4s)-4-(r-2-(benziloxi) tridecil) - 3 - hexil -2- oxetanona e novos intermediários utilizados BRPI0919629A8 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR1020080108991A KR101126084B1 (ko)	2008-11-04	2008-11-04	(3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
PCT/KR2009/006338 WO2010053275A2 (en)	2008-11-04	2009-10-30	Method for preparing (3s,4s)-4-((r)-2-(benzyloxy)tridecyl)-3-hexyl-2-oxetanone and novel intermediate used therefor

Publications (2)

Publication Number	Publication Date
BRPI0919629A2 true BRPI0919629A2 (pt)	2015-08-18
BRPI0919629A8 BRPI0919629A8 (pt)	2016-06-07

Family

ID=42153375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0919629A BRPI0919629A8 (pt)	2008-11-04	2009-10-30	Método para preparação da (3s,4s)-4-(r-2-(benziloxi) tridecil) - 3 - hexil -2- oxetanona e novos intermediários utilizados

Country Status (14)

Country	Link
US (1)	US8637700B2 (pt)
EP (1)	EP2376469B1 (pt)
JP (1)	JP5301676B2 (pt)
KR (1)	KR101126084B1 (pt)
CN (1)	CN102177149A (pt)
AU (1)	AU2009311846B2 (pt)
BR (1)	BRPI0919629A8 (pt)
CA (1)	CA2741690C (pt)
ES (1)	ES2467677T3 (pt)
IL (1)	IL212632A (pt)
MX (1)	MX2011004657A (pt)
NZ (1)	NZ591735A (pt)
TW (1)	TWI383974B (pt)
WO (1)	WO2010053275A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010084502A1 (en) *	2009-01-22	2010-07-29	Biocon Limited	A crystalline form of orlistat and a process thereof
CN112625009A (zh) *	2020-12-18	2021-04-09	植恩生物技术股份有限公司	一种奥利司他关键中间体的精制方法
CN114702383B (zh) *	2022-03-24	2024-03-15	中山万汉制药有限公司	一种苄氧基取代的脂肪酸衍生物及其制备方法与用途
CN115403464A (zh) *	2022-08-01	2022-11-29	湖南迪诺制药股份有限公司	奥利司他中间体、其制备方法及奥利司他合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3918364A1 (de) *	1989-06-06	1990-12-13	Hoechst Ag	3-desmethyl-2-methyl-mevalonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, sowie zwischenprodukte
CA2035972C (en)	1990-02-23	2006-07-11	Martin Karpf	Process for the preparation of oxetanones
US6545165B1 (en) *	2000-02-04	2003-04-08	Roche Colorado Corporation	Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
US6392061B1 (en) *	2000-10-16	2002-05-21	Zpro Chemical, Inc.	Process for making (2S, 3S, 5S) oxetanone derivatives
US6734177B2 (en) *	2001-04-17	2004-05-11	Novartis Ag	Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors
BR0210426A (pt) *	2001-06-13	2004-08-17	Ranbaxy Lab Ltd	Metil análogo de sinvastatina para inibição de hmg-coa redutase e processo de obtenção do mesmo
JPWO2004065346A1 (ja)	2003-01-21	2006-05-18	住友化学株式会社	（−）−テトラヒドロリプスタチンおよびその中間体の製造方法

2008
- 2008-11-04 KR KR1020080108991A patent/KR101126084B1/ko not_active Expired - Fee Related
2009
- 2009-10-30 JP JP2011534391A patent/JP5301676B2/ja not_active Expired - Fee Related
- 2009-10-30 ES ES09824958.4T patent/ES2467677T3/es active Active
- 2009-10-30 WO PCT/KR2009/006338 patent/WO2010053275A2/en not_active Ceased
- 2009-10-30 US US13/120,561 patent/US8637700B2/en not_active Expired - Fee Related
- 2009-10-30 AU AU2009311846A patent/AU2009311846B2/en not_active Ceased
- 2009-10-30 CN CN2009801404828A patent/CN102177149A/zh active Pending
- 2009-10-30 EP EP09824958.4A patent/EP2376469B1/en not_active Not-in-force
- 2009-10-30 BR BRPI0919629A patent/BRPI0919629A8/pt not_active Application Discontinuation
- 2009-10-30 CA CA2741690A patent/CA2741690C/en not_active Expired - Fee Related
- 2009-10-30 MX MX2011004657A patent/MX2011004657A/es active IP Right Grant
- 2009-10-30 NZ NZ591735A patent/NZ591735A/en not_active IP Right Cessation
- 2009-11-03 TW TW098137215A patent/TWI383974B/zh not_active IP Right Cessation
2011
- 2011-05-02 IL IL212632A patent/IL212632A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US20110178330A1 (en)	2011-07-21
TWI383974B (zh)	2013-02-01
ES2467677T3 (es)	2014-06-12
KR101126084B1 (ko)	2012-03-29
IL212632A (en)	2014-12-31
BRPI0919629A8 (pt)	2016-06-07
MX2011004657A (es)	2011-05-30
CA2741690C (en)	2013-11-19
EP2376469A4 (en)	2012-05-02
IL212632A0 (en)	2011-07-31
EP2376469B1 (en)	2014-04-30
WO2010053275A3 (en)	2010-08-19
AU2009311846B2 (en)	2011-11-10
TW201024273A (en)	2010-07-01
AU2009311846A1 (en)	2011-06-30
CN102177149A (zh)	2011-09-07
CA2741690A1 (en)	2010-05-14
WO2010053275A2 (en)	2010-05-14
NZ591735A (en)	2012-03-30
JP5301676B2 (ja)	2013-09-25
KR20100049941A (ko)	2010-05-13
RU2011122677A (ru)	2012-12-20
EP2376469A2 (en)	2011-10-19
US8637700B2 (en)	2014-01-28
JP2012507506A (ja)	2012-03-29

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Legal Events

Date	Code	Title	Description
2016-04-12	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2016-06-07	B25D	Requested change of name of applicant approved	Owner name: HANMI SCIENCE CO., LTD. (KR)
2016-06-28	B25G	Requested change of headquarter approved	Owner name: HANMI SCIENCE CO., LTD. (KR)
2016-10-18	B11B	Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements