BRPI0919882A2 - métodos para avaliar padrões de rna - Google Patents
métodos para avaliar padrões de rnaInfo
- Publication number
- BRPI0919882A2 BRPI0919882A2 BRPI0919882A BRPI0919882A BRPI0919882A2 BR PI0919882 A2 BRPI0919882 A2 BR PI0919882A2 BR PI0919882 A BRPI0919882 A BR PI0919882A BR PI0919882 A BRPI0919882 A BR PI0919882A BR PI0919882 A2 BRPI0919882 A2 BR PI0919882A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- rna patterns
- evaluate rna
- evaluate
- patterns
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10974208P | 2008-10-30 | 2008-10-30 | |
| US11257108P | 2008-11-07 | 2008-11-07 | |
| US11404508P | 2008-11-12 | 2008-11-12 | |
| US11405808P | 2008-11-12 | 2008-11-12 | |
| US11406508P | 2008-11-13 | 2008-11-13 | |
| US15118309P | 2009-02-09 | 2009-02-09 | |
| US27804909P | 2009-10-02 | 2009-10-02 | |
| US25045409P | 2009-10-09 | 2009-10-09 | |
| US25302709P | 2009-10-19 | 2009-10-19 | |
| PCT/US2009/062880 WO2010062706A2 (en) | 2008-10-30 | 2009-10-30 | Methods for assessing rna patterns |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0919882A2 true BRPI0919882A2 (pt) | 2016-02-16 |
| BRPI0919882A8 BRPI0919882A8 (pt) | 2017-09-19 |
Family
ID=42226337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0919882A BRPI0919882A8 (pt) | 2008-10-30 | 2009-10-30 | Métodos para avaliar padrões de rna |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7888035B2 (pt) |
| EP (1) | EP2358912B1 (pt) |
| JP (1) | JP2012507300A (pt) |
| CN (1) | CN102308004A (pt) |
| BR (1) | BRPI0919882A8 (pt) |
| CA (1) | CA2742324A1 (pt) |
| IL (2) | IL212591A (pt) |
| WO (1) | WO2010062706A2 (pt) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| US8021847B2 (en) | 2004-06-02 | 2011-09-20 | Proxy Life Science Holdings, Inc. | Microvesicle-based compositions and methods |
| US20080268429A1 (en) * | 2004-06-02 | 2008-10-30 | Sourcepharm, Inc. | Rna - Containing Microvesicles and Methods Therefor |
| JP2009531324A (ja) | 2006-03-20 | 2009-09-03 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌標的化のための操作された抗前立腺幹細胞抗原(psca)抗体 |
| WO2009006258A1 (en) * | 2007-07-03 | 2009-01-08 | Spine Tek, Inc. | Interspinous mesh |
| US20100255514A1 (en) | 2007-08-16 | 2010-10-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Tumor cell-derived microvesicles |
| JP5769417B2 (ja) | 2007-08-16 | 2015-08-26 | ザ ロイヤル インスティチューション フォー ザ アドバンスメント オブ ラーニング/マギル ユニバーシティ | 腫瘍細胞由来微小胞 |
| WO2009032949A2 (en) * | 2007-09-04 | 2009-03-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
| CA2698152C (en) * | 2007-09-05 | 2018-08-14 | Laurentian University | Method of using tumour rna integrity to measure response to chemotherapy in cancer patients |
| CA2700410C (en) * | 2007-10-03 | 2020-10-06 | Cornell University | Treatment of proliferative disorders using antibodies to psma |
| US20100069616A1 (en) * | 2008-08-06 | 2010-03-18 | The Regents Of The University Of California | Engineered antibody-nanoparticle conjugates |
| DK2324126T3 (da) | 2008-08-12 | 2014-06-16 | Zinfandel Pharmaceuticals Inc | FREMGANGSMÅDE TIL IDENTIFICERING AF Alzheimers SYGDOMSRISIKOFAKTORER |
| US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
| BRPI0919882A8 (pt) * | 2008-10-30 | 2017-09-19 | Caris Life Sciences Luxembourg Holdings | Métodos para avaliar padrões de rna |
| WO2013022995A2 (en) * | 2011-08-08 | 2013-02-14 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Biomarker compositions and methods |
| US20140113310A9 (en) * | 2008-12-05 | 2014-04-24 | Myriad Genetics, Incorporated | Cancer detection markers |
| WO2010096486A1 (en) * | 2009-02-17 | 2010-08-26 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| US20120231970A1 (en) * | 2009-09-30 | 2012-09-13 | Japan Health Sciences Foundation | Colon cancer marker and method for testing for colon cancer |
| EP2316972A1 (en) * | 2009-10-29 | 2011-05-04 | Deutsches Krebsforschungszentrum | Circulating miRNAs as non-invasive markers for diagnosis and staging in prostate cancer |
| US20130203061A1 (en) | 2009-11-30 | 2013-08-08 | Michael KLASS | Methods and systems for isolating, storing, and analyzing vesicles |
| EP2506876B1 (en) | 2009-12-02 | 2016-10-12 | Imaginab, Inc. | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| WO2011106104A2 (en) * | 2010-02-26 | 2011-09-01 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for the detection and treatment of cancer involving mirnas and mirna inhibitors and targets |
| KR20130056855A (ko) | 2010-03-01 | 2013-05-30 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 치료진단용 생물학적 지표들 |
| KR20130043104A (ko) | 2010-04-06 | 2013-04-29 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 질병용 순환 생물학적 지표들 |
| WO2011156734A2 (en) * | 2010-06-11 | 2011-12-15 | Hitachi Chemical Co., Ltd. | Method of characterizing vascular diseases |
| JP5755326B2 (ja) | 2010-06-11 | 2015-07-29 | 日立化成株式会社 | 腎機能の特徴を決定する方法 |
| EP2913405B1 (en) | 2010-07-27 | 2016-11-09 | Genomic Health, Inc. | Method for using gene expression to determine prognosis of prostate cancer |
| ES2548039T3 (es) * | 2010-12-01 | 2015-10-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Modo de predicción del desenlace de un cáncer de colon analizando la expresión de miARN |
| CN103501783A (zh) | 2011-01-10 | 2014-01-08 | 金帆德尔制药股份有限公司 | 用于治疗阿尔茨海默病的方法和药物产品 |
| US20120251619A1 (en) * | 2011-03-31 | 2012-10-04 | Gunaratne Preethi H | MicroRNA-29a,b,c as a Tumor Suppressor and Sensitizing Agent for Chemotherapy |
| EP2691548B1 (en) * | 2011-03-31 | 2017-11-22 | University of Houston | Microrna 130a,b as a tumor suppressor and sensitizing agent for chemotherapy |
| WO2012140660A1 (en) | 2011-04-14 | 2012-10-18 | Exalenz Bioscience Ltd. | Methods for diagnosis, prognosis, monitoring and treatment of hepatocellular carcinoma |
| JP6011945B2 (ja) * | 2011-05-20 | 2016-10-25 | 公一 中城 | マイクロrna又はその発現系を含む組成物 |
| EP2717989B1 (en) | 2011-06-10 | 2018-05-30 | Hitachi Chemical Co., Ltd. | Vesicle capturing devices and methods for using same |
| WO2012174282A2 (en) * | 2011-06-16 | 2012-12-20 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Biomarker compositions and methods |
| EP2739734A1 (en) | 2011-08-03 | 2014-06-11 | The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System | Treatment of fibrosis using microrna-19b |
| WO2013020201A1 (en) | 2011-08-10 | 2013-02-14 | Amadeo Mark Parissenti | Diagnostic methods and kits for monitoring response to chemotherapy in ovarian cancer |
| EP2748335B1 (en) * | 2011-08-22 | 2018-10-03 | Exosome Diagnostics, Inc. | Urine biomarkers |
| US20150024389A1 (en) * | 2011-09-16 | 2015-01-22 | Lsip, Llc | Method for detecting bladder cancer cells, primer used in method for detecting bladder cancer cells, and bladder cancer marker |
| ES2691296T3 (es) * | 2012-04-03 | 2018-11-26 | Reneuron Limited | Micropartículas de células madre |
| EP2653554A1 (en) * | 2012-04-17 | 2013-10-23 | Istituto Nazionale Di Genetica Molecolare-INGM | Immune response biomarkers |
| BR112014026440A8 (pt) | 2012-04-24 | 2018-01-16 | Rna Diagnostics Inc | análises, métodos e aparelhos para avaliação de disrupção de rna. |
| US8846316B2 (en) | 2012-04-30 | 2014-09-30 | Industrial Technology Research Institute | Biomarker for human liver cancer |
| KR101667169B1 (ko) | 2012-08-20 | 2016-10-17 | 국립연구개발법인 고쿠리츠간켄큐센터 | 암 치료제 |
| KR101933620B1 (ko) * | 2012-09-18 | 2018-12-28 | 삼성전자주식회사 | 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법 |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| AU2013340414B2 (en) | 2012-10-23 | 2019-05-02 | Caris Science, Inc. | Aptamers and uses thereof |
| WO2014071226A1 (en) | 2012-11-02 | 2014-05-08 | The Regents Of The University Of California | Methods and systems for determining a likelihood of adverse prostate cancer pathology |
| CN102912030B (zh) * | 2012-11-08 | 2014-07-30 | 端鹏 | 用于前列腺癌早期诊断的引物对、探针和试剂盒 |
| HK1215875A1 (zh) | 2012-12-03 | 2016-09-23 | Rna Diagnostics Inc. | 用於监视放射治疗癌症反应的方法和试剂盒 |
| EP2935628B1 (en) | 2012-12-19 | 2018-03-21 | Caris Life Sciences Switzerland Holdings GmbH | Compositions and methods for aptamer screening |
| KR101504817B1 (ko) * | 2013-04-05 | 2015-03-24 | 연세대학교 산학협력단 | 국소 진행형 위암에 대한 예후 예측 시스템 |
| JP6297676B2 (ja) | 2013-05-06 | 2018-03-20 | 日立化成株式会社 | 標的分子を捕捉するためのデバイス及び方法 |
| CN104164474A (zh) * | 2013-05-17 | 2014-11-26 | 刘代新 | 一种检测尿液中pca3基因和psa基因表达量的荧光定量pcr法及其诊断试剂盒 |
| GB201317887D0 (en) | 2013-10-09 | 2013-11-20 | Reneuron Ltd | Product |
| CN105980615A (zh) * | 2013-08-28 | 2016-09-28 | 卡里斯生命科学瑞士控股有限公司 | 寡核苷酸探针及其用途 |
| US9550989B2 (en) * | 2013-10-03 | 2017-01-24 | Washington University | Rational design of microRNA-siRNA chimeras for multi-functional target suppression |
| US10731222B2 (en) | 2013-10-04 | 2020-08-04 | Rna Diagnostics Inc. | RNA disruption assay for predicting survival |
| GB201322034D0 (en) | 2013-12-12 | 2014-01-29 | Almac Diagnostics Ltd | Prostate cancer classification |
| CN103882118A (zh) * | 2014-02-13 | 2014-06-25 | 绍兴市人民医院 | 用于检测前列腺癌的miRNAs |
| CN111961725B (zh) | 2014-05-30 | 2024-03-26 | 东丽株式会社 | 胰腺癌的检测试剂盒或装置以及检测方法 |
| US20170145515A1 (en) * | 2014-06-04 | 2017-05-25 | Atossa Genetics Inc. | Molecular mammography |
| CN119220676A (zh) | 2014-06-12 | 2024-12-31 | 东丽株式会社 | 前列腺癌的检测试剂盒或装置以及检测方法 |
| US10597726B2 (en) | 2014-06-13 | 2020-03-24 | Toray Industries, Inc. | Breast cancer detection kit or device, and detection method |
| CA2953220C (en) | 2014-06-16 | 2023-10-24 | Toray Industries, Inc. | Stomach cancer detection kit or device, and detection method |
| US10266895B2 (en) | 2014-11-05 | 2019-04-23 | Hitachi Chemical Company Ltd. | Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease |
| US10370719B2 (en) | 2014-11-12 | 2019-08-06 | Hitachi Chemical Co., Ltd. | Method and device for diagnosing organ injury |
| US20170360842A1 (en) * | 2014-12-03 | 2017-12-21 | Capricor, Inc. | Processes for producing stable exosome formulations |
| WO2016125243A1 (ja) * | 2015-02-03 | 2016-08-11 | 株式会社日立製作所 | エクソソーム測定方法及びエクソソーム抽出方法 |
| IL318703A (en) | 2015-06-29 | 2025-03-01 | Caris Science Inc | Therapeutic oligonucleotides |
| US10941176B2 (en) | 2015-07-28 | 2021-03-09 | Caris Science, Inc. | Therapeutic oligonucleotides |
| WO2017027325A1 (en) | 2015-08-07 | 2017-02-16 | Imaginab, Inc. | Antigen binding constructs to target molecules |
| US11028443B2 (en) | 2015-08-31 | 2021-06-08 | Showa Denko Materials Co., Ltd. | Molecular methods for assessing urothelial disease |
| CA3014773C (en) | 2016-03-07 | 2025-11-18 | Father Flanagan's Boys' Home Doing Business As Boys Town National Research Hospital | NON-INVASIVE MOLECULAR WITRS |
| US10731166B2 (en) | 2016-03-18 | 2020-08-04 | Caris Science, Inc. | Oligonucleotide probes and uses thereof |
| JP7340184B2 (ja) | 2016-03-31 | 2023-09-07 | 東レ株式会社 | 早期膵がん又は膵がん前駆病変の検出キット又はデバイス及び検出方法 |
| IL298701B2 (en) | 2016-05-25 | 2024-03-01 | Caris Science Inc | Oligonucleotide probes and uses thereof |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| JP7368856B2 (ja) | 2017-07-25 | 2023-10-25 | トゥルーバインディング,インコーポレイテッド | Tim-3とそのリガンドとの相互作用の遮断によるがん治療 |
| CN108841962B (zh) * | 2018-08-01 | 2021-11-19 | 博奥生物集团有限公司 | 一种非小细胞肺癌检测试剂盒及其应用 |
| US11535899B2 (en) | 2018-08-10 | 2022-12-27 | Toray Industries, Inc. | Kit, device and method for detecting prostate cancer |
| CN111041081B (zh) * | 2018-10-11 | 2024-10-15 | 上海自然堂集团有限公司 | 一种以皮肤外源性老化靶标筛选活性物的方法及改善皮肤外源性老化的活性物 |
| CN109234362A (zh) * | 2018-10-15 | 2019-01-18 | 北京艾迪康医学检验实验室有限公司 | 检测样本中cltc-tfe3融合基因的寡核苷酸、方法和试剂盒 |
| CN109136379A (zh) * | 2018-10-15 | 2019-01-04 | 济南艾迪康医学检验中心有限公司 | 检测样本中NonO-TFE3融合基因的寡核苷酸、方法和试剂盒 |
| CA3121170A1 (en) | 2018-11-30 | 2020-06-04 | Caris Mpi, Inc. | Next-generation molecular profiling |
| TWI758670B (zh) * | 2018-12-24 | 2022-03-21 | 奎克生技光電股份有限公司 | 健康風險評估方法 |
| CN120058944A (zh) | 2019-01-30 | 2025-05-30 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| CN110305964B (zh) * | 2019-07-26 | 2023-03-21 | 安徽医科大学第一附属医院 | 一种前列腺癌患者预后复发风险预测标志工具及其风险评估模型的建立 |
| MX2022006589A (es) | 2019-12-02 | 2023-01-11 | Caris Mpi Inc | Predictor de respuesta de platino pan-cancer. |
| US20240117434A1 (en) * | 2021-02-18 | 2024-04-11 | The Johns Hopkins University | Methods and related aspects for detecting diseases, conditions, or disorders in subjects using extracelluar vesicles |
| CN117255861A (zh) * | 2022-01-28 | 2023-12-19 | 香港城市大学 | 测量多重rna表达的方法和系统 |
| EP4536861A1 (en) * | 2022-06-10 | 2025-04-16 | City of Hope | Biomarkers in pancreatic cancer |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3812023A (en) * | 1972-12-11 | 1974-05-21 | Reynolds Metals Co | Anodic production of pigmented siliceous coatings for aluminous metals |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| DE3924454A1 (de) | 1989-07-24 | 1991-02-07 | Cornelis P Prof Dr Hollenberg | Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips) |
| EP0834576B1 (en) | 1990-12-06 | 2002-01-16 | Affymetrix, Inc. (a Delaware Corporation) | Detection of nucleic acid sequences |
| IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
| US5472672A (en) | 1993-10-22 | 1995-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for polymer synthesis using arrays |
| US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
| US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
| US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5658734A (en) | 1995-10-17 | 1997-08-19 | International Business Machines Corporation | Process for synthesizing chemical compounds |
| PT938320E (pt) | 1996-03-26 | 2010-09-22 | Michael S Kopreski | Método que permite a utilização de arn extracelular extraído de plasma ou de soro para detectar, monitorizar ou avaliar o cancro |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| FR2788780B1 (fr) | 1999-01-27 | 2001-03-30 | Ap Cells Inc | Procede de preparation de vesicules membranaires |
| GB9927320D0 (en) | 1999-11-18 | 2000-01-12 | Chiron Spa | Exosome separation |
| US6812023B1 (en) | 2000-04-27 | 2004-11-02 | Anosys, Inc. | Methods of producing membrane vesicles |
| US20040241176A1 (en) | 2000-04-27 | 2004-12-02 | Ap Cells. Inc. | Method of producing membrane vesicles |
| US7704964B2 (en) | 2001-08-17 | 2010-04-27 | Exothera L.L.C. | Methods and compounds for the targeting of protein to exosomes |
| US20070203333A1 (en) | 2001-11-30 | 2007-08-30 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| AUPS187002A0 (en) * | 2002-04-22 | 2002-05-30 | Queensland University Of Technology | Condition-specific molecules and uses therefor |
| CA2504605C (en) | 2002-11-13 | 2016-01-19 | Thomas Jefferson University | Treatment of chronic lymphocytic leukemia and prostate cancer with microrna mir15 |
| US7914792B2 (en) | 2003-02-14 | 2011-03-29 | Exothera L.L.C. | Methods and compounds for raising antibodies and for screening antibody repertoires |
| GB0318096D0 (en) | 2003-08-01 | 2003-09-03 | Queen Mary & Westfield College | Vaccine |
| CA2453198A1 (en) | 2004-01-07 | 2005-07-07 | Wei-Ping Min | Quantification and generation of immune suppressive exosomes |
| CA2555866A1 (en) | 2004-02-16 | 2005-08-25 | Proteosys Ag | Diagnostic markers for cancer |
| US20080268429A1 (en) | 2004-06-02 | 2008-10-30 | Sourcepharm, Inc. | Rna - Containing Microvesicles and Methods Therefor |
| CA2491067A1 (en) * | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| US20060211000A1 (en) * | 2005-03-21 | 2006-09-21 | Sorge Joseph A | Methods, compositions, and kits for detection of microRNA |
| CN101341259B (zh) | 2005-08-01 | 2011-12-21 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
| US20070092882A1 (en) | 2005-10-21 | 2007-04-26 | Hui Wang | Analysis of microRNA |
| US7197923B1 (en) * | 2005-11-07 | 2007-04-03 | Halliburton Energy Services, Inc. | Single phase fluid sampler systems and associated methods |
| JP5490413B2 (ja) | 2006-01-05 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常 |
| EP2487261B1 (en) | 2006-01-05 | 2015-07-01 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| ES2429404T3 (es) | 2006-01-05 | 2013-11-14 | The Ohio State University Research Foundation | Procedimientos basados en los microARN para el diagnóstico y el pronóstico del cáncer de pulmón |
| US7593913B2 (en) | 2006-01-11 | 2009-09-22 | Siemens Medical Solutions Usa, Inc. | Systems and method for integrative medical decision support |
| US9394569B2 (en) | 2006-01-31 | 2016-07-19 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Methods and kits for early detection of cancer or predisposition thereto |
| US9198981B2 (en) | 2006-02-01 | 2015-12-01 | The University Of Kentucky | Modulation of angiogenesis |
| WO2007103808A2 (en) | 2006-03-02 | 2007-09-13 | The Ohio State University | Microrna expression profile associated with pancreatic cancer |
| EP1993600B1 (en) | 2006-03-09 | 2019-04-24 | Aethlon Medical, Inc. | Extracorporeal removal of microvesicular particles |
| US9085778B2 (en) | 2006-05-03 | 2015-07-21 | VL27, Inc. | Exosome transfer of nucleic acids to cells |
| US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| US7462489B2 (en) | 2006-11-09 | 2008-12-09 | Ley Klaus F | Methods for identifying and analyzing biomarkers from plasma-derived microparticles |
| WO2008091948A2 (en) | 2007-01-23 | 2008-07-31 | University Of Virginia Patent Foundation | Galectin-3-binding, protein as a biomarker of cardiovascular disease |
| US20100055724A1 (en) | 2007-01-26 | 2010-03-04 | University Of Louisville Research Foundation, Inc. | Methods of detecting autoantibodies for diagnosing and characterizing disorders |
| US8314220B2 (en) * | 2007-01-26 | 2012-11-20 | Agilent Technologies, Inc. | Methods compositions, and kits for detection of microRNA |
| CA2676143A1 (en) | 2007-01-26 | 2008-07-31 | University Of Louisville Research Foundation, Inc. | Modification of exosomal components for use as a vaccine |
| CN103555825B (zh) | 2007-01-31 | 2015-09-30 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| WO2008112283A2 (en) | 2007-03-12 | 2008-09-18 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Microrna profiling of androgen responsiveness for predicting the appropriate prostate cancer treatment |
| CA2678919A1 (en) * | 2007-03-27 | 2008-10-02 | Ranit Aharonov | Gene expression signature for classification of cancers |
| WO2008138578A2 (en) | 2007-05-11 | 2008-11-20 | Medical Prognosis Institute | Methods, kits, and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| CA2676113C (en) | 2007-07-25 | 2014-07-08 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
| US8568994B2 (en) | 2007-08-03 | 2013-10-29 | Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Offentlichen Rechts | Method for prenatal diagnosis |
| JP5769417B2 (ja) | 2007-08-16 | 2015-08-26 | ザ ロイヤル インスティチューション フォー ザ アドバンスメント オブ ラーニング/マギル ユニバーシティ | 腫瘍細胞由来微小胞 |
| JP5624470B2 (ja) | 2007-09-14 | 2014-11-12 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation | ヒト末梢血微小胞におけるmiRNAの発現およびその使用 |
| WO2009058893A2 (en) | 2007-10-29 | 2009-05-07 | University Of Southern California | Preventing hyaluronan-mediated tumorigenetic mechanisms using intronic rnas |
| US20100323357A1 (en) | 2007-11-30 | 2010-12-23 | The Ohio State University Research Foundation | MicroRNA Expression Profiling and Targeting in Peripheral Blood in Lung Cancer |
| US8617806B2 (en) | 2008-01-25 | 2013-12-31 | Hansabiomed Ou | Method to measure and characterize microvesicles in the human body fluids |
| CN105734128B (zh) | 2008-02-01 | 2021-05-18 | 总医院有限公司 | 微泡在医学疾病和病况的诊断、预后以及治疗中的用途 |
| AU2009209415A1 (en) | 2008-02-01 | 2009-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions relating to carcinoma stem cells |
| EP2260109A4 (en) | 2008-02-28 | 2011-06-08 | Univ Ohio State Res Found | MICRORNA BASED METHOD AND COMPOSITIONS FOR THE DIAGNOSIS, FORECAST AND TREATMENT OF DISEASES RELATED TO THE PROSTATE |
| EP2294196A1 (en) | 2008-06-06 | 2011-03-16 | Centre National de la Recherche Scientifique - CNRS | Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna |
| CA2728736A1 (en) | 2008-06-20 | 2009-12-23 | Proxy Life Science Holdings, Inc. | Microvesicle-based compositions and methods |
| EP2334339A4 (en) | 2008-09-18 | 2012-09-26 | Univ Ohio State Res Found | DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC USES OF MIR IN ADAPTIVE PATHWAYS AND / OR PATHOLOGICAL PATHWAYS |
| US10545149B2 (en) | 2008-10-06 | 2020-01-28 | Morehouse School Of Medicine | Detection of HIV-related proteins in urine |
| BRPI0919882A8 (pt) * | 2008-10-30 | 2017-09-19 | Caris Life Sciences Luxembourg Holdings | Métodos para avaliar padrões de rna |
| CN107254538A (zh) * | 2008-11-12 | 2017-10-17 | 卡里斯生命科学瑞士控股有限责任公司 | 使用外来体来确定表现型的方法和系统 |
| GB0822836D0 (en) | 2008-12-15 | 2009-01-21 | Oxford Biomedica Ltd | Method |
-
2009
- 2009-10-30 BR BRPI0919882A patent/BRPI0919882A8/pt not_active IP Right Cessation
- 2009-10-30 EP EP09829654.4A patent/EP2358912B1/en active Active
- 2009-10-30 US US12/609,847 patent/US7888035B2/en not_active Expired - Fee Related
- 2009-10-30 WO PCT/US2009/062880 patent/WO2010062706A2/en not_active Ceased
- 2009-10-30 CA CA 2742324 patent/CA2742324A1/en not_active Abandoned
- 2009-10-30 JP JP2011534831A patent/JP2012507300A/ja active Pending
- 2009-10-30 CN CN2009801505509A patent/CN102308004A/zh active Pending
-
2010
- 2010-12-08 US US12/963,468 patent/US8192954B2/en not_active Expired - Fee Related
-
2011
- 2011-04-28 IL IL21259111A patent/IL212591A/en not_active IP Right Cessation
-
2012
- 2012-07-06 US US13/543,101 patent/US20130045882A1/en not_active Abandoned
-
2014
- 2014-06-17 IL IL233188A patent/IL233188A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012507300A (ja) | 2012-03-29 |
| WO2010062706A3 (en) | 2010-09-02 |
| EP2358912B1 (en) | 2016-10-12 |
| US8192954B2 (en) | 2012-06-05 |
| US20130045882A1 (en) | 2013-02-21 |
| IL233188A0 (en) | 2014-07-31 |
| IL233188A (en) | 2016-05-31 |
| CA2742324A1 (en) | 2010-06-03 |
| IL212591A0 (en) | 2011-07-31 |
| EP2358912A4 (en) | 2012-10-31 |
| CN102308004A (zh) | 2012-01-04 |
| EP2358912A2 (en) | 2011-08-24 |
| US20110159506A1 (en) | 2011-06-30 |
| US7888035B2 (en) | 2011-02-15 |
| US20100113290A1 (en) | 2010-05-06 |
| IL212591A (en) | 2014-07-31 |
| BRPI0919882A8 (pt) | 2017-09-19 |
| WO2010062706A2 (en) | 2010-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0919882A2 (pt) | métodos para avaliar padrões de rna | |
| BRPI0817547A2 (pt) | Método para realizar pirólise | |
| BRPI0919426A2 (pt) | métodos melhorado de exposição de rna | |
| BRPI0914054A2 (pt) | método para produzir etilenoaminas | |
| BRPI0919116A2 (pt) | método | |
| PT2231689T (pt) | Novos nucleósidos 7-deazapurina citostáticos | |
| BRPI0916973A2 (pt) | anticorpos para ccr2 | |
| SMT201400100B (it) | Processo migliorato | |
| EP2499661A4 (en) | PHOTO PAINT SIMULATION | |
| BRPI0914614A2 (pt) | 2-arilaminoquinazolinas para tratar doenças proliferativas | |
| BRPI0822695A2 (pt) | Processo para produzir um isocianato | |
| DK2313489T3 (da) | Fremstillingsmetode | |
| BRPI0822694A2 (pt) | Processo para produzir um isocianato | |
| BRPI0922490A2 (pt) | Método para produção de beta-santaleno | |
| BRPI0918157A2 (pt) | acessório em y para raspa-tubos | |
| BRPI0909488A2 (pt) | brocha | |
| BRPI0911625A2 (pt) | Métodos | |
| BRPI0819633A2 (pt) | Métodos para produzir poliolefinas | |
| BR112012009097A2 (pt) | processo para produzir colagens | |
| BRPI0908778A2 (pt) | Processo para produzir material de carbono | |
| BRPI0818678A2 (pt) | Processo para preparar eteno | |
| BRPI1013718A2 (pt) | processo integrado para produzir hidrocarbonetos | |
| BRPI0814117A2 (pt) | Método para ativar catalisador para produção de cloro | |
| BRPI0916597A2 (pt) | Método | |
| BRPI0912435A2 (pt) | processo melhorado para telomerizar butadieno |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: CARIS LIFE SCIENCES SWITZERLAND HOLDINGS GMBH (CH) |
|
| B25G | Requested change of headquarter approved |
Owner name: CARIS LIFE SCIENCES SWITZERLAND HOLDINGS GMBH (CH) |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |