BRPI0919882A2 - métodos para avaliar padrões de rna - Google Patents

métodos para avaliar padrões de rna

Info

Publication number
BRPI0919882A2
BRPI0919882A2 BRPI0919882A BRPI0919882A BRPI0919882A2 BR PI0919882 A2 BRPI0919882 A2 BR PI0919882A2 BR PI0919882 A BRPI0919882 A BR PI0919882A BR PI0919882 A BRPI0919882 A BR PI0919882A BR PI0919882 A2 BRPI0919882 A2 BR PI0919882A2
Authority
BR
Brazil
Prior art keywords
methods
rna patterns
evaluate rna
evaluate
patterns
Prior art date
Application number
BRPI0919882A
Other languages
English (en)
Inventor
Christine Kuslich
George Poste
Michael Klass
Original Assignee
Caris Life Sciences Luxembourg Holdings
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caris Life Sciences Luxembourg Holdings filed Critical Caris Life Sciences Luxembourg Holdings
Publication of BRPI0919882A2 publication Critical patent/BRPI0919882A2/pt
Publication of BRPI0919882A8 publication Critical patent/BRPI0919882A8/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
BRPI0919882A 2008-10-30 2009-10-30 Métodos para avaliar padrões de rna BRPI0919882A8 (pt)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US10974208P 2008-10-30 2008-10-30
US11257108P 2008-11-07 2008-11-07
US11404508P 2008-11-12 2008-11-12
US11405808P 2008-11-12 2008-11-12
US11406508P 2008-11-13 2008-11-13
US15118309P 2009-02-09 2009-02-09
US27804909P 2009-10-02 2009-10-02
US25045409P 2009-10-09 2009-10-09
US25302709P 2009-10-19 2009-10-19
PCT/US2009/062880 WO2010062706A2 (en) 2008-10-30 2009-10-30 Methods for assessing rna patterns

Publications (2)

Publication Number Publication Date
BRPI0919882A2 true BRPI0919882A2 (pt) 2016-02-16
BRPI0919882A8 BRPI0919882A8 (pt) 2017-09-19

Family

ID=42226337

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0919882A BRPI0919882A8 (pt) 2008-10-30 2009-10-30 Métodos para avaliar padrões de rna

Country Status (8)

Country Link
US (3) US7888035B2 (pt)
EP (1) EP2358912B1 (pt)
JP (1) JP2012507300A (pt)
CN (1) CN102308004A (pt)
BR (1) BRPI0919882A8 (pt)
CA (1) CA2742324A1 (pt)
IL (2) IL212591A (pt)
WO (1) WO2010062706A2 (pt)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136311A (en) 1996-05-06 2000-10-24 Cornell Research Foundation, Inc. Treatment and diagnosis of cancer
US20080268429A1 (en) * 2004-06-02 2008-10-30 Sourcepharm, Inc. Rna - Containing Microvesicles and Methods Therefor
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
EP1996716B1 (en) 2006-03-20 2011-05-11 The Regents of the University of California Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting
CA2693069C (en) * 2007-07-03 2013-12-10 Spine Tek, Inc. Interspinous mesh
EP2696203A3 (en) 2007-08-16 2014-05-28 The Royal Institution for the Advancement of Learning/McGill University Tumor cell-derived microvesicles
US20100255514A1 (en) * 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
US8940298B2 (en) * 2007-09-04 2015-01-27 The Regents Of The University Of California High affinity anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting and detection
WO2009030029A1 (en) * 2007-09-05 2009-03-12 Laurentian University Method of using tumour rna integrity to measure response to chemotherapy in cancer patients
WO2009046294A2 (en) * 2007-10-03 2009-04-09 Cornell University Treatment of proliferative disorders using antibodies to psma
US20100069616A1 (en) * 2008-08-06 2010-03-18 The Regents Of The University Of California Engineered antibody-nanoparticle conjugates
PE20110565A1 (es) 2008-08-12 2011-09-02 Zinfandel Pharmaceuticals Inc Metodo de identificacion de factores de riesgo de la enfermedad
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
CN102308004A (zh) * 2008-10-30 2012-01-04 卡里斯生命科学卢森堡控股有限责任公司 评价rna图案的方法
US20140113310A9 (en) * 2008-12-05 2014-04-24 Myriad Genetics, Incorporated Cancer detection markers
EP3495000A1 (en) * 2009-02-17 2019-06-12 Cornell Research Foundation, Inc. Methods and kits for diagnosis of cancer and prediction of therapeutic value
WO2011040525A1 (ja) * 2009-09-30 2011-04-07 財団法人ヒューマンサイエンス振興財団 大腸がん検査マーカーおよび大腸がんの検査方法
EP2316972A1 (en) * 2009-10-29 2011-05-04 Deutsches Krebsforschungszentrum Circulating miRNAs as non-invasive markers for diagnosis and staging in prostate cancer
US20130203061A1 (en) 2009-11-30 2013-08-08 Michael KLASS Methods and systems for isolating, storing, and analyzing vesicles
MX337600B (es) 2009-12-02 2016-03-11 Imaginab Inc Minicuerpos j591 y diacuerpos-cys para apuntar con especificidad de objetivo a un antigeno de membrana especifico para prostata de humano (psma) y metodos para su uso.
CA2789404C (en) * 2010-02-26 2020-03-24 Columbia University Methods and compositions for the detection and treatment of cancer involving mirnas and mirna inhibitors and targets
US9128101B2 (en) 2010-03-01 2015-09-08 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
WO2011156734A2 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
WO2011156763A1 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Methods for characterizing kidney function
DK2598659T3 (en) 2010-07-27 2015-05-26 Genomic Health Inc PROCEDURE FOR USING GENEPRESSION FOR DETERMINING PROSTATE CANCER FORECAST
ES2632145T3 (es) * 2010-12-01 2017-09-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Modo de predicción del desenlace de un cáncer analizando la expresión de miARN
EA201391017A1 (ru) 2011-01-10 2014-04-30 Зинфандел Фармасьютикалз, Инк. Способы и готовые лекарственные формы для лечения болезни альцгеймера
US20120251619A1 (en) * 2011-03-31 2012-10-04 Gunaratne Preethi H MicroRNA-29a,b,c as a Tumor Suppressor and Sensitizing Agent for Chemotherapy
US9192622B2 (en) 2011-03-31 2015-11-24 University Of Houston MicroRNA-130a,b as a tumor suppressor and sensitizing agent for chemotherapy
WO2012140660A1 (en) 2011-04-14 2012-10-18 Exalenz Bioscience Ltd. Methods for diagnosis, prognosis, monitoring and treatment of hepatocellular carcinoma
JP6011945B2 (ja) * 2011-05-20 2016-10-25 公一 中城 マイクロrna又はその発現系を含む組成物
JP5823031B2 (ja) 2011-06-10 2015-11-25 日立化成株式会社 小胞捕捉デバイスおよびそれを用いるための方法
KR20140072014A (ko) * 2011-06-16 2014-06-12 카리스 라이프 사이언스 룩셈부르크 홀딩스, 에스.에이.알.엘. 생물지표 조성물 및 방법
EP2739734A1 (en) 2011-08-03 2014-06-11 The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System Treatment of fibrosis using microrna-19b
KR20140067001A (ko) * 2011-08-08 2014-06-03 카리스 라이프 사이언스 룩셈부르크 홀딩스, 에스.에이.알.엘. 생물지표 조성물 및 방법
HK1199072A1 (en) 2011-08-10 2015-06-19 Laurentian University Of Sudbury Diagnostic methods and kits for monitoring response to chemotherapy in ovarian cancer
WO2013028788A1 (en) 2011-08-22 2013-02-28 Exosome Diagnostics, Inc. Urine biomarkers
JPWO2013038737A1 (ja) * 2011-09-16 2015-03-23 Lsipファンド運営合同会社 膀胱癌細胞の検出方法、膀胱癌細胞の検出方法に用いるプライマー及び膀胱癌マーカ
JP6450673B2 (ja) * 2012-04-03 2019-01-09 リニューロン・リミテッドReNeuron Limited 幹細胞微粒子
EP2653554A1 (en) * 2012-04-17 2013-10-23 Istituto Nazionale Di Genetica Molecolare-INGM Immune response biomarkers
CA2871195C (en) 2012-04-24 2023-01-10 Rna Diagnostics Inc. Assays, methods and apparatus for assessing rna disruption
US8846316B2 (en) 2012-04-30 2014-09-30 Industrial Technology Research Institute Biomarker for human liver cancer
JP5933010B2 (ja) 2012-08-20 2016-06-08 国立研究開発法人国立がん研究センター 癌治療剤
KR101933620B1 (ko) * 2012-09-18 2018-12-28 삼성전자주식회사 소포를 검출하기 위한 조성물, 키트 및 이를 이용하여 소포를 분석하는 방법
KR20150090072A (ko) 2012-10-23 2015-08-05 카리스 라이프 사이언스 스위스 홀딩스 게엠베하 압타머 및 이의 용도
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
WO2014071226A1 (en) * 2012-11-02 2014-05-08 The Regents Of The University Of California Methods and systems for determining a likelihood of adverse prostate cancer pathology
CN102912030B (zh) * 2012-11-08 2014-07-30 端鹏 用于前列腺癌早期诊断的引物对、探针和试剂盒
HK1215875A1 (zh) 2012-12-03 2016-09-23 Rna Diagnostics Inc. 用於监视放射治疗癌症反应的方法和试剂盒
EP2935628B1 (en) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Compositions and methods for aptamer screening
KR101504817B1 (ko) * 2013-04-05 2015-03-24 연세대학교 산학협력단 국소 진행형 위암에 대한 예후 예측 시스템
JP6297676B2 (ja) 2013-05-06 2018-03-20 日立化成株式会社 標的分子を捕捉するためのデバイス及び方法
CN104164474A (zh) * 2013-05-17 2014-11-26 刘代新 一种检测尿液中pca3基因和psa基因表达量的荧光定量pcr法及其诊断试剂盒
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
WO2015031694A2 (en) * 2013-08-28 2015-03-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
US9550989B2 (en) * 2013-10-03 2017-01-24 Washington University Rational design of microRNA-siRNA chimeras for multi-functional target suppression
US10731222B2 (en) 2013-10-04 2020-08-04 Rna Diagnostics Inc. RNA disruption assay for predicting survival
GB201322034D0 (en) 2013-12-12 2014-01-29 Almac Diagnostics Ltd Prostate cancer classification
CN103882118A (zh) * 2014-02-13 2014-06-25 绍兴市人民医院 用于检测前列腺癌的miRNAs
RU2016152143A (ru) 2014-05-30 2018-07-04 Торэй Индастриз, Инк. Набор или устройство для обнаружения рака поджелудочной железы и способ обнаружения
WO2015187727A2 (en) * 2014-06-04 2015-12-10 Atossa Genetics Inc. Molecular mammography
CN111996254B (zh) 2014-06-12 2024-10-18 东丽株式会社 前列腺癌的检测试剂盒或装置以及检测方法
KR102401222B1 (ko) 2014-06-13 2022-05-24 국립연구개발법인 고쿠리츠간켄큐센터 유방암 검출 키트 또는 디바이스 및 검출 방법
US10597727B2 (en) 2014-06-16 2020-03-24 Toray Industries, Inc. Stomach cancer detection kit or device, and detection method
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
US10370719B2 (en) 2014-11-12 2019-08-06 Hitachi Chemical Co., Ltd. Method and device for diagnosing organ injury
EP3226875B1 (en) * 2014-12-03 2020-05-27 Capricor, Inc. Processes for producing stable exosome formulations
WO2016125243A1 (ja) * 2015-02-03 2016-08-11 株式会社日立製作所 エクソソーム測定方法及びエクソソーム抽出方法
IL318703A (en) 2015-06-29 2025-03-01 Caris Science Inc Therapeutic oligonucleotides
EP3328873B1 (en) 2015-07-28 2025-09-17 Caris Science, Inc. Targeted oligonucleotides
KR20250008141A (ko) 2015-08-07 2025-01-14 이미지냅 인코포레이티드 분자를 표적화하기 위한 항원 결합 구조체
JP6624704B2 (ja) 2015-08-31 2019-12-25 日立化成株式会社 尿路上皮疾患の評価のための分子法
EP3427060B1 (en) 2016-03-07 2025-08-13 Father Flanagan's Boys' Home doing Business as Boys Town National Research Hospital Noninvasive molecular controls
WO2017161357A1 (en) 2016-03-18 2017-09-21 Caris Science, Inc. Oligonucleotide probes and uses thereof
EP3438284B1 (en) 2016-03-31 2021-12-22 Toray Industries, Inc. Kit or device for detecting early stage pancreatic cancer or pancreatic cancer precursor lesions and detection method therefor
CA3025486A1 (en) 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2018147960A1 (en) 2017-02-08 2018-08-16 Imaginab, Inc. Extension sequences for diabodies
EP3658172A4 (en) 2017-07-25 2021-05-05 TrueBinding, Inc. TREATING CANCER BY BLOCKING THE INTERACTION OF TIM-3 AND HIS LIGAND
CN108841962B (zh) * 2018-08-01 2021-11-19 博奥生物集团有限公司 一种非小细胞肺癌检测试剂盒及其应用
US11535899B2 (en) 2018-08-10 2022-12-27 Toray Industries, Inc. Kit, device and method for detecting prostate cancer
CN111041081B (zh) * 2018-10-11 2024-10-15 上海自然堂集团有限公司 一种以皮肤外源性老化靶标筛选活性物的方法及改善皮肤外源性老化的活性物
CN109234362A (zh) * 2018-10-15 2019-01-18 北京艾迪康医学检验实验室有限公司 检测样本中cltc-tfe3融合基因的寡核苷酸、方法和试剂盒
CN109136379A (zh) * 2018-10-15 2019-01-04 济南艾迪康医学检验中心有限公司 检测样本中NonO-TFE3融合基因的寡核苷酸、方法和试剂盒
WO2020113237A1 (en) 2018-11-30 2020-06-04 Caris Mpi, Inc. Next-generation molecular profiling
TWI758670B (zh) * 2018-12-24 2022-03-21 奎克生技光電股份有限公司 健康風險評估方法
CN113711036B (zh) 2019-01-30 2025-03-18 真和制药有限公司 抗gal3抗体及其用途
CN110305964B (zh) * 2019-07-26 2023-03-21 安徽医科大学第一附属医院 一种前列腺癌患者预后复发风险预测标志工具及其风险评估模型的建立
KR20260043144A (ko) 2019-12-02 2026-03-31 캐리스 엠피아이, 아이엔씨. 범-암 백금 반응 예측기
WO2022178313A1 (en) * 2021-02-18 2022-08-25 The Johns Hopkins University Detecting diseases in subjects using extracelluar vesicles
CN117255861A (zh) * 2022-01-28 2023-12-19 香港城市大学 测量多重rna表达的方法和系统
CA3254846A1 (en) * 2022-06-10 2023-12-14 City Of Hope Biomarkers in pancreatic cancer

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812023A (en) * 1972-12-11 1974-05-21 Reynolds Metals Co Anodic production of pigmented siliceous coatings for aluminous metals
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5424186A (en) 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5242974A (en) 1991-11-22 1993-09-07 Affymax Technologies N.V. Polymer reversal on solid surfaces
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
DE3924454A1 (de) 1989-07-24 1991-02-07 Cornelis P Prof Dr Hollenberg Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips)
WO1992010588A1 (en) 1990-12-06 1992-06-25 Affymax Technologies N.V. Sequencing by hybridization of a target nucleic acid to a matrix of defined oligonucleotides
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5384261A (en) 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5554501A (en) 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
US5472672A (en) 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5658734A (en) 1995-10-17 1997-08-19 International Business Machines Corporation Process for synthesizing chemical compounds
ES2347854T5 (es) 1996-03-26 2014-07-24 Michael S. Kopreski Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer
FR2766205B1 (fr) 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
FR2788780B1 (fr) 1999-01-27 2001-03-30 Ap Cells Inc Procede de preparation de vesicules membranaires
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
US20040241176A1 (en) 2000-04-27 2004-12-02 Ap Cells. Inc. Method of producing membrane vesicles
CA2454756C (en) 2001-08-17 2014-02-18 Anosys, Inc. Methods and compounds for the targeting of protein to exosomes
US20070203333A1 (en) 2001-11-30 2007-08-30 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
AUPS187002A0 (en) * 2002-04-22 2002-05-30 Queensland University Of Technology Condition-specific molecules and uses therefor
JP4939055B2 (ja) 2002-11-13 2012-05-23 トマス ジェファソン ユニバーシティ 癌の診断および治療のための組成物および方法
US7914792B2 (en) 2003-02-14 2011-03-29 Exothera L.L.C. Methods and compounds for raising antibodies and for screening antibody repertoires
GB0318096D0 (en) 2003-08-01 2003-09-03 Queen Mary & Westfield College Vaccine
CA2453198A1 (en) 2004-01-07 2005-07-07 Wei-Ping Min Quantification and generation of immune suppressive exosomes
WO2005078124A2 (de) 2004-02-16 2005-08-25 Proteosys Ag Diagnostische marker für krebs
US20080268429A1 (en) 2004-06-02 2008-10-30 Sourcepharm, Inc. Rna - Containing Microvesicles and Methods Therefor
CA2491067A1 (en) * 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
US20060211000A1 (en) * 2005-03-21 2006-09-21 Sorge Joseph A Methods, compositions, and kits for detection of microRNA
CN103820562B (zh) 2005-08-01 2015-05-13 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
US20070092882A1 (en) 2005-10-21 2007-04-26 Hui Wang Analysis of microRNA
US7197923B1 (en) * 2005-11-07 2007-04-03 Halliburton Energy Services, Inc. Single phase fluid sampler systems and associated methods
CN101384273B (zh) 2006-01-05 2013-07-10 俄亥俄州立大学研究基金会 胰腺内分泌和腺泡肿瘤中的微小rna表达异常
EP2484782B1 (en) 2006-01-05 2015-11-18 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers
EP2502630B1 (en) 2006-01-05 2015-03-11 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
US7593913B2 (en) 2006-01-11 2009-09-22 Siemens Medical Solutions Usa, Inc. Systems and method for integrative medical decision support
US9394569B2 (en) 2006-01-31 2016-07-19 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Methods and kits for early detection of cancer or predisposition thereto
US9198981B2 (en) 2006-02-01 2015-12-01 The University Of Kentucky Modulation of angiogenesis
ES2448491T3 (es) 2006-03-02 2014-03-14 The Ohio State University Research Foundation Perfil de expresión de microARN asociado con cáncer de páncreas
CA3061952C (en) 2006-03-09 2022-07-19 Aethlon Medical, Inc. Extracorporeal removal of microvesicular particles
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US7462489B2 (en) 2006-11-09 2008-12-09 Ley Klaus F Methods for identifying and analyzing biomarkers from plasma-derived microparticles
EP2109688A4 (en) 2007-01-23 2010-02-17 Univ Virginia GALECTIN-3 BINDING PROTEIN AS BIOMARKER FOR HEART CIRCULATION DISEASES
US8314220B2 (en) * 2007-01-26 2012-11-20 Agilent Technologies, Inc. Methods compositions, and kits for detection of microRNA
WO2008092164A2 (en) 2007-01-26 2008-07-31 University Of Louisville Research Foundation, Inc. Methods of detecting autoantibodies for diagnosing and characterizing disorders
WO2008092153A2 (en) 2007-01-26 2008-07-31 University Of Louisville Research Foundation, Inc. Modification of exosomal components for use as a vaccine
CN103555825B (zh) 2007-01-31 2015-09-30 俄亥俄州立大学研究基金会 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物
WO2008112283A2 (en) 2007-03-12 2008-09-18 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Microrna profiling of androgen responsiveness for predicting the appropriate prostate cancer treatment
WO2008117278A2 (en) 2007-03-27 2008-10-02 Rosetta Genomics Ltd. Gene expression signature for classification of cancers
WO2008138578A2 (en) 2007-05-11 2008-11-20 Medical Prognosis Institute Methods, kits, and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
EP2613149B1 (en) 2007-07-25 2014-09-17 University Of Louisville Research Foundation, Inc. Exosome-associated microRNA as a diagnostic marker
US8568994B2 (en) 2007-08-03 2013-10-29 Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Offentlichen Rechts Method for prenatal diagnosis
EP2696203A3 (en) 2007-08-16 2014-05-28 The Royal Institution for the Advancement of Learning/McGill University Tumor cell-derived microvesicles
EP2610342B1 (en) 2007-09-14 2016-05-04 The Ohio State University Research Foundation MiRNA Expression in Human Peripheral Blood Microvesicles and uses Thereof
US8895525B2 (en) 2007-10-29 2014-11-25 University Of Southern California Preventing hyaluronan-mediated tumorigenetic mechanisms using intronic RNAs
CN101918594A (zh) 2007-11-30 2010-12-15 俄亥俄州立大学研究基金会 肺癌中外周血中的微rna表达特征谱和靶向
US8617806B2 (en) 2008-01-25 2013-12-31 Hansabiomed Ou Method to measure and characterize microvesicles in the human body fluids
ES2936256T3 (es) 2008-02-01 2023-03-15 Massachusetts Gen Hospital Uso de microvesículas en el diagnóstico, y pronóstico de enfermedades y afecciones médicas
EP2247750A4 (en) 2008-02-01 2011-10-26 Univ Leland Stanford Junior METHODS AND COMPOSITIONS RELATING TO CANCER STEM CELLS
US20110054009A1 (en) 2008-02-28 2011-03-03 The Ohio State University Research Foundation MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders
US20110177054A1 (en) 2008-06-06 2011-07-21 Derrick Gibbings Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
AU2009259893A1 (en) 2008-06-20 2009-12-23 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
EP2334339A4 (en) 2008-09-18 2012-09-26 Univ Ohio State Res Found DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC USES OF MIR IN ADAPTIVE PATHWAYS AND / OR PATHOLOGICAL PATHWAYS
US10545149B2 (en) 2008-10-06 2020-01-28 Morehouse School Of Medicine Detection of HIV-related proteins in urine
CN102308004A (zh) * 2008-10-30 2012-01-04 卡里斯生命科学卢森堡控股有限责任公司 评价rna图案的方法
CA2743211A1 (en) * 2008-11-12 2010-05-20 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems of using exosomes for determining phenotypes
GB0822836D0 (en) 2008-12-15 2009-01-21 Oxford Biomedica Ltd Method

Also Published As

Publication number Publication date
CA2742324A1 (en) 2010-06-03
US20100113290A1 (en) 2010-05-06
IL233188A (en) 2016-05-31
US20130045882A1 (en) 2013-02-21
IL233188A0 (en) 2014-07-31
WO2010062706A3 (en) 2010-09-02
WO2010062706A2 (en) 2010-06-03
BRPI0919882A8 (pt) 2017-09-19
CN102308004A (zh) 2012-01-04
EP2358912A2 (en) 2011-08-24
US20110159506A1 (en) 2011-06-30
US7888035B2 (en) 2011-02-15
IL212591A (en) 2014-07-31
US8192954B2 (en) 2012-06-05
EP2358912B1 (en) 2016-10-12
EP2358912A4 (en) 2012-10-31
JP2012507300A (ja) 2012-03-29
IL212591A0 (en) 2011-07-31

Similar Documents

Publication Publication Date Title
BRPI0817547A2 (pt) Método para realizar pirólise
BRPI0919426A2 (pt) métodos melhorado de exposição de rna
BRPI0914054A2 (pt) método para produzir etilenoaminas
BRPI0919116A2 (pt) método
PT2231689T (pt) Novos nucleósidos 7-deazapurina citostáticos
BRPI0916973A2 (pt) anticorpos para ccr2
SMT201400100B (it) Processo migliorato
IL212591A0 (en) Methods for assessing rna patterns
EP2499661A4 (en) PHOTO PAINT SIMULATION
BRPI0914614A2 (pt) 2-arilaminoquinazolinas para tratar doenças proliferativas
BRPI0822695A2 (pt) Processo para produzir um isocianato
DK2313489T3 (da) Fremstillingsmetode
BRPI0922490A2 (pt) Método para produção de beta-santaleno
BRPI0822694A2 (pt) Processo para produzir um isocianato
BRPI0918157A2 (pt) acessório em y para raspa-tubos
BRPI0909488A2 (pt) brocha
BRPI0911625A2 (pt) Métodos
BRPI0819633A2 (pt) Métodos para produzir poliolefinas
BR112012009097A2 (pt) processo para produzir colagens
BRPI0908778A2 (pt) Processo para produzir material de carbono
BRPI0818678A2 (pt) Processo para preparar eteno
BRPI1013718A2 (pt) processo integrado para produzir hidrocarbonetos
BRPI0814117A2 (pt) Método para ativar catalisador para produção de cloro
BRPI0916597A2 (pt) Método
BRPI0912435A2 (pt) processo melhorado para telomerizar butadieno

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: CARIS LIFE SCIENCES SWITZERLAND HOLDINGS GMBH (CH)

B25G Requested change of headquarter approved

Owner name: CARIS LIFE SCIENCES SWITZERLAND HOLDINGS GMBH (CH)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]