BRPI0919426A2 - métodos melhorado de exposição de rna - Google Patents
métodos melhorado de exposição de rnaInfo
- Publication number
- BRPI0919426A2 BRPI0919426A2 BRPI0919426A BRPI0919426A BRPI0919426A2 BR PI0919426 A2 BRPI0919426 A2 BR PI0919426A2 BR PI0919426 A BRPI0919426 A BR PI0919426A BR PI0919426 A BRPI0919426 A BR PI0919426A BR PI0919426 A2 BRPI0919426 A2 BR PI0919426A2
- Authority
- BR
- Brazil
- Prior art keywords
- exposure methods
- enhanced rna
- rna exposure
- enhanced
- methods
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/534—Production of labelled immunochemicals with radioactive label
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10147108P | 2008-09-30 | 2008-09-30 | |
| PCT/US2009/059057 WO2010039850A1 (en) | 2008-09-30 | 2009-09-30 | Improved method of rna display |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0919426A2 true BRPI0919426A2 (pt) | 2015-12-15 |
Family
ID=42073857
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0919426A BRPI0919426A2 (pt) | 2008-09-30 | 2009-09-30 | métodos melhorado de exposição de rna |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8916504B2 (pt) |
| EP (1) | EP2342562B1 (pt) |
| JP (1) | JP5968624B2 (pt) |
| KR (1) | KR20110076906A (pt) |
| CN (1) | CN102227638B (pt) |
| AU (1) | AU2009298499A1 (pt) |
| BR (1) | BRPI0919426A2 (pt) |
| CA (1) | CA2737035A1 (pt) |
| ES (1) | ES2434850T3 (pt) |
| IL (1) | IL211551A (pt) |
| MX (1) | MX2011003381A (pt) |
| NZ (1) | NZ591544A (pt) |
| RU (1) | RU2011117210A (pt) |
| TW (1) | TW201024731A (pt) |
| WO (1) | WO2010039850A1 (pt) |
| ZA (1) | ZA201102120B (pt) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002231736A1 (en) | 2000-12-22 | 2002-07-08 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Use of repulsive guidance molecule (rgm) and its modulators |
| CN101277974A (zh) * | 2005-09-30 | 2008-10-01 | 阿伯特有限及两合公司 | 排斥性引导分子(rgm)蛋白质家族的蛋白质的结合结构域及其功能性片段和它们的用途 |
| EP2033971A1 (de) * | 2007-09-06 | 2009-03-11 | Abbott GmbH & Co. KG | Bone Morphogenetic Protein (BMP)-bindende Domänen von Proteinen der Repulsive Guidance Molecule (RGM) Proteinfamilie und funktionale Fragmente davon sowie deren Verwendung |
| US8962803B2 (en) * | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
| EP2282769A4 (en) * | 2008-04-29 | 2012-04-25 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES |
| EP2297209A4 (en) * | 2008-06-03 | 2012-08-01 | Abbott Lab | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF |
| KR20110016959A (ko) * | 2008-06-03 | 2011-02-18 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| US8822645B2 (en) * | 2008-07-08 | 2014-09-02 | Abbvie Inc. | Prostaglandin E2 dual variable domain immunoglobulins and uses thereof |
| BRPI1012195A2 (pt) * | 2009-05-01 | 2018-04-24 | Abbott Laboratories | imunoglobulinas de domínio variável duplo e usos das mesmas |
| TW201109438A (en) * | 2009-07-29 | 2011-03-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| AR078651A1 (es) * | 2009-10-15 | 2011-11-23 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| PH12012501070A1 (en) * | 2009-12-08 | 2017-08-23 | Abbott Gmbh & Co Kg | Monoclonal antibodies against the rgm a protein for use in the treatment of retinal nerve fiber layer degeneration |
| KR20130100118A (ko) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| US9046513B2 (en) * | 2010-08-26 | 2015-06-02 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| EP3798236B1 (en) | 2011-03-15 | 2022-08-10 | X-Body, Inc. | Antibody screening methods |
| US9347058B2 (en) | 2011-05-17 | 2016-05-24 | Bristol-Myers Squibb Company | Methods for the selection of binding proteins |
| AR089529A1 (es) | 2011-12-30 | 2014-08-27 | Abbvie Inc | Proteinas de union especificas duales dirigidas contra il-13 y/o il-17 |
| AU2013211939C1 (en) | 2012-01-27 | 2018-06-07 | AbbVie Deutschland GmbH & Co. KG | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
| PE20151179A1 (es) | 2012-11-01 | 2015-09-12 | Abbvie Inc | Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas |
| EP2975121A4 (en) * | 2013-03-13 | 2016-07-20 | Univ Tokyo | NUCLEIC LEFT |
| AU2014227732A1 (en) | 2013-03-15 | 2015-09-17 | Abbvie Inc. | Dual specific binding proteins directed against IL-1 beta and IL-17 |
| US10370651B2 (en) * | 2013-06-28 | 2019-08-06 | X-Body, Inc. | Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes |
| JP6814634B2 (ja) | 2014-02-05 | 2021-01-20 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | リボ毒性の一時的な減少に基づき、細胞毒性組換えポリペプチドをスクリーニングし、選択し、同定する方法 |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| EP3549606A1 (en) * | 2015-05-28 | 2019-10-09 | Bio-rad Laboratories, Inc. | Affinity ligands and methods relating thereto |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
| KR20190014525A (ko) | 2016-05-27 | 2019-02-12 | 애브비 바이오테라퓨틱스 인크. | 면역 조절 단백질과 종양 항원을 결합하는 이중특이적 결합 단백질 |
| CN111511768B (zh) * | 2017-11-20 | 2024-03-26 | 南特生物科学公司 | mRNA展示抗体文库和方法 |
| CN113710801B (zh) * | 2019-02-22 | 2024-07-09 | 爱普思隆分子进化工程株式会社 | 一种使用cDNA展示的新型免疫PCR方法 |
| CN114585736B (zh) * | 2020-10-27 | 2023-05-02 | 北京寻因生物科技有限公司 | 一种嘌呤霉素连接子及其在体外核酸展示肽合成中的应用 |
| WO2022104001A1 (en) | 2020-11-13 | 2022-05-19 | Bristol-Myers Squibb Company | Expanded protein libraries and uses thereof |
| WO2026025103A1 (en) * | 2024-07-26 | 2026-01-29 | The Children's Medical Center Corporation | Methods of modulating growth factor activity |
| WO2026063389A1 (ja) * | 2024-09-17 | 2026-03-26 | Jnc株式会社 | 多孔質粒子ならびにそれを含む吸着剤およびクロマトグラフィー担体 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5310652A (en) * | 1986-08-22 | 1994-05-10 | Hoffman-La Roche Inc. | Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription |
| US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| US5922545A (en) * | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| US8207093B2 (en) * | 1997-01-21 | 2012-06-26 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| DK0985032T4 (da) * | 1997-05-28 | 2009-08-31 | Crescendo Biolog Ltd | Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner |
| US6927025B1 (en) * | 1997-09-03 | 2005-08-09 | Biovation Limited | Methods for protein screening |
| US6914128B1 (en) * | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| SI1187632T1 (sl) * | 1999-05-14 | 2009-04-30 | Genentech Inc | Zdravljenje z anti-ErbB2 protitelesi |
| US6830902B1 (en) * | 1999-07-02 | 2004-12-14 | Invitrogen Corporation | Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis |
| CA2377468C (en) * | 1999-07-27 | 2010-04-20 | Phylos, Inc. | Peptide acceptor ligation methods |
| US7264932B2 (en) * | 1999-09-24 | 2007-09-04 | Applera Corporation | Nuclease inhibitor cocktail |
| WO2001075097A2 (en) * | 2000-03-31 | 2001-10-11 | Cambridge Antibody Technology Limited | Improvements to ribosome display |
| JP4963142B2 (ja) * | 2000-12-14 | 2012-06-27 | 学校法人慶應義塾 | 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法 |
| ES2615362T3 (es) * | 2001-07-27 | 2017-06-06 | Glaxosmithkline Biologicals Sa | Adhesinas de meningococos |
| EP1554392A4 (en) * | 2002-05-06 | 2007-08-08 | Us Gov Health & Human Serv | IDENTIFICATION OF NEW NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES WITH WIDE CROSS-REACTIVITY USING SEQUENTIAL ANTIGEN PANNING OF PHAG DISPLAY LIBRARIES |
| US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
| CA2504443A1 (en) * | 2002-10-30 | 2004-05-13 | Pointilliste, Inc. | Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides |
| BRPI0417302A (pt) * | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
| US8822191B2 (en) * | 2004-02-04 | 2014-09-02 | Novo Nordisk A/S | Methods of refolding mammalian glycosyltransferases |
| US7662926B2 (en) * | 2004-09-02 | 2010-02-16 | Genentech, Inc. | Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor |
| JP2006141348A (ja) * | 2004-11-24 | 2006-06-08 | Zoegene Corp | 標的物質と相互作用するドメインポリペプチドの選抜取得方法および構造モチーフ配列の同定方法並びに分子設計方法 |
| GB0500099D0 (en) * | 2005-01-05 | 2005-02-09 | Cambridge Antibody Tech | Methods and means relating to protein variants |
| US20070218478A1 (en) * | 2005-12-16 | 2007-09-20 | Affymetrix, Inc. | Methods for fragmentation and analysis of nucleic acid |
| JP2007191477A (ja) * | 2005-12-22 | 2007-08-02 | Cellfree Sciences Co Ltd | 風疹ウイルスタンパク質の製造方法 |
| EA015992B1 (ru) * | 2006-03-17 | 2012-01-30 | Байоджен Айдек Эмэй Инк. | Стабилизированное антитело и многовалентная антигенсвязывающая молекула на его основе, способы получения и использования вышеназванного стабилизированного антитела |
| AR059900A1 (es) * | 2006-03-17 | 2008-05-07 | Genentech Inc | Anticuerpos anti-tat226 e inmunoconjugados |
| US7749957B2 (en) * | 2006-04-06 | 2010-07-06 | E.I. Du Pont De Nemours And Company | Clay-binding peptides and methods of use |
| WO2007136835A2 (en) * | 2006-05-19 | 2007-11-29 | Codon Devices, Inc | Methods and cells for creating functional diversity and uses thereof |
-
2009
- 2009-09-30 MX MX2011003381A patent/MX2011003381A/es active IP Right Grant
- 2009-09-30 NZ NZ591544A patent/NZ591544A/xx not_active IP Right Cessation
- 2009-09-30 JP JP2011530178A patent/JP5968624B2/ja not_active Expired - Fee Related
- 2009-09-30 AU AU2009298499A patent/AU2009298499A1/en not_active Abandoned
- 2009-09-30 EP EP09818450.0A patent/EP2342562B1/en active Active
- 2009-09-30 BR BRPI0919426A patent/BRPI0919426A2/pt not_active IP Right Cessation
- 2009-09-30 KR KR1020117007259A patent/KR20110076906A/ko not_active Abandoned
- 2009-09-30 TW TW098133223A patent/TW201024731A/zh unknown
- 2009-09-30 ES ES09818450T patent/ES2434850T3/es active Active
- 2009-09-30 WO PCT/US2009/059057 patent/WO2010039850A1/en not_active Ceased
- 2009-09-30 CA CA2737035A patent/CA2737035A1/en not_active Abandoned
- 2009-09-30 CN CN200980147651.0A patent/CN102227638B/zh active Active
- 2009-09-30 US US12/570,931 patent/US8916504B2/en active Active
- 2009-09-30 RU RU2011117210/15A patent/RU2011117210A/ru unknown
-
2011
- 2011-03-03 IL IL211551A patent/IL211551A/en active IP Right Grant
- 2011-03-22 ZA ZA2011/02120A patent/ZA201102120B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2737035A1 (en) | 2010-04-08 |
| EP2342562A1 (en) | 2011-07-13 |
| MX2011003381A (es) | 2011-04-21 |
| US20100105569A1 (en) | 2010-04-29 |
| EP2342562B1 (en) | 2013-09-18 |
| KR20110076906A (ko) | 2011-07-06 |
| ES2434850T3 (es) | 2013-12-17 |
| JP5968624B2 (ja) | 2016-08-10 |
| NZ591544A (en) | 2013-01-25 |
| US8916504B2 (en) | 2014-12-23 |
| AU2009298499A1 (en) | 2010-04-08 |
| IL211551A (en) | 2014-06-30 |
| EP2342562A4 (en) | 2012-03-21 |
| ZA201102120B (en) | 2011-12-28 |
| TW201024731A (en) | 2010-07-01 |
| WO2010039850A1 (en) | 2010-04-08 |
| CN102227638A (zh) | 2011-10-26 |
| RU2011117210A (ru) | 2012-11-10 |
| JP2012504415A (ja) | 2012-02-23 |
| HK1159250A1 (en) | 2012-07-27 |
| CN102227638B (zh) | 2015-05-20 |
| IL211551A0 (en) | 2011-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: ABBVIE INC. (US) |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |