BRPI0921464A2 - processo para preparação de agente de contraste iodado - Google Patents

processo para preparação de agente de contraste iodado

Info

Publication number
BRPI0921464A2
BRPI0921464A2 BRPI0921464A BRPI0921464A BRPI0921464A2 BR PI0921464 A2 BRPI0921464 A2 BR PI0921464A2 BR PI0921464 A BRPI0921464 A BR PI0921464A BR PI0921464 A BRPI0921464 A BR PI0921464A BR PI0921464 A2 BRPI0921464 A2 BR PI0921464A2
Authority
BR
Brazil
Prior art keywords
contrast agent
iodinated contrast
preparing iodinated
preparing
agent
Prior art date
Application number
BRPI0921464A
Other languages
English (en)
Inventor
Giovanni Ciarciello
Pietro Minotti
Salvatore Incandela
Silvia Ceragioli
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Publication of BRPI0921464A2 publication Critical patent/BRPI0921464A2/pt
Publication of BRPI0921464B1 publication Critical patent/BRPI0921464B1/pt
Publication of BRPI0921464B8 publication Critical patent/BRPI0921464B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0921464A 2008-11-18 2009-11-02 processo para preparação de agente de contraste iodado BRPI0921464B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20082042 2008-11-18
ITMI2008A002042 2008-11-18
PCT/EP2009/064413 WO2010057765A1 (en) 2008-11-18 2009-11-02 Process for the preparation of iodinated contrast agent

Publications (3)

Publication Number Publication Date
BRPI0921464A2 true BRPI0921464A2 (pt) 2016-01-12
BRPI0921464B1 BRPI0921464B1 (pt) 2020-10-06
BRPI0921464B8 BRPI0921464B8 (pt) 2021-05-25

Family

ID=40940416

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0921464A BRPI0921464B8 (pt) 2008-11-18 2009-11-02 processo para preparação de agente de contraste iodado

Country Status (19)

Country Link
US (1) US8624061B2 (pt)
EP (1) EP2365963B1 (pt)
JP (1) JP5536087B2 (pt)
KR (1) KR101668042B1 (pt)
CN (1) CN102216259B (pt)
AU (1) AU2009317450B2 (pt)
BR (1) BRPI0921464B8 (pt)
CA (1) CA2743079C (pt)
DK (1) DK2365963T3 (pt)
ES (1) ES2637010T3 (pt)
HR (1) HRP20171443T1 (pt)
HU (1) HUE034436T2 (pt)
IL (1) IL212907A (pt)
MX (1) MX2011005236A (pt)
PL (1) PL2365963T3 (pt)
PT (1) PT2365963T (pt)
RU (1) RU2493146C2 (pt)
SI (1) SI2365963T1 (pt)
WO (1) WO2010057765A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100976097B1 (ko) * 2008-12-05 2010-08-16 주식회사 대웅제약 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
GB2496971A (en) * 2011-11-25 2013-05-29 Ge Healthcare As Preparation of X-ray contrast agents
CN105705483B (zh) 2013-11-05 2018-09-04 伯拉考成像股份公司 碘帕醇的制备方法
PT108524B (pt) * 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN106831480B (zh) * 2015-12-07 2019-01-15 北京大学 基于碘帕醇脂质衍生物的造影剂及其制备方法与用途
CN110023279B (zh) 2016-12-05 2022-03-11 伯拉考成像股份公司 放射照相剂中间体的机械化学合成
CN116063195A (zh) * 2023-01-07 2023-05-05 安庆朗坤药业有限公司 一种碘帕醇中间体碘化物的制备方法
WO2024256322A1 (en) 2023-06-13 2024-12-19 Bracco Imaging Spa Synthesis of non-ionic radiographic contrast agents by means of reactive extrusion
CN119528755A (zh) * 2024-11-21 2025-02-28 江西司太立制药有限公司 一种碘佛醇杂质及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3835121A (en) * 1972-07-18 1974-09-10 Essex International Inc Theic-hydantoin-ester resins for wire coatings
CH608189A5 (pt) * 1974-12-13 1978-12-29 Savac Ag
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US4822890A (en) * 1983-05-20 1989-04-18 Hoffmann-La Roche Inc. Method for the production of amino terminus protected naturally occurring amino acids
DE3937118A1 (de) * 1989-11-03 1991-05-08 Schering Ag Nichtionische roentgenkontrastmittel mit hohem jodgehalt
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1286522B1 (it) * 1996-12-04 1998-07-15 Dibra Spa Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
IT1292037B1 (it) * 1997-05-30 1999-01-25 Bracco Spa Processo per la preparazione di 5-(acetil 62,3-diidrossipropil)- ammino)-n,n'-bis(2,3-diidrossipropil)-2,4,6-triiodo-1,3-benzen-
IT1299202B1 (it) * 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
US6420604B1 (en) * 1998-05-14 2002-07-16 Cosmoferm B.V. Process for the acylation of amino alcohols
IT1319671B1 (it) 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
JP4402497B2 (ja) * 2004-03-30 2010-01-20 大日本印刷株式会社 イオパミドールの製造方法

Also Published As

Publication number Publication date
AU2009317450A1 (en) 2010-05-27
HUE034436T2 (en) 2018-02-28
US8624061B2 (en) 2014-01-07
DK2365963T3 (en) 2017-10-09
CA2743079A1 (en) 2010-05-27
SI2365963T1 (sl) 2017-11-30
ES2637010T3 (es) 2017-10-10
JP5536087B2 (ja) 2014-07-02
AU2009317450B2 (en) 2015-05-07
RU2011124888A (ru) 2012-12-27
US20110207960A1 (en) 2011-08-25
CA2743079C (en) 2014-03-25
HRP20171443T1 (hr) 2017-11-03
JP2012509290A (ja) 2012-04-19
KR101668042B1 (ko) 2016-10-20
EP2365963A1 (en) 2011-09-21
EP2365963B1 (en) 2017-06-28
WO2010057765A1 (en) 2010-05-27
CN102216259A (zh) 2011-10-12
BRPI0921464B8 (pt) 2021-05-25
RU2493146C2 (ru) 2013-09-20
PL2365963T3 (pl) 2017-12-29
MX2011005236A (es) 2011-06-16
IL212907A0 (en) 2011-07-31
CN102216259B (zh) 2016-01-20
KR20110093805A (ko) 2011-08-18
BRPI0921464B1 (pt) 2020-10-06
IL212907A (en) 2015-03-31
PT2365963T (pt) 2017-08-22

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Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/10/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/11/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B22B Petition not considered [chapter 22.2 patent gazette]

Free format text: NAO CONHECIDA A PETICAO NO 870210067450, DE 26/07/2021, EM VIRTUDE DO DISPOSTO NO ART. 219 , INCISO II DA LPI