BRPI0921479A2 - método para tratamento ou prevenção de trombose usando etexilato de dabigatran ou um sal do mesmo com aprimorado perfil de segurança em relação à terapia convencional com varfarina - Google Patents

método para tratamento ou prevenção de trombose usando etexilato de dabigatran ou um sal do mesmo com aprimorado perfil de segurança em relação à terapia convencional com varfarina

Info

Publication number
BRPI0921479A2
BRPI0921479A2 BRPI0921479A BRPI0921479A BRPI0921479A2 BR PI0921479 A2 BRPI0921479 A2 BR PI0921479A2 BR PI0921479 A BRPI0921479 A BR PI0921479A BR PI0921479 A BRPI0921479 A BR PI0921479A BR PI0921479 A2 BRPI0921479 A2 BR PI0921479A2
Authority
BR
Brazil
Prior art keywords
treating
salt
improved safety
safety profile
profile compared
Prior art date
Application number
BRPI0921479A
Other languages
English (en)
Inventor
Paul A Reilly
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0921479A2 publication Critical patent/BRPI0921479A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0921479A 2008-11-11 2009-11-10 método para tratamento ou prevenção de trombose usando etexilato de dabigatran ou um sal do mesmo com aprimorado perfil de segurança em relação à terapia convencional com varfarina BRPI0921479A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11340408P 2008-11-11 2008-11-11
US23755209P 2009-08-27 2009-08-27
PCT/EP2009/064873 WO2010055021A1 (en) 2008-11-11 2009-11-10 Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy

Publications (1)

Publication Number Publication Date
BRPI0921479A2 true BRPI0921479A2 (pt) 2016-01-12

Family

ID=41463076

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0921479A BRPI0921479A2 (pt) 2008-11-11 2009-11-10 método para tratamento ou prevenção de trombose usando etexilato de dabigatran ou um sal do mesmo com aprimorado perfil de segurança em relação à terapia convencional com varfarina

Country Status (21)

Country Link
US (3) US8962574B2 (pt)
EP (1) EP2358368A1 (pt)
JP (1) JP2013510072A (pt)
KR (1) KR20110086700A (pt)
CN (2) CN103356614A (pt)
AR (1) AR074313A1 (pt)
AU (1) AU2009315729A1 (pt)
BR (1) BRPI0921479A2 (pt)
CA (1) CA2738883A1 (pt)
CL (1) CL2011000798A1 (pt)
CO (1) CO6361938A2 (pt)
EA (1) EA201100756A1 (pt)
EC (1) ECSP11011030A (pt)
IL (1) IL211852A0 (pt)
MA (1) MA32786B1 (pt)
MX (1) MX2011004614A (pt)
NZ (1) NZ592616A (pt)
PE (1) PE20110431A1 (pt)
TN (1) TN2011000228A1 (pt)
TW (1) TW201022237A (pt)
WO (1) WO2010055021A1 (pt)

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WO2012122024A2 (en) * 2011-03-04 2012-09-13 Russell Medford Screening method for identifying patients at risk of drug induced liver injury
CA2860098A1 (en) * 2011-12-22 2013-06-27 Boehringer Ingelheim International Gmbh Immediate release multi unit pellet system
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EP2722033A1 (en) * 2012-10-19 2014-04-23 Sanovel Ilac Sanayi ve Ticaret A.S. Pharmaceutical Compositions of Dabigatran Free Base
WO2014060561A1 (en) * 2012-10-19 2014-04-24 Sanovel Ilac Sanayi Ve Ticaret A.S. Oral pharmaceutical formulations comprising dabigatran
CN103788063B (zh) * 2012-10-29 2016-01-20 天津药物研究院 四水合达比加群酯晶体及其制备方法和药物用途
IN2013CH05441A (pt) * 2013-11-26 2015-05-29 Aurobindo Pharma Ltd
CN104291789B (zh) * 2014-09-28 2016-03-02 定远县绿苑新型建材有限公司 一种吸水性强的多孔砖及其制备方法
CN105560236B (zh) * 2014-10-30 2019-03-15 成都百裕制药股份有限公司 一种含有银杏内酯b和非肽类凝血酶抑制剂的药物组合物及其制备方法和用途
CN108133754B (zh) * 2017-12-19 2019-03-12 中国医学科学院阜外医院 一种溶栓后出血风险的预测系统
CN110339193B (zh) 2018-04-04 2022-04-29 上海汉都医药科技有限公司 含达比加群酯的药物组合物及其制备方法
US12673049B2 (en) 2018-04-04 2026-07-07 Shanghai Wd Pharmaceutical Co., Ltd Pharmaceutical composition containing dabigatran etexilate and preparation method thereof
US12396970B2 (en) 2021-08-20 2025-08-26 AltaThera Pharmaceuticals LLC Anti-arrhythmic compositions and methods
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US10512620B1 (en) 2018-08-14 2019-12-24 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
US11344518B2 (en) 2018-08-14 2022-05-31 AltaThera Pharmaceuticals LLC Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
CN111983085B (zh) * 2020-08-21 2022-05-31 江苏省食品药品监督检验研究院 一组血清代谢标志物在预测华法林个体药效和指导华法林个体化用药中的应用

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Also Published As

Publication number Publication date
TN2011000228A1 (en) 2012-12-17
US20110269703A1 (en) 2011-11-03
CA2738883A1 (en) 2010-05-20
EP2358368A1 (en) 2011-08-24
IL211852A0 (en) 2011-06-30
MA32786B1 (fr) 2011-11-01
US20120282187A1 (en) 2012-11-08
CO6361938A2 (es) 2012-01-20
WO2010055021A1 (en) 2010-05-20
PE20110431A1 (es) 2011-07-13
US20100322869A1 (en) 2010-12-23
JP2013510072A (ja) 2013-03-21
CN103356614A (zh) 2013-10-23
CL2011000798A1 (es) 2012-01-27
CN102209544A (zh) 2011-10-05
NZ592616A (en) 2013-04-26
AU2009315729A1 (en) 2010-05-20
MX2011004614A (es) 2011-05-31
AR074313A1 (es) 2011-01-05
ECSP11011030A (es) 2011-07-29
KR20110086700A (ko) 2011-07-29
EA201100756A1 (ru) 2011-12-30
US8962574B2 (en) 2015-02-24
TW201022237A (en) 2010-06-16

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.