BRPI0922326B8 - sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, métodos de preparação e método in vitro para rotulagem ou detecção de proteína tau ou proteína tau agregada - Google Patents

sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, métodos de preparação e método in vitro para rotulagem ou detecção de proteína tau ou proteína tau agregada

Info

Publication number
BRPI0922326B8
BRPI0922326B8 BRPI0922326A BRPI0922326A BRPI0922326B8 BR PI0922326 B8 BRPI0922326 B8 BR PI0922326B8 BR PI0922326 A BRPI0922326 A BR PI0922326A BR PI0922326 A BRPI0922326 A BR PI0922326A BR PI0922326 B8 BRPI0922326 B8 BR PI0922326B8
Authority
BR
Brazil
Prior art keywords
tau protein
methods
labeling
pharmaceutical composition
preparation
Prior art date
Application number
BRPI0922326A
Other languages
English (en)
Inventor
Robert Harrington Charles
Michel Wischik Claude
Horsley David
Elizabeth Rickard Janet
Mervyn David Storey John
Clunas Scott
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Priority to BR122020004984-7A priority Critical patent/BR122020004984B1/pt
Priority to BR122020004985-5A priority patent/BR122020004985B1/pt
Publication of BRPI0922326A2 publication Critical patent/BRPI0922326A2/pt
Publication of BRPI0922326B1 publication Critical patent/BRPI0922326B1/pt
Publication of BRPI0922326B8 publication Critical patent/BRPI0922326B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/46—Phenazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/38—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/28—Pyronines ; Xanthon, thioxanthon, selenoxanthan, telluroxanthon dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B17/00—Azine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B19/00—Oxazine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B21/00—Thiazine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
    • C07D335/12—Thioxanthenes
    • C07D335/20—Thioxanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7047—Fibrils-Filaments-Plaque formation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)

Abstract

sais de xantílio 3,6-dissubstituído, uso dos mesmos, composição farmacêutica que os compreende, métodos de preparação da dita composição, de rotulagem ou detecção de proteína tau ou proteína tau agregada e de inverter ou inibir a agregação de proteína tau esta invenção geralmente refere-se a processo, usos, métodos e utilização de materiais que xantílico particular compõe, inclusive compostos de fórmula (i) e (ii), como ainda definindo aqui. estes compostos são úteis como fármacos, por exemplo, no tratamento de tauopatias, como a doença de alzheimer.
BRPI0922326A 2008-12-10 2009-12-10 sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, métodos de preparação e método in vitro para rotulagem ou detecção de proteína tau ou proteína tau agregada BRPI0922326B8 (pt)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BR122020004984-7A BR122020004984B1 (pt) 2008-12-10 2009-12-10 Sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, e seu método de preparação
BR122020004985-5A BR122020004985B1 (pt) 2008-12-10 2009-12-10 Sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, e seu método de preparação

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12128808P 2008-12-10 2008-12-10
US61/121,288 2008-12-10
PCT/GB2009/002865 WO2010067078A2 (en) 2008-12-10 2009-12-10 3,6-disubstituted xanthylium salts as medicaments

Publications (3)

Publication Number Publication Date
BRPI0922326A2 BRPI0922326A2 (pt) 2016-01-05
BRPI0922326B1 BRPI0922326B1 (pt) 2021-02-02
BRPI0922326B8 true BRPI0922326B8 (pt) 2021-05-25

Family

ID=41716277

Family Applications (3)

Application Number Title Priority Date Filing Date
BRPI0922326A BRPI0922326B8 (pt) 2008-12-10 2009-12-10 sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, métodos de preparação e método in vitro para rotulagem ou detecção de proteína tau ou proteína tau agregada
BR122020004985-5A BR122020004985B1 (pt) 2008-12-10 2009-12-10 Sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, e seu método de preparação
BR122020004984-7A BR122020004984B1 (pt) 2008-12-10 2009-12-10 Sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, e seu método de preparação

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR122020004985-5A BR122020004985B1 (pt) 2008-12-10 2009-12-10 Sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, e seu método de preparação
BR122020004984-7A BR122020004984B1 (pt) 2008-12-10 2009-12-10 Sais de xantílio 3,6-dissubstituído, seus usos, composição farmacêutica, e seu método de preparação

Country Status (17)

Country Link
US (3) US8658665B2 (pt)
EP (4) EP3689346B1 (pt)
JP (3) JP5814125B2 (pt)
KR (6) KR102508594B1 (pt)
CN (2) CN104367571A (pt)
AU (1) AU2009326173B2 (pt)
BR (3) BRPI0922326B8 (pt)
CA (3) CA2745203C (pt)
DK (3) DK2373660T3 (pt)
ES (3) ES2799892T3 (pt)
FI (1) FI3689346T3 (pt)
HK (1) HK1207319A1 (pt)
MX (3) MX367131B (pt)
PL (3) PL3112358T3 (pt)
PT (3) PT3689346T (pt)
SI (3) SI3689346T1 (pt)
WO (1) WO2010067078A2 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3689346B1 (en) 2008-12-10 2024-01-24 WisTa Laboratories Ltd. 3,6-disubstituted xanthylium salts for treating tauopathies
US8785434B2 (en) 2010-04-30 2014-07-22 Prosetta Antiviral Inc. Antiviral compounds
US8828986B2 (en) 2011-04-20 2014-09-09 Prosetta Antiviral Inc. Antiviral compounds
US9084720B2 (en) * 2013-05-07 2015-07-21 BioBlast Pharma Ltd. Compositions and methods for treating oculopharyngeal muscular dystrophy
WO2014181333A2 (en) 2013-05-07 2014-11-13 Bio Blast Pharma Ltd. Treatment of protein aggregation myopathic and neurodegenerative diseases by parenteral administration of trehalose
KR102229645B1 (ko) 2013-06-07 2021-03-18 가부시키가이샤 아데카 착색 감광성 조성물 및 신규 화합물
WO2016184911A1 (en) * 2015-05-18 2016-11-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of the neuropathology of patients suffering from myotonic dystrophy type 1 (dm1)
CN106009761B (zh) * 2016-05-31 2017-08-15 延边大学 一种派洛宁染料的制备方法
EP3357928B1 (en) 2017-02-03 2021-01-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel dyes with phosphinic acid, phosphinate, phosphonate and phosphonamidate substituents as auxochromic groups and methods for preparing the same
CN108570032B (zh) * 2017-03-09 2021-04-02 华东理工大学 新型罗丹明染料及其在抗致病菌中的应用
WO2020019289A1 (zh) * 2018-07-27 2020-01-30 华东理工大学 新型罗丹明染料及其在抗致病菌中的应用
KR102496845B1 (ko) * 2018-08-08 2023-02-08 서울대학교산학협력단 진단 지표로서 베타-아밀로이드 수준과 함께 혈장 타우 수준을 사용하는 알츠하이머병의 진단 및 치료 방법
CA3150309A1 (en) 2019-10-01 2021-04-08 Seelos Therapeutics, Inc. Trehalose formulations and uses thereof
CA3164184A1 (en) 2020-01-24 2021-07-29 Oregon Health & Science University Oxazine-based fluorophore compounds for nerve-specific imaging
GB2703562A (en) * 2024-12-13 2026-08-05 Wista Lab Ltd Fused heterocyclic compounds and uses thereof

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE65282C (de) A. Leonhardt & Co. in Mühlheim i. H Verfahren zur Ueberführung von Rhodaminfarbstoffen in gelbere Farbstoffe durch Oxydationsmittel
US2397423A (en) 1943-03-17 1946-03-26 Us Rubber Co Parasiticidal preparations
US3284205A (en) * 1963-09-17 1966-11-08 Horizons Inc Benzotriazole and heterocyclic ketimide activators for leuco compounds
US3620748A (en) 1966-01-07 1971-11-16 Horizons Research Inc N-vinyl amine/halogen liberating composition sensitized with 9-vinyl carbazoles or polyacenes, or transannular peroxides of polyacenes
DE1915910A1 (de) * 1969-03-28 1970-10-08 Agfa Gevaert Ag Spektral sensibilisierte photographische Direktpositiv-Emulsion
BE756085A (de) 1969-09-12 1971-03-15 Agfa Gevaert Nv Spectraal gesensibiliseerd fotografisch materiaal
US3873940A (en) * 1971-08-09 1975-03-25 Eastman Kodak Co Laser media containing rigidized dyes
US3932415A (en) * 1972-04-17 1976-01-13 Eastman Kodak Company Pyrylium dyes having a fused rigidized nitrogen-containing ring
BE806408A (nl) 1973-10-23 1974-04-23 Oce Van Der Grinten Nv Tonerpoeder voor het ontwikkelen van elektrostatische beelden
JPS52113738A (en) * 1976-03-19 1977-09-24 Canon Inc Electrostatically developing toner
US4065315A (en) 1976-04-26 1977-12-27 Dynachem Corporation Phototropic dye system and photosensitive compositions containing the same
CS193815B1 (en) 1977-03-28 1979-11-30 Jaroslav Senkyr Fluid membranes in function of the ionto-convertors for the nitrate iont selective electrode
DE3322945A1 (de) 1983-06-25 1985-01-03 Bayer Ag, 5090 Leverkusen Laserfarbstoffe
JPS61165307A (ja) * 1985-01-18 1986-07-26 Asahi Chem Ind Co Ltd ３，６−ジアミノキサンテン誘導体を含有する除草剤
JPS62278571A (ja) 1986-05-27 1987-12-03 Ricoh Co Ltd 静電荷像現像用トナ−
JPS63131148A (ja) 1986-11-21 1988-06-03 Ricoh Co Ltd 静電潜像現像用乾式トナ−
DE3714288A1 (de) 1987-04-29 1988-11-10 Bayer Ag Fanalpigmente ringgeschlossener indamin- und diphenylmethanfarbstoffe enthaltende trockentoner
DE3714289A1 (de) * 1987-04-29 1988-11-10 Bayer Ag Fanalpigmente ringgeschlossener indamin- und diphenylmethanfarbstoffe enthaltende trockentoner
AU3008289A (en) 1988-02-22 1989-08-24 Eastman Kodak Company Novel thiorhodamines and a novel method of preparation
JPH01229003A (ja) 1988-03-09 1989-09-12 Fuji Photo Film Co Ltd 光重合性組成物
DE4326460A1 (de) 1992-08-10 1994-02-17 Ciba Geigy Verfahren zum Färben von Materialien auf der Basis von Hydroxyapatit
JPH06208191A (ja) 1992-11-18 1994-07-26 Oriental Photo Ind Co Ltd 乾式銀塩感光体及びこの乾式銀塩感光体を用いた画像形成方法
EP0599184A3 (en) * 1992-11-18 1996-12-04 Canon Kk Dry process silver salt photosensitive material and image forming method making use of this dry process silver salt photosensitive material.
JPH06236000A (ja) 1993-02-12 1994-08-23 Showa Denko Kk 光消色性記録材料
JPH0785972A (ja) 1993-09-20 1995-03-31 Toshiba Corp 有機ｅｌ素子
US5459268A (en) 1993-10-25 1995-10-17 Molecular Probes, Inc. Xanthylium dyes that are well retained in mitochondria
GB9506197D0 (en) * 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
JPH08324117A (ja) 1995-05-30 1996-12-10 Ricoh Co Ltd 光情報記録媒体
EP0805441B1 (de) * 1996-05-03 2003-10-08 Ciba SC Holding AG Optische Speichermedien mit hoher Kapazität, die Xanthenfarbstoffe enthalten
US20030044776A1 (en) 1998-09-25 2003-03-06 James A. Dykens Compositions and methods for identifying agents that alter mitochondrial permeability transition pores
JP3886271B2 (ja) 1998-11-27 2007-02-28 シスメックス株式会社 赤芽球の分類計数用試薬及び分類計数方法
JP2000344684A (ja) 1999-03-26 2000-12-12 Bf Kenkyusho:Kk ピロニンｂ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
JP4647187B2 (ja) * 2001-04-02 2011-03-09 セルメド バイオサイエンシズ インコーポレイテッド ハロゲン化ローダミン誘導体およびその適用
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
WO2004005389A1 (ja) 2002-07-09 2004-01-15 Orient Chemical Industries, Ltd. 核効果抑制剤、結晶性樹脂組成物及び結晶性樹脂組成物の結晶化制御法
JP2004061947A (ja) * 2002-07-30 2004-02-26 Fuji Photo Film Co Ltd 平版印刷版原版
EP1654326A1 (en) * 2003-08-01 2006-05-10 VersaMatrix A/S Triangulenium fluorescent dyes and polymers comprising such dyes
ATE531767T1 (de) 2003-08-21 2011-11-15 Merck Patent Gmbh Cyanoborat-farbstoffe
WO2005034855A2 (en) * 2003-09-05 2005-04-21 The General Hospital Corporation Photodynamic inactivation of bacterial spores
AU2004294243B2 (en) * 2003-12-05 2011-02-17 Hopital Maisonneuve-Rosemont Immunologic compounds for prevention, protection, prophylaxis or treatment of immunological disorders, infections and cancer
US8029765B2 (en) 2003-12-24 2011-10-04 Masimo Laboratories, Inc. SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
EP1713457A2 (de) * 2004-02-11 2006-10-25 Max-Delbrück-Centrum Für Molekulare Medizin Neue arzneimittel und diagnostische zusammensetzungen f r be handlung und diagnose von neurodegenerativen erkrankungen und amyloid-krankheiten
CN1594463A (zh) 2004-07-02 2005-03-16 林劲冬 光催化氧化还原降解消色板书墨水及其降解促进剂
WO2006026033A2 (en) 2004-08-02 2006-03-09 The Research Foundation Of State University Of New York Stor Novel chalcogenoxanthylium dyes for purging blood pathogens and for photodynamic therapy
CN101132796A (zh) * 2005-02-17 2008-02-27 独立行政法人科学技术振兴机构 含有吩嗪化合物作为活性成分的药物组合物
CA2607475A1 (en) * 2005-04-22 2006-11-02 Genentech, Inc. Method for treating dementia or alzheimer's disease with a cd20 antibody
FR2889060B1 (fr) 2005-08-01 2009-05-15 Oreal Composition de teinture des fibres keratiniques comprenant un colorant direct amidoxanthenique et procede de teinture l a mettant en oeuvre
KR101341855B1 (ko) * 2005-10-06 2013-12-20 시바 홀딩 인코포레이티드 옥사진 디설파이드 염료
DK2853293T3 (en) * 2006-03-29 2018-01-22 Wista Lab Ltd Thioninium compounds and their use
CN104119294B (zh) * 2006-03-29 2018-10-30 维斯塔实验室有限公司 3,7-二氨基-10h-吩噻嗪化合物的制备方法
FR2915878B1 (fr) 2007-05-07 2009-08-21 Oreal Compositions comprenant des colorants directs xantheniques fluores, procedes de mise en oeuvre et utilisations.
US8247145B2 (en) 2007-09-07 2012-08-21 Konica Minolta Business Technologies, Inc. Magenta toner for developing electrostatic image
WO2009030871A1 (en) 2007-09-07 2009-03-12 Vernalis R & D Ltd Pyrrolopyrimidine derivatives having hsp90 inhibitory activity
WO2010033011A1 (en) * 2008-09-19 2010-03-25 Cancer Research Initiatives Foundation Rosamine derivatives as agents for the treatment of cancer
EP3689346B1 (en) 2008-12-10 2024-01-24 WisTa Laboratories Ltd. 3,6-disubstituted xanthylium salts for treating tauopathies

Also Published As

Publication number Publication date
DK3112358T3 (da) 2020-06-02
CA3039907C (en) 2022-12-13
SI3689346T1 (sl) 2024-05-31
EP2373660A2 (en) 2011-10-12
CN102307878A (zh) 2012-01-04
KR20180054900A (ko) 2018-05-24
US8658665B2 (en) 2014-02-25
EP3112358A2 (en) 2017-01-04
CA2745203C (en) 2019-06-04
US10399955B2 (en) 2019-09-03
EP4327874A2 (en) 2024-02-28
WO2010067078A3 (en) 2010-11-18
MX2011005842A (es) 2011-06-17
EP3689346B1 (en) 2024-01-24
EP4327874A3 (en) 2024-06-12
PT3689346T (pt) 2024-03-06
BRPI0922326B1 (pt) 2021-02-02
ES2600278T3 (es) 2017-02-08
WO2010067078A2 (en) 2010-06-17
EP2373660B1 (en) 2016-08-17
DK2373660T3 (en) 2016-11-28
ES2799892T3 (es) 2020-12-22
WO2010067078A8 (en) 2010-09-02
PT2373660T (pt) 2016-11-04
US9549933B2 (en) 2017-01-24
MX367131B (es) 2019-08-06
KR20200133394A (ko) 2020-11-27
PL2373660T3 (pl) 2017-02-28
EP3112358A3 (en) 2017-01-11
AU2009326173B2 (en) 2014-10-30
BRPI0922326A2 (pt) 2016-01-05
KR102358299B1 (ko) 2022-02-08
PL3112358T3 (pl) 2020-11-16
US20170088534A1 (en) 2017-03-30
FI3689346T3 (fi) 2024-03-18
US20110300074A1 (en) 2011-12-08
BR122020004984B1 (pt) 2021-04-27
CA3176480A1 (en) 2010-06-17
HK1207319A1 (en) 2016-01-29
BR122020004985B1 (pt) 2021-04-27
CA2745203A1 (en) 2010-06-17
CN102307878B (zh) 2014-10-15
AU2009326173A1 (en) 2010-06-17
CN104367571A (zh) 2015-02-25
EP3689346A1 (en) 2020-08-05
EP3112358B1 (en) 2020-04-29
JP2017019823A (ja) 2017-01-26
ES2973458T3 (es) 2024-06-20
SI2373660T1 (sl) 2016-12-30
KR20190117818A (ko) 2019-10-16
MX385354B (es) 2025-03-18
US20140161731A1 (en) 2014-06-12
JP2012511560A (ja) 2012-05-24
KR20110092357A (ko) 2011-08-17
JP6148270B2 (ja) 2017-06-14
HK1163078A1 (zh) 2012-09-07
PT3112358T (pt) 2020-06-23
PL3689346T3 (pl) 2024-06-24
KR102508594B1 (ko) 2023-03-09
CA3039907A1 (en) 2010-06-17
KR101750119B1 (ko) 2017-06-22
KR102035442B1 (ko) 2019-10-22
KR102194167B1 (ko) 2020-12-22
KR20220018077A (ko) 2022-02-14
DK3689346T3 (da) 2024-02-26
MX339644B (es) 2016-06-03
KR101892885B1 (ko) 2018-08-28
KR20170070258A (ko) 2017-06-21
SI3112358T1 (sl) 2020-09-30
JP2015134797A (ja) 2015-07-27
JP5814125B2 (ja) 2015-11-17

Similar Documents

Publication Publication Date Title
BRPI0910832B8 (pt) derivados de tienopiridona como ativadores de proteína quinase ativada por amp (ampk), seus usos, seu processo de preparação e seus intermediários, e medicamentos.
BR112015014372A8 (pt) inibidores de autotaxina, seus usos, e composição e combinação farmacêuticas".
BR112016022553A2 (pt) Compostos e métodos para entrega transmembrana de moléculas?
BR112013006344A2 (pt) lactamas substituídas por piperdinila como moduladores de gpr119, composição farmacêutica as compreendendo, uso e processso para preparação das mesmas
BR112014018990A8 (pt) Derivados de ácido benzotiazol-6-il acético e seu uso para tratamento de uma infecção
BR112015014458A2 (pt) derivados de manose para o tratamento de infecções bacterianas
BR112014002958A2 (pt) "3,4-di-hidro-1h-[1,8]naftiridinonas substituídas com piperidinila antibacterianas, composição farmacêutica compreendendo os referidos compostos, processos para preparação destes e uso".
BR112012022223A8 (pt) Formulação de proteína concentrada, uso e método de preparação da mesma
BR112013000920A2 (pt) compostos para a redução de produção de beta-amiloide
BR112013000255A2 (pt) ácidos hidróxifenil-hexinoicos substituídos por ariloxialquileno, método para preparação dos mesmos e seu uso dos mesmos como um medicamento
BRPI0913831A2 (pt) "peptídeo com a fórmula geral (i), seus estereoisômeros, suas misturas, ou seus sais cosmética ou farmaceuticamente aceitáveis, processo para a preparação de um peptídeo com a fórmula geral (i), seus estereoisômeros, suas misturas, ou seus sais cosmética ou farmaceuticamente aceitáveis e composição cosmética ou farmacêutica"
BR112013020005A8 (pt) peptídeo de fórmula geral r1-wn-xm-aa1-aa2-aa3-aa4-aa5-aa6-yp-zq-r2, seus estereoisômeros, misturas dos mesmos e/ou seus sais cosmética ou farmaceuticamente aceitáveis e composição cosmética ou farmacêutica
BRPI0410037B8 (pt) inibidores de fosfatidilinositol 3-cinase, sua composição farmacêutica, e seu uso
BRPI0910439B8 (pt) derivados de tienopiridona como ativadores da proteína quinase ativada por amp (ampk), seu processo de preparação, e medicamentos
UY31673A1 (es) "derivados heterocíclicos de urea y métodos de uso de los mismos-211"
BR112014015845A8 (pt) derivados de azetidina, composições farmacêuticas e seu uso
BRPI0815111A2 (pt) Processo para a preparação ou purificação de olmesartan medoxomil, sais de olmesartan medoxomil e seus usos e composições farmacêuticas
BR112016016854A2 (pt) Derivados de 7-oxo-1,6-diazabiciclo[3.2.1]octana, seu processo de preparação e seu uso, composição farmacêutica e seu uso pedidos de patente relacionados
MX385354B (es) Sales de xantilio 3,6-disustituidas.
BRPI0713443A2 (pt) Derivados de piperazinila úteis no tratamento de doenças medianas por receptor gpr38, uso e composição farmacêutica contendo tais compostos e processos para preparação dos mesmos
BRPI0905687A8 (pt) composto da fórmula i ou i', composição farmacêutica, método de tratamento de um paciente com uma doença, uso do composto
BR112015001207A8 (pt) derivados de carbamato/ureia, seus usos, composição farmacêutica, forma livre e seu método de preparação
BR112023017274A2 (pt) Vacina contra metapneumovírus humano
BR112015006063A2 (pt) compostos heteroaromáticos, processo para preparar os compostos, composições farmacêuticas, usos e método de tratamento para as dores aguda e crônica
BRPI0915513B8 (pt) compostos derivados de ácido fenóxi-cromano carboxílico 6-substituído, composições farmacêuticas compreendendo os referidos compostos, uso dos mesmos, e processo para a preparação destes

Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: WISTA LABORATORIES LTD. (SG)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/02/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/12/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF