BRPI0922355A8 - Ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso do ácido nucléico, complexo de rna e uso do complexo de rna - Google Patents

Ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso do ácido nucléico, complexo de rna e uso do complexo de rna

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Publication number
BRPI0922355A8
BRPI0922355A8 BRPI0922355A BRPI0922355A BRPI0922355A8 BR PI0922355 A8 BRPI0922355 A8 BR PI0922355A8 BR PI0922355 A BRPI0922355 A BR PI0922355A BR PI0922355 A BRPI0922355 A BR PI0922355A BR PI0922355 A8 BRPI0922355 A8 BR PI0922355A8
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Brazil
Prior art keywords
rna complex
rna
gene
vitro
cell
Prior art date
Application number
BRPI0922355A
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English (en)
Inventor
V Templin Michael
K Vaish Narendra
A Polisky Barry
E Houston Michael
Original Assignee
Marina Biotech Inc
Arcturus Therapeutics Inc
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Publication date
Application filed by Marina Biotech Inc, Arcturus Therapeutics Inc filed Critical Marina Biotech Inc
Publication of BRPI0922355A2 publication Critical patent/BRPI0922355A2/pt
Publication of BRPI0922355A8 publication Critical patent/BRPI0922355A8/pt

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Abstract

ÁCIDOS NUCLÉICOS, MÉTODOS PARA REDUZIR A EXPRESSÃO DE UM GENE EM UMA CÉLULA IN VITRO, USO DO ÁCIDO NUCLÉICO, COMPLEXO DE RNA e USO DO COMPLEXO DE RNA Esta divulgação fornece complexos de RNA com fita dupla tendo um ou mais nucleomonômeros substituído(s) com hidroximetilna fita passageira (ou fita senso) de um complexo de RNA. Complexos de RNA do presente pedido podem ser úteis para aplicações terapêuticas, aplicações de diagnóstico ou de aplicações de pesquisa. Complexos de RNA incluem complexos de RNA de interferência curtos (siRNA) capazes de modular a expressão de gene compreendendo uma fita antisenso e uma fita passageira contínua ou descontínua ("fita senso"). Além disso, um ou mais nucleomonômero substituído(s) com hidroximetil da presente divulgação podem ser posicionados na terminação 3', na terminação-5', em ambos as terminações 3' e 5'.
BRPI0922355A 2008-12-03 2009-12-03 Ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso do ácido nucléico, complexo de rna e uso do complexo de rna BRPI0922355A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11962408P 2008-12-03 2008-12-03
US25208509P 2009-10-15 2009-10-15
PCT/US2009/066610 WO2010065756A2 (en) 2008-12-03 2009-12-03 Usirna complexes

Publications (2)

Publication Number Publication Date
BRPI0922355A2 BRPI0922355A2 (pt) 2017-10-24
BRPI0922355A8 true BRPI0922355A8 (pt) 2017-12-12

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BRPI0922355A BRPI0922355A8 (pt) 2008-12-03 2009-12-03 Ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso do ácido nucléico, complexo de rna e uso do complexo de rna

Country Status (12)

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US (2) US9340789B2 (pt)
EP (1) EP2370577B1 (pt)
JP (3) JP5816556B2 (pt)
KR (1) KR20110097915A (pt)
CN (2) CN102239259A (pt)
AU (2) AU2009322290B2 (pt)
BR (1) BRPI0922355A8 (pt)
CA (1) CA2744093A1 (pt)
IL (1) IL212941A (pt)
SG (2) SG10201500318SA (pt)
WO (1) WO2010065756A2 (pt)
ZA (1) ZA201104540B (pt)

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CN104673798B (zh) 2018-03-20
WO2010065756A2 (en) 2010-06-10
JP5816556B2 (ja) 2015-11-18
WO2010065756A3 (en) 2010-11-25
AU2016228247A1 (en) 2016-10-06
KR20110097915A (ko) 2011-08-31
EP2370577B1 (en) 2019-08-28
CN102239259A (zh) 2011-11-09
IL212941A0 (en) 2011-07-31
US20160215293A1 (en) 2016-07-28
US20110313020A1 (en) 2011-12-22
JP2012510297A (ja) 2012-05-10
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US9340789B2 (en) 2016-05-17
IL212941A (en) 2016-05-31
CN104673798A (zh) 2015-06-03
SG171879A1 (en) 2011-07-28
BRPI0922355A2 (pt) 2017-10-24
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