MX2022013606A - Composiciones de ácido ribonucleico interferente (arni) del factor b de complemento (cfb) y métodos de uso de las mismas. - Google Patents

Composiciones de ácido ribonucleico interferente (arni) del factor b de complemento (cfb) y métodos de uso de las mismas.

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Publication number
MX2022013606A
MX2022013606A MX2022013606A MX2022013606A MX2022013606A MX 2022013606 A MX2022013606 A MX 2022013606A MX 2022013606 A MX2022013606 A MX 2022013606A MX 2022013606 A MX2022013606 A MX 2022013606A MX 2022013606 A MX2022013606 A MX 2022013606A
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Mexico
Prior art keywords
cfb
methods
arni
interferent
complement factor
Prior art date
Application number
MX2022013606A
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English (en)
Inventor
Elane Fishilevich
Mark K Schlegel
James D Mcininch
Adam Castoreno
Kristina Yucius
Charalambos Kaittanis
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Alnylam Pharmaceuticals Inc
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Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2022013606A publication Critical patent/MX2022013606A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

La presente invención se refiere a agentes de ARNi, por ejemplo, agentes de ARNdh, dirigidos al gen del fator B del complemento (CFB). La invención también se refiere a métodos para usar los agentes ARNi para inhibir la expresión de un gen CFB y a métodos para tratar o prevenir una enfermedad asociada a CFB en un individuo.
MX2022013606A 2020-04-30 2021-04-29 Composiciones de ácido ribonucleico interferente (arni) del factor b de complemento (cfb) y métodos de uso de las mismas. MX2022013606A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063017725P 2020-04-30 2020-04-30
US202063119009P 2020-11-30 2020-11-30
US202163157899P 2021-03-08 2021-03-08
PCT/US2021/029872 WO2021222549A1 (en) 2020-04-30 2021-04-29 Complement factor b (cfb) irna compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2022013606A true MX2022013606A (es) 2023-01-16

Family

ID=76012030

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Application Number Title Priority Date Filing Date
MX2022013606A MX2022013606A (es) 2020-04-30 2021-04-29 Composiciones de ácido ribonucleico interferente (arni) del factor b de complemento (cfb) y métodos de uso de las mismas.

Country Status (13)

Country Link
US (1) US20240018515A1 (es)
EP (1) EP4142738A1 (es)
JP (2) JP2023523790A (es)
KR (1) KR20230017789A (es)
CN (1) CN116096381A (es)
AU (1) AU2021265813A1 (es)
BR (1) BR112022021136A2 (es)
CA (1) CA3181198A1 (es)
CL (1) CL2022002951A1 (es)
CO (1) CO2022016196A2 (es)
IL (1) IL297680A (es)
MX (1) MX2022013606A (es)
WO (1) WO2021222549A1 (es)

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TW202134435A (zh) 2019-10-22 2021-09-16 美商阿尼拉製藥公司 補體成分ｃ３ ｉｒｎａ組成物及其使用方法
JP2024525868A (ja) 2021-07-17 2024-07-12 サーナオミクス インコーポレイテッド 産物及び組成物
KR20240051221A (ko) 2021-09-02 2024-04-19 사일런스 테라퓨틱스 게엠베하 세포에서 보체 인자 b (cfb)의 발현을 억제하기 위한 핵산
TW202333749A (zh) 2021-10-29 2023-09-01 美商艾拉倫製藥股份有限公司 補體因子ｂ（ｃｆｂ）ｉｒｎａ組成物及其使用方法
PE20241340A1 (es) 2021-11-24 2024-07-03 Adarx Pharmaceuticals Inc Composiciones moduladoras de complemento del factor b y metodos de uso de estas
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CN116769780A (zh) * 2022-07-08 2023-09-19 北京福元医药股份有限公司 用于抑制补体因子B表达的siRNA、其缀合物和药物组合物及其用途
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CN117136236B (zh) * 2022-09-29 2024-03-15 广州必贝特医药股份有限公司 用于抑制TMPRSS6基因表达的siRNA或其盐、药物及其应用
EP4638743A2 (en) * 2022-12-19 2025-10-29 Sanegene Bio USA Inc. Small interfering rna targeting cfb and uses thereof
WO2024197017A2 (en) * 2023-03-21 2024-09-26 Arrowhead Pharmaceuticals, Inc. Rnai agents for inhibiting expression of complement factor b (cfb) pharmaceutical compositions thereof, and methods of use
TW202513799A (zh) * 2023-06-02 2025-04-01 大陸商維亞臻生物技術（蘇州）有限公司 用於免疫類疾病的雙鏈核苷酸化合物及其用途
WO2025113592A1 (zh) * 2023-12-01 2025-06-05 厦门甘宝利生物医药有限公司 一种抑制补体系统基因表达的rna抑制剂及其应用
CN120209051A (zh) * 2023-12-27 2025-06-27 武汉人福创新药物研发中心有限公司 用于递送的靶向化合物及其用途
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