BRPI0922410A8 - Organismo recombinante geneticamente modificado para converter semialdeído de glutarato ou 5-aminopentanoato em um monômero, polímero ou copolímero com 5 carbonos dos mesmo, método para a produção de monômeros com base em 5 carbonos, polímeros ou co-polímeros dos mesmos, método para a super produção de glutarato a partir de substratos de carbono renováveis, 1,5-pentanodiol. - Google Patents

Organismo recombinante geneticamente modificado para converter semialdeído de glutarato ou 5-aminopentanoato em um monômero, polímero ou copolímero com 5 carbonos dos mesmo, método para a produção de monômeros com base em 5 carbonos, polímeros ou co-polímeros dos mesmos, método para a super produção de glutarato a partir de substratos de carbono renováveis, 1,5-pentanodiol.

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Publication number
BRPI0922410A8
BRPI0922410A8 BRPI0922410A BRPI0922410A BRPI0922410A8 BR PI0922410 A8 BRPI0922410 A8 BR PI0922410A8 BR PI0922410 A BRPI0922410 A BR PI0922410A BR PI0922410 A BRPI0922410 A BR PI0922410A BR PI0922410 A8 BRPI0922410 A8 BR PI0922410A8
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BR
Brazil
Prior art keywords
production
glutarate
hydroxy
poly
aminopentanoate
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BRPI0922410A
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English (en)
Inventor
r farmer William
Bickmeier Jeff
Lu Chenfeng
Chang Dong-Eun
Skraly Frank
Martin Ramseier Thomas
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Cj Cheiljedang Corp
Metabolix Inc
Cj Res Center Llc
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Application filed by Cj Cheiljedang Corp, Metabolix Inc, Cj Res Center Llc filed Critical Cj Cheiljedang Corp
Publication of BRPI0922410A2 publication Critical patent/BRPI0922410A2/pt
Publication of BRPI0922410A8 publication Critical patent/BRPI0922410A8/pt
Publication of BRPI0922410B1 publication Critical patent/BRPI0922410B1/pt

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Abstract

ORGANISMO RECOMBINANTE GENETICAMENTE MODIFICADO PARA CONVERTER SEMIALDEÍDO DE GLUTARATO OU 5-AMINOPENTANOATO EM UM MONÔMERO, POLÍMERO OU COPOLÍMERO COM 5 CARBONOS DO MESMO, MÉTODO PARA A PRODUÇÃO DE MONÔMEROS COM BASE EM 5 CARBONOS, POLÍMEROS OU CO-POLÍMEROS DOS MESMOS, MÉTODO PARA A SUPER PRODUÇÃO DE GLUTARATO A PARTIR DE SUBSTRATOS DE CARBONO RENOVÁVEIS, 1,5-PENTANODIOL Trata-se de hospedeiros recombinantes para a produção de poli(hidróxi alcanoatos) e de métodos de produção de poli(hidróxi alcanoatos) a partir de substratos de carbono renováveis. Também são apresentados determinados hospedeiros recombinantes que produzem substâncias químicas com 5 carbonos como o 5-amino-pentanoato (5AP), 5-hidróxi-valerato (5HV), glutarato e 1,5-pentanodiol (PDO). Uma modalidade confere um hospedeiro recombinante expressando um gene que codifica uma enzima heteróloga selecionada do grupo que consiste em uma poli(hidróxi alcanoato) sintetase e uma 5-hidróxi-valerato-CoA (5HV-CoA) transferase, em que o hospedeiro produz um polímero que contém 5-hidróxi-valetato. Preferencialmente, o hospedeiro expressa tanto uma poli(hidróxi alcanoato) sintetase quanto uma 5HV-CoA transferase. O hospedeiro pode ser procariítico ou eucariótico. Um hospedeiro procariótico preferencial é a E. coli. Os polímeros produzidos pelos hospedeiros recombinantes podem ser homopolímeros ou copolímeros de 5-hidróxi-valerato. Um copolímero preferencial é o poli(3-hidróxi-butirato-5-hidróxi-valerato).
BRPI0922410-6A 2008-12-12 2009-12-14 Microrganismo recombinante geneticamente modificado para converter 5aminopentanoato em um polímero ou copolímero de polihidroxialcanoato (pha) do mesmo compreendendo 5-hidróxi-valerato, e método para a produção de polímeros ou copolímeros de polihidroxialcanoato (pha) com base em carbonos dos mesmos BRPI0922410B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12225008P 2008-12-12 2008-12-12
US61/122,250 2008-12-12
PCT/US2009/067943 WO2010068953A2 (en) 2008-12-12 2009-12-14 Green process and compositions for producing poly(5hv) and 5 carbon chemicals

Publications (3)

Publication Number Publication Date
BRPI0922410A2 BRPI0922410A2 (pt) 2015-08-11
BRPI0922410A8 true BRPI0922410A8 (pt) 2017-10-03
BRPI0922410B1 BRPI0922410B1 (pt) 2024-05-14

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WO2010068953A2 (en) 2010-06-17
KR20160025043A (ko) 2016-03-07
CN103396978A (zh) 2013-11-20
US9090898B2 (en) 2015-07-28
EP2376622A2 (en) 2011-10-19
JP5770099B2 (ja) 2015-08-26
JP2015211681A (ja) 2015-11-26
KR20170132896A (ko) 2017-12-04
JP6223386B2 (ja) 2017-11-01
KR101886012B1 (ko) 2018-08-06
ES2639413T3 (es) 2017-10-26
BRPI0922410A2 (pt) 2015-08-11
MY183971A (en) 2021-03-17
CN102317437A (zh) 2012-01-11
WO2010068953A3 (en) 2010-08-05
EP2376622B1 (en) 2017-06-07
KR20110104492A (ko) 2011-09-22
CN102317437B (zh) 2013-08-21
EP3260532A1 (en) 2017-12-27
JP2012511912A (ja) 2012-05-31
US20100168481A1 (en) 2010-07-01

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