BRPI0922691A2 - conjugados de leptina e análogo de leptina e usos dos mesmos - Google Patents
conjugados de leptina e análogo de leptina e usos dos mesmosInfo
- Publication number
- BRPI0922691A2 BRPI0922691A2 BRPI0922691A BRPI0922691A BRPI0922691A2 BR PI0922691 A2 BRPI0922691 A2 BR PI0922691A2 BR PI0922691 A BRPI0922691 A BR PI0922691A BR PI0922691 A BRPI0922691 A BR PI0922691A BR PI0922691 A2 BRPI0922691 A2 BR PI0922691A2
- Authority
- BR
- Brazil
- Prior art keywords
- leptin
- conjugates
- analogs
- leptin analogs
- leptin conjugates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20094708P | 2008-12-05 | 2008-12-05 | |
| US17883709P | 2009-05-15 | 2009-05-15 | |
| PCT/CA2009/001780 WO2010063123A1 (en) | 2008-12-05 | 2009-12-07 | Leptin and leptin analog conjugates and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0922691A2 true BRPI0922691A2 (pt) | 2018-11-06 |
Family
ID=42232847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0922691A BRPI0922691A2 (pt) | 2008-12-05 | 2009-12-07 | conjugados de leptina e análogo de leptina e usos dos mesmos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20110288009A1 (pt) |
| EP (1) | EP2370472A4 (pt) |
| JP (1) | JP2012510797A (pt) |
| CN (1) | CN102272163A (pt) |
| AU (1) | AU2009322044A1 (pt) |
| BR (1) | BRPI0922691A2 (pt) |
| CA (1) | CA2745527A1 (pt) |
| MX (1) | MX2011005965A (pt) |
| RU (1) | RU2011125367A (pt) |
| WO (1) | WO2010063123A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0406647A (pt) | 2003-01-06 | 2005-12-06 | Angiochem Inc | Método para transportar um composto através da barreira sanguìnea do cérebro |
| US7557182B2 (en) | 2005-02-18 | 2009-07-07 | Angiochem Inc. | Molecules for transporting a compound across the blood-brain barrier |
| JP5436856B2 (ja) | 2005-07-15 | 2014-03-05 | アンジオケム インコーポレーティッド | 薬学的複合体における担体としてのアプロチニンポリペプチドの使用 |
| EP2074142A4 (en) | 2006-10-19 | 2010-10-27 | Angiochem Inc | COMPOUNDS FOR STIMULATING THE FUNCTION OF P-GLYCOPROTEIN AND APPLICATIONS THEREOF |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| BRPI0920209A2 (pt) | 2008-10-15 | 2015-12-22 | Angiochem Inc | conjugados de agonistas de glp-1 e usos dos mesmos |
| CA2745524C (en) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| WO2010069074A1 (en) | 2008-12-17 | 2010-06-24 | Universite Du Quebec A Montreal | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| WO2010121379A1 (en) | 2009-04-20 | 2010-10-28 | Angiochem Inc | Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog |
| AU2010268726A1 (en) | 2009-07-02 | 2012-01-19 | Angiochem Inc. | Multimeric peptide conjugates and uses thereof |
| WO2011153642A1 (en) * | 2010-06-10 | 2011-12-15 | Angiochem Inc. | Leptin and leptin analog conjugates and fusion proteins and uses thereof |
| EP2885318A4 (en) | 2012-08-14 | 2016-03-30 | Angiochem Inc | PEPTIDE DENDRIMER CONJUGATES AND ITS USES |
| CN105189465B (zh) | 2013-03-21 | 2019-02-26 | 赛诺菲-安万特德国有限公司 | 合成含有乙内酰脲的肽产物 |
| WO2014147129A1 (en) | 2013-03-21 | 2014-09-25 | Sanofi-Aventis Deutschland Gmbh | Synthesis of cyclic imide containing peptide products |
| CA2957714A1 (en) * | 2014-08-11 | 2016-02-18 | Albany Medical College | Myristoylated leptin-related peptides and uses thereof |
| MX390967B (es) * | 2014-11-19 | 2025-03-21 | Novopyxis Inc | Composiciones y métodos para la modulación de la actividad at2r |
| CN104829708B (zh) * | 2015-05-06 | 2017-11-28 | 广东省生物资源应用研究所 | 一条d螺旋区突变的瘦素活性肽及其编码基因和应用 |
| CN104829707B (zh) * | 2015-05-06 | 2017-12-19 | 广东省生物资源应用研究所 | 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用 |
| CN104829705B (zh) * | 2015-05-06 | 2017-11-14 | 广东省生物资源应用研究所 | 一条c螺旋区突变的瘦素活性肽及其编码基因和应用 |
| DK3307326T3 (da) | 2015-06-15 | 2020-10-19 | Angiochem Inc | Fremgangsmåder til behandling af leptomeningeal karcinomatose |
| KR102770650B1 (ko) | 2015-07-06 | 2025-02-19 | 유씨비 바이오파마 에스알엘 | 타우 결합 항체 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7557182B2 (en) * | 2005-02-18 | 2009-07-07 | Angiochem Inc. | Molecules for transporting a compound across the blood-brain barrier |
| EP2789628A3 (en) * | 2007-05-29 | 2015-03-04 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
-
2009
- 2009-12-07 CA CA2745527A patent/CA2745527A1/en not_active Abandoned
- 2009-12-07 CN CN2009801544077A patent/CN102272163A/zh active Pending
- 2009-12-07 MX MX2011005965A patent/MX2011005965A/es not_active Application Discontinuation
- 2009-12-07 EP EP09829935.7A patent/EP2370472A4/en not_active Withdrawn
- 2009-12-07 BR BRPI0922691A patent/BRPI0922691A2/pt not_active Application Discontinuation
- 2009-12-07 WO PCT/CA2009/001780 patent/WO2010063123A1/en not_active Ceased
- 2009-12-07 AU AU2009322044A patent/AU2009322044A1/en not_active Abandoned
- 2009-12-07 JP JP2011538810A patent/JP2012510797A/ja active Pending
- 2009-12-07 RU RU2011125367/10A patent/RU2011125367A/ru not_active Application Discontinuation
- 2009-12-07 US US13/132,838 patent/US20110288009A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2011125367A (ru) | 2013-01-10 |
| EP2370472A1 (en) | 2011-10-05 |
| AU2009322044A1 (en) | 2011-07-07 |
| JP2012510797A (ja) | 2012-05-17 |
| EP2370472A4 (en) | 2013-04-24 |
| CN102272163A (zh) | 2011-12-07 |
| US20110288009A1 (en) | 2011-11-24 |
| WO2010063123A1 (en) | 2010-06-10 |
| MX2011005965A (es) | 2011-09-01 |
| CA2745527A1 (en) | 2010-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |