BRPI0922871A2 - metodos para o tratamento da esclerose múltipla usando pirazinoindóis tetracíclicos - Google Patents

metodos para o tratamento da esclerose múltipla usando pirazinoindóis tetracíclicos

Info

Publication number
BRPI0922871A2
BRPI0922871A2 BRPI0922871A BRPI0922871A BRPI0922871A2 BR PI0922871 A2 BRPI0922871 A2 BR PI0922871A2 BR PI0922871 A BRPI0922871 A BR PI0922871A BR PI0922871 A BRPI0922871 A BR PI0922871A BR PI0922871 A2 BRPI0922871 A2 BR PI0922871A2
Authority
BR
Brazil
Prior art keywords
methods
multiple sclerosis
treating multiple
tetracyclic pyrazinoindoles
pyrazinoindoles
Prior art date
Application number
BRPI0922871A
Other languages
English (en)
Inventor
Andreas Persidis
Spyros Deftereos
Original Assignee
Biovista Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovista Inc filed Critical Biovista Inc
Publication of BRPI0922871A2 publication Critical patent/BRPI0922871A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI0922871A 2008-12-11 2009-12-11 metodos para o tratamento da esclerose múltipla usando pirazinoindóis tetracíclicos BRPI0922871A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12157408P 2008-12-11 2008-12-11
US23323509P 2009-08-12 2009-08-12
PCT/US2009/067673 WO2010068867A1 (en) 2008-12-11 2009-12-11 Methods for treating multiple sclerosis using tetracyclic pyrazinoindoles

Publications (1)

Publication Number Publication Date
BRPI0922871A2 true BRPI0922871A2 (pt) 2016-11-16

Family

ID=42243090

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0922871A BRPI0922871A2 (pt) 2008-12-11 2009-12-11 metodos para o tratamento da esclerose múltipla usando pirazinoindóis tetracíclicos

Country Status (9)

Country Link
US (1) US20110268699A1 (pt)
EP (1) EP2375900B1 (pt)
JP (1) JP2012512165A (pt)
CN (1) CN102395275A (pt)
AU (1) AU2009324495B2 (pt)
BR (1) BRPI0922871A2 (pt)
CA (1) CA2747235C (pt)
IL (1) IL213476A0 (pt)
WO (1) WO2010068867A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2340254B8 (en) 2008-09-15 2014-05-21 Biovista, Inc. Compositions and methods for treating epilepsy
US10052299B2 (en) 2009-10-30 2018-08-21 Retrotope, Inc. Alleviating oxidative stress disorders with PUFA derivatives
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
KR102112087B1 (ko) 2011-04-26 2020-05-18 레트로토프 인코포레이티드 에너지 프로세싱 손상 장애 및 미토콘드리아 결함
JP6145087B2 (ja) 2011-04-26 2017-06-07 レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． Ｐｕｆａ酸化関与障害
JP6106157B2 (ja) 2011-04-26 2017-03-29 レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． 神経変性障害および筋疾患に関与するｐｕｆａ
WO2012148930A2 (en) 2011-04-26 2012-11-01 Retrotope, Inc. Oxidative retinal diseases
WO2013130422A1 (en) * 2012-02-27 2013-09-06 Biovista, Inc. Compositions and methods for treating mitochondrial diseases
BR112015019564A2 (pt) * 2013-02-15 2017-07-18 Teva Pharma tratamento de esclerose múltipla com laquinimod
KR101521807B1 (ko) * 2014-01-20 2015-05-20 한국전자통신연구원 데이터 전송 제어 장치 및 그 방법
SMT202400359T1 (it) * 2014-05-09 2024-11-15 Tecnimede Sociedade Tecnico Medicinal S Sali mandelati degli enantiomeri del pirlindolo per l'uso in medicina
EP3950649A1 (en) 2015-11-23 2022-02-09 Retrotope, Inc. Site-specific isotopic labeling of 1, 4-diene systems
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN109982712A (zh) 2016-08-31 2019-07-05 Mapi医药公司 包含醋酸格拉替雷的储库系统
CN110382052A (zh) 2017-03-26 2019-10-25 Mapi医药公司 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统
EP3520803A1 (en) * 2018-01-31 2019-08-07 Zarodex Therapeutics Limited Novel uses
IL295783B2 (en) 2020-02-21 2026-03-01 Retrotope Inc Processes for isotopic alteration of polyunsaturated fatty acids and their derivatives
US12109194B2 (en) 2021-02-05 2024-10-08 Biojiva Llc Synergistic combination therapy for treating ALS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959470A (en) * 1972-11-28 1976-05-25 Mikhail Davidovich Mashkovsky Psychotropic medicinal preparation
US5300645A (en) * 1993-04-14 1994-04-05 Eli Lilly And Company Tetrahydro-pyrido-indole
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
WO2004098638A1 (ja) * 2003-05-06 2004-11-18 Ono Pharmaceutical Co., Ltd. エフェクター細胞機能阻害剤
RU2281085C2 (ru) * 2004-05-25 2006-08-10 Закрытое акционерное общество "Мастерлек" Антидепрессивные лекарственные средства для парентерального применения на основе сульфонатных солей пирлиндола
EP1688161A1 (en) * 2004-11-02 2006-08-09 Switch Biotech Aktiengesellschaft Use of pirlindole for the treatment of diseases which are characterized by proliferation of t-lymphocytes and/or hyperproliferation of keratinocytes in particular atopic dermatitis and psoriasis
KR20080034171A (ko) * 2005-07-28 2008-04-18 브리스톨-마이어스 스큅 컴퍼니 세로토닌 수용체 효능제 및 길항제로서의 치환된테트라히드로-1ｈ-피리도[4,3,ｂ]인돌
MX2009012788A (es) * 2007-05-25 2010-01-14 Medivation Neurology Inc Metodos y composiciones para estimular celulas.

Also Published As

Publication number Publication date
IL213476A0 (en) 2011-07-31
JP2012512165A (ja) 2012-05-31
AU2009324495B2 (en) 2015-12-24
EP2375900A1 (en) 2011-10-19
US20110268699A1 (en) 2011-11-03
CA2747235A1 (en) 2010-06-17
CA2747235C (en) 2021-02-09
EP2375900B1 (en) 2016-03-02
CN102395275A (zh) 2012-03-28
EP2375900A4 (en) 2012-05-02
WO2010068867A1 (en) 2010-06-17
AU2009324495A1 (en) 2011-07-28

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL