BRPI0923326A2 - Composto, composição farmacêutica, métodos para inibir girasse de dna bacteriana e/ou topisomerase iv bacteriana, para produzir um efeito antibacteriano em um animal de sangue quente, e para tratar uma infecção bacteriana, uso de um composto, e, processo para preparar um composto. - Google Patents

Composto, composição farmacêutica, métodos para inibir girasse de dna bacteriana e/ou topisomerase iv bacteriana, para produzir um efeito antibacteriano em um animal de sangue quente, e para tratar uma infecção bacteriana, uso de um composto, e, processo para preparar um composto.

Info

Publication number
BRPI0923326A2
BRPI0923326A2 BRPI0923326A BRPI0923326A BRPI0923326A2 BR PI0923326 A2 BRPI0923326 A2 BR PI0923326A2 BR PI0923326 A BRPI0923326 A BR PI0923326A BR PI0923326 A BRPI0923326 A BR PI0923326A BR PI0923326 A2 BRPI0923326 A2 BR PI0923326A2
Authority
BR
Brazil
Prior art keywords
compound
bacterial
treatment
warm
preparing
Prior art date
Application number
BRPI0923326A
Other languages
English (en)
Inventor
Steven Basarab Gregory
Hill Pamela
Sherer Brian
Zhou Fei
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0923326A2 publication Critical patent/BRPI0923326A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, MÉTODOS PARA INIBIR GIRASE DE DNA BACTERIANA E/OU TOPOISOMERASE IV BACTERIANA, PARA PRODUZIR UM EFEITO ANTIBACTERIANO EM 5 UM ANIMAL DE SANGUE QUENTE, E PARA TRATAR UMA INFECÇÃO BACTERIANA, USO DE UM COMPOSTO, E, PROCESSO PARA PREPARAR UM COMPOSTO. Descreve-se compostos de fórmula (I) e seus sais farmaceuticamente aceitáveis. Descreve-se também processos para sua preparação, composições farmacêuticas contendo os mesmos, seu uso como medicamentos e seu uso no tratamento de infecções bacterianas. Anel A é selecionado da fórmula (a), (b) ou (b').
BRPI0923326A 2008-12-12 2009-12-11 Composto, composição farmacêutica, métodos para inibir girasse de dna bacteriana e/ou topisomerase iv bacteriana, para produzir um efeito antibacteriano em um animal de sangue quente, e para tratar uma infecção bacteriana, uso de um composto, e, processo para preparar um composto. BRPI0923326A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12195308P 2008-12-12 2008-12-12
PCT/GB2009/051691 WO2010067123A1 (en) 2008-12-12 2009-12-11 2- (piperidin-1-yl) -4-heterocyclyl-thiazole-5-carboxylic acid derivatives against bacterial infections

Publications (1)

Publication Number Publication Date
BRPI0923326A2 true BRPI0923326A2 (pt) 2017-07-11

Family

ID=41818426

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923326A BRPI0923326A2 (pt) 2008-12-12 2009-12-11 Composto, composição farmacêutica, métodos para inibir girasse de dna bacteriana e/ou topisomerase iv bacteriana, para produzir um efeito antibacteriano em um animal de sangue quente, e para tratar uma infecção bacteriana, uso de um composto, e, processo para preparar um composto.

Country Status (13)

Country Link
US (2) US8071605B2 (pt)
EP (1) EP2376488A1 (pt)
JP (1) JP2012511561A (pt)
KR (1) KR20110097825A (pt)
CN (1) CN102317286A (pt)
AR (1) AR074608A1 (pt)
AU (1) AU2009326141A1 (pt)
BR (1) BRPI0923326A2 (pt)
CA (1) CA2745063A1 (pt)
MX (1) MX2011005909A (pt)
TW (1) TW201026695A (pt)
UY (1) UY32315A (pt)
WO (1) WO2010067123A1 (pt)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2430569T3 (es) * 2005-02-18 2013-11-21 Astrazeneca Ab Compuestos antibacterianos derivados de piperidina
TW201026694A (en) * 2008-12-12 2010-07-16 Astrazeneca Ab Compound 468
KR20120117905A (ko) 2010-01-28 2012-10-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 프로테아좀 활성을 향상시키는 조성물 및 방법
TR201906779T4 (tr) * 2011-05-12 2019-05-21 Proteostasis Therapeutics Inc Proteostaz regülatörleri.
WO2014116228A1 (en) 2013-01-25 2014-07-31 President And Fellows Of Harvard College Usp14 inhibitors for treating or preventing viral infections
WO2015073528A1 (en) 2013-11-12 2015-05-21 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
WO2015108881A1 (en) 2014-01-14 2015-07-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
TN2016000270A1 (en) 2014-01-14 2017-10-06 Millennium Pharm Inc Heteroaryls and uses thereof.
EP3282933B1 (en) * 2015-05-13 2020-07-08 Alivecor, Inc. Discordance monitoring
CN105067814A (zh) * 2015-07-24 2015-11-18 中国科学院成都生物研究所 解旋酶水解atp活性测定方法
ES2817749T3 (es) 2015-09-30 2021-04-08 Daiichi Sankyo Co Ltd Derivados de hidroxialquil tiadiazol
US11857352B2 (en) 2016-09-06 2024-01-02 The Research Foundation For The State University Of New York Positron imaging tomography imaging agent composition and method for bacterial infection
JP2020511457A (ja) 2017-03-14 2020-04-16 第一三共株式会社 ヒドロキシアルキルチアジアゾール誘導体のｎ−ホスホノキシメチルプロドラッグ
RU2019133662A (ru) 2017-03-24 2021-04-26 Тайсо Фармасьютикал Ко., Лтд. Производное 2(1h)-хинолинона
EP3847172A1 (en) 2018-09-03 2021-07-14 Univerza v Ljubljani New class of dna gyrase and/or topoisomerase iv inhibitors with activity against gram-positive and gram-negative bacteria
EP4263503A1 (en) 2020-12-17 2023-10-25 Univerza V Ljubljani New n-phenylpyrrolamide inhibitors of dna gyrase and topoisomerase iv with antibacterial activity
CN115466246B (zh) * 2021-06-11 2024-02-06 中国医学科学院药物研究所 吡咯酰哌啶胺类化合物及其用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2735475B1 (fr) 1995-06-13 1997-07-11 Synthelabo Derives de n-((1,4-diazabicyclo(2.2.2)oct-2-yl)methyl) benzamide, leur preparation et leur application en therapeutique
TW538046B (en) 1998-01-08 2003-06-21 Hoechst Marion Roussel Inc Aromatic amides having antiobiotic activities and the preparation processes, intermediates and pharmaceutical composition thereof
MXPA02007134A (es) 2000-01-18 2003-03-27 Vertex Pharma Inhibidores de girasa y usos de los mismos.
PL362691A1 (en) 2000-12-15 2004-11-02 Vertex Pharmaceuticals Incorporated Bacterial gyrase inhibitors and uses thereof
CA2467718C (en) 2001-12-21 2011-04-26 Anormed Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
TW200526626A (en) 2003-09-13 2005-08-16 Astrazeneca Ab Chemical compounds
ES2430569T3 (es) 2005-02-18 2013-11-21 Astrazeneca Ab Compuestos antibacterianos derivados de piperidina
EP1856103A2 (en) 2005-02-18 2007-11-21 AstraZeneca AB Pyrrole derivatives as dna gyrase and topoisomerase inhibitors
WO2006087548A2 (en) 2005-02-18 2006-08-24 Astrazeneca Ab Pyrrole derivatives as dna gyrase and topoisomerase inhibitors
JP2008531673A (ja) 2005-03-04 2008-08-14 アストラゼネカ アクチボラグ 抗菌活性をもつアゼチジン及びピロールの三環式誘導体
US20080269214A1 (en) 2005-03-04 2008-10-30 Astrazeneca Ab Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors
TW200819437A (en) 2006-08-17 2008-05-01 Astrazeneca Ab Chemical compounds
TW200906412A (en) 2007-06-12 2009-02-16 Astrazeneca Ab Piperidine compounds and uses thereof

Also Published As

Publication number Publication date
AR074608A1 (es) 2011-01-26
US20100173909A1 (en) 2010-07-08
TW201026695A (en) 2010-07-16
EP2376488A1 (en) 2011-10-19
JP2012511561A (ja) 2012-05-24
WO2010067123A1 (en) 2010-06-17
US20120028979A1 (en) 2012-02-02
AU2009326141A1 (en) 2011-06-30
CN102317286A (zh) 2012-01-11
MX2011005909A (es) 2011-06-20
UY32315A (es) 2010-07-30
KR20110097825A (ko) 2011-08-31
US8071605B2 (en) 2011-12-06
CA2745063A1 (en) 2010-06-17

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]