DK1506214T3 - 6-11 bicykliske ketolidderivater - Google Patents

6-11 bicykliske ketolidderivater

Info

Publication number
DK1506214T3
DK1506214T3 DK03733983.5T DK03733983T DK1506214T3 DK 1506214 T3 DK1506214 T3 DK 1506214T3 DK 03733983 T DK03733983 T DK 03733983T DK 1506214 T3 DK1506214 T3 DK 1506214T3
Authority
DK
Denmark
Prior art keywords
present
compounds
subject
ketolide derivatives
invention further
Prior art date
Application number
DK03733983.5T
Other languages
English (en)
Inventor
Yanchun Wang
Yulin Peng
Yat Sun Or
Guoqiang Wang
Deqiang Niu
Yao-Ling Qiu
Marina Busuyek
Ying Hou
Tongzhu Liu
Guoyou Xu
Ly Tam Phan
Heejin Kim
Nha Huu Vo
Jay Judson Farmer
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Priority claimed from PCT/US2003/014669 external-priority patent/WO2003097659A1/en
Application granted granted Critical
Publication of DK1506214T3 publication Critical patent/DK1506214T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK03733983.5T 2002-05-13 2003-05-09 6-11 bicykliske ketolidderivater DK1506214T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14455802A 2002-05-13 2002-05-13
US10/429,485 US6878691B2 (en) 2002-05-13 2003-05-05 6-11 bicyclic ketolide derivatives
PCT/US2003/014669 WO2003097659A1 (en) 2002-05-13 2003-05-09 6-11 bicyclic ketolide derivatives

Publications (1)

Publication Number Publication Date
DK1506214T3 true DK1506214T3 (da) 2010-05-25

Family

ID=34134634

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03733983.5T DK1506214T3 (da) 2002-05-13 2003-05-09 6-11 bicykliske ketolidderivater

Country Status (10)

Country Link
US (1) US6878691B2 (da)
KR (1) KR100687956B1 (da)
CN (1) CN102127133B (da)
AT (1) ATE455786T1 (da)
CY (1) CY1109970T1 (da)
DE (1) DE60331056D1 (da)
DK (1) DK1506214T3 (da)
ES (1) ES2339647T3 (da)
PT (1) PT1506214E (da)
TW (1) TWI327573B (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135573B2 (en) * 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
NZ536402A (en) * 2002-05-13 2006-08-31 Enanta Pharm Inc 6,11 bicyclic erythromycin derivatives
US7091196B2 (en) * 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
AU2004217919A1 (en) * 2003-03-05 2004-09-16 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using the same
US20050101548A1 (en) * 2003-09-12 2005-05-12 Xiaodong Lin Antimicrobial derivatives
WO2005042554A1 (en) * 2003-10-30 2005-05-12 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
JP2007512256A (ja) * 2003-11-18 2007-05-17 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法
WO2005067564A2 (en) * 2004-01-07 2005-07-28 Enanta Pharmaceuticals, Inc. 6-11 bicyclic erythromycin derivatives
US7265094B2 (en) * 2004-01-09 2007-09-04 Enanta Pharmaceuticals, Inc. 9N-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
EP2716647A3 (en) * 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US20060058247A1 (en) * 2004-09-16 2006-03-16 Yujiro Hata Methods and compositions for treating cystic fibrosis
US7538225B2 (en) * 2005-05-02 2009-05-26 Enanta Pharmaceuticals, Inc. Processes for the preparation of o-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
CA2605295A1 (en) * 2005-05-04 2006-11-09 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US20060264386A1 (en) * 2005-05-17 2006-11-23 Rongqi Sun Pharmaceutical formulations of 6-11 bicyclic ketolide derivatives and related macrolides and methods for preparation thereof
US7589067B2 (en) * 2005-10-12 2009-09-15 Enanta Pharmaceuticals, Inc. 6, 11-bridged tricyclic macrolides
EP1960413A2 (en) * 2005-11-23 2008-08-27 Ranbaxy Laboratories Limited Macrolides derivatives as antibacterial agents
US7563877B2 (en) * 2006-03-02 2009-07-21 Enanta Pharmaceuticals, Inc. Processes for the preparation of 0-(2-aminobenzo[d]oxazol-5-yl)methyl hydroxylamine for the synthesis of 6,11-bicyclic erythromycin derivative EDP-182
US20070231368A1 (en) * 2006-03-30 2007-10-04 Enanta Pharmaceuticals, Inc. Pharmaceutical formulations of 6-11 bicyclic macrolide derivative known as edp-182 and methods for preparation thereof
WO2007143507A2 (en) * 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted erythromycin analogs
WO2008014221A2 (en) * 2006-07-24 2008-01-31 Enanta Pharmaceuticals, Inc. Bridged carbamate macrolides
US20080039406A1 (en) * 2006-08-04 2008-02-14 Yao-Ling Qiu 3,6-bridged tylosin derivatives
WO2008061189A1 (en) * 2006-11-16 2008-05-22 Enanta Pharmaceuticals, Inc. C-9 alkenylidine bridged macrolides
US7524512B2 (en) * 2007-07-13 2009-04-28 Di Bartolomeo Joseph R Composition and method for the prevention and relief of the symptoms of an incompetent or patulous Eustachian tube
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
MX2010002932A (es) 2007-09-17 2010-05-27 Enanta Pharm Inc Macrolidos de biarilo con puente en 6, 11.
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
US20090131343A1 (en) * 2007-11-15 2009-05-21 Ly Tam Phan Use of bridged macrolides or tylosin derivatives in treating inflammatory bowel diseases
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
US7842813B2 (en) * 2008-05-09 2010-11-30 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-[5-(4-amino-thiazol-2-yl)-pyridin-2-ylmethyl]-hydroxylamine
US8552162B2 (en) * 2008-05-09 2013-10-08 Enanta Pharmaceuticals, Inc. Processes for the preparation of 2 fluoro 6-11 bicyclic erythromycin derivatives
KR101118597B1 (ko) * 2008-12-24 2012-02-27 한국전자통신연구원 모바일용 컴퓨터 그래픽 랜더링 방법 및 시스템
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
SG11201509544WA (en) * 2011-12-19 2015-12-30 Biosynthetic Technologies Llc Processes for preparing estolide base oils and oligomeric compounds that include cross metathesis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960000434B1 (ko) 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
US4921836A (en) 1989-05-17 1990-05-01 Burroughs Wellcome Co. Substituted glutamic acids
IL99995A (en) 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
EP0559896B1 (en) 1990-11-28 1997-08-27 Taisho Pharmaceutical Co. Ltd 6-o-methylerythromycin a derivative
US5202434A (en) 1991-04-05 1993-04-13 Merck & Co., Inc. 8a-aza-8a-homoerythromycin lactams
US5556839A (en) 1991-04-29 1996-09-17 Eli Lilly And Company Form II Dirithromycin
ES2087737T3 (es) 1992-04-22 1996-07-16 Taisho Pharmaceutical Co Ltd Un derivado 5-o-desosaminil-eritronoluro a.
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
US5441939A (en) 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
FR2738571B1 (fr) 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
UA51730C2 (uk) 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
US6046171A (en) 1997-10-29 2000-04-04 Abbott Laboratories 6,11-bridged erythromycin derivatives
US6124269A (en) 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
US6399582B1 (en) 1999-04-16 2002-06-04 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials

Also Published As

Publication number Publication date
ATE455786T1 (de) 2010-02-15
ES2339647T3 (es) 2010-05-24
KR100687956B1 (ko) 2007-02-28
CY1109970T1 (el) 2014-09-10
PT1506214E (pt) 2010-04-27
DE60331056D1 (de) 2010-03-11
KR20050003455A (ko) 2005-01-10
US20050037982A1 (en) 2005-02-17
CN102127133B (zh) 2015-04-15
CN102127133A (zh) 2011-07-20
US6878691B2 (en) 2005-04-12
TW200400969A (en) 2004-01-16
TWI327573B (en) 2010-07-21
HK1074447A1 (en) 2005-11-11

Similar Documents

Publication Publication Date Title
ATE455786T1 (de) 6-11 bicyclische ketolidderivate
WO2004062601A3 (en) Antibacterial agents
WO2005000863A3 (en) 6, 11-4c-bicyclic 9a-azalide derivatives
UA94901C2 (ru) Антибактериальные производные пиперидина
WO2004087728A3 (en) 6,11-3c-bicyclic 9a-azalide derivatives
WO2008154642A3 (en) Antibacterial agents
NO20092542L (no) Antibakterielle kinolin-derivater
WO2004096823A3 (en) Novel ketolide derivatives
BR0310050A (pt) Derivados de cetolida 6-11 bicìclicas, composições farmacêuticas e processos referentes aos mesmos
NO20092539L (no) Antibakterielle kinolin-derivater
CA2483875A1 (en) 6,11 bicyclic erythromycin derivatives
MX2010002932A (es) Macrolidos de biarilo con puente en 6, 11.
TW200634021A (en) 3,6-bicyclolides
WO2005070113A3 (en) 9n-substituted 6-11 bicyclic erythromycin derivatives
NO20092547L (no) Antibakterielle kinolin-derivater
WO2007071965A3 (en) Antibacterial pyrrolopyridines, pyrrolopyrimidines, and pyrroloazepines
WO2006039263A3 (en) NOVEL BICYCLIC 9a-AZALIDE DERIVATIVES
WO2005067564A3 (en) 6-11 bicyclic erythromycin derivatives
WO2006065721A3 (en) 11, 12-lactone bicyclolides
NO20092536L (no) Antibakterielle kinolin-derivater
NO20092540L (no) Antibakterielle kinolin-derivater
TW200635600A (en) Tetracyclic bicyclolides
NO20092541L (no) Antibakterielle kinolin-derivater
WO2007044927A3 (en) 6, 11-bridged tricyclic macrolides
WO2008014221A3 (en) Bridged carbamate macrolides