BRPI0923380A2 - Processos para a preparação de compostos de piperazina e sais de hidrocloreto dos mesmos - Google Patents

Processos para a preparação de compostos de piperazina e sais de hidrocloreto dos mesmos

Info

Publication number
BRPI0923380A2
BRPI0923380A2 BRPI0923380-6A BRPI0923380A BRPI0923380A2 BR PI0923380 A2 BRPI0923380 A2 BR PI0923380A2 BR PI0923380 A BRPI0923380 A BR PI0923380A BR PI0923380 A2 BRPI0923380 A2 BR PI0923380A2
Authority
BR
Brazil
Prior art keywords
processes
preparation
hydrochloride salts
piperazine compounds
piperazine
Prior art date
Application number
BRPI0923380-6A
Other languages
English (en)
Inventor
László Czibula
Bálint Juhász
Éva Ágainé Csongor
Ferenc Sebök
János Galambos
Katalim Nógrádi
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of BRPI0923380A2 publication Critical patent/BRPI0923380A2/pt
Publication of BRPI0923380B1 publication Critical patent/BRPI0923380B1/pt
Publication of BRPI0923380B8 publication Critical patent/BRPI0923380B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0923380A 2008-12-18 2009-12-18 Processo para preparação de compostos trans de n-{4-{2-[4-(2,3-diclorofenil)-piperazina-1-il]-etil}-ciclohexil}-carbamida e sais hidrocloretos dos mesmos BRPI0923380B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0800765A HUP0800765A2 (en) 2008-12-18 2008-12-18 A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800765 2008-12-18
PCT/HU2009/000109 WO2010070370A1 (en) 2008-12-18 2009-12-18 Process for the preparation of piperazine compounds and hydrochloride salts thereof

Publications (3)

Publication Number Publication Date
BRPI0923380A2 true BRPI0923380A2 (pt) 2015-07-28
BRPI0923380B1 BRPI0923380B1 (pt) 2022-05-24
BRPI0923380B8 BRPI0923380B8 (pt) 2022-07-19

Family

ID=89988674

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923380A BRPI0923380B8 (pt) 2008-12-18 2009-12-18 Processo para preparação de compostos trans de n-{4-{2-[4-(2,3-diclorofenil)-piperazina-1-il]-etil}-ciclohexil}-carbamida e sais hidrocloretos dos mesmos

Country Status (27)

Country Link
US (1) US8569498B2 (pt)
EP (1) EP2358691B8 (pt)
JP (1) JP5744751B2 (pt)
CN (1) CN102256954B (pt)
AU (1) AU2009329295B2 (pt)
BR (1) BRPI0923380B8 (pt)
CA (1) CA2744073C (pt)
CY (1) CY1113923T1 (pt)
DK (1) DK2358691T3 (pt)
EA (1) EA019329B1 (pt)
ES (1) ES2407182T3 (pt)
GE (1) GEP20125712B (pt)
HR (1) HRP20130394T1 (pt)
HU (1) HUP0800765A2 (pt)
IL (1) IL212640A (pt)
IN (1) IN2011KN02904A (pt)
MX (1) MX2011006590A (pt)
NZ (1) NZ592906A (pt)
PL (1) PL2358691T3 (pt)
PT (1) PT2358691E (pt)
RS (1) RS52738B (pt)
SG (1) SG171716A1 (pt)
SI (1) SI2358691T1 (pt)
SM (1) SMT201300063B (pt)
TW (1) TWI460164B (pt)
UA (1) UA102422C2 (pt)
WO (1) WO2010070370A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
KR20130115393A (ko) * 2008-02-21 2013-10-21 미쓰비시 타나베 파마 코퍼레이션 경구 투여용 고형 제제
AP2975A (en) 2008-07-16 2014-09-30 Richter Gedeon Nyrt Pharmaceutical formulations containing dopamine receptor ligands
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0900790A2 (en) * 2009-12-17 2011-09-28 Richter Gedeon Nyrt A new process for the preparation of piperazine and their hydrochloric salts
EP2508525A1 (en) 2011-04-05 2012-10-10 Bayer Pharma Aktiengesellschaft Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts
CN104140421B (zh) 2013-05-08 2017-04-05 上海医药工业研究院 苯并异噻唑类化合物及在制备抗精神分裂症药物中的应用
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
CN110317182B (zh) * 2018-03-29 2021-10-15 上虞京新药业有限公司 一种卡利拉嗪的制备方法
CN108586389B (zh) * 2018-06-29 2020-06-12 成都福柯斯医药技术有限公司 一种合成卡利拉嗪的方法
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN111892556A (zh) * 2019-05-06 2020-11-06 北京万全德众医药生物技术有限公司 新的卡利拉嗪制备方法
CN110372557B (zh) * 2019-08-06 2021-05-18 上海勋和医药科技有限公司 环己烷胺类d3/d2受体部分激动剂
CN113754580B (zh) 2020-06-05 2023-04-25 上海中泽医药科技有限公司 一种吡啶吗啉类化合物、其制备方法及其应用
CN113912565A (zh) * 2020-07-11 2022-01-11 广东东阳光药业有限公司 一种卡利拉嗪的新晶型及其制备方法
KR102921799B1 (ko) 2023-01-11 2026-02-04 리히터 게데온 닐트. 도파민 d3/d2 수용체 조절 화합물

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US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
US5047406A (en) 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
CN1087725C (zh) 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
AU6859096A (en) 1995-09-22 1997-04-09 Warner-Lambert Company Substituted cyclohexylamines as central nervous system agents
AU762726B2 (en) 1998-03-31 2003-07-03 Acadia Pharmaceuticals, Inc. Compounds with activity on muscarinic receptors
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
US6489341B1 (en) 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
HUP0303261A3 (en) 2001-02-27 2012-07-30 Ortho Mcneil Pharm Inc Carbamate compounds for use in preventing or treating bipolar disorder
US6566550B2 (en) 2001-06-21 2003-05-20 Pfizer Inc Substituted aromatic ethers as inhibitors of glycine transport
HU227543B1 (en) 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
SE0200301D0 (sv) 2002-02-01 2002-02-01 Axon Biochemicals Bv Thio-carbostyril derivative
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
DE102004047517A1 (de) 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
AU2008251520B2 (en) 2007-05-11 2014-03-06 Richter Gedeon Nyrt. Novel solvate and crystalline forms of carbamoyl-cyclohexane derivatives
HU230748B1 (hu) 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700370A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
EP2185149A1 (en) 2007-08-01 2010-05-19 H. Lundbeck A/S Use of kncq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
KR20130115393A (ko) 2008-02-21 2013-10-21 미쓰비시 타나베 파마 코퍼레이션 경구 투여용 고형 제제
AP2975A (en) 2008-07-16 2014-09-30 Richter Gedeon Nyrt Pharmaceutical formulations containing dopamine receptor ligands
HU230067B1 (hu) 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives

Also Published As

Publication number Publication date
BRPI0923380B8 (pt) 2022-07-19
WO2010070370A8 (en) 2011-04-28
HK1160849A1 (zh) 2012-08-17
IN2011KN02904A (pt) 2015-07-10
SG171716A1 (en) 2011-07-28
PT2358691E (pt) 2013-05-22
EA201170808A1 (ru) 2011-12-30
EP2358691B8 (en) 2013-05-01
EP2358691A1 (en) 2011-08-24
EA019329B1 (ru) 2014-02-28
DK2358691T3 (da) 2013-05-21
RS52738B (sr) 2013-08-30
WO2010070370A1 (en) 2010-06-24
CN102256954B (zh) 2016-09-28
TWI460164B (zh) 2014-11-11
TW201033180A (en) 2010-09-16
BRPI0923380B1 (pt) 2022-05-24
CA2744073C (en) 2016-07-12
ES2407182T3 (es) 2013-06-12
CA2744073A1 (en) 2010-06-24
CY1113923T1 (el) 2016-07-27
CN102256954A (zh) 2011-11-23
IL212640A (en) 2014-06-30
EP2358691B1 (en) 2013-03-20
HU0800765D0 (en) 2009-03-02
AU2009329295A1 (en) 2010-06-24
JP2012512861A (ja) 2012-06-07
HRP20130394T1 (en) 2013-06-30
GEP20125712B (en) 2012-12-10
HUP0800765A2 (en) 2010-11-29
UA102422C2 (ru) 2013-07-10
SMT201300063B (it) 2013-07-09
US20110275804A1 (en) 2011-11-10
JP5744751B2 (ja) 2015-07-08
MX2011006590A (es) 2011-07-12
PL2358691T3 (pl) 2013-08-30
AU2009329295B2 (en) 2014-02-06
SI2358691T1 (sl) 2013-07-31
NZ592906A (en) 2013-07-26
US8569498B2 (en) 2013-10-29
IL212640A0 (en) 2011-07-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 295/135

Ipc: C07D 295/135 (2006.01), A61K 31/495 (2006.01)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/12/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REF. RPI 2681 DE 24/05/2022 QUANTO AO INVENTOR.