BRPI0923871B8 - compostos dipirrometenos substituídos por boro fluorescentes e uso dos mesmos para diagnósticos - Google Patents

compostos dipirrometenos substituídos por boro fluorescentes e uso dos mesmos para diagnósticos

Info

Publication number
BRPI0923871B8
BRPI0923871B8 BRPI0923871A BRPI0923871A BRPI0923871B8 BR PI0923871 B8 BRPI0923871 B8 BR PI0923871B8 BR PI0923871 A BRPI0923871 A BR PI0923871A BR PI0923871 A BRPI0923871 A BR PI0923871A BR PI0923871 B8 BRPI0923871 B8 BR PI0923871B8
Authority
BR
Brazil
Prior art keywords
diagnostics
fluorescent
substituted
dipyrromethene compounds
boron
Prior art date
Application number
BRPI0923871A
Other languages
English (en)
Inventor
Haefele Alexandre
Liegeois Corinne
Ulrich Gilles
De Barry Jean
Ziessel Raymond
Bura Thomas
Original Assignee
Centre Nat Rech Scient
Univ Strasbourg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Univ Strasbourg filed Critical Centre Nat Rech Scient
Publication of BRPI0923871A2 publication Critical patent/BRPI0923871A2/pt
Publication of BRPI0923871B1 publication Critical patent/BRPI0923871B1/pt
Publication of BRPI0923871B8 publication Critical patent/BRPI0923871B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)

Abstract

compostos dipirrometenos substituídos por boro fluorescentes e uso dos mesmos para diagnóstico a invenção refere-se a novos compostos fluorescentes derivados de dipirrometeno não fluorados, a um método para a preparação dos mesmos e uso dos mesmos para a marcação fluorescente de moléculas biológicas. a invenção também se refere a moléculas biológicas marcadas com os referidos compostos fluorescentes, e ao uso das mesmas em métodos de detecção, tais como métodos de diagnóstico médico. mais particularmente, os métodos de detecção da invenção são particularmente úteis para o diagnóstico de doenças neurodegenerativas tais como doenças de alzheimer.
BRPI0923871A 2008-12-29 2009-12-28 compostos dipirrometenos substituídos por boro fluorescentes e uso dos mesmos para diagnósticos BRPI0923871B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0807473A FR2940653B1 (fr) 2008-12-29 2008-12-29 Nouveaux composes dipyrromethenes-borosubstitues fluorescents et leur utilisation pour le diagnostic
FR0807473 2008-12-29
PCT/FR2009/001486 WO2010076433A1 (fr) 2008-12-29 2009-12-28 Nouveaux composes dipyrromethenes-borosubstitues fluorescents et leur utilisation pour le diagnostic

Publications (3)

Publication Number Publication Date
BRPI0923871A2 BRPI0923871A2 (pt) 2015-08-11
BRPI0923871B1 BRPI0923871B1 (pt) 2020-12-15
BRPI0923871B8 true BRPI0923871B8 (pt) 2021-07-27

Family

ID=40934092

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923871A BRPI0923871B8 (pt) 2008-12-29 2009-12-28 compostos dipirrometenos substituídos por boro fluorescentes e uso dos mesmos para diagnósticos

Country Status (10)

Country Link
US (1) US8993781B2 (pt)
EP (1) EP2384329B1 (pt)
JP (1) JP5924939B2 (pt)
CN (1) CN102300867B (pt)
AU (1) AU2009334648B2 (pt)
BR (1) BRPI0923871B8 (pt)
CA (1) CA2748313C (pt)
FR (1) FR2940653B1 (pt)
IL (1) IL213832A (pt)
WO (1) WO2010076433A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2940654B1 (fr) * 2008-12-29 2012-01-13 Centre Nat Rech Scient Composes flurorescents hydrophiles a base de dipyrromethenes-bore
WO2013164763A2 (en) * 2012-04-30 2013-11-07 Innovative Health Diagnostics A biological complex specific for alzheimer's disease detection in vitro and use thereof
US10005793B2 (en) 2012-10-01 2018-06-26 The General Hospital Corporation Bodipy dyes for biological imaging
CN103183697B (zh) * 2013-02-26 2015-08-26 南京大学 基于二联杂环并吡咯基团的近红外氟硼二吡咯化合物及其制法和用途
US9588129B2 (en) 2013-03-15 2017-03-07 Amira Medical Technologies Inc. Methods for analyzing blood to detect diseases associated with abnormal protein aggregation
AU2015311836B2 (en) * 2014-09-05 2021-03-11 Presympto, Inc. Methods for detecting amyloid beta oligomers
CN104628998B (zh) * 2015-01-14 2016-08-24 合肥工业大学 一种手性荧光自分类聚合双官能团引发剂及其制备方法及其应用
JP6710435B2 (ja) * 2015-03-06 2020-06-17 国立研究開発法人科学技術振興機構 ジピリンホウ素錯体及びこれを含有する医薬
WO2017153922A2 (en) * 2016-03-07 2017-09-14 Amoneta Diagnostics Sas Detection of neurodegenerative diseases
EP3517146A1 (en) * 2018-01-26 2019-07-31 Université de Strasbourg Fluorescent polymeric coating film for medical devices
JP6867962B2 (ja) * 2018-02-22 2021-05-12 富士フイルム株式会社 測定対象物質を測定するためのキット、蛍光標識剤および蛍光標識抗体
US20200048469A1 (en) * 2018-08-07 2020-02-13 Becton, Dickinson And Company Polymeric tandem dyes having pendant narrow emission acceptor
CN109234759B (zh) * 2018-11-02 2019-10-25 陕西师范大学 一种bodipy的合成方法
FR3101875A1 (fr) * 2019-10-10 2021-04-16 Centre National De La Recherche Scientifique Analogue fluorescent de la vancomycine
US11193891B2 (en) 2019-12-20 2021-12-07 Robert Bosch Gmbh Receptors and spacers for a fluorescence-based lead ion chemosensor
IL299971B2 (en) 2020-09-05 2026-02-01 Council Scient Ind Res Self-assembled thermoresponsive organic material as photonic ink and its fabrication process
CN116731056B (zh) * 2023-06-14 2025-10-21 淮阴工学院 一种亲水性等边三角形bodipy光动力灭菌荧光探针3n-ibdp及其制备方法
CN117964606B (zh) * 2024-03-28 2024-06-21 华南理工大学 一种光氧化与成像Aβ1-42聚集体双功能荧光探针及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4744339A (en) 1986-06-06 1988-05-17 Honda Giken Kogyo Kabushiki Kaisha Centrifugal spark-advance control device
US4774339A (en) 1987-08-10 1988-09-27 Molecular Probes, Inc. Chemically reactive dipyrrometheneboron difluoride dyes
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5187288A (en) 1991-05-22 1993-02-16 Molecular Probes, Inc. Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis
FR2882056B1 (fr) * 2005-02-15 2007-06-01 Centre Nat Rech Scient Dipyrromethenes-bore borocarbones insatures
FR2882055B1 (fr) 2005-02-15 2008-08-22 Centre Nat Rech Scient Dibenzopyrromethenes-bore borocarbones insatures
FR2940654B1 (fr) * 2008-12-29 2012-01-13 Centre Nat Rech Scient Composes flurorescents hydrophiles a base de dipyrromethenes-bore

Also Published As

Publication number Publication date
IL213832A0 (en) 2011-07-31
EP2384329B1 (fr) 2018-05-23
BRPI0923871B1 (pt) 2020-12-15
CN102300867B (zh) 2014-07-16
CN102300867A (zh) 2011-12-28
JP5924939B2 (ja) 2016-05-25
JP2012513973A (ja) 2012-06-21
EP2384329A1 (fr) 2011-11-09
US20110287473A1 (en) 2011-11-24
BRPI0923871A2 (pt) 2015-08-11
AU2009334648A1 (en) 2011-07-21
US8993781B2 (en) 2015-03-31
FR2940653A1 (fr) 2010-07-02
WO2010076433A1 (fr) 2010-07-08
AU2009334648B2 (en) 2015-09-24
IL213832A (en) 2016-03-31
CA2748313C (fr) 2017-07-25
CA2748313A1 (fr) 2010-07-08
FR2940653B1 (fr) 2011-02-04

Similar Documents

Publication Publication Date Title
HaileMariam et al. S-Trap, an ultrafast sample-preparation approach for shotgun proteomics
BR112012001984B8 (pt) anticorpos humanos com alta afinidade para angiopoietina-2 humana, uso dos mesmos e composição farmacêutica
Serrano et al. The S100A4 transcriptional inhibitor niclosamide reduces pro-inflammatory and migratory phenotypes of microglia: implications for amyotrophic lateral sclerosis
WO2009106073A3 (en) Mhc multimers in borrelia diagnostics and disease
EP2326336A4 (en) TISSUE DESIGNS FROM EXTRA CELLULAR PRESENTATION MATRIX
AR083715A1 (es) Composiciones y metodos para la distribucion selectiva de moleculas de oligonucleotidos a tipos especificos de neuronas
BR112012007876A2 (pt) "membranas de troca de íons"
BRPI0807318B8 (pt) "microrna associado a exossomos como marcador diagnóstico"
AR095374A1 (es) Moléculas de unión para bcma y cd3
ES2530843T3 (es) Métodos basados en microARN para el diagnóstico de cáncer de páncreas
BR122018069446B8 (pt) método in vitro para detectar a presença de um célula de câncer em um indivíduo
BR112013010015A2 (pt) aparelho e método para detecção não invasiva de doenças que afetam as propriedades estruturais em tecidos biológicos
BR112014030110A8 (pt) métodos e aparelhos para coletar informação de usuário distribuída para impressões de mídia e termos de pesquisa
EA201000427A1 (ru) Секвенирование нуклеиново-кислотных полимеров с использованием электронной микроскопии
BR112012033406A2 (pt) anticorpo para diagnóstico e/ou prognóstico de câncer
AR080680A1 (es) Proteinas de union a basigina
AU2010202926B2 (en) Markers and methods relating to the assessment of Alzheimer's disease
BR112012033591A2 (pt) processo de detecção de interações moleculares.
BR112014010955A2 (pt) sistema e método para processar amostras
EP2366691A4 (en) NITROPYRIDINYLETHYLENIMINE COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
BRPI0809143B8 (pt) método in vitro para identificar um indivíduo que apresente um risco alterado para desenvolver doença cardíaca coronária (chd) ou aneurisma/dissecção
Dutta et al. Ginsentide TP1 protects hypoxia-induced dysfunction and ER stress-linked apoptosis
Fabrizi et al. Low-invasive sampling method with tape-disc sampling for the taxonomic identification of archeological and paleontological bones by proteomics
WO2009147658A3 (en) Compositions and methods for diagnosis, prognosis and treatment of mesothelioma
Wang et al. 2H solid-state NMR analysis of the dynamics and organization of water in hydrated chitosan

Legal Events

Date Code Title Description
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/12/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/12/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 12A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2650 DE 19-10-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.