BRPI0807318B8 - "microrna associado a exossomos como marcador diagnóstico" - Google Patents

"microrna associado a exossomos como marcador diagnóstico"

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Publication number
BRPI0807318B8
BRPI0807318B8 BRPI0807318A BRPI0807318A BRPI0807318B8 BR PI0807318 B8 BRPI0807318 B8 BR PI0807318B8 BR PI0807318 A BRPI0807318 A BR PI0807318A BR PI0807318 A BRPI0807318 A BR PI0807318A BR PI0807318 B8 BRPI0807318 B8 BR PI0807318B8
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BR
Brazil
Prior art keywords
exosomes
micron
diagnostic marker
individual
present
Prior art date
Application number
BRPI0807318A
Other languages
English (en)
Inventor
Cicek Gercel-Taylor
Douglas D Taylor
Original Assignee
Univ Louisville Res Found Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Louisville Res Found Inc filed Critical Univ Louisville Res Found Inc
Publication of BRPI0807318A2 publication Critical patent/BRPI0807318A2/pt
Publication of BRPI0807318B1 publication Critical patent/BRPI0807318B1/pt
Publication of BRPI0807318B8 publication Critical patent/BRPI0807318B8/pt

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
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  • Biomedical Technology (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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Abstract

microrna associado a exossomos como marcador diagnóstico a matéria revelada na presente invenção provê métodos para o diagnóstico de câncer ou de resultados adversos de gestações em um indivíduo por meio da medição das quantidades de um ou mais micrornas presentes em exossomos derivados de câncer de uma amostra biológica de um indivíduo.
BRPI0807318A 2007-07-25 2008-07-25 "microrna associado a exossomos como marcador diagnóstico" BRPI0807318B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95181207P 2007-07-25 2007-07-25
US60/951,812 2007-07-25
US5043808P 2008-05-05 2008-05-05
US61/050,438 2008-05-05
PCT/US2008/071235 WO2009015357A1 (en) 2007-07-25 2008-07-25 Exosome-associated microrna as a diagnostic marker

Publications (3)

Publication Number Publication Date
BRPI0807318A2 BRPI0807318A2 (pt) 2015-03-24
BRPI0807318B1 BRPI0807318B1 (pt) 2018-11-13
BRPI0807318B8 true BRPI0807318B8 (pt) 2021-07-27

Family

ID=40281854

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0807318A BRPI0807318B8 (pt) 2007-07-25 2008-07-25 "microrna associado a exossomos como marcador diagnóstico"

Country Status (11)

Country Link
US (5) US8216784B2 (pt)
EP (3) EP2181332B1 (pt)
JP (3) JP5156829B2 (pt)
CN (2) CN101755208B (pt)
AU (1) AU2008279016B2 (pt)
BR (1) BRPI0807318B8 (pt)
CA (1) CA2676113C (pt)
ES (1) ES2420973T3 (pt)
GB (1) GB2459228B (pt)
IL (3) IL200028A (pt)
WO (1) WO2009015357A1 (pt)

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US20190085410A1 (en) 2019-03-21
US20100151480A1 (en) 2010-06-17
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JP2013188212A (ja) 2013-09-26
EP2613149A1 (en) 2013-07-10
EP2181332B1 (en) 2013-04-10
BRPI0807318B1 (pt) 2018-11-13
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IL200028A (en) 2015-11-30
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