BRPI0924135A2 - composição farmacêutica sólida compreendendo anlodipino e losartan - Google Patents

composição farmacêutica sólida compreendendo anlodipino e losartan

Info

Publication number: BRPI0924135A2
Authority: BR; Brazil
Prior art keywords: losartan; amlodipine; pharmaceutical composition; solid pharmaceutical; solid
Prior art date: 2009-01-23

Application number

BRPI0924135A

Other languages

English (en)

Inventor

Ho Taek Yim

Jae Hyun Park

Ji Hyun Im

Jong Soo Woo

Kyeong Soo Kim

Yong Ii Kim

Original Assignee

Hanmi Holdings Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-01-23

Filing date

2009-12-28

Publication date

2016-02-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42306870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0924135(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-12-28 Application filed by Hanmi Holdings Co Ltd filed Critical Hanmi Holdings Co Ltd

2016-02-10 Publication of BRPI0924135A2 publication Critical patent/BRPI0924135A2/pt

Links

239000002083 C09CA01 - Losartan Substances 0.000 title 1
HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title 1
229960000528 amlodipine Drugs 0.000 title 1
KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 title 1
229960004773 losartan Drugs 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000007787 solid Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

BRPI0924135A 2009-01-23 2009-12-28 composição farmacêutica sólida compreendendo anlodipino e losartan BRPI0924135A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
KR20090005840		2009-01-23
KR1020090090540A KR101160151B1 (ko)	2009-01-23	2009-09-24	암로디핀 및 로자탄을 함유하는 고형 약제학적 조성물
PCT/KR2009/007829 WO2010085047A2 (en)	2009-01-23	2009-12-28	Solid pharmaceutical composition comprising amlodipine and losartan

Publications (1)

Publication Number	Publication Date
BRPI0924135A2 true BRPI0924135A2 (pt)	2016-02-10

Family

ID=42306870

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
BRPI0924136A BRPI0924136B8 (pt)	2009-01-23	2009-02-13	composição farmacêutica sólida compreendendo amlodipina e losartan e método para a preparação da mesma
BRPI0924137A BRPI0924137A2 (pt)	2009-01-23	2009-06-05	composição farmacêutica sólida compreendendo amlodipina e losartan com melhor estabilidade
BRPI0924135A BRPI0924135A2 (pt)	2009-01-23	2009-12-28	composição farmacêutica sólida compreendendo anlodipino e losartan

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
BRPI0924136A BRPI0924136B8 (pt)	2009-01-23	2009-02-13	composição farmacêutica sólida compreendendo amlodipina e losartan e método para a preparação da mesma
BRPI0924137A BRPI0924137A2 (pt)	2009-01-23	2009-06-05	composição farmacêutica sólida compreendendo amlodipina e losartan com melhor estabilidade

Country Status (32)

Country	Link
US (3)	US9161933B2 (pt)
EP (3)	EP2413931B1 (pt)
JP (3)	JP5658172B2 (pt)
KR (2)	KR101232296B1 (pt)
CN (4)	CN102292085B (pt)
AR (3)	AR070897A1 (pt)
AU (3)	AU2009338267B2 (pt)
BR (3)	BRPI0924136B8 (pt)
CA (3)	CA2749903C (pt)
CL (1)	CL2011001781A1 (pt)
CO (3)	CO6361915A2 (pt)
CR (3)	CR20110449A (pt)
DO (3)	DOP2011000231A (pt)
EA (3)	EA020103B1 (pt)
EC (1)	ECSP11011253A (pt)
ES (3)	ES2580777T3 (pt)
HN (2)	HN2011002022A (pt)
IL (3)	IL214146A0 (pt)
JO (2)	JO2981B1 (pt)
MA (3)	MA33056B1 (pt)
MX (3)	MX349221B (pt)
MY (3)	MY173823A (pt)
NI (3)	NI201100145A (pt)
NZ (3)	NZ594738A (pt)
PE (4)	PE20140978A1 (pt)
SA (1)	SA110310070B1 (pt)
SG (3)	SG173044A1 (pt)
TW (3)	TWI404534B (pt)
UA (3)	UA102721C2 (pt)
UY (2)	UY32389A (pt)
WO (3)	WO2010085014A1 (pt)
ZA (3)	ZA201106160B (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG173044A1 (en)	2009-01-23	2011-08-29	Hanmi Holdings Co Ltd	Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same
JP6106359B2 (ja) *	2010-12-13	2017-03-29	第一三共ヘルスケア株式会社	ロキソプロフェンナトリウムとビタミンｂ１を含有する固形製剤
JP6041591B2 (ja) *	2011-09-13	2016-12-14	大日本住友製薬株式会社	イルベサルタンとアムロジピンまたはその塩を含有する安定化された医薬組成物
KR101861307B1 (ko) *	2011-10-13	2018-07-06	한미약품 주식회사	정제를 포함하는 경질 캡슐 복합 제형
KR101907881B1 (ko) *	2011-12-30	2018-12-11	한미약품 주식회사	로자탄, 암로디핀 및 히드로클로로티아자이드를 포함하는 고정 용량 조합 제형
CN102600146B (zh) *	2012-04-11	2014-10-08	兆科药业（合肥）有限公司	一种盐酸乐卡地平和氯沙坦钾复方制剂及其制备方法
KR101392364B1 (ko) *	2012-04-17	2014-05-07	한국유나이티드제약 주식회사	안정성이 향상된 암로디핀 및 로잘탄을 함유하는 복합제 조성물
JP6160263B2 (ja) *	2012-06-07	2017-07-12	大正製薬株式会社	ロキソプロフェン含有医薬組成物
KR101506148B1 (ko) *	2013-09-24	2015-03-26	대봉엘에스 주식회사	직접 타정할 수 있는 암로디핀 및 로사르탄을 포함하는 약제학적 조성물, 및 이에 의해 제조된 정제
WO2015072700A1 (en) *	2013-11-15	2015-05-21	Hanmi Pharm. Co., Ltd.	Composite formulation comprising tadalafil and amlodipine
KR20150056443A (ko) *	2013-11-15	2015-05-26	한미약품 주식회사	타다라필 및 암로디핀을 포함하는 복합제제
KR101910901B1 (ko) *	2013-11-29	2018-10-24	한미약품 주식회사	암로디핀, 로자탄 및 로수바스타틴을 포함하는 약제학적 복합 제제
KR102369607B1 (ko)	2014-09-30	2022-03-03	한미약품 주식회사	암로디핀 및 로잘탄을 포함하는 고형 약제학적 조성물
CN104610130A (zh) *	2015-01-22	2015-05-13	华东理工常熟研究院有限公司	氨氯地平-棕榈酸离子液体及其制备方法和用途
KR101914930B1 (ko)	2015-03-31	2018-11-05	한미약품 주식회사	암로디핀, 로자탄 및 클로르탈리돈을 포함하는 약제학적 복합 제제
KR20170003459A (ko) *	2015-06-30	2017-01-09	한미약품 주식회사	암로디핀, 로자탄 및 로수바스타틴을 포함하는 약제학적 복합 제제
KR101750689B1 (ko) *	2015-09-15	2017-06-26	주식회사 종근당	약제학적 복합제제
CN119523985A (zh) *	2017-05-27	2025-02-28	青岛海蓝医药有限公司	川芎嗪硝酮衍生物在预防和治疗糖尿病并发症疾病中的应用
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JP7166754B2 (ja)	2017-11-22	2022-11-08	沢井製薬株式会社	ダサチニブ無水物含有製剤
CN108542891A (zh) *	2018-06-07	2018-09-18	董贵雨	一种含有替格瑞洛的固体药物组合物
JP2020090471A (ja) *	2018-12-07	2020-06-11	ニプロ株式会社	アジルサルタン及びアムロジピンを含有する医薬組成物及びその製造方法
KR102233986B1 (ko) *	2019-06-25	2021-03-30	경남과학기술대학교 산학협력단	라푸티딘 및 이르소글라딘을 함유하는 고형 약제학적 조성물 및 이의 제조방법
KR102900997B1 (ko)	2019-12-11	2025-12-22	한미약품 주식회사	암로디핀, 로자탄 및 클로르탈리돈을 포함하는 약제학적 복합제제
CN115666564B (zh)	2020-06-09	2024-07-16	韩美药品株式会社	在单层片剂中包括氨氯地平、氯沙坦和氯噻酮的预防或治疗心血管系统疾病的药学上组合制剂
CN112274490B (zh) *	2020-11-19	2022-11-22	四川尚锐生物医药有限公司	一种氨氯地平氯沙坦钾复方组合物的制备方法
WO2025224756A1 (en) *	2024-04-23	2025-10-30	Mestastop Solutions Private Limited	Composition, method and use thereof for delaying primary tumor metastasis using amlodipine

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8608335D0 (en)	1986-04-04	1986-05-08	Pfizer Ltd	Pharmaceutically acceptable salts
US5138069A (en)	1986-07-11	1992-08-11	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking imidazoles
EP0736021A4 (en)	1993-12-23	1997-04-02	Merck & Co Inc	LOSARTAN POLYMORPH AND METHOD FOR PRODUCING FORM II LOSARTAN
GT199800126A (es) *	1997-08-29	2000-01-29		Terapia de combinacion.
WO2001013900A2 (en) *	1999-08-24	2001-03-01	Medicure International Inc.	Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds
US20020068740A1 (en) *	1999-12-07	2002-06-06	Mylari Banavara L.	Combination of aldose reductase inhibitors and antihypertensive agents for the treatment of diabetic complications
WO2002002081A1 (en) *	2000-07-05	2002-01-10	Capricorn Pharma, Inc.	Rapid-melt semi-solid compositions, methods of making same and methods of using same
EP1314425A4 (en)	2000-08-30	2004-06-02	Sankyo Co	MEDICINAL COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE
AT5874U1 (de)	2000-12-29	2003-01-27	Bioorg Bv	Pharmazeutische zubereitungen enthaltend amlodipinmaleat
KR100452491B1 (ko) *	2001-03-29	2004-10-12	한미약품 주식회사	신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법
CN1571668A (zh)	2001-10-18	2005-01-26	诺瓦提斯公司	At1－受体拮抗剂和心血管药物形成的盐
KR20050044450A (ko)	2001-11-14	2005-05-12	테바 파마슈티컬 인더스트리즈 리미티드	로사르탄 칼륨의 무정형 및 결정형 형태 및 이의 제조 방법
EG24716A (en)	2002-05-17	2010-06-07	Novartis Ag	Combination of organic compounds
US7157100B2 (en)	2002-06-04	2007-01-02	J.B. Chemicals & Pharmaceuticals Ltd.	Pharmaceutical composition for controlled drug delivery system
EP1587792B1 (en)	2003-01-27	2014-08-27	Hanmi Science Co., Ltd.	Stable amorphous amlodipine camsylate, process for preparing same and composition for oral administration thereof
WO2005007046A2 (en) *	2003-07-18	2005-01-27	Pneu Medex Inc.	Fluid operated actuators and pneumatic unloading orthoses
DK1653950T3 (da)	2003-07-31	2008-05-26	Nicox Sa	Nitrooxyderivater af Losartan, Valsatan, Candesartan, Telmisartan, Eprosartan og Olmesartan som angiotensin II-receptorblokkere til behandling af cardiovaskulære sygdomme
WO2005070463A2 (en)	2004-01-12	2005-08-04	Sepracor, Inc.	Compositions comprising (s)-amlodipine malate and an angiotensin receptor blocker and methods of their use
PL1814527T5 (pl)	2004-11-05	2021-08-02	Boehringer Ingelheim International Gmbh	Dwuwarstwowa tabletka zawierająca telmisartan i amlodypinę
KR100582347B1 (ko) *	2004-12-30	2006-05-22	한미약품 주식회사	3-하이드록시-3-메틸글루타릴 조효소 ａ 환원효소 억제제및 고혈압 치료제의 복합제제 및 그의 제조방법
TWI407978B (zh)	2005-06-27	2013-09-11	Sankyo Co	濕粒狀藥物之製備方法
JP5110697B2 (ja) *	2005-06-27	2012-12-26	第一三共株式会社	固形製剤
US20090304755A1 (en) *	2005-10-27	2009-12-10	Raghu Rami Reddy Kasu	Pharmaceutical formulation of losartan
EP1951309A2 (en)	2005-11-08	2008-08-06	Novartis AG	Combination of an angiotensin ii receptor blocker, a calcium channel blocker and another active agent
WO2007072992A2 (en) *	2005-12-22	2007-06-28	Takeda Pharmaceutical Company Limited	Solid preparation containing an insulin sensitizer
KR100742432B1 (ko) *	2005-12-27	2007-07-24	한미약품 주식회사	암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법
KR100913791B1 (ko)	2006-07-21	2009-08-26	한미약품 주식회사	(ｓ)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물
US20080051438A1 (en)	2006-08-11	2008-02-28	Shinobu Nagahama	Preventive/Therapeutic Compositions Useful for Treating Cardiovascular Diseases
WO2008023869A1 (en)	2006-08-24	2008-02-28	Hanall Pharmaceutical Co., Ltd.	Combined pharmeceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
US20080241240A1 (en)	2006-08-24	2008-10-02	Hanall Pharmaceutical Co., Ltd.	Combined pharmaceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
WO2008023958A1 (en)	2006-08-24	2008-02-28	Hanall Pharmaceutical Co., Ltd.	Combined pharmaceutical formulation with controlled-release comprising dihydropyridine calcium channel blockers and hmg-coa reductase inhibitors
KR100888131B1 (ko)	2006-10-10	2009-03-11	한올제약주식회사	시간차 투약 원리를 이용한 심혈관계 질환 치료용 복합제제
KR101247583B1 (ko)	2006-12-08	2013-03-26	한미사이언스 주식회사	암로디핀 또는 이의 약제학적 허용가능한 염, 및 로자탄또는 이의 약제학적 허용가능한 염을 함유하는 약제학적조성물
SG173044A1 (en)	2009-01-23	2011-08-29	Hanmi Holdings Co Ltd	Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same

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Publication number	Publication date
US8673945B2 (en)	2014-03-18
CA2749903C (en)	2016-09-06
EP2413931B1 (en)	2016-06-01
US20110245302A1 (en)	2011-10-06
NZ594738A (en)	2013-11-29
CO6361915A2 (es)	2012-01-20
CN102292085A (zh)	2011-12-21
HK1163539A1 (en)	2012-09-14
BRPI0924136B8 (pt)	2021-05-25
SA110310070B1 (ar)	2014-09-02
PE20100739A1 (es)	2010-11-19
SG173044A1 (en)	2011-08-29
TWI395583B (zh)	2013-05-11
CL2011001781A1 (es)	2012-03-23
CO6361905A2 (es)	2012-01-20
TWI404534B (zh)	2013-08-11
EP2391365A4 (en)	2012-07-25
EA201170960A1 (ru)	2012-01-30
BRPI0924136B1 (pt)	2019-10-15
US9161933B2 (en)	2015-10-20
ZA201106160B (en)	2012-10-31
PE20100559A1 (es)	2010-09-12
BRPI0924136A2 (pt)	2017-06-13
MY173823A (en)	2020-02-24
SG173046A1 (en)	2011-08-29
BRPI0924137A2 (pt)	2019-09-24
MA33058B1 (fr)	2012-02-01
MY150974A (en)	2014-03-31
ES2526606T3 (es)	2015-01-13
ES2580777T3 (es)	2016-08-26
EA021763B1 (ru)	2015-08-31
AU2009338267A2 (en)	2011-09-29
EA020103B1 (ru)	2014-08-29
SG173045A1 (en)	2011-08-29
AR075027A1 (es)	2011-03-02
KR101232296B1 (ko)	2013-02-13
TW201028151A (en)	2010-08-01
CN102292084A (zh)	2011-12-21
JP2012515767A (ja)	2012-07-12
CR20110448A (es)	2011-11-10
MX2011006008A (es)	2011-06-28
BRPI0924136A8 (pt)	2017-10-03
AU2009338280B2 (en)	2014-05-01
KR20100086921A (ko)	2010-08-02
AR075028A1 (es)	2011-03-02
EA019471B1 (ru)	2014-03-31
JP5466716B2 (ja)	2014-04-09
CN102292085B (zh)	2017-01-18
US20110251245A1 (en)	2011-10-13
EP2391365A2 (en)	2011-12-07
ECSP11011253A (es)	2011-09-30
ES2505116T3 (es)	2014-10-09
NI201100144A (es)	2012-11-06
AU2009338267A1 (en)	2011-09-15
AU2009338251B2 (en)	2014-03-13
MX345956B (es)	2017-02-28
ZA201106161B (en)	2012-10-31
ES2580777T8 (es)	2016-09-22
IL214145A0 (en)	2011-08-31
ZA201106162B (en)	2012-10-31
AU2009338267B2 (en)	2014-09-18
MX345868B (es)	2017-02-21
NZ594739A (en)	2013-11-29
JP5658172B2 (ja)	2015-01-21
KR20100086913A (ko)	2010-08-02
JP5660544B2 (ja)	2015-01-28
UY32389A (es)	2010-02-26
CN102292084B (zh)	2014-01-29
MY151550A (en)	2014-06-13
WO2010085027A1 (en)	2010-07-29
CA2749955A1 (en)	2010-07-29
CA2749903A1 (en)	2010-07-29
WO2010085047A3 (en)	2010-11-04
CA2749957C (en)	2016-07-26
MA33056B1 (fr)	2012-02-01
JP2012515770A (ja)	2012-07-12
CR20110450A (es)	2011-11-10
EP2391348A1 (en)	2011-12-07
EP2391348B1 (en)	2014-08-27
UA102721C2 (uk)	2013-08-12
IL214146A0 (en)	2011-08-31
UA105203C2 (ru)	2014-04-25
NI201100143A (es)	2012-08-17
AU2009338251A1 (en)	2011-09-15
HN2011002020A (es)	2014-02-03
MA33057B1 (fr)	2012-02-01
NI201100145A (es)	2012-08-17
PE20120428A1 (es)	2012-05-17
JO2981B1 (ar)	2016-09-05
WO2010085047A2 (en)	2010-07-29
UY32388A (es)	2010-02-26
KR101160151B1 (ko)	2012-06-27
MX2011006009A (es)	2011-06-28
TW201031404A (en)	2010-09-01
AU2009338280A1 (en)	2011-09-15
JO3328B1 (ar)	2019-03-13
EP2391348A4 (en)	2012-07-25
IL214147A0 (en)	2011-08-31
MX2011006061A (es)	2011-06-24
DOP2011000231A (es)	2011-10-15
CA2749955C (en)	2016-07-26
PE20140978A1 (es)	2014-08-16
EP2391365B1 (en)	2014-11-26
EP2413931A4 (en)	2012-08-08
DOP2011000230A (es)	2011-10-15
US20110245301A1 (en)	2011-10-06
WO2010085014A1 (en)	2010-07-29
EA201170959A1 (ru)	2011-12-30
AR070897A1 (es)	2010-05-12
MX349221B (es)	2017-07-19
CA2749957A1 (en)	2010-07-29
EP2413931A1 (en)	2012-02-08
JP2012515768A (ja)	2012-07-12
DOP2011000229A (es)	2011-10-15
HN2011002022A (es)	2014-02-03
IL214147A (en)	2016-08-31
UA102720C2 (ru)	2013-08-12
US8673944B2 (en)	2014-03-18
CO6361914A2 (es)	2012-01-20
CR20110449A (es)	2011-11-10
NZ594740A (en)	2013-11-29
EA201170958A1 (ru)	2012-01-30
CN102292070A (zh)	2011-12-21
CN105998017A (zh)	2016-10-12

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Date	Code	Title	Description
2016-06-07	B25D	Requested change of name of applicant approved	Owner name: HANMI SCIENCE CO., LTD. (KR)
2016-06-28	B25G	Requested change of headquarter approved	Owner name: HANMI SCIENCE CO., LTD. (KR)
2017-10-10	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-04-24	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-08-07	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2018-10-30	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 9A ANUIDADE.
2019-03-19	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2495 DE 30-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.
2021-06-01	B350	Update of information on the portal [chapter 15.35 patent gazette]

Publication	Publication Date	Title
BRPI0924137A2 (pt)	2019-09-24	composição farmacêutica sólida compreendendo amlodipina e losartan com melhor estabilidade
LTC2140867I2 (lt)	2018-11-12	Farmacinė kompozicija
DK3097925T3 (da)	2019-08-05	Farmaceutisk sammensætning
BRPI1004940A2 (pt)	2018-06-19	composição farmacêutica
SMT201400005B (it)	2014-03-07	Composto anticancro e composizione farmaceutica che l contiene
BRPI0920521A2 (pt)	2018-01-16	combinação farmacêutica
SMT201700095B (is)	2017-03-08	Composizioni farmaceutiche per inalazione
HRP20160579T1 (hr)	2016-07-29	Spoj indola i njegova farmaceutska upotreba
BRPI0906962A2 (pt)	2015-07-14	Composto, e, composição farmacêutica
BRPI0906556A2 (pt)	2015-07-07	Composto, e, composição farmacêutica
BRPI1011587A2 (pt)	2016-03-22	compostos e composições terapèuticas
BRPI1012539A2 (pt)	2016-03-29	composições farmacêuticas
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BRPI1015939A2 (pt)	2016-09-27	composição farmacêutica
BRPI0721651A2 (pt)	2014-04-01	Composição farmacêutica
EP2519104A4 (en)	2014-04-09	PESTICIDE COMPOSITION
BRPI1009372A2 (pt)	2016-05-31	compostos, composição farmacêutica e respectivos usos
DK2285357T3 (da)	2014-06-02	Farmaceutisk sammensætning omfattende brivaracetam
BRPI0917681A2 (pt)	2015-08-04	Composto, e, composição farmacêutica
DK2391349T3 (da)	2014-11-03	Farmaceutisk sammensætning omfattende 2-oco-1-pyrrolidin-derivater
DK2285413T3 (da)	2012-08-27	Farmaceutisk sammensætning
IT1394400B1 (it)	2012-06-15	Composizioni farmaceutiche
EP2236149A4 (en)	2012-12-26	MEDICAL COMPOSITION
BR112012000831A2 (pt)	2019-09-24	compostos, composições farmacêuticas e métodos relacionados
DK2475649T3 (da)	2014-11-03	Indenonderivat og farmaceutisk sammensætning omfattende samme