BRPI1009372A2 - compostos, composição farmacêutica e respectivos usos - Google Patents

compostos, composição farmacêutica e respectivos usos

Info

Publication number: BRPI1009372A2
Authority: BR; Brazil
Prior art keywords: compounds; pharmaceutical composition; pharmaceutical; composition
Prior art date: 2009-03-23

Application number

BRPI1009372A

Other languages

English (en)

Inventor

Abraham Thomas

Indranil Mukhopadhyay

Neelima Khairatkar-Joshi

Sanjay Margal

Sukeerthi Kumar

Original Assignee

Glenmark Pharmaceuticals Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-23

Filing date

2010-03-22

Publication date

2016-05-31

2010-03-22 Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa

2016-05-31 Publication of BRPI1009372A2 publication Critical patent/BRPI1009372A2/pt

Links

150000001875 compounds Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Otolaryngology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

BRPI1009372A 2009-03-23 2010-03-22 compostos, composição farmacêutica e respectivos usos BRPI1009372A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
IN665MU2009		2009-03-23
US17135509P	2009-04-21	2009-04-21
PCT/IB2010/000834 WO2010109328A1 (en)	2009-03-23	2010-03-22	Isothiazolo-pyrimidinedione derivatives as trpa1 modulators

Publications (1)

Publication Number	Publication Date
BRPI1009372A2 true BRPI1009372A2 (pt)	2016-05-31

Family

ID=42236291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1009372A BRPI1009372A2 (pt)	2009-03-23	2010-03-22	compostos, composição farmacêutica e respectivos usos

Country Status (22)

Country	Link
US (1)	US8575178B2 (pt)
EP (1)	EP2411397B1 (pt)
JP (1)	JP2012521405A (pt)
KR (1)	KR20120001746A (pt)
CN (1)	CN102395592A (pt)
AP (1)	AP2011005888A0 (pt)
AU (1)	AU2010227224A1 (pt)
BR (1)	BRPI1009372A2 (pt)
CA (1)	CA2756534A1 (pt)
DK (1)	DK2411397T3 (pt)
EA (1)	EA201190191A1 (pt)
ES (1)	ES2424340T3 (pt)
IL (1)	IL215179A0 (pt)
MX (1)	MX2011009821A (pt)
PE (1)	PE20120764A1 (pt)
PL (1)	PL2411397T3 (pt)
PT (1)	PT2411397E (pt)
SG (2)	SG174403A1 (pt)
SI (1)	SI2411397T1 (pt)
UA (1)	UA107342C2 (pt)
WO (1)	WO2010109328A1 (pt)
ZA (1)	ZA201107646B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2411395B1 (en)	2009-03-23	2013-05-29	Glenmark Pharmaceuticals S.A.	Furopyrimidinedione derivatives as trpa1 modulators
BRPI1013559A2 (pt)	2009-03-23	2016-04-12	Glenmark Pharmaceuticals Sa	compostos, composição farmacêutica, método de tratamento de doença ou condição associada à função trpa1 e respectivos usos
AR084294A1 (es) *	2010-12-20	2013-05-08	Glenmark Pharmaceuticals Sa	Compuestos de 2-amino-4-ariltiazol, metodos para su sintesis y uso como antagonista de trpa1
EP2520566A1 (en)	2011-05-06	2012-11-07	Orion Corporation	New Pharmaceutical Compounds
CA2836856A1 (en)	2011-06-13	2012-12-20	Glenmark Pharmaceuticals, S.A.	Treatment of respiratory disorders using trpa1 antagonists
WO2012176105A1 (en)	2011-06-22	2012-12-27	Glenmark Pharmaceuticals Sa	Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist
BR112013031820A2 (pt)	2011-06-22	2016-12-13	Glenmark Pharmaceutical S A	composições farmacêuticas, incluindo para administração oral e por inalação, usos de quantidade sinergicamente eficaz de antagonista trpa1 e métodos para tratar distúrbios respiratórios e para melhorar a função pulmonar
JP2014521634A (ja)	2011-07-25	2014-08-28	グレンマークファーマシューティカルズ，エセ．アー．	Ｔｒｐａ１アンタゴニスト及びステロイドを含む医薬組成物
TWI640519B (zh) *	2011-11-29	2018-11-11	泰緯生命科技股份有限公司	Ｈｅｃ１活性調控因子及其調節方法
EP2787991A1 (en)	2011-12-05	2014-10-15	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent
IN2014MN02467A (pt)	2012-06-08	2015-07-10	Glenmark Pharmaceuticals Sa
CA2884922C (en)	2012-10-01	2020-11-10	Orion Corporation	N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists
HK1214244A1 (zh)	2012-11-14	2016-07-22	霍夫曼-拉罗奇有限公司	咪唑并吡啶衍生物
CA2912578A1 (en)	2013-06-20	2014-12-24	Glenmark Pharmaceuticals S.A.	Nanoparticulate formulation comprising a trpa1 antagonist
CN105813638A (zh)	2013-10-15	2016-07-27	格兰马克药品股份有限公司	包含trpa1拮抗剂和镇痛剂的药物组合物
WO2015155306A1 (en) *	2014-04-11	2015-10-15	Almirall, S.A.	New trpa1 antagonists
WO2016042501A1 (en)	2014-09-16	2016-03-24	Glenmark Pharmaceuticals S.A.	Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
WO2017060488A1 (en)	2015-10-09	2017-04-13	Almirall, S.A.	New trpa1 antagonists
WO2017064068A1 (en)	2015-10-14	2017-04-20	Almirall, S.A.	New trpa1 antagonists
WO2018233648A1 (zh) *	2017-06-21	2018-12-27	南京明德新药研发股份有限公司	作为TLR8激动剂的异噻唑并[4,3-d]嘧啶-5,7-二胺衍生物
CN112794860B (zh) *	2021-03-24	2021-06-29	上海肇钰医药科技有限公司	噁唑嘧啶酮酰胺类化合物或其可药用盐，制备方法及用途
CN114656480B (zh) *	2022-04-27	2024-01-26	成都施贝康生物医药科技有限公司	噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途
WO2025264860A2 (en)	2024-06-18	2025-12-26	Yale University	Methods of treating post-covid airway disease

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DE2248231A1 (de) *	1972-10-02	1974-04-11	Basf Ag	3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine
SE9701398D0 (sv)	1997-04-15	1997-04-15	Astra Pharma Prod	Novel compounds
ES2193839B1 (es)	2001-06-22	2005-02-16	Almirall Prodesfarma, S.A.	Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
AU2003253165A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidine fused bicyclic metalloproteinase inhibitors
US7465581B2 (en)	2002-12-18	2008-12-16	The Scripps Research Institute	ANKTM1, a cold-activated TRP-like channel expressed in nociceptive neurons
SE0300119D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
EP1713815A4 (en) *	2004-02-11	2009-03-11	Smithkline Beecham Corp	PTH AGONISTS
US20070196866A1 (en)	2004-03-13	2007-08-23	Irm Llc	Modulators of ion channel trpa1
EP1847541A4 (en)	2005-02-03	2009-12-30	Takeda Pharmaceutical	CONDENSED PYRIMIDINE DERIVATIVE AND USE THEREOF
TW201900217A (zh)	2005-12-22	2019-01-01	美商海卓勒生物科學公司	用於調節ｔｒｐａ１功能之化合物
TW200800997A (en)	2006-03-22	2008-01-01	Astrazeneca Ab	Chemical compounds
CL2008000252A1 (es)	2007-01-29	2008-03-14	Xenon Pharmaceuticals Inc	Compuestos derivados de quinazolinona o pirimidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades mediadas por los canales de calcio, tales como dolor, depresion, enfermedades cardiovasculares, respir
SI3184527T1 (sl) *	2007-06-22	2020-03-31	Eli Lilly And Company	Spojine 2,6-diokso,-2,3-dihidro-1H-purina uporabne za zdravljenje stanj povezanih z aktivnostjo TRPA1 kanala
WO2009158719A2 (en)	2008-06-27	2009-12-30	Hydra Biosciences, Inc.	Methods and compositions for treating disorders

2010
- 2010-03-22 DK DK10716049.1T patent/DK2411397T3/da active
- 2010-03-22 JP JP2012501411A patent/JP2012521405A/ja not_active Withdrawn
- 2010-03-22 KR KR1020117023383A patent/KR20120001746A/ko not_active Withdrawn
- 2010-03-22 MX MX2011009821A patent/MX2011009821A/es unknown
- 2010-03-22 PE PE2011001703A patent/PE20120764A1/es not_active Application Discontinuation
- 2010-03-22 SG SG2011066495A patent/SG174403A1/en unknown
- 2010-03-22 SI SI201030232T patent/SI2411397T1/sl unknown
- 2010-03-22 CN CN2010800168801A patent/CN102395592A/zh active Pending
- 2010-03-22 BR BRPI1009372A patent/BRPI1009372A2/pt not_active IP Right Cessation
- 2010-03-22 AP AP2011005888A patent/AP2011005888A0/xx unknown
- 2010-03-22 AU AU2010227224A patent/AU2010227224A1/en not_active Abandoned
- 2010-03-22 US US13/257,241 patent/US8575178B2/en not_active Expired - Fee Related
- 2010-03-22 EP EP10716049.1A patent/EP2411397B1/en not_active Not-in-force
- 2010-03-22 PL PL10716049T patent/PL2411397T3/pl unknown
- 2010-03-22 WO PCT/IB2010/000834 patent/WO2010109328A1/en not_active Ceased
- 2010-03-22 CA CA2756534A patent/CA2756534A1/en not_active Abandoned
- 2010-03-22 PT PT107160491T patent/PT2411397E/pt unknown
- 2010-03-22 SG SG2012069464A patent/SG184766A1/en unknown
- 2010-03-22 ES ES10716049T patent/ES2424340T3/es active Active
- 2010-03-22 EA EA201190191A patent/EA201190191A1/ru unknown
- 2010-03-23 UA UAA201111149A patent/UA107342C2/ru unknown
2011
- 2011-09-15 IL IL215179A patent/IL215179A0/en unknown
- 2011-10-19 ZA ZA2011/07646A patent/ZA201107646B/en unknown

Also Published As

Publication number	Publication date
UA107342C2 (en)	2014-12-25
MX2011009821A (es)	2012-01-25
JP2012521405A (ja)	2012-09-13
AU2010227224A2 (en)	2011-10-27
AU2010227224A1 (en)	2011-09-29
ES2424340T3 (es)	2013-10-01
CN102395592A (zh)	2012-03-28
DK2411397T3 (da)	2013-08-05
PE20120764A1 (es)	2012-06-27
SG184766A1 (en)	2012-10-30
CA2756534A1 (en)	2010-09-30
WO2010109328A1 (en)	2010-09-30
SG174403A1 (en)	2011-10-28
US20120010223A1 (en)	2012-01-12
PL2411397T3 (pl)	2013-10-31
EA201190191A1 (ru)	2012-11-30
AP2011005888A0 (en)	2011-10-31
EP2411397B1 (en)	2013-05-29
PT2411397E (pt)	2013-06-06
US8575178B2 (en)	2013-11-05
SI2411397T1 (sl)	2013-07-31
EP2411397A1 (en)	2012-02-01
ZA201107646B (en)	2012-06-25
KR20120001746A (ko)	2012-01-04
HK1166081A1 (en)	2012-10-19
IL215179A0 (en)	2011-12-29

Legal Events

Date	Code	Title	Description
2016-09-27	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE AS 5A E 6A ANUIDADES.
2017-01-17	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

Publication	Publication Date	Title
BRPI1009372A2 (pt)	2016-05-31	compostos, composição farmacêutica e respectivos usos
BRPI0910503A2 (pt)	2015-09-29	compostos, composições farmacêuticas e respectivos usos.
DK3097925T3 (da)	2019-08-05	Farmaceutisk sammensætning
BRPI1004940A2 (pt)	2018-06-19	composição farmacêutica
SMT201700095B (is)	2017-03-08	Composizioni farmaceutiche per inalazione
BRPI1010772A2 (pt)	2016-11-01	composto,e, composição farmacêutica.
BRPI0918360A2 (pt)	2017-10-10	composto, composição farmacêutica e usos de um composto
BRPI1008709A2 (pt)	2016-03-08	composições e usos das mesmas.
BRPI0906962A2 (pt)	2015-07-14	Composto, e, composição farmacêutica
BRPI0906556A2 (pt)	2015-07-07	Composto, e, composição farmacêutica
BRPI1015939A2 (pt)	2016-09-27	composição farmacêutica
EP2419097A4 (en)	2012-09-05	PHARMACEUTICAL COMPOSITIONS
EP2451274A4 (en)	2014-04-02	Pharmaceutical compositions
BR112012012108A2 (pt)	2016-04-05	composição farmacêutica compreendendo propofol
BR112013011968A2 (pt)	2016-08-30	composição farmacêutica, métodos de tratamento e usos da mesma
DK3246018T3 (da)	2022-01-17	Farmaceutisk sammensætning
SMT201400069B (it)	2014-07-07	Formulazione farmaceutica
DK2391349T3 (da)	2014-11-03	Farmaceutisk sammensætning omfattende 2-oco-1-pyrrolidin-derivater
BR112014010290A2 (pt)	2017-05-02	composição farmacêutica, métodos, composições e usos
BRPI0917681A2 (pt)	2015-08-04	Composto, e, composição farmacêutica
BR112012000831A2 (pt)	2019-09-24	compostos, composições farmacêuticas e métodos relacionados
EE201300005A (et)	2013-08-15	Ravimkoostis
DK2285413T3 (da)	2012-08-27	Farmaceutisk sammensætning
EP2236149A4 (en)	2012-12-26	MEDICAL COMPOSITION
IT1394400B1 (it)	2012-06-15	Composizioni farmaceutiche