BRPI1007945A2 - Composição farmacêutica, comprimido, e, métodos de tratar um paciente sofrendo de hepatite c, de reduzir um ou mais dos efeitos colaterais associados ao tratamento com nitazoxanida ou tizoxanida em um paciente, de aumentar a biodisponibilidade de nitazoxinida ou de um seu análogo em um paciente, e de prolongar a absorção de nitazoxanida ou de um seu análogo em um paciente - Google Patents

Composição farmacêutica, comprimido, e, métodos de tratar um paciente sofrendo de hepatite c, de reduzir um ou mais dos efeitos colaterais associados ao tratamento com nitazoxanida ou tizoxanida em um paciente, de aumentar a biodisponibilidade de nitazoxinida ou de um seu análogo em um paciente, e de prolongar a absorção de nitazoxanida ou de um seu análogo em um paciente

Info

Publication number: BRPI1007945A2
Authority: BR; Brazil
Prior art keywords: patient; nitazoxanide; nitazoxinide; tizoxanide; bioavailability
Prior art date: 2009-02-13

Application number

BRPI1007945-9A

Other languages

English (en)

Inventor

Jean-François Rossignol

Marc Ayers

Original Assignee

Romark Lab Lc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-02-13

Filing date

2010-02-12

Publication date

2015-09-01

2010-02-12 Application filed by Romark Lab Lc filed Critical Romark Lab Lc

2015-09-01 Publication of BRPI1007945A2 publication Critical patent/BRPI1007945A2/pt

2020-08-04 Publication of BRPI1007945B1 publication Critical patent/BRPI1007945B1/pt

2020-08-18 Publication of BRPI1007945B8 publication Critical patent/BRPI1007945B8/pt

2020-09-01 Publication of BRPI1007945C1 publication Critical patent/BRPI1007945C1/pt

2021-05-25 Publication of BRPI1007945C8 publication Critical patent/BRPI1007945C8/pt

Links

YQNQNVDNTFHQSW-UHFFFAOYSA-N acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester Chemical compound CC(=O)OC1=CC=CC=C1C(=O)NC1=NC=C([N+]([O-])=O)S1 YQNQNVDNTFHQSW-UHFFFAOYSA-N 0.000 title 2
229960002480 nitazoxanide Drugs 0.000 title 2
FDTZUTSGGSRHQF-UHFFFAOYSA-N Desacetyl-nitazoxanide Chemical compound OC1=CC=CC=C1C(=O)NC1=NC=C([N+]([O-])=O)S1 FDTZUTSGGSRHQF-UHFFFAOYSA-N 0.000 title 1
238000010521 absorption reaction Methods 0.000 title 1
230000000694 effects Effects 0.000 title 1
208000006454 hepatitis Diseases 0.000 title 1
231100000283 hepatitis Toxicity 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Rheumatology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BRPI1007945A 2009-02-13 2010-02-12 formulação farmacêutica de liberação controlada de nitazoxanida, tizoxanida ou uma combinação dos mesmos, e, comprimido de bicamada para administração oral BRPI1007945C8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US20228509P	2009-02-13	2009-02-13
US61/202285		2009-02-13
PCT/US2010/024000 WO2010093854A1 (en)	2009-02-13	2010-02-12	Controlled release pharmaceutical formulations of nitazoxanide

Publications (5)

Publication Number	Publication Date
BRPI1007945A2 true BRPI1007945A2 (pt)	2015-09-01
BRPI1007945B1 BRPI1007945B1 (pt)	2020-08-04
BRPI1007945B8 BRPI1007945B8 (pt)	2020-08-18
BRPI1007945C1 BRPI1007945C1 (pt)	2020-09-01
BRPI1007945C8 BRPI1007945C8 (pt)	2021-05-25

Family

ID=42560126

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1007945A BRPI1007945C8 (pt)	2009-02-13	2010-02-12	formulação farmacêutica de liberação controlada de nitazoxanida, tizoxanida ou uma combinação dos mesmos, e, comprimido de bicamada para administração oral

Country Status (23)

Country	Link
US (5)	US8524278B2 (pt)
EP (1)	EP2395840B1 (pt)
JP (3)	JP5726766B2 (pt)
KR (1)	KR101697800B1 (pt)
CN (2)	CN107260695A (pt)
AU (3)	AU2010213678B2 (pt)
BR (1)	BRPI1007945C8 (pt)
CA (1)	CA2752233C (pt)
CO (1)	CO6501159A2 (pt)
CY (1)	CY1123162T1 (pt)
DK (1)	DK2395840T3 (pt)
EA (1)	EA029018B1 (pt)
ES (1)	ES2797493T3 (pt)
HR (1)	HRP20201055T1 (pt)
HU (1)	HUE049501T2 (pt)
IL (1)	IL214624A0 (pt)
LT (1)	LT2395840T (pt)
MX (2)	MX381895B (pt)
PL (1)	PL2395840T3 (pt)
PT (1)	PT2395840T (pt)
SI (1)	SI2395840T1 (pt)
UA (1)	UA107564C2 (pt)
WO (1)	WO2010093854A1 (pt)

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JP2023537237A (ja)	2020-07-20	2023-08-31	ロマークラボラトリーズ，リミティドカンパニー	チゾキサニドおよび２－ヒドロキシ－ｎ－（５－クロロ－１，３－チアゾル－２－イル）ベンズアミド（ｒｍ－４８４８）とエタノールアミン、モルホリン、プロパノールアミン、ピペラジン、およびｎ－メチルピペラジンの結晶塩
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MX381895B (es) *	2009-02-13	2025-03-13	Romark Laboratories Lc	Formulaciones farmaceuticas de liberacion controlada de nitazoxanida.

2010
- 2010-02-12 MX MX2017006915A patent/MX381895B/es unknown
- 2010-02-12 LT LTEP10741758.6T patent/LT2395840T/lt unknown
- 2010-02-12 BR BRPI1007945A patent/BRPI1007945C8/pt not_active IP Right Cessation
- 2010-02-12 SI SI201032014T patent/SI2395840T1/sl unknown
- 2010-02-12 DK DK10741758.6T patent/DK2395840T3/da active
- 2010-02-12 HU HUE10741758A patent/HUE049501T2/hu unknown
- 2010-02-12 EP EP10741758.6A patent/EP2395840B1/en active Active
- 2010-02-12 KR KR1020117020973A patent/KR101697800B1/ko not_active Expired - Fee Related
- 2010-02-12 HR HRP20201055TT patent/HRP20201055T1/hr unknown
- 2010-02-12 JP JP2011550246A patent/JP5726766B2/ja active Active
- 2010-02-12 WO PCT/US2010/024000 patent/WO2010093854A1/en not_active Ceased
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Publication number	Publication date
US20160243087A1 (en)	2016-08-25
JP6117845B2 (ja)	2017-04-19
KR101697800B1 (ko)	2017-01-18
CA2752233C (en)	2017-01-03
EA201190127A1 (ru)	2012-03-30
EP2395840B1 (en)	2020-04-15
BRPI1007945B1 (pt)	2020-08-04
MX348282B (es)	2017-06-05
US20190321338A1 (en)	2019-10-24
AU2017203148A1 (en)	2017-06-01
IL214624A0 (en)	2011-09-27
BRPI1007945C1 (pt)	2020-09-01
HUE049501T2 (hu)	2020-09-28
CA2752233A1 (en)	2010-08-19
SI2395840T1 (sl)	2020-08-31
US11426388B2 (en)	2022-08-30
US20100209505A1 (en)	2010-08-19
PL2395840T3 (pl)	2020-09-07
BRPI1007945C8 (pt)	2021-05-25
CO6501159A2 (es)	2012-08-15
EA029018B1 (ru)	2018-01-31
JP5726766B2 (ja)	2015-06-03
EP2395840A4 (en)	2013-12-25
JP6491174B2 (ja)	2019-03-27
CN107260695A (zh)	2017-10-20
US20180085353A1 (en)	2018-03-29
JP2012518002A (ja)	2012-08-09
JP2015143258A (ja)	2015-08-06
US9827227B2 (en)	2017-11-28
LT2395840T (lt)	2020-07-10
DK2395840T3 (da)	2020-06-08
EP2395840A1 (en)	2011-12-21
CY1123162T1 (el)	2021-10-29
AU2010213678B2 (en)	2015-11-26
MX2011008530A (es)	2011-10-14
US20140065215A1 (en)	2014-03-06
WO2010093854A1 (en)	2010-08-19
UA107564C2 (uk)	2015-01-26
ES2797493T3 (es)	2020-12-02
PT2395840T (pt)	2020-07-06
BRPI1007945B8 (pt)	2020-08-18
HRP20201055T1 (hr)	2020-10-30
MX381895B (es)	2025-03-13
CN102395276A (zh)	2012-03-28
US10383855B2 (en)	2019-08-20
AU2016200971A1 (en)	2016-03-03
JP2017061561A (ja)	2017-03-30
KR20120008024A (ko)	2012-01-25
US8524278B2 (en)	2013-09-03
AU2017203148B2 (en)	2018-08-09
US9351937B2 (en)	2016-05-31
AU2016200971B2 (en)	2017-02-23
AU2010213678A1 (en)	2011-09-01

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