BRPI1008173A2 - "derivados de piridina espiroindolinona" - Google Patents
"derivados de piridina espiroindolinona"Info
- Publication number
- BRPI1008173A2 BRPI1008173A2 BRPI1008173A BRPI1008173A BRPI1008173A2 BR PI1008173 A2 BRPI1008173 A2 BR PI1008173A2 BR PI1008173 A BRPI1008173 A BR PI1008173A BR PI1008173 A BRPI1008173 A BR PI1008173A BR PI1008173 A2 BRPI1008173 A2 BR PI1008173A2
- Authority
- BR
- Brazil
- Prior art keywords
- spiroindolinone
- pyridine derivatives
- pyridine
- derivatives
- spiroindolinone pyridine
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15127909P | 2009-02-10 | 2009-02-10 | |
| PCT/EP2010/051252 WO2010091979A1 (en) | 2009-02-10 | 2010-02-02 | Spiroindolinone pyridine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1008173A2 true BRPI1008173A2 (pt) | 2016-03-01 |
Family
ID=41820540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1008173A BRPI1008173A2 (pt) | 2009-02-10 | 2010-02-02 | "derivados de piridina espiroindolinona" |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7928233B2 (pt) |
| EP (1) | EP2396326A1 (pt) |
| JP (1) | JP2012512849A (pt) |
| KR (1) | KR20110100678A (pt) |
| CN (1) | CN102264738A (pt) |
| AU (1) | AU2010212995A1 (pt) |
| BR (1) | BRPI1008173A2 (pt) |
| CA (1) | CA2751243A1 (pt) |
| IL (1) | IL213466A0 (pt) |
| MX (1) | MX2011007886A (pt) |
| SG (1) | SG173591A1 (pt) |
| WO (1) | WO2010091979A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104876938A (zh) | 2009-11-12 | 2015-09-02 | 密歇根大学董事会 | 螺-吲哚酮mdm2拮抗剂 |
| PE20140408A1 (es) | 2010-11-12 | 2014-04-10 | Univ Michigan | Derivados espiro-oxindol como antagonistas de mdm2 |
| TR201807311T4 (tr) | 2011-03-10 | 2018-06-21 | Daiichi Sankyo Co Ltd | Dispiropirolidin derivesi. |
| MX346375B (es) | 2011-05-11 | 2017-03-16 | Univ Michigan Regents | Antagonistas de espiro-oxindol de mdm2. |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| JP6564449B2 (ja) | 2015-02-20 | 2019-08-21 | 第一三共株式会社 | がんの併用治療法 |
| KR20170134462A (ko) | 2015-04-13 | 2017-12-06 | 다이이찌 산쿄 가부시키가이샤 | Mdm2 저해제와 btk 저해제의 병용 치료법 |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| US20190240210A1 (en) | 2016-10-17 | 2019-08-08 | Daiichi Sankyo Company, Limited | Treatment Method by Combined Use of MDM2 Inhibitor and DNA Methyltransferase Inhibitor |
| WO2022183006A1 (en) | 2021-02-25 | 2022-09-01 | Mayo Foundation For Medical Education And Research | Compounds for programmable protein degradation and methods of use for the disease treatment |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3714473A1 (de) | 1987-04-30 | 1988-11-10 | Basf Ag | Kontinuierliches verfahren zur epimerisierung von zuckern, insbesondere von d-arabinose zu d-ribose |
| EP0947511A1 (en) | 1998-03-30 | 1999-10-06 | F. Hoffmann-La Roche Ag | Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity |
| JP2003505388A (ja) | 1999-07-21 | 2003-02-12 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| EP1664050B1 (en) * | 2003-09-03 | 2015-12-09 | Neuren Pharmaceuticals Limited | Neuroprotective bicyclic compounds and pharmaceutical compositions containing them |
| AU2006216780B8 (en) | 2005-02-22 | 2010-04-22 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and uses thereof |
| US7576082B2 (en) * | 2005-06-24 | 2009-08-18 | Hoffman-La Roche Inc. | Oxindole derivatives |
| US20070213341A1 (en) * | 2006-03-13 | 2007-09-13 | Li Chen | Spiroindolinone derivatives |
| US7495007B2 (en) * | 2006-03-13 | 2009-02-24 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| DE602007011902D1 (de) | 2006-03-13 | 2011-02-24 | Hoffmann La Roche | Spiroindolinon-derivate |
| WO2008005268A1 (en) | 2006-06-30 | 2008-01-10 | Schering Corporation | Substituted piperidines that increase p53 activity and the uses thereof |
| US7638548B2 (en) * | 2006-11-09 | 2009-12-29 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| WO2008080822A1 (en) | 2006-12-29 | 2008-07-10 | F. Hoffmann-La Roche Ag | Epimerization methodologies for recovering stereo isomers in high yield and purity |
| US7553833B2 (en) * | 2007-05-17 | 2009-06-30 | Hoffmann-La Roche Inc. | 3,3-spiroindolinone derivatives |
-
2010
- 2010-01-12 US US12/685,748 patent/US7928233B2/en not_active Expired - Fee Related
- 2010-02-02 CA CA2751243A patent/CA2751243A1/en not_active Abandoned
- 2010-02-02 WO PCT/EP2010/051252 patent/WO2010091979A1/en not_active Ceased
- 2010-02-02 KR KR1020117018526A patent/KR20110100678A/ko not_active Ceased
- 2010-02-02 CN CN2010800037877A patent/CN102264738A/zh active Pending
- 2010-02-02 EP EP10701882A patent/EP2396326A1/en not_active Withdrawn
- 2010-02-02 BR BRPI1008173A patent/BRPI1008173A2/pt not_active Application Discontinuation
- 2010-02-02 JP JP2011541521A patent/JP2012512849A/ja active Pending
- 2010-02-02 AU AU2010212995A patent/AU2010212995A1/en not_active Abandoned
- 2010-02-02 SG SG2011056983A patent/SG173591A1/en unknown
- 2010-02-02 MX MX2011007886A patent/MX2011007886A/es not_active Application Discontinuation
-
2011
- 2011-06-09 IL IL213466A patent/IL213466A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7928233B2 (en) | 2011-04-19 |
| SG173591A1 (en) | 2011-09-29 |
| CN102264738A (zh) | 2011-11-30 |
| WO2010091979A1 (en) | 2010-08-19 |
| EP2396326A1 (en) | 2011-12-21 |
| CA2751243A1 (en) | 2010-08-19 |
| US20100204257A1 (en) | 2010-08-12 |
| JP2012512849A (ja) | 2012-06-07 |
| AU2010212995A1 (en) | 2011-06-23 |
| MX2011007886A (es) | 2011-08-15 |
| KR20110100678A (ko) | 2011-09-14 |
| IL213466A0 (en) | 2011-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |