BRPI1008300A2 - processo de purificação de daptomicina - Google Patents

processo de purificação de daptomicina

Info

Publication number: BRPI1008300A2
Authority: BR; Brazil
Prior art keywords: purification process; daptomycin; daptomycin purification; purification
Prior art date: 2009-02-19

Application number

BRPI1008300A

Other languages

English (en)

Inventor

Carsten Overballe-Petersen

Dennis Brian Hansen

Eli Karin Dale

Kjersti Aastorp Hirth

Martin Mansson

Martins Mansson

Sissel Hauge

Original Assignee

Xellia Pharmaceuticals Aps

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-02-19

Filing date

2010-02-19

Publication date

2016-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42116034&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1008300(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-02-19 Application filed by Xellia Pharmaceuticals Aps filed Critical Xellia Pharmaceuticals Aps

2016-03-15 Publication of BRPI1008300A2 publication Critical patent/BRPI1008300A2/pt

2021-05-11 Publication of BRPI1008300A8 publication Critical patent/BRPI1008300A8/pt

2021-07-13 Publication of BRPI1008300B1 publication Critical patent/BRPI1008300B1/pt

Links

108010013198 Daptomycin Proteins 0.000 title 1
DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 title 1
229960005484 daptomycin Drugs 0.000 title 1
238000000746 purification Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

BRPI1008300-6A 2009-02-19 2010-02-19 Processo de purificação de daptomicina BRPI1008300B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US15366009P	2009-02-19	2009-02-19
US61/153,660		2009-02-19
PCT/NO2010/000066 WO2010095953A1 (en)	2009-02-19	2010-02-19	Process for purifying lipopeptides

Publications (3)

Publication Number	Publication Date
BRPI1008300A2 true BRPI1008300A2 (pt)	2016-03-15
BRPI1008300A8 BRPI1008300A8 (pt)	2021-05-11
BRPI1008300B1 BRPI1008300B1 (pt)	2021-07-13

Family

ID=42116034

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1008300-6A BRPI1008300B1 (pt)	2009-02-19	2010-02-19	Processo de purificação de daptomicina

Country Status (21)

Country	Link
US (1)	US9150894B2 (pt)
EP (1)	EP2398817B2 (pt)
JP (1)	JP5752609B2 (pt)
KR (1)	KR101666144B1 (pt)
CN (1)	CN102325785B (pt)
AU (1)	AU2010216475B2 (pt)
BR (1)	BRPI1008300B1 (pt)
CA (1)	CA2748932C (pt)
DK (1)	DK2398817T4 (pt)
ES (1)	ES2543457T5 (pt)
HR (1)	HRP20150761T4 (pt)
HU (1)	HUE026818T2 (pt)
IL (1)	IL214374A (pt)
MX (1)	MX2011008621A (pt)
PL (1)	PL2398817T5 (pt)
PT (1)	PT2398817E (pt)
RU (1)	RU2526391C2 (pt)
SI (1)	SI2398817T2 (pt)
UA (1)	UA105785C2 (pt)
WO (1)	WO2010095953A1 (pt)
ZA (1)	ZA201104848B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL2398817T5 (pl)	2009-02-19	2021-10-04	Xellia Pharmaceuticals Aps	Sposób oczyszczania lipopeptydów
CN102690329B (zh) *	2011-03-25	2014-06-04	杭州九源基因工程有限公司	一种戈舍瑞林多肽的纯化生产方法
CN102875652A (zh) *	2011-07-13	2013-01-16	北大方正集团有限公司	一种分离纯化达托霉素的方法
CN103159829B (zh) *	2011-12-08	2014-11-05	北大方正集团有限公司	达托霉素的提取方法
CN102675426B (zh) *	2012-04-26	2013-12-11	杭州华东医药集团生物工程研究所有限公司	一种达托霉素的提取纯化方法
CN102924572B (zh) *	2012-11-12	2014-12-03	华北制药集团新药研究开发有限责任公司	一种高纯度达托霉素的制备方法
CN104387444B (zh) *	2014-11-13	2017-12-08	北大医药重庆大新药业股份有限公司	一种达托霉素杂质rs‑2高纯度样品的制备方法
US10617975B2 (en) *	2014-12-15	2020-04-14	Merck Patent Gmbh	Target molecule capture from crude solutions
CN105001305A (zh) *	2015-04-29	2015-10-28	利穗科技(苏州)有限公司	利用层析技术提取高纯度达托霉素的方法
CN105481950B (zh) *	2016-01-28	2019-01-04	丽珠集团福州福兴医药有限公司	一种达托霉素提取方法
IT201600127655A1 (it)	2016-12-16	2018-06-16	Gnosis Spa	Processo per la purificazione di antibiotici lipopolipeptidici
CN108250270A (zh) *	2016-12-29	2018-07-06	天津领世生物科技开发有限公司	一种从发酵液中富集提取达托霉素的方法
CN112979756B (zh) *	2019-12-13	2023-01-03	浙江昌海制药有限公司	达托霉素的提纯方法
CN113004373B (zh) *	2019-12-19	2024-08-13	鲁南制药集团股份有限公司	一种达托霉素的纯化方法
RU2762182C1 (ru) *	2020-12-08	2021-12-16	Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт по изысканию новых антибиотиков имени Г.Ф. Гаузе"	Гауземицины А и В - гликолипопептидные антибактериальные антибиотики и способ их получения
CN113340691B (zh) *	2021-06-05	2023-12-12	清华大学	一种提取海洋沉积物中不同赋存形态磷的方法
CN119119201A (zh) *	2024-09-10	2024-12-13	丽珠集团福州福兴医药有限公司	一种达托霉素的生产方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4537717A (en)	1982-05-21	1985-08-27	Eli Lilly And Company	Derivatives of A-21978C cyclic peptides
US4885243A (en) *	1984-10-09	1989-12-05	Eli Lilly And Company	Process for producing A-21978C derivatives
US4667016A (en)	1985-06-20	1987-05-19	Kirin-Amgen, Inc.	Erythropoietin purification
US4874843A (en)	1987-12-03	1989-10-17	Eli Lilly And Company	Chromatographic purification process
ZA883887B (en)	1987-06-10	1990-02-28	Lilly Co Eli	Chromatographic purification process
JP2661790B2 (ja) *	1990-11-27	1997-10-08	電気化学工業株式会社	入尿トリプシンインヒビターの精製方法
CN1057534C (zh) *	1993-08-17	2000-10-18	柯瑞英-艾格公司	促红细胞生成素类似物
US5650496A (en) *	1995-04-14	1997-07-22	Cephalon, Inc.	IGF-I purification process
US6696412B1 (en)	2000-01-20	2004-02-24	Cubist Pharmaceuticals, Inc.	High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20030045484A1 (en) *	2000-12-18	2003-03-06	Dennis Keith	Methods for preparing purified daptomycin
US20060014674A1 (en)	2000-12-18	2006-01-19	Dennis Keith	Methods for preparing purified lipopeptides
US20100075375A1 (en) *	2006-10-03	2010-03-25	Novo Nordisk A/S	Methods for the purification of polypeptide conjugates
WO2009144739A1 (en)	2008-05-26	2009-12-03	Biocon Limited	Amorphous daptomycin and a method of purification thereof
PL2398817T5 (pl)	2009-02-19	2021-10-04	Xellia Pharmaceuticals Aps	Sposób oczyszczania lipopeptydów
CN101899094B (zh) *	2009-06-01	2012-11-21	安徽丰原发酵技术工程研究有限公司	一种高纯达托霉素的制备方法

2010
- 2010-02-19 PL PL10707694T patent/PL2398817T5/pl unknown
- 2010-02-19 KR KR1020117021714A patent/KR101666144B1/ko active Active
- 2010-02-19 SI SI201030966T patent/SI2398817T2/sl unknown
- 2010-02-19 DK DK10707694.5T patent/DK2398817T4/da active
- 2010-02-19 HR HRP20150761TT patent/HRP20150761T4/hr unknown
- 2010-02-19 AU AU2010216475A patent/AU2010216475B2/en active Active
- 2010-02-19 CN CN201080008292.3A patent/CN102325785B/zh active Active
- 2010-02-19 ES ES10707694T patent/ES2543457T5/es active Active
- 2010-02-19 BR BRPI1008300-6A patent/BRPI1008300B1/pt active IP Right Grant
- 2010-02-19 JP JP2011551028A patent/JP5752609B2/ja active Active
- 2010-02-19 MX MX2011008621A patent/MX2011008621A/es active IP Right Grant
- 2010-02-19 HU HUE10707694A patent/HUE026818T2/en unknown
- 2010-02-19 EP EP10707694.5A patent/EP2398817B2/en active Active
- 2010-02-19 RU RU2011137010/04A patent/RU2526391C2/ru active
- 2010-02-19 CA CA2748932A patent/CA2748932C/en active Active
- 2010-02-19 PT PT107076945T patent/PT2398817E/pt unknown
- 2010-02-19 UA UAA201111075A patent/UA105785C2/uk unknown
- 2010-02-19 WO PCT/NO2010/000066 patent/WO2010095953A1/en not_active Ceased
- 2010-02-19 US US12/708,539 patent/US9150894B2/en active Active
2011
- 2011-06-30 ZA ZA2011/04848A patent/ZA201104848B/en unknown
- 2011-08-01 IL IL214374A patent/IL214374A/en active IP Right Grant

Also Published As

Publication number	Publication date
CN102325785A (zh)	2012-01-18
ES2543457T3 (es)	2015-08-19
IL214374A0 (en)	2011-09-27
CA2748932A1 (en)	2010-08-26
ES2543457T5 (es)	2021-12-22
PT2398817E (pt)	2015-08-28
AU2010216475A1 (en)	2011-08-11
US9150894B2 (en)	2015-10-06
SI2398817T1 (sl)	2015-08-31
RU2526391C2 (ru)	2014-08-20
EP2398817B1 (en)	2015-04-29
RU2011137010A (ru)	2013-03-27
SI2398817T2 (sl)	2021-09-30
ZA201104848B (en)	2012-10-31
HUE026818T2 (en)	2016-07-28
PL2398817T3 (pl)	2015-10-30
WO2010095953A1 (en)	2010-08-26
JP2012518034A (ja)	2012-08-09
EP2398817B2 (en)	2021-06-23
KR101666144B1 (ko)	2016-10-13
US20100228006A1 (en)	2010-09-09
PL2398817T5 (pl)	2021-10-04
UA105785C2 (uk)	2014-06-25
EP2398817A1 (en)	2011-12-28
DK2398817T3 (en)	2015-07-27
AU2010216475B2 (en)	2015-07-09
HRP20150761T1 (hr)	2015-08-14
IL214374A (en)	2017-03-30
JP5752609B2 (ja)	2015-07-22
KR20110134884A (ko)	2011-12-15
MX2011008621A (es)	2011-09-15
CN102325785B (zh)	2015-01-21
DK2398817T4 (da)	2021-08-23
BRPI1008300B1 (pt)	2021-07-13
BRPI1008300A8 (pt)	2021-05-11
HRP20150761T4 (hr)	2021-08-06
CA2748932C (en)	2019-11-19

Legal Events

Date	Code	Title	Description
2018-02-27	B06T	Formal requirements before examination [chapter 6.20 patent gazette]
2018-04-17	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2018-10-23	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]	Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.
2019-12-03	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2020-12-01	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2021-03-23	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2021-06-22	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2021-07-13	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/02/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

Publication	Publication Date	Title
BRPI1008300A2 (pt)	2016-03-15	processo de purificação de daptomicina
BRPI1007829A2 (pt)	2017-04-25	processo de separação
SMT201400100B (it)	2014-11-10	Processo migliorato
BR112012000822A2 (pt)	2017-06-13	processo
BR112012012338A2 (pt)	2017-10-10	processo
BRPI1015393A2 (pt)	2016-04-19	processo de produção de propileno
BRPI0821944A2 (pt)	2015-06-23	Processo
BRPI0919868A2 (pt)	2015-12-15	processo
BRPI1011689A2 (pt)	2016-03-22	processo de autofocalização e conjunto de autofocalização
BRPI0921374A2 (pt)	2015-12-29	processo
BRPI1010093A2 (pt)	2016-03-15	processo de polimerização em solução
BR112012000821A2 (pt)	2017-08-08	"processo"
PT2165971T (pt)	2016-11-16	Processo de hidrotratamento
BRPI1012134A2 (pt)	2016-03-29	processo de carbolinação
BRPI1009187A2 (pt)	2016-03-01	processo de produção de olefina
BRPI1008843A2 (pt)	2019-09-24	processo e dispositivo de purificação de efluentes
BRPI1006478A2 (pt)	2016-02-16	processo de fabricação de poliamida
BR112012014943A2 (pt)	2016-04-05	processo de secagem por atomização
BRPI1009095A2 (pt)	2016-03-01	processo de secagem por atomização
BR112012004842A2 (pt)	2016-03-15	processo de preparação de sílica precipitada
BRPI1007573A2 (pt)	2019-09-24	processo
DE112009001953T8 (de)	2013-03-21	Siliziumreinigungsverfahren
BRPI1010643A2 (pt)	2016-06-07	processo de hidroformilação
BRPI0816237A2 (pt)	2015-02-24	Processo de ciclopropanação
BR112012029016A2 (pt)	2016-08-02	processo de redução direta