BRPI1008743A8 - Processo para o preparo de olopatadina - Google Patents

Processo para o preparo de olopatadina

Info

Publication number
BRPI1008743A8
BRPI1008743A8 BRPI1008743A BRPI1008743A BRPI1008743A8 BR PI1008743 A8 BRPI1008743 A8 BR PI1008743A8 BR PI1008743 A BRPI1008743 A BR PI1008743A BR PI1008743 A BRPI1008743 A BR PI1008743A BR PI1008743 A8 BRPI1008743 A8 BR PI1008743A8
Authority
BR
Brazil
Prior art keywords
olopatadine
preparation
oxepin
dibenz
derivative
Prior art date
Application number
BRPI1008743A
Other languages
English (en)
Inventor
Guidi Alberto
Orru' Gianmauro
Verzini Massimo
Cotarca Livius
Kizirian Jean-Claude
Trepat Guixer Elisenda
Marquillas Olondriz Francisco
Original Assignee
Zach System Spa
Fis Fabbrica Italiana Sintetici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System Spa, Fis Fabbrica Italiana Sintetici Spa filed Critical Zach System Spa
Publication of BRPI1008743A2 publication Critical patent/BRPI1008743A2/pt
Publication of BRPI1008743A8 publication Critical patent/BRPI1008743A8/pt
Publication of BRPI1008743B1 publication Critical patent/BRPI1008743B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCESSO PARA O PREPARO DE OLOPATADINA E/OU UM SAL FARMACEUTICAMENTE ACEITÁVEL DA MESMA A presente invenção refere-se a um processo para o preparo de olopatadina e, mais particularmente, a um método melhorado de síntese da olopatadina que compreende a reação de um derivado de dibenz [b,e] oxepin-1 1-ona de fórmula (III) e um reagente adequado sob condi¢&o de Witting.
BRPI1008743-5A 2009-02-05 2010-02-01 Processo para o preparo de olopatadina BRPI1008743B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09152194.8 2009-02-05
EP09152194 2009-02-05
PCT/EP2010/051148 WO2010089268A2 (en) 2009-02-05 2010-02-01 Process for preparing olopatadine and/or a pharmaceutically acceptable salt thereof

Publications (3)

Publication Number Publication Date
BRPI1008743A2 BRPI1008743A2 (pt) 2015-09-01
BRPI1008743A8 true BRPI1008743A8 (pt) 2017-07-11
BRPI1008743B1 BRPI1008743B1 (pt) 2021-09-08

Family

ID=42109900

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1008743-5A BRPI1008743B1 (pt) 2009-02-05 2010-02-01 Processo para o preparo de olopatadina

Country Status (14)

Country Link
US (1) US8835655B2 (pt)
EP (1) EP2393797B1 (pt)
JP (1) JP5564060B2 (pt)
CN (1) CN102292326B (pt)
AU (1) AU2010211085B2 (pt)
BR (1) BRPI1008743B1 (pt)
CA (1) CA2746331C (pt)
ES (1) ES2581833T3 (pt)
HR (1) HRP20160567T1 (pt)
HU (1) HUE028705T2 (pt)
IL (1) IL213364A (pt)
PL (1) PL2393797T3 (pt)
SI (1) SI2393797T1 (pt)
WO (1) WO2010089268A2 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014147647A1 (en) 2013-03-19 2014-09-25 Council Of Scientific & Industrial Research A process for the synthesis of olopatadine
CN106117176B (zh) * 2016-06-24 2018-12-11 四川大学 二氢双苯并恶庚衍生物及其组合物与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282365A (en) * 1978-11-24 1981-08-04 Merck & Co., Inc. Dibenz[b,e]oxepin compounds
EP0069810B1 (en) 1981-07-09 1986-12-03 Merck & Co. Inc. Novel dibenzoxepins, their preparation, compositions containing them and the use of dibenzoxepins in the treatment of allergic conditions
GB8520662D0 (en) 1985-08-17 1985-09-25 Wellcome Found Tricyclic aromatic compounds
JPS6310784A (ja) 1986-03-03 1988-01-18 Kyowa Hakko Kogyo Co Ltd 抗アレルギー剤
BRPI0512732A (pt) * 2004-06-28 2008-04-08 Alcon Inc formulações tópicas para tratamento de doenças alérgicas
ES2253996B1 (es) 2004-07-28 2007-08-16 Urquima, S.A. Procedimiento para la preparacion del acido 11-((z)-3-(dimetilamino)propiliden)-6,11-dihidrodibenz(b,e)oxepinacetico.
CA2634665A1 (en) 2005-12-22 2007-10-25 Medichem, S.A. Crystalline polymorphic forms of olopatadine hydrochloride and processes for their preparation
US7687646B2 (en) * 2006-03-28 2010-03-30 Azad Pharmaceutical Ingredients, Ag Polymorphic forms of olopatadine hydrochloride and methods for producing olopatadine and salts thereof

Also Published As

Publication number Publication date
AU2010211085A1 (en) 2011-07-07
CN102292326A (zh) 2011-12-21
US8835655B2 (en) 2014-09-16
BRPI1008743B1 (pt) 2021-09-08
PL2393797T3 (pl) 2016-12-30
CN102292326B (zh) 2015-04-22
WO2010089268A2 (en) 2010-08-12
WO2010089268A3 (en) 2010-10-14
HUE028705T2 (en) 2016-12-28
EP2393797B1 (en) 2016-04-20
CA2746331A1 (en) 2010-08-12
AU2010211085B2 (en) 2016-08-25
HRP20160567T1 (hr) 2016-07-01
EP2393797A2 (en) 2011-12-14
JP5564060B2 (ja) 2014-07-30
US20120016138A1 (en) 2012-01-19
CA2746331C (en) 2016-09-06
JP2012516869A (ja) 2012-07-26
IL213364A (en) 2016-06-30
ES2581833T3 (es) 2016-09-07
BRPI1008743A2 (pt) 2015-09-01
SI2393797T1 (sl) 2016-07-29
IL213364A0 (en) 2011-07-31

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 313/12

Ipc: C07D 313/12 (2006.01), A61P 11/02 (2006.01), A61P

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 01/02/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.