PL2411397T3 - Pochodne izotiazolo-pirymidynodionu jako modulatory TRPA1 - Google Patents

Pochodne izotiazolo-pirymidynodionu jako modulatory TRPA1

Info

Publication number: PL2411397T3
Authority: PL; Poland
Prior art keywords: isothiazolo; pyrimidinedione derivatives; trpa1 modulators; trpa1; modulators
Prior art date: 2009-03-23

Application number

PL10716049T

Other languages

English (en)

Inventor

Sukeerthi Kumar

Abraham Thomas

Sanjay Margal

Neelima Khairatkar-Joshi

Indranil Mukhopadhyay

Original Assignee

Glenmark Pharmaceuticals Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-23

Filing date

2010-03-22

Publication date

2013-10-31

2010-03-22 Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa

2013-10-31 Publication of PL2411397T3 publication Critical patent/PL2411397T3/pl

Links

101100482465 Caenorhabditis elegans trpa-1 gene Proteins 0.000 title 1
CBFZADDDBQLSPS-UHFFFAOYSA-N [1,2]thiazolo[4,3-d]pyrimidine 2,2-dioxide Chemical class N1=CN=CC2=NS(=O)(=O)C=C21 CBFZADDDBQLSPS-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PL10716049T 2009-03-23 2010-03-22 Pochodne izotiazolo-pirymidynodionu jako modulatory TRPA1 PL2411397T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
IN665MU2009		2009-03-23
US17135509P	2009-04-21	2009-04-21
PCT/IB2010/000834 WO2010109328A1 (en)	2009-03-23	2010-03-22	Isothiazolo-pyrimidinedione derivatives as trpa1 modulators
EP10716049.1A EP2411397B1 (en)	2009-03-23	2010-03-22	Isothiazolo-pyrimidinedione derivatives as trpa1 modulators

Publications (1)

Publication Number	Publication Date
PL2411397T3 true PL2411397T3 (pl)	2013-10-31

Family

ID=42236291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL10716049T PL2411397T3 (pl)	2009-03-23	2010-03-22	Pochodne izotiazolo-pirymidynodionu jako modulatory TRPA1

Country Status (22)

Country	Link
US (1)	US8575178B2 (pl)
EP (1)	EP2411397B1 (pl)
JP (1)	JP2012521405A (pl)
KR (1)	KR20120001746A (pl)
CN (1)	CN102395592A (pl)
AP (1)	AP2011005888A0 (pl)
AU (1)	AU2010227224A1 (pl)
BR (1)	BRPI1009372A2 (pl)
CA (1)	CA2756534A1 (pl)
DK (1)	DK2411397T3 (pl)
EA (1)	EA201190191A1 (pl)
ES (1)	ES2424340T3 (pl)
IL (1)	IL215179A0 (pl)
MX (1)	MX2011009821A (pl)
PE (1)	PE20120764A1 (pl)
PL (1)	PL2411397T3 (pl)
PT (1)	PT2411397E (pl)
SG (2)	SG174403A1 (pl)
SI (1)	SI2411397T1 (pl)
UA (1)	UA107342C2 (pl)
WO (1)	WO2010109328A1 (pl)
ZA (1)	ZA201107646B (pl)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PE20120834A1 (es)	2009-03-23	2012-07-25	Glenmark Pharmaceuticals Sa	Derivados de furopirimidindiona como moduladores de trpa1
ES2456515T3 (es)	2009-03-23	2014-04-22	Glenmark Pharmaceuticals S.A.	Derivados de pirimidindiona fusionados como moduladores de TRPA1
KR101591153B1 (ko)	2010-12-20	2016-02-02	그렌마크 파머수티칼스 에스. 아.	Trpa1 길항제로서의 2-아미노-4-아릴티아졸 화합물
EP2520566A1 (en)	2011-05-06	2012-11-07	Orion Corporation	New Pharmaceutical Compounds
RU2014100744A (ru)	2011-06-13	2015-07-20	Гленмарк Фармасьютикалс С.А.	Лечение респираторных нарушений с помощью trpa1 антагонистов
WO2012176105A1 (en)	2011-06-22	2012-12-27	Glenmark Pharmaceuticals Sa	Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist
JP2014517062A (ja)	2011-06-22	2014-07-17	グレンマークファーマシューティカルズ，エセ．アー．	ＴＲＰＡ１アンタゴニスト及びβ２アゴニストを含む医薬組成物
US20140148423A1 (en)	2011-07-25	2014-05-29	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition comprising a trpa1 antagonist and a steroid
TWI640519B (zh) *	2011-11-29	2018-11-11	泰緯生命科技股份有限公司	Ｈｅｃ１活性調控因子及其調節方法
US20140364445A1 (en) *	2011-12-05	2014-12-11	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent
AU2013273118B2 (en)	2012-06-08	2015-11-05	Glenmark Pharmaceuticals S.A.	Amides of 2-amino-4-arylthiazole compounds and their salts
PE20150598A1 (es)	2012-10-01	2015-05-20	Orion Corp	Derivados de n-prop-2-inil carboxamida y su uso como antagonistas del receptor transitorio potencial de la subfamilia a, miembro 1
CN105209461A (zh)	2012-11-14	2015-12-30	霍夫曼-拉罗奇有限公司	咪唑并吡啶衍生物
WO2014203210A1 (en)	2013-06-20	2014-12-24	Glenmark Pharmaceuticals S.A.	Nanoparticulate formulation comprising a trpa1 antagonist
MX2016004741A (es)	2013-10-15	2016-07-26	Glenmark Pharmaceuticals Sa	Composicion farmaceutica que comprende un antagonista de trpa1 y un agente analgesico.
WO2015155306A1 (en) *	2014-04-11	2015-10-15	Almirall, S.A.	New trpa1 antagonists
WO2016042501A1 (en)	2014-09-16	2016-03-24	Glenmark Pharmaceuticals S.A.	Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
WO2017060488A1 (en)	2015-10-09	2017-04-13	Almirall, S.A.	New trpa1 antagonists
WO2017064068A1 (en)	2015-10-14	2017-04-20	Almirall, S.A.	New trpa1 antagonists
WO2018233648A1 (zh) *	2017-06-21	2018-12-27	南京明德新药研发股份有限公司	作为TLR8激动剂的异噻唑并[4,3-d]嘧啶-5,7-二胺衍生物
CN112794860B (zh) *	2021-03-24	2021-06-29	上海肇钰医药科技有限公司	噁唑嘧啶酮酰胺类化合物或其可药用盐，制备方法及用途
CN114656480B (zh) *	2022-04-27	2024-01-26	成都施贝康生物医药科技有限公司	噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途
WO2025264860A2 (en)	2024-06-18	2025-12-26	Yale University	Methods of treating post-covid airway disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2248231A1 (de)	1972-10-02	1974-04-11	Basf Ag	3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine
SE9701398D0 (sv)	1997-04-15	1997-04-15	Astra Pharma Prod	Novel compounds
ES2193839B1 (es)	2001-06-22	2005-02-16	Almirall Prodesfarma, S.A.	Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
AU2003253165A1 (en)	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidine fused bicyclic metalloproteinase inhibitors
WO2004055054A1 (en)	2002-12-18	2004-07-01	Novartis Ag	Anktm1, a cold-activated trp-like channel expressed in nociceptive neurons
SE0300119D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
EP1713815A4 (en)	2004-02-11	2009-03-11	Smithkline Beecham Corp	PTH AGONISTS
WO2005089206A2 (en)	2004-03-13	2005-09-29	Irm Llc	Modulators of ion channel trpa1
JPWO2006083005A1 (ja)	2005-02-03	2008-06-26	武田薬品工業株式会社	縮合ピリミジン誘導体およびその用途
EP1962855B1 (en) *	2005-12-22	2013-08-21	Hydra Biosciences, Inc.	Trpa1 inhibitors for treating pain
TW200800997A (en)	2006-03-22	2008-01-01	Astrazeneca Ab	Chemical compounds
WO2008094909A2 (en)	2007-01-29	2008-08-07	Xenon Pharmaceuticals Inc.	Quinazolinone and fused pyrimidinone compounds and their use in treating sodium channel-mediated diseases or conditions
WO2009002933A1 (en)	2007-06-22	2008-12-31	Hydra Biosciences, Inc.	Methods and compositions for treating disorders
WO2009158719A2 (en)	2008-06-27	2009-12-30	Hydra Biosciences, Inc.	Methods and compositions for treating disorders

2010
- 2010-03-22 BR BRPI1009372A patent/BRPI1009372A2/pt not_active IP Right Cessation
- 2010-03-22 JP JP2012501411A patent/JP2012521405A/ja not_active Withdrawn
- 2010-03-22 AU AU2010227224A patent/AU2010227224A1/en not_active Abandoned
- 2010-03-22 DK DK10716049.1T patent/DK2411397T3/da active
- 2010-03-22 EA EA201190191A patent/EA201190191A1/ru unknown
- 2010-03-22 ES ES10716049T patent/ES2424340T3/es active Active
- 2010-03-22 PE PE2011001703A patent/PE20120764A1/es not_active Application Discontinuation
- 2010-03-22 PT PT107160491T patent/PT2411397E/pt unknown
- 2010-03-22 SG SG2011066495A patent/SG174403A1/en unknown
- 2010-03-22 SI SI201030232T patent/SI2411397T1/sl unknown
- 2010-03-22 CN CN2010800168801A patent/CN102395592A/zh active Pending
- 2010-03-22 SG SG2012069464A patent/SG184766A1/en unknown
- 2010-03-22 PL PL10716049T patent/PL2411397T3/pl unknown
- 2010-03-22 EP EP10716049.1A patent/EP2411397B1/en not_active Not-in-force
- 2010-03-22 MX MX2011009821A patent/MX2011009821A/es unknown
- 2010-03-22 AP AP2011005888A patent/AP2011005888A0/xx unknown
- 2010-03-22 WO PCT/IB2010/000834 patent/WO2010109328A1/en not_active Ceased
- 2010-03-22 CA CA2756534A patent/CA2756534A1/en not_active Abandoned
- 2010-03-22 KR KR1020117023383A patent/KR20120001746A/ko not_active Withdrawn
- 2010-03-22 US US13/257,241 patent/US8575178B2/en not_active Expired - Fee Related
- 2010-03-23 UA UAA201111149A patent/UA107342C2/ru unknown
2011
- 2011-09-15 IL IL215179A patent/IL215179A0/en unknown
- 2011-10-19 ZA ZA2011/07646A patent/ZA201107646B/en unknown

Also Published As

Publication number	Publication date
AU2010227224A2 (en)	2011-10-27
SI2411397T1 (sl)	2013-07-31
SG184766A1 (en)	2012-10-30
HK1166081A1 (en)	2012-10-19
EP2411397B1 (en)	2013-05-29
IL215179A0 (en)	2011-12-29
WO2010109328A1 (en)	2010-09-30
SG174403A1 (en)	2011-10-28
CN102395592A (zh)	2012-03-28
EP2411397A1 (en)	2012-02-01
MX2011009821A (es)	2012-01-25
US8575178B2 (en)	2013-11-05
US20120010223A1 (en)	2012-01-12
PT2411397E (pt)	2013-06-06
BRPI1009372A2 (pt)	2016-05-31
ES2424340T3 (es)	2013-10-01
PE20120764A1 (es)	2012-06-27
UA107342C2 (en)	2014-12-25
EA201190191A1 (ru)	2012-11-30
CA2756534A1 (en)	2010-09-30
DK2411397T3 (da)	2013-08-05
ZA201107646B (en)	2012-06-25
JP2012521405A (ja)	2012-09-13
AU2010227224A1 (en)	2011-09-29
AP2011005888A0 (en)	2011-10-31
KR20120001746A (ko)	2012-01-04

Publication	Publication Date	Title
AP2948A (en)	2014-07-31	Thienopyrmidinedione derivatives as TRPA1 modulators
ZA201107646B (en)	2012-06-25	Isothiazolo-prrimidinedione derivatives as trpa1 modulators
AP3280A (en)	2015-05-31	Fused pyrimidine-dione derivatives as TRPA1 modulators
IL219087A0 (en)	2012-06-28	Benzimidazole-imidazole derivatives
IL217956A0 (en)	2012-03-29	N1-sulfonyl-5-fluoropyrimidinone derivatives
IL217953A0 (en)	2012-03-29	5-fluoropyrimidinone derivatives
IL215169A0 (en)	2011-12-29	Isoxazole -pyridine derivatives as gaba modulators
IL216007A0 (en)	2012-01-31	Isoxazole-pyridine derivatives
IL215109A0 (en)	2011-12-29	Isoxazole-pyridazine derivatives
IL214941A0 (en)	2011-11-30	Isoxazole-pyrazole derivatives
IL217952A0 (en)	2012-03-29	N1-acyl-5-fluoropyrimidinone derivatives
IL213927A0 (en)	2011-07-31	Deoxyactagardine derivatives
IL216761A0 (en)	2012-02-29	Pyrazinooxazepine derivatives
GB0921967D0 (en)	2010-02-03	Novel Aryloxyanilide Derivatives
ZA201104279B (en)	2012-02-29	Tetrahydronaphthalen-2-ol derivatives
GB0912499D0 (en)	2009-08-26	Indopyl-pyridone derivatives
AP2011005883A0 (en)	2011-10-31	Furopyrimidinedione derivatives as TRPA1 modulators.