BRPI1009900A2 - métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursores - Google Patents
métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursoresInfo
- Publication number
- BRPI1009900A2 BRPI1009900A2 BRPI1009900A BRPI1009900A BRPI1009900A2 BR PI1009900 A2 BRPI1009900 A2 BR PI1009900A2 BR PI1009900 A BRPI1009900 A BR PI1009900A BR PI1009900 A BRPI1009900 A BR PI1009900A BR PI1009900 A2 BRPI1009900 A2 BR PI1009900A2
- Authority
- BR
- Brazil
- Prior art keywords
- dioxo
- diazabicyclo
- precursors
- ethyl
- preparation
- Prior art date
Links
- BDABGOLMYNHHTR-UHFFFAOYSA-N Perzinfotel Chemical compound OP(O)(=O)CCN1CCCNC2=C1C(=O)C2=O BDABGOLMYNHHTR-UHFFFAOYSA-N 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16151309P | 2009-03-19 | 2009-03-19 | |
| PCT/US2010/027908 WO2010108063A1 (en) | 2009-03-19 | 2010-03-19 | Methods for the preparation of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid and precursors thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1009900A2 true BRPI1009900A2 (pt) | 2016-03-15 |
Family
ID=42227623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1009900A BRPI1009900A2 (pt) | 2009-03-19 | 2010-03-19 | métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursores |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20120116074A1 (pt) |
| EP (1) | EP2408790A1 (pt) |
| JP (1) | JP2012521352A (pt) |
| KR (1) | KR20110139274A (pt) |
| CN (1) | CN102356087A (pt) |
| AR (1) | AR075900A1 (pt) |
| AU (1) | AU2010226479A1 (pt) |
| BR (1) | BRPI1009900A2 (pt) |
| CA (1) | CA2754390A1 (pt) |
| MX (1) | MX2011009716A (pt) |
| WO (1) | WO2010108063A1 (pt) |
| ZA (1) | ZA201107412B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2496125C2 (ru) * | 2008-02-25 | 2013-10-20 | Конинклейке Филипс Электроникс Н.В. | Передающая среда для детекторов излучения, расположенная в изометрической плоскости |
| WO2010121133A2 (en) * | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
| KR101474063B1 (ko) | 2012-05-23 | 2014-12-19 | 동국대학교 산학협력단 | 피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 ｃｔ 조영제 |
| US20170050989A1 (en) * | 2013-12-03 | 2017-02-23 | The General Hospital Corporation | Molecular Imaging Probes |
| WO2018204872A2 (en) | 2017-05-05 | 2018-11-08 | Fusion Pharmaceuticals Inc. | Igf-1r monoclonal antibodies and uses thereof |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| AU2018261888B2 (en) | 2017-05-05 | 2022-06-30 | Centre For Probe Development And Commercialization | Pharmacokinetic enhancements of bifunctional chelates and uses thereof |
| CA3128891A1 (en) | 2019-12-09 | 2021-06-17 | Sino Canada Health Institute Inc. | Method for monitoring pet readout positions using mri fiducials |
| AU2022282449A1 (en) * | 2021-05-27 | 2023-11-30 | Fusion Pharmaceuticals Inc. | 2,6-dichlorophenyl ester compounds and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CH584232A5 (pt) * | 1973-07-26 | 1977-01-31 | Ciba Geigy Ag | |
| US4899755A (en) | 1985-05-08 | 1990-02-13 | The General Hospital Corporation | Hepatobiliary NMR contrast agents |
| US5021556A (en) | 1987-07-22 | 1991-06-04 | Neorx Corporation | Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides |
| US5075099A (en) | 1988-05-31 | 1991-12-24 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| EP0489869B1 (en) | 1989-08-28 | 1998-11-11 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic nmr imaging |
| US5367080A (en) | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
| US5168103A (en) | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| JP2774378B2 (ja) | 1991-02-08 | 1998-07-09 | ダイアテク，インコーポレイテッド | 映像用テクネチウム−９９ｍ標識化ポリペプチド |
| US5849261A (en) | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5965107A (en) | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
| JP3812680B2 (ja) | 1994-03-16 | 2006-08-23 | マリンクロッド・インコーポレイテッド | 放射性医薬用途のペプチド類およびタンパク質類の安定化 |
| US5582814A (en) | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
| TW319763B (pt) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US5672877A (en) | 1996-03-27 | 1997-09-30 | Adac Laboratories | Coregistration of multi-modality data in a medical imaging system |
| KR20060025233A (ko) | 1996-04-01 | 2006-03-20 | 에픽스 메디칼, 인코포레이티드 | 생체활성화 진단용 영상 콘트라스트 제제 |
| ATE314097T1 (de) | 1996-10-28 | 2006-01-15 | Amersham Health As | Kontrastmittel |
| US5919967A (en) | 1997-04-11 | 1999-07-06 | Epix Medical, Inc. | Process for synthesizing phosphodiesters |
| US5886142A (en) | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
| BR9811807A (pt) * | 1997-08-01 | 2000-08-15 | American Home Prod | Processo para a preparação de ácido [2-(8,9)-dioxo-2,6-diazabiciclo-[5.2.0]-non-1(7)-en-2-il)-etil] fosfÈnico |
| ES2206996T3 (es) | 1997-10-02 | 2004-05-16 | Epix Medical Inc | Metodo de formacion de imagenes para diagnostico con contraste mejorado para monitorizar terapias de intervencion. |
| EP1203026A4 (en) | 1999-07-29 | 2005-03-16 | Dyax Corp | BINDING CENTERS FOR FIBRIN |
| US6984373B2 (en) | 2000-12-23 | 2006-01-10 | Dyax Corp. | Fibrin binding moieties useful as imaging agents |
| US6549798B2 (en) | 2001-02-07 | 2003-04-15 | Epix Medical, Inc. | Magnetic resonance angiography data |
| TWI284539B (en) | 2001-07-30 | 2007-08-01 | Epix Pharm Inc | A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide |
| TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| DE10141186A1 (de) | 2001-08-22 | 2003-03-20 | Siemens Ag | Einrichtung zum Bearbeiten von Bildern, insbesondere medizinischen Bildern |
| UA78529C2 (en) | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
| US6898331B2 (en) | 2002-08-28 | 2005-05-24 | Bae Systems Aircraft Controls, Inc. | Image fusion system and method |
| CA2526760A1 (en) | 2003-05-23 | 2005-01-06 | Epix Pharmaceuticals, Inc. | Optically pure and enriched isomers of chelating ligands and contrast agents |
| CN100418585C (zh) | 2003-07-24 | 2008-09-17 | 伯拉考成像股份公司 | 稳定的放射性药物组合物及制备方法 |
| TW200514775A (en) | 2003-10-22 | 2005-05-01 | Wyeth Corp | Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof |
| WO2007047608A2 (en) | 2005-10-14 | 2007-04-26 | Epix Pharmaceuticals, Inc. | Fibrin targeted therapeutics |
| EP2111237B1 (en) * | 2006-12-11 | 2015-03-18 | BRACCO IMAGING S.p.A. | Fibrin-binding peptides and conjugates thereof |
| US20090061024A1 (en) | 2007-08-27 | 2009-03-05 | Wyeth | Compositions and methods employing nmda antagonists for achieving an anesthetic-sparing effect |
-
2010
- 2010-03-19 BR BRPI1009900A patent/BRPI1009900A2/pt not_active Application Discontinuation
- 2010-03-19 AR ARP100100895A patent/AR075900A1/es not_active Application Discontinuation
- 2010-03-19 WO PCT/US2010/027908 patent/WO2010108063A1/en not_active Ceased
- 2010-03-19 KR KR1020117024351A patent/KR20110139274A/ko not_active Ceased
- 2010-03-19 MX MX2011009716A patent/MX2011009716A/es not_active Application Discontinuation
- 2010-03-19 CA CA2754390A patent/CA2754390A1/en not_active Abandoned
- 2010-03-19 AU AU2010226479A patent/AU2010226479A1/en not_active Abandoned
- 2010-03-19 CN CN2010800119434A patent/CN102356087A/zh active Pending
- 2010-03-19 EP EP10710739A patent/EP2408790A1/en not_active Withdrawn
- 2010-03-19 US US13/256,777 patent/US20120116074A1/en not_active Abandoned
- 2010-03-19 JP JP2012500984A patent/JP2012521352A/ja not_active Withdrawn
- 2010-04-16 US US13/256,795 patent/US9200017B2/en active Active
-
2011
- 2011-10-10 ZA ZA2011/07412A patent/ZA201107412B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2011009716A (es) | 2011-10-17 |
| CA2754390A1 (en) | 2010-09-23 |
| EP2408790A1 (en) | 2012-01-25 |
| KR20110139274A (ko) | 2011-12-28 |
| WO2010108063A1 (en) | 2010-09-23 |
| US20120077958A1 (en) | 2012-03-29 |
| AR075900A1 (es) | 2011-05-04 |
| CN102356087A (zh) | 2012-02-15 |
| US20120116074A1 (en) | 2012-05-10 |
| ZA201107412B (en) | 2012-07-25 |
| JP2012521352A (ja) | 2012-09-13 |
| US9200017B2 (en) | 2015-12-01 |
| AU2010226479A1 (en) | 2011-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |