BRPI1010163A2 - "método para analisar metabólitos polares e método para arrefecer bruscamente uma amostra biológica que compreende material celular". - Google Patents

"método para analisar metabólitos polares e método para arrefecer bruscamente uma amostra biológica que compreende material celular".

Info

Publication number
BRPI1010163A2
BRPI1010163A2 BRPI1010163A BRPI1010163A BRPI1010163A2 BR PI1010163 A2 BRPI1010163 A2 BR PI1010163A2 BR PI1010163 A BRPI1010163 A BR PI1010163A BR PI1010163 A BRPI1010163 A BR PI1010163A BR PI1010163 A2 BRPI1010163 A2 BR PI1010163A2
Authority
BR
Brazil
Prior art keywords
quenching
biological sample
cellular material
polar metabolites
analyzing polar
Prior art date
Application number
BRPI1010163A
Other languages
English (en)
Inventor
Gerd Balcke
Martin Dostler
Ralf Looser
Susan Carvalho
Tilmann B Walk
Original Assignee
Basf Plant Science Co Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Plant Science Co Gmbh filed Critical Basf Plant Science Co Gmbh
Publication of BRPI1010163A2 publication Critical patent/BRPI1010163A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173845—Amine and quaternary ammonium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/19—Halogen containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BRPI1010163A 2009-07-08 2010-07-07 "método para analisar metabólitos polares e método para arrefecer bruscamente uma amostra biológica que compreende material celular". BRPI1010163A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09164949A EP2273267A1 (en) 2009-07-08 2009-07-08 Methods or analyzing polar metabolites of the engergy metabolism
US22816509P 2009-07-24 2009-07-24
PCT/EP2010/059740 WO2011003945A1 (en) 2009-07-08 2010-07-07 Methods for analyzing polar metabolites of the energy metabolism

Publications (1)

Publication Number Publication Date
BRPI1010163A2 true BRPI1010163A2 (pt) 2016-03-29

Family

ID=41382136

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1010163A BRPI1010163A2 (pt) 2009-07-08 2010-07-07 "método para analisar metabólitos polares e método para arrefecer bruscamente uma amostra biológica que compreende material celular".

Country Status (9)

Country Link
US (1) US8586367B2 (pt)
EP (3) EP2273267A1 (pt)
JP (1) JP5735500B2 (pt)
CN (1) CN102472741B (pt)
AU (1) AU2010270261B2 (pt)
BR (1) BRPI1010163A2 (pt)
CA (1) CA2764937A1 (pt)
DK (1) DK2937694T3 (pt)
WO (1) WO2011003945A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6173667B2 (ja) * 2012-09-20 2017-08-02 ヒューマン・メタボローム・テクノロジーズ株式会社 代謝物の抽出方法
WO2014079696A1 (de) 2012-11-21 2014-05-30 Basf Plant Science Company Gmbh Verfahren und vorrichtung zur isotopenmarkierung
WO2015071883A1 (en) * 2013-11-15 2015-05-21 Basf Plant Science Company Gmbh Process for growing and preparing cells in-vitro for metabolic profiling
CN104614212B (zh) * 2015-01-20 2017-06-06 济宁神康生物科技有限公司 一种贴壁细胞定量代谢组学分析样品预处理的方法
CN105004825A (zh) * 2015-05-05 2015-10-28 南京工业大学 一种基于成骨细胞细胞组织gc/ms代谢组学分析方法
CN106324159A (zh) * 2015-07-02 2017-01-11 中国科学院大连化学物理研究所 一种贴壁细胞内小分子代谢产物检测分析的前处理方法
CN105606693B (zh) * 2016-03-15 2018-12-04 南昌大学 电喷雾萃取电离质谱直接检测蜂胶中五种化学污染物的方法
JP6909466B2 (ja) * 2017-07-25 2021-07-28 大陽日酸株式会社 標識代謝物の製造方法、代謝物の定量方法、及び標識代謝物製造キット
CN111351877A (zh) * 2020-04-01 2020-06-30 上海中科新生命生物科技有限公司 基于uplc-msms的组织能量代谢物质的分析方法
CN112697894A (zh) * 2020-11-30 2021-04-23 重庆医科大学附属口腔医院 氨基酸同位素标记物的定量分析方法
JP7459814B2 (ja) * 2021-02-03 2024-04-02 株式会社島津製作所 液体クロマトグラフ質量分析装置を用いた一次代謝物の分析方法
JPWO2023032268A1 (pt) * 2021-08-31 2023-03-09
CN116448915A (zh) * 2023-04-17 2023-07-18 贵州汉方药业有限公司 阿胶中的特征多肽和小分子代谢物同步快速分析的方法
CN116773823A (zh) * 2023-06-25 2023-09-19 济宁医学院附属医院 一种快速鉴定与蛋白相互作用的小分子代谢物配体的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540884A (en) 1982-12-29 1985-09-10 Finnigan Corporation Method of mass analyzing a sample by use of a quadrupole ion trap
US5397894A (en) 1993-05-28 1995-03-14 Varian Associates, Inc. Method of high mass resolution scanning of an ion trap mass spectrometer
WO2002038556A2 (en) * 2000-11-08 2002-05-16 Actipharm, Inc. Process for mass production of gmp paclitaxel and related taxanes
PT1446210E (pt) * 2001-11-13 2007-04-30 Metanomics Gmbh Processo para a extracção e para a analise de componentes de material orgânico
WO2003041834A1 (de) * 2001-11-13 2003-05-22 Metanomics Gmbh & Co. Kgaa Verfahren zur extraktion von inhaltsstoffen aus organischem material
WO2005039381A2 (en) * 2003-05-05 2005-05-06 Drug Risk Solutions, L.L.C. Compositions and processes for analysis of pharmacologic agents in biological samples
US20040259221A1 (en) * 2003-05-21 2004-12-23 Large Scale Biology Corporation Separation of cytosolic and nuclear proteins
CN100376893C (zh) * 2006-08-18 2008-03-26 中国水产科学研究院黄海水产研究所 同时测定鱼肉中磺胺甲唑、乙酰化磺胺甲唑及甲氧苄啶的液相色谱法
CN101430306A (zh) * 2008-12-18 2009-05-13 浙江大学 一种尿液中邻二羟基类代谢物谱的检测方法

Also Published As

Publication number Publication date
JP2012533053A (ja) 2012-12-20
US8586367B2 (en) 2013-11-19
CN102472741A (zh) 2012-05-23
EP2937694A1 (en) 2015-10-28
JP5735500B2 (ja) 2015-06-17
EP2937694B1 (en) 2017-05-24
WO2011003945A1 (en) 2011-01-13
AU2010270261B2 (en) 2015-10-08
EP2273267A1 (en) 2011-01-12
CN102472741B (zh) 2015-02-18
EP2452191A1 (en) 2012-05-16
DK2937694T3 (en) 2017-09-11
US20120107940A1 (en) 2012-05-03
AU2010270261A1 (en) 2012-01-19
CA2764937A1 (en) 2011-01-13

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]