BRPI1010884A2 - composto inibidores hdac de alcanoilamino benzamida anilina - Google Patents

composto inibidores hdac de alcanoilamino benzamida anilina

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Publication number
BRPI1010884A2
BRPI1010884A2 BRPI1010884A BRPI1010884A BRPI1010884A2 BR PI1010884 A2 BRPI1010884 A2 BR PI1010884A2 BR PI1010884 A BRPI1010884 A BR PI1010884A BR PI1010884 A BRPI1010884 A BR PI1010884A BR PI1010884 A2 BRPI1010884 A2 BR PI1010884A2
Authority
BR
Brazil
Prior art keywords
hdac
alkanoylamino
inhibitors compound
benzamide aniline
benzamide
Prior art date
Application number
BRPI1010884A
Other languages
English (en)
Inventor
Chandrasekar Venkataramani
Michael Graupe
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of BRPI1010884A2 publication Critical patent/BRPI1010884A2/pt

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    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/47—Quinolines; Isoquinolines
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NZ596863A (en) 2014-02-28
JP2014043463A (ja) 2014-03-13
US8431610B2 (en) 2013-04-30
CA2763786A1 (en) 2010-12-16
AU2010259035A1 (en) 2011-12-08
CA2763786C (en) 2014-09-30
JP5586692B2 (ja) 2014-09-10
CN102459159A (zh) 2012-05-16
US20120301426A1 (en) 2012-11-29
US8258316B2 (en) 2012-09-04
EP2440519A1 (en) 2012-04-18
WO2010144371A1 (en) 2010-12-16
US20100310500A1 (en) 2010-12-09
JP2012529435A (ja) 2012-11-22
KR20120031170A (ko) 2012-03-30

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