BRPI1011931A2 - trans-4[[(5s)-5-[[[3,5-bis(trifluorometil)fenil]metil] de ácido(2-metil-2h-tetrazol-5-il)amino]-2,3,4,5-tetra-hidro-7,9-dimetil-1h-1-benzazepin-1-il]metil]-ciclo-hexanocarboxílico - Google Patents

trans-4[[(5s)-5-[[[3,5-bis(trifluorometil)fenil]metil] de ácido(2-metil-2h-tetrazol-5-il)amino]-2,3,4,5-tetra-hidro-7,9-dimetil-1h-1-benzazepin-1-il]metil]-ciclo-hexanocarboxílico

Info

Publication number: BRPI1011931A2
Authority: BR; Brazil
Prior art keywords: methyl; trans; benzazepin; tetrazol; tetrahydro
Prior art date: 2009-06-30

Application number

BRPI1011931A

Other languages

English (en)

Inventor

David Michael Remick

Scott Alan Frank

Steven Wayne Pedersen

Xinchao Chen

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-06-30

Filing date

2010-06-28

Publication date

2016-04-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42352717&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1011931(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-06-28 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2016-04-19 Publication of BRPI1011931A2 publication Critical patent/BRPI1011931A2/pt

Links

NZNMSOFKMUBTKW-UHFFFAOYSA-N cyclohexanecarboxylic acid Chemical compound OC(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-N 0.000 title 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 2
-1 2-methyl-2h-tetrazol-5-yl Chemical group 0.000 title 1
VZFUCHSFHOYXIS-UHFFFAOYSA-N cycloheptane carboxylic acid Natural products OC(=O)C1CCCCCC1 VZFUCHSFHOYXIS-UHFFFAOYSA-N 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

BRPI1011931A 2009-06-30 2010-06-28 trans-4[[(5s)-5-[[[3,5-bis(trifluorometil)fenil]metil] de ácido(2-metil-2h-tetrazol-5-il)amino]-2,3,4,5-tetra-hidro-7,9-dimetil-1h-1-benzazepin-1-il]metil]-ciclo-hexanocarboxílico BRPI1011931A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22170809P	2009-06-30	2009-06-30
PCT/US2010/040125 WO2011002696A1 (en)	2009-06-30	2010-06-28	Trans-4-[[(5s)-5-[[[3,5-bis(trifluoromethyl)phenyl]methyl] (2-methyl-2h-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1h-1-benzazepin-1-yl]methyl]-cyclohexanecarboxylic acid

Publications (1)

Publication Number	Publication Date
BRPI1011931A2 true BRPI1011931A2 (pt)	2016-04-19

Family

ID=42352717

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1011931A BRPI1011931A2 (pt)	2009-06-30	2010-06-28	trans-4[[(5s)-5-[[[3,5-bis(trifluorometil)fenil]metil] de ácido(2-metil-2h-tetrazol-5-il)amino]-2,3,4,5-tetra-hidro-7,9-dimetil-1h-1-benzazepin-1-il]metil]-ciclo-hexanocarboxílico

Country Status (37)

Country	Link
US (2)	US8299060B2 (pt)
EP (1)	EP2448933B1 (pt)
JP (1)	JP5689875B2 (pt)
KR (1)	KR101404893B1 (pt)
CN (1)	CN102639528B (pt)
AR (1)	AR077208A1 (pt)
AU (1)	AU2010266537B2 (pt)
BR (1)	BRPI1011931A2 (pt)
CA (1)	CA2764425C (pt)
CL (1)	CL2011003263A1 (pt)
CO (1)	CO6480934A2 (pt)
CR (1)	CR20110669A (pt)
DK (1)	DK2448933T3 (pt)
DO (1)	DOP2011000405A (pt)
EA (1)	EA020600B1 (pt)
EC (1)	ECSP11011551A (pt)
ES (1)	ES2435293T3 (pt)
GT (1)	GT201100321A (pt)
HR (1)	HRP20130950T1 (pt)
IL (1)	IL216655A (pt)
JO (1)	JO2867B1 (pt)
MA (1)	MA33385B1 (pt)
ME (1)	ME01606B (pt)
MX (1)	MX2011014024A (pt)
MY (1)	MY157121A (pt)
NZ (1)	NZ596820A (pt)
PE (1)	PE20120538A1 (pt)
PL (1)	PL2448933T3 (pt)
PT (1)	PT2448933E (pt)
RS (1)	RS52988B (pt)
SG (1)	SG177413A1 (pt)
SI (1)	SI2448933T1 (pt)
TN (1)	TN2011000638A1 (pt)
TW (1)	TWI450896B (pt)
UA (1)	UA109409C2 (pt)
WO (1)	WO2011002696A1 (pt)
ZA (1)	ZA201108707B (pt)

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JP2008504266A (ja) *	2004-06-24	2008-02-14	イーライリリーアンドカンパニー	異脂肪血症を治療するための化合物及び方法
TWI450896B (zh) *	2009-06-30	2014-09-01	Lilly Co Eli	反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸
PL2729142T3 (pl) *	2011-07-08	2018-10-31	Novartis Ag	Sposób leczenia miażdżycy tętnic u osobników z wysokim poziomem triglicerydów
CN103958501B (zh) *	2012-07-16	2016-08-17	上海恒瑞医药有限公司	苯并七元杂环类衍生物、其制备方法及其在医药上的应用
HUE033790T2 (en)	2013-01-31	2017-12-28	Chong Kun Dang Pharmaceutical Corp	Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as cetp inhibitors
CN105017085B (zh) *	2014-04-28	2018-06-29	中国科学院上海药物研究所	一类kcnq钾通道激动剂、其制备方法和用途
RU2703192C2 (ru)	2014-07-30	2019-10-15	Ф. Хоффманн-Ля Рош Аг	Генетические маркеры для прогнозирования ответа на терапию поднимающими уровень hdl или имитирующими hdl агентами
TWI691331B (zh)	2014-09-26	2020-04-21	日商興和股份有限公司	脂質異常症治療劑
CN108456213B (zh) *	2017-02-22	2021-01-15	浙江九洲药业股份有限公司	一种3-氟-4-羟基环己烷羧酸酯的制备方法
WO2025093129A1 (en)	2023-11-01	2025-05-08	Newamsterdam Pharma B.V.	Treatment and prevention of age-related macular degeneration using a cetp inhibitor

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JPS4948639B1 (pt)	1970-12-15	1974-12-23
US6147089A (en)	1998-09-17	2000-11-14	Pfizer Inc.	Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
GT199900147A (es) *	1998-09-17	1999-09-06		1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
US6197786B1 (en)	1998-09-17	2001-03-06	Pfizer Inc	4-Carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines
CO5271716A1 (es)	1999-11-30	2003-04-30	Pfizer Prod Inc	Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida
HN2000000203A (es) *	1999-11-30	2001-06-13	Pfizer Prod Inc	Procedimiento para la obtencion de 1,2,3,4-tetrahidroquinolinas 4-carboxiamino-2- sustituidas.
ES2256461T3 (es) *	2001-04-30	2006-07-16	Pfizer Products Inc.	Compuestos utiles como intermediarios de derivados de 4-aminoquinolina.
ES2277142T3 (es)	2002-08-30	2007-07-01	Japan Tobacco Inc.	Compuesto de dibencilamina y su uso medicinal.
PL376156A1 (en)	2002-10-04	2005-12-27	Millennium Pharmaceuticals, Inc.	Pgd2 receptor antagonists for the treatment of inflammatory diseases
EP1601655A2 (en) *	2003-03-04	2005-12-07	Takasago International Corporation	Method for producing optically active amines
US20040204450A1 (en) *	2003-03-28	2004-10-14	Pfizer Inc	Quinoline and quinoxaline compounds
PL1670768T3 (pl) *	2003-10-08	2010-01-29	Lilly Co Eli	Związki i sposoby leczenia dyslipidemii
EA200601785A1 (ru)	2004-03-26	2007-02-27	Эли Лилли Энд Компани	Соединения и способы лечения дислипидемии
CN1972927A (zh) *	2004-06-24	2007-05-30	伊莱利利公司	用于治疗血脂障碍的化合物和方法
JP2008504266A (ja) *	2004-06-24	2008-02-14	イーライリリーアンドカンパニー	異脂肪血症を治療するための化合物及び方法
WO2006069162A1 (en) *	2004-12-20	2006-06-29	Reddy Us Therapeutics, Inc.	Novel heterocyclic compounds and their pharmaceutical compositions
TWI450896B (zh) *	2009-06-30	2014-09-01	Lilly Co Eli	反式－４－〔〔（５ｓ）－５－〔〔〔３，５－雙（三氟甲基）苯基〕甲基〕（２－甲基－２ｈ－四唑－５－基）胺基〕－２，３，４，５－四氫－７，９－二甲基－１ｈ－１－苯并氮呯－１－基〕甲基〕－環己基羧酸

2010
- 2010-06-23 TW TW099120507A patent/TWI450896B/zh not_active IP Right Cessation
- 2010-06-23 AR ARP100102219A patent/AR077208A1/es unknown
- 2010-06-24 JO JO2010211A patent/JO2867B1/en active
- 2010-06-28 UA UAA201115555A patent/UA109409C2/ru unknown
- 2010-06-28 US US13/318,874 patent/US8299060B2/en not_active Expired - Fee Related
- 2010-06-28 CN CN201080029957.9A patent/CN102639528B/zh not_active Expired - Fee Related
- 2010-06-28 PL PL10728558T patent/PL2448933T3/pl unknown
- 2010-06-28 KR KR1020117031449A patent/KR101404893B1/ko not_active Expired - Fee Related
- 2010-06-28 MA MA34490A patent/MA33385B1/fr unknown
- 2010-06-28 CA CA2764425A patent/CA2764425C/en not_active Expired - Fee Related
- 2010-06-28 US US12/824,355 patent/US8329688B2/en not_active Expired - Fee Related
- 2010-06-28 EA EA201270099A patent/EA020600B1/ru not_active IP Right Cessation
- 2010-06-28 HR HRP20130950AT patent/HRP20130950T1/hr unknown
- 2010-06-28 SG SG2011097128A patent/SG177413A1/en unknown
- 2010-06-28 ME MEP-2013-114A patent/ME01606B/me unknown
- 2010-06-28 PE PE2011002156A patent/PE20120538A1/es not_active Application Discontinuation
- 2010-06-28 MX MX2011014024A patent/MX2011014024A/es active IP Right Grant
- 2010-06-28 MY MYPI2011006319A patent/MY157121A/en unknown
- 2010-06-28 WO PCT/US2010/040125 patent/WO2011002696A1/en not_active Ceased
- 2010-06-28 AU AU2010266537A patent/AU2010266537B2/en not_active Ceased
- 2010-06-28 PT PT107285587T patent/PT2448933E/pt unknown
- 2010-06-28 EP EP10728558.7A patent/EP2448933B1/en active Active
- 2010-06-28 RS RS20130453A patent/RS52988B/sr unknown
- 2010-06-28 ES ES10728558T patent/ES2435293T3/es active Active
- 2010-06-28 NZ NZ596820A patent/NZ596820A/xx not_active IP Right Cessation
- 2010-06-28 JP JP2012517814A patent/JP5689875B2/ja not_active Expired - Fee Related
- 2010-06-28 DK DK10728558.7T patent/DK2448933T3/da active
- 2010-06-28 SI SI201030386T patent/SI2448933T1/sl unknown
- 2010-06-28 BR BRPI1011931A patent/BRPI1011931A2/pt not_active IP Right Cessation
2011
- 2011-11-25 ZA ZA2011/08707A patent/ZA201108707B/en unknown
- 2011-11-28 IL IL216655A patent/IL216655A/en not_active IP Right Cessation
- 2011-12-12 CR CR20110669A patent/CR20110669A/es not_active Application Discontinuation
- 2011-12-13 GT GT201100321A patent/GT201100321A/es unknown
- 2011-12-13 TN TNP2011000638A patent/TN2011000638A1/en unknown
- 2011-12-22 CO CO11177215A patent/CO6480934A2/es active IP Right Grant
- 2011-12-22 CL CL2011003263A patent/CL2011003263A1/es unknown
- 2011-12-23 EC EC2011011551A patent/ECSP11011551A/es unknown
- 2011-12-26 DO DO2011000405A patent/DOP2011000405A/es unknown

Also Published As

Publication number	Publication date
GT201100321A (es)	2012-11-15
MA33385B1 (fr)	2012-06-01
EA201270099A1 (ru)	2012-05-30
ZA201108707B (en)	2013-05-29
ME01606B (me)	2014-09-20
RS52988B (sr)	2014-02-28
KR101404893B1 (ko)	2014-06-20
KR20120027426A (ko)	2012-03-21
ES2435293T3 (es)	2013-12-18
HRP20130950T1 (hr)	2013-11-22
MX2011014024A (es)	2012-04-20
SG177413A1 (en)	2012-02-28
JO2867B1 (en)	2015-03-15
US20100331309A1 (en)	2010-12-30
EP2448933A1 (en)	2012-05-09
MY157121A (en)	2016-05-13
SI2448933T1 (sl)	2013-11-29
US8329688B2 (en)	2012-12-11
JP5689875B2 (ja)	2015-03-25
ECSP11011551A (es)	2012-01-31
DOP2011000405A (es)	2012-01-15
CN102639528B (zh)	2014-07-16
TW201113275A (en)	2011-04-16
TWI450896B (zh)	2014-09-01
AU2010266537A1 (en)	2012-02-02
IL216655A0 (en)	2012-02-29
CN102639528A (zh)	2012-08-15
TN2011000638A1 (en)	2013-05-24
CO6480934A2 (es)	2012-07-16
EP2448933B1 (en)	2013-08-28
US8299060B2 (en)	2012-10-30
AR077208A1 (es)	2011-08-10
PT2448933E (pt)	2013-10-29
US20120058990A1 (en)	2012-03-08
CA2764425A1 (en)	2011-01-06
AU2010266537B2 (en)	2013-04-18
PL2448933T3 (pl)	2014-01-31
DK2448933T3 (da)	2013-10-07
EA020600B1 (ru)	2014-12-30
IL216655A (en)	2015-02-26
CR20110669A (es)	2012-03-16
PE20120538A1 (es)	2012-05-09
UA109409C2 (ru)	2015-08-25
WO2011002696A1 (en)	2011-01-06
CL2011003263A1 (es)	2012-07-27
JP2012532106A (ja)	2012-12-13
CA2764425C (en)	2015-01-06
NZ596820A (en)	2013-07-26

Legal Events

Date	Code	Title	Description
2017-04-25	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2017-08-08	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Publication	Publication Date	Title
SMT201400010B (it)	2014-03-07	Purificazione di 1-[2-(2,4-dimetilfenilsolfanil)fenilÜpiperazin a
DK2448933T3 (da)	2013-10-07	Trans-4-[[(5S)-5-[[[3,5-bis(trifluormethyl)phenyl]methyl](2-methyl-2H-tetrazol-5-yl)amino]-2,3,4,5-tetrahydro-7,9-dimethyl-1H-1-benzazepin-1-yl]methyl]-cyclohexancarboxylsyre
ITCO20080005A1 (it)	2009-08-20	"shaker monouso"
EP2421537A4 (en)	2012-06-13	PYRAZOLYLAMINOPYRIDINE AS A FAK HEMMER
BRPI0922904A2 (pt)	2018-05-29	"compostos"
IT1399597B1 (it)	2013-04-26	"shaker monouso"
EP2018416A4 (en)	2012-04-25	DISPOSABLE BIOREACTOR
BRPI0906055A2 (pt)	2015-06-30	"embalagem refechável"
BRPI0918045A2 (pt)	2015-12-01	compostos de carboxamida heterocíclicos
BRPI1015540A2 (pt)	2019-09-24	''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750''
EP2317847A4 (en)	2014-10-15	SELECTIVE INHIBITION OF POLYGLUTAMINE PROTEIN EXPRESSION
EP2491025A4 (en)	2013-01-23	AZAAZULENVERBINDUNGEN
IL200543A0 (en)	2010-04-29	Ppar active compounds
BRPI1007878A2 (pt)	2015-09-01	"compostos inseticidas"
FR2954857B3 (fr)	2011-12-30	Accumulateur ion-lithium specifique pour l'allumage de motos
EP2347962A4 (en)	2012-02-22	DISPOSABLE CONTAINER
IL209197A0 (en)	2011-01-31	5-[5-[2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoylmethylamino]-4-(4-fluoro-2-methylphenyl)]-2-pyridinyl-2-alkyl-prolinamide as nk1 receptor antagonists
UA19037S (uk)	2009-06-10	Кільце-виштовхувач для насоса
IL213328A0 (en)	2011-07-31	Regeneration of 2,2'-cyclopropylidene-bis (oxazolines)
TH99771B (th)	2010-01-15	"กระปุกเกลือ"
BRPI1007935A2 (pt)	2015-09-01	"combinações de compostos ativos"
UA19376S (uk)	2009-08-25	Комплект етикеток для вина «есмеральда»
UA19262S (uk)	2009-07-27	Комплект етикеток для вина «кагор»
UA19409S (uk)	2009-08-25	Етикетка для кондитерського виробу «amour»
UA20932S (uk)	2010-10-11	Торт «камачо»