BRPI1015540A2 - ''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750'' - Google Patents

''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750''

Info

Publication number
BRPI1015540A2
BRPI1015540A2 BRPI1015540A BRPI1015540A BRPI1015540A2 BR PI1015540 A2 BRPI1015540 A2 BR PI1015540A2 BR PI1015540 A BRPI1015540 A BR PI1015540A BR PI1015540 A BRPI1015540 A BR PI1015540A BR PI1015540 A2 BRPI1015540 A2 BR PI1015540A2
Authority
BR
Brazil
Prior art keywords
cyanoethylheterocyclylcarboxamide
substituted
compound
cyanoethylheterocyclylcarboxamide compound
Prior art date
Application number
BRPI1015540A
Other languages
English (en)
Inventor
Mather Andrew
Mete Antonio
Millichip Ian
Ford Rhonan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI1015540A2 publication Critical patent/BRPI1015540A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI1015540A 2009-05-07 2010-05-05 ''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750'' BRPI1015540A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17627909P 2009-05-07 2009-05-07
US18562909P 2009-06-10 2009-06-10
PCT/GB2010/050736 WO2010128324A1 (en) 2009-05-07 2010-05-05 Substituted 1-cyanoethylheterocyclylcarboxamide compounds 750

Publications (1)

Publication Number Publication Date
BRPI1015540A2 true BRPI1015540A2 (pt) 2019-09-24

Family

ID=42271991

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015540A BRPI1015540A2 (pt) 2009-05-07 2010-05-05 ''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750''

Country Status (22)

Country Link
US (2) US8193239B2 (pt)
EP (1) EP2427445A1 (pt)
JP (1) JP2012526093A (pt)
KR (1) KR20120034639A (pt)
CN (1) CN102574830A (pt)
AR (1) AR076551A1 (pt)
AU (1) AU2010244218B2 (pt)
BR (1) BRPI1015540A2 (pt)
CA (1) CA2759581A1 (pt)
CL (1) CL2011002787A1 (pt)
CO (1) CO6450612A2 (pt)
CR (1) CR20110579A (pt)
CU (1) CU20110204A7 (pt)
EA (1) EA201190235A1 (pt)
EC (1) ECSP11011439A (pt)
IL (1) IL215615A0 (pt)
MX (1) MX2011011661A (pt)
SG (1) SG175090A1 (pt)
TW (1) TW201041889A (pt)
UY (1) UY32611A (pt)
WO (1) WO2010128324A1 (pt)
ZA (1) ZA201108962B (pt)

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BR112013003879B1 (pt) 2010-08-20 2020-12-22 Chugai Seiyaku Kabushiki Kaisha composição compreendendo compostos tetracíclicos e formulação oralmente administrável que a compreende
US8841463B2 (en) 2011-02-11 2014-09-23 Glaxosmithkline Intellectual Property Development Limited Cathepsin C inhibitors
WO2012119941A1 (en) 2011-03-04 2012-09-13 Prozymex A/S Peptidyl nitrilcompounds as peptidase inhibitors
TR201815994T4 (tr) 2012-09-25 2018-11-21 Chugai Pharmaceutical Co Ltd Ret inhibitörü.
JP6437929B2 (ja) * 2013-03-14 2018-12-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング カテプシンｃの置換二環式１−カルボン酸（ベンジル−シアノ−メチル）−アミド阻害剤
WO2014140091A1 (en) 2013-03-14 2014-09-18 Boehringer Ingelheim International Gmbh Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
JP6441830B2 (ja) * 2013-03-14 2018-12-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング カテプシンｃの置換２−アザ−ビシクロ［２．２．１］ヘプタン−３−カルボン酸（シアノ−メチル）−アミド阻害剤
GEP201706780B (en) 2013-03-14 2017-11-27 Boehringer Ingelheim Int Substituted 2-aza-bicyclo [2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
EP3010586A1 (en) 2013-06-21 2016-04-27 Lupin Limited Substituted heterocyclic compounds as crac modulators
EP3013810A1 (en) 2013-06-24 2016-05-04 Lupin Limited Chromane and chromene derivatives and their use as crac modulators
DK3044214T3 (da) 2013-09-09 2017-11-13 Prozymex As Peptidylnitrilforbindelser som dipeptidylpeptidase-I-inhibitorer
NO2699580T3 (pt) 2014-01-24 2018-02-24
CN106456651A (zh) 2014-04-25 2017-02-22 中外制药株式会社 以高用量含有四环性化合物的制剂
CN106458967A (zh) 2014-04-25 2017-02-22 中外制药株式会社 四环化合物的新结晶
US9802945B2 (en) 2014-06-12 2017-10-31 Pfizer Limited Imidazopyridazine derivatives as modulators of the GABAA receptor activity
JP6529575B2 (ja) 2014-08-01 2019-06-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換オキセタンおよびそれらのカテプシンｃの阻害薬としての使用
TWI718102B (zh) 2014-08-08 2021-02-11 日商中外製藥股份有限公司 ４環性化合物的非晶質體
UA118610C2 (uk) 2014-09-12 2019-02-11 Бьорінгер Інгельхайм Інтернаціональ Гмбх Спіроциклічні інгібітори катепсину c
US11077093B2 (en) 2015-01-16 2021-08-03 Chugai Seiyaku Kabushiki Kaisha Combination drug
AU2016227618B2 (en) * 2015-03-05 2020-06-04 Neuprozyme Therapeutics ApS Peptidyl nitril compounds as dipeptidyl peptidase I inhibitors
WO2016139355A1 (en) 2015-03-05 2016-09-09 Prozymex A/S N-substituted 3,3'-(biphenyl-4,4'-diyl)bis-2-aminopropanenitriles as dppi inhibitors
CN106478629A (zh) * 2015-08-24 2017-03-08 上海医药工业研究院 一种利格列汀的制备工艺
WO2017147701A1 (en) 2016-03-01 2017-09-08 Ontario Institute For Cancer Research (Oicr) Inhibitors of wdr5 protein-protein binding
DK3423451T3 (da) 2016-03-01 2022-11-28 Propellon Therapeutics Inc Inhibitorer af wdr5-protein-proteinbinding
KR20250107292A (ko) * 2016-07-29 2025-07-11 인스메드 인코포레이티드 기관지확장증을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카르복스아미드
SI3758708T1 (sl) 2018-03-01 2025-04-30 Astrazeneca Ab Farmacevtski sestavki, ki vsebujejo (2S)-{(1S)-1-ciano-2-[4-(3-metil-2-okso-2,3-dihidro-1,3-benzoksazol-5-il)fenil]etil}-1,4-oksazepan-2-karboksamid
EP3815688B1 (en) 2018-06-29 2023-12-06 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition containing poorly-soluble basic medicine
AU2019305565A1 (en) * 2018-07-17 2021-03-04 Insmed Incorporated Certain (2S)- N-[(1A)-1-cyano-2-phenylethyl]-1,4- oxazepane-2-carboxamides for treating inflammatory bowel disease
CA3106269A1 (en) * 2018-07-17 2020-01-23 Insmed Incorporated Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis
AU2019337018B2 (en) 2018-09-04 2024-03-07 Chugai Seiyaku Kabushiki Kaisha Method of producing tetracyclic compound
MX2023002371A (es) 2020-08-26 2023-05-19 Haisco Pharmaceuticals Pte Ltd Derivado de nitrilo que actua como inhibidor de la dipeptidil peptidasa 1 y uso del mismo.
JP2023551488A (ja) * 2020-12-04 2023-12-08 瑞石生物医薬有限公司 カテプシンｃの小分子阻害剤及びその医薬的使用
CN116783189B (zh) * 2021-02-05 2026-01-30 上海复星医药产业发展有限公司 含1，4-氧杂氮杂环庚烷的并环类衍生物
US20250179060A1 (en) * 2022-02-22 2025-06-05 Haisco Pharmaceuticals Pte. Ltd. Preparation method of nitrogen-containing heterocyclic compound
CN119156384B (zh) 2022-06-07 2025-12-09 瑞石生物医药有限公司 苯并[c]色满化合物的多晶型及其制备方法和用途
CN119156391A (zh) 2022-06-07 2024-12-17 瑞石生物医药有限公司 苯并[c]色满化合物的可药用盐、其多晶型及用途
WO2024008680A1 (en) 2022-07-06 2024-01-11 Chiesi Farmaceutici S.P.A. Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors
EP4646265A1 (en) 2023-01-06 2025-11-12 Insmed Incorporated Novel, reversible dpp1 inhibitors and uses thereof
WO2025059526A1 (en) * 2023-09-15 2025-03-20 Insmed Incorporated Dipeptidyl peptidase 1 inhibitors and uses thereof
WO2025165806A1 (en) * 2024-01-29 2025-08-07 Insmed Incorporated Dipeptidyl peptidase 1 inhibitors and uses thereof
WO2025162472A1 (en) * 2024-01-31 2025-08-07 Insmed Incorporated Linear dipeptidyl peptidase 1 inhibitors and uses thereof

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Also Published As

Publication number Publication date
CN102574830A (zh) 2012-07-11
SG175090A1 (en) 2011-11-28
US20100286118A1 (en) 2010-11-11
CO6450612A2 (es) 2012-05-31
MX2011011661A (es) 2011-11-18
WO2010128324A1 (en) 2010-11-11
EA201190235A1 (ru) 2012-05-30
UY32611A (es) 2010-12-31
KR20120034639A (ko) 2012-04-12
CU20110204A7 (es) 2012-03-15
IL215615A0 (en) 2011-12-29
CA2759581A1 (en) 2010-11-11
AU2010244218A1 (en) 2011-11-03
ECSP11011439A (es) 2011-12-30
AU2010244218B2 (en) 2012-07-19
US20120329775A1 (en) 2012-12-27
US8193239B2 (en) 2012-06-05
CL2011002787A1 (es) 2012-06-22
JP2012526093A (ja) 2012-10-25
CR20110579A (es) 2012-01-09
TW201041889A (en) 2010-12-01
EP2427445A1 (en) 2012-03-14
AR076551A1 (es) 2011-06-22
ZA201108962B (en) 2012-08-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.