BRPI1015540A2 - ''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750'' - Google Patents

''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750''

Info

Publication number
BRPI1015540A2
BRPI1015540A2 BRPI1015540A BRPI1015540A BRPI1015540A2 BR PI1015540 A2 BRPI1015540 A2 BR PI1015540A2 BR PI1015540 A BRPI1015540 A BR PI1015540A BR PI1015540 A BRPI1015540 A BR PI1015540A BR PI1015540 A2 BRPI1015540 A2 BR PI1015540A2
Authority
BR
Brazil
Prior art keywords
cyanoethylheterocyclylcarboxamide
substituted
compound
cyanoethylheterocyclylcarboxamide compound
Prior art date
Application number
BRPI1015540A
Other languages
English (en)
Inventor
Mather Andrew
Mete Antonio
Millichip Ian
Ford Rhonan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI1015540A2 publication Critical patent/BRPI1015540A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BRPI1015540A 2009-05-07 2010-05-05 ''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750'' BRPI1015540A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17627909P 2009-05-07 2009-05-07
US18562909P 2009-06-10 2009-06-10
PCT/GB2010/050736 WO2010128324A1 (en) 2009-05-07 2010-05-05 Substituted 1-cyanoethylheterocyclylcarboxamide compounds 750

Publications (1)

Publication Number Publication Date
BRPI1015540A2 true BRPI1015540A2 (pt) 2019-09-24

Family

ID=42271991

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1015540A BRPI1015540A2 (pt) 2009-05-07 2010-05-05 ''composto de 1-cianoetil-heterociclilcarboxamida substituídos 750''

Country Status (22)

Country Link
US (2) US8193239B2 (pt)
EP (1) EP2427445A1 (pt)
JP (1) JP2012526093A (pt)
KR (1) KR20120034639A (pt)
CN (1) CN102574830A (pt)
AR (1) AR076551A1 (pt)
AU (1) AU2010244218B2 (pt)
BR (1) BRPI1015540A2 (pt)
CA (1) CA2759581A1 (pt)
CL (1) CL2011002787A1 (pt)
CO (1) CO6450612A2 (pt)
CR (1) CR20110579A (pt)
CU (1) CU20110204A7 (pt)
EA (1) EA201190235A1 (pt)
EC (1) ECSP11011439A (pt)
IL (1) IL215615A0 (pt)
MX (1) MX2011011661A (pt)
SG (1) SG175090A1 (pt)
TW (1) TW201041889A (pt)
UY (1) UY32611A (pt)
WO (1) WO2010128324A1 (pt)
ZA (1) ZA201108962B (pt)

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MX355836B (es) 2010-08-20 2018-05-02 Chugai Pharmaceutical Co Ltd Composicion que comprende compuestos tetraciclicos.
MX2013009279A (es) * 2011-02-11 2013-10-28 Glaxosmithkline Ip Dev Ltd Inhibidores de catepsina c.
WO2012119941A1 (en) 2011-03-04 2012-09-13 Prozymex A/S Peptidyl nitrilcompounds as peptidase inhibitors
US10668075B2 (en) 2012-09-25 2020-06-02 Chugai Seiyaku Kabushiki Kaisha RET inhibitor
AU2014230814B2 (en) 2013-03-14 2017-12-21 Boehringer Ingelheim International Gmbh Substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C
US8889708B2 (en) 2013-03-14 2014-11-18 Boehringer Ingelheim International Gmbh Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
JP6441830B2 (ja) * 2013-03-14 2018-12-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング カテプシンｃの置換２−アザ−ビシクロ［２．２．１］ヘプタン−３−カルボン酸（シアノ−メチル）−アミド阻害剤
WO2014140091A1 (en) 2013-03-14 2014-09-18 Boehringer Ingelheim International Gmbh Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c
US9725463B2 (en) 2013-06-21 2017-08-08 Lupin Limited Substituted heterocyclic compounds as CRAC modulators
US9790231B2 (en) 2013-06-24 2017-10-17 Lupin Limited Chromane and chromene derivatives and their use as CRAC modulators
DK3044214T3 (da) * 2013-09-09 2017-11-13 Prozymex As Peptidylnitrilforbindelser som dipeptidylpeptidase-I-inhibitorer
NO2699580T3 (pt) * 2014-01-24 2018-02-24
EP3135671B1 (en) 2014-04-25 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Novel crystal of tetracyclic compound
WO2015163448A1 (ja) 2014-04-25 2015-10-29 中外製薬株式会社 ４環性化合物を高用量含有する製剤
EP3154979B1 (en) 2014-06-12 2018-03-07 Pfizer Limited Imidazopyridazine derivatives as modulators of the gabaa receptor activity.
EP3174879B1 (en) 2014-08-01 2018-07-18 Boehringer Ingelheim International GmbH Substituted oxetanes and their use as inhibitors of cathepsin c
TWI831347B (zh) 2014-08-08 2024-02-01 日商中外製藥股份有限公司 包含４環性化合物的非晶質體之固體分散體及製劑
UA118610C2 (uk) 2014-09-12 2019-02-11 Бьорінгер Інгельхайм Інтернаціональ Гмбх Спіроциклічні інгібітори катепсину c
JP6741596B2 (ja) 2015-01-16 2020-08-19 中外製薬株式会社 併用医薬
WO2016139355A1 (en) 2015-03-05 2016-09-09 Prozymex A/S N-substituted 3,3'-(biphenyl-4,4'-diyl)bis-2-aminopropanenitriles as dppi inhibitors
DK3265452T3 (en) * 2015-03-05 2020-06-08 Neuprozyme Therapeutics ApS Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors
CN106478629A (zh) * 2015-08-24 2017-03-08 上海医药工业研究院 一种利格列汀的制备工艺
DK3423451T3 (da) 2016-03-01 2022-11-28 Propellon Therapeutics Inc Inhibitorer af wdr5-protein-proteinbinding
CA3015417A1 (en) 2016-03-01 2017-09-08 Propellon Therapeutics Inc. Inhibitors of wdr5 protein-protein binding
WO2018022978A1 (en) * 2016-07-29 2018-02-01 Insmed Incorporated Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating bronchiectasis
FI3758708T3 (fi) 2018-03-01 2025-02-18 Astrazeneca Ab (2s)-{(1s)-1-syano-2-[4-(3-metyyli-2-okso-2,3-dihydro-1,3-bentsoksatsol-5-yyli)fenyyli]etyyli}-1,4-oksatsepaani-2-karboksamidia käsittäviä farmaseuttisia koostumuksia
CN112384223B (zh) 2018-06-29 2024-08-27 中外制药株式会社 含有难溶性碱性药剂的药物组合物
KR20210032439A (ko) * 2018-07-17 2021-03-24 인스메드 인코포레이티드 염증성 장 질환을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드
KR20210032431A (ko) 2018-07-17 2021-03-24 인스메드 인코포레이티드 루푸스 신염을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드
WO2020050241A1 (ja) 2018-09-04 2020-03-12 中外製薬株式会社 ４環性化合物の製造方法
RS66302B1 (sr) * 2020-08-26 2025-01-31 Haisco Pharmaceuticals Pte Ltd Derivat nitrila koji deluje kao inhibitor dipeptidil peptidaze 1 i njegova upotreba
CA3199568A1 (en) * 2020-12-04 2022-06-09 Reistone Biopharma Company Limited Small molecule inhibitor of cathepsin c and medicinal use thereof
AU2022218443B2 (en) * 2021-02-05 2025-03-13 Shanghai Fosun Pharmaceutical Industrial Development Co., Ltd. Fused ring derivatives containing 1,4-oxazepane
EP4484423A4 (en) * 2022-02-22 2026-01-07 Haisco Pharmaceuticals Pte Ltd PROCESS FOR PREPARING A HETEROCYCLIC COMPOUND CONTAINING NITROGEN
JP2025518345A (ja) 2022-06-07 2025-06-12 瑞石生物医薬有限公司 ベンゾ［ｃ］クロマン化合物の薬学的に許容される塩、ならびに薬学的に許容される塩の多形及び使用
TW202404960A (zh) 2022-06-07 2024-02-01 大陸商瑞石生物醫藥有限公司 苯并［ｃ］色滿化合物的多晶型及其製備方法和用途
WO2024008680A1 (en) 2022-07-06 2024-01-11 Chiesi Farmaceutici S.P.A. Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors
EP4646265A1 (en) 2023-01-06 2025-11-12 Insmed Incorporated Novel, reversible dpp1 inhibitors and uses thereof
AU2024340032A1 (en) * 2023-09-15 2026-04-09 Insmed Incorporated Dipeptidyl peptidase 1 inhibitors and uses thereof
WO2025165806A1 (en) * 2024-01-29 2025-08-07 Insmed Incorporated Dipeptidyl peptidase 1 inhibitors and uses thereof
WO2025162472A1 (en) * 2024-01-31 2025-08-07 Insmed Incorporated Linear dipeptidyl peptidase 1 inhibitors and uses thereof

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Also Published As

Publication number Publication date
EA201190235A1 (ru) 2012-05-30
JP2012526093A (ja) 2012-10-25
US8193239B2 (en) 2012-06-05
WO2010128324A1 (en) 2010-11-11
SG175090A1 (en) 2011-11-28
CL2011002787A1 (es) 2012-06-22
CO6450612A2 (es) 2012-05-31
ZA201108962B (en) 2012-08-29
CR20110579A (es) 2012-01-09
CU20110204A7 (es) 2012-03-15
KR20120034639A (ko) 2012-04-12
US20120329775A1 (en) 2012-12-27
US20100286118A1 (en) 2010-11-11
EP2427445A1 (en) 2012-03-14
IL215615A0 (en) 2011-12-29
AU2010244218A1 (en) 2011-11-03
TW201041889A (en) 2010-12-01
AU2010244218B2 (en) 2012-07-19
CA2759581A1 (en) 2010-11-11
CN102574830A (zh) 2012-07-11
UY32611A (es) 2010-12-31
MX2011011661A (es) 2011-11-18
ECSP11011439A (es) 2011-12-30
AR076551A1 (es) 2011-06-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.