BRPI1012141A2 - conjugado de sirna e método de preparação do mesmo - Google Patents

conjugado de sirna e método de preparação do mesmo

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Publication number
BRPI1012141A2
BRPI1012141A2 BRPI1012141A BRPI1012141A BRPI1012141A2 BR PI1012141 A2 BRPI1012141 A2 BR PI1012141A2 BR PI1012141 A BRPI1012141 A BR PI1012141A BR PI1012141 A BRPI1012141 A BR PI1012141A BR PI1012141 A2 BRPI1012141 A2 BR PI1012141A2
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BR
Brazil
Prior art keywords
siren
conjugate
sirna
preparation
preparing
Prior art date
Application number
BRPI1012141A
Other languages
English (en)
Inventor
Bo Ram Han
Han Oh Park
Mi Sik Shin
Sam Young Lee
Original Assignee
Bioneer Corp
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Publication date
Application filed by Bioneer Corp filed Critical Bioneer Corp
Publication of BRPI1012141A2 publication Critical patent/BRPI1012141A2/pt
Publication of BRPI1012141B1 publication Critical patent/BRPI1012141B1/pt

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    • C—CHEMISTRY; METALLURGY
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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Abstract

conjugado de sirma e método de preparação do mesmo. são providos um conjugado de sirna-polímero e um método para preparação do mesmo e mais especificamente, um conjugado híbrido formado por ligação covalente de sirna e um composto polimérico para aperfeiçoar a estabilidade in vivo de sirna e um método de preparação do conjugado híbrido. o conjugado da presente invenção pode aperfeiçoar a estabilidade in vivo de sirna, pelo que, obtendo uma liberação eficiente de sirna terapêutico nas células e exibindo a atividade de sirna mesmo com uma dose pequena de uma concentração relativa baixa. portanto, o conjugado pode ser usado vantajosamente não apenas como uma ferramenta para tratamento com sirna dos cânceres e outras doenças infecciosas, porém também um novo tipo de sistema de liberação de sirna.
BRPI1012141A 2009-05-14 2010-05-13 conjugado de sirna e método de preparação do mesmo BRPI1012141B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090042297A KR101224828B1 (ko) 2009-05-14 2009-05-14 ｓｉＲＮＡ 접합체 및 그 제조방법
PCT/KR2010/003039 WO2010131916A2 (ko) 2009-05-14 2010-05-13 siRNA 접합체 및 그 제조방법

Publications (2)

Publication Number Publication Date
BRPI1012141A2 true BRPI1012141A2 (pt) 2016-03-29
BRPI1012141B1 BRPI1012141B1 (pt) 2020-04-07

Family

ID=43085466

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012141A BRPI1012141B1 (pt) 2009-05-14 2010-05-13 conjugado de sirna e método de preparação do mesmo

Country Status (10)

Country Link
US (4) US8779114B2 (pt)
EP (3) EP2463371B1 (pt)
JP (3) JP5758381B2 (pt)
KR (1) KR101224828B1 (pt)
CN (3) CN102888404B (pt)
AU (1) AU2010248239B2 (pt)
BR (1) BRPI1012141B1 (pt)
CA (2) CA2761749C (pt)
RU (2) RU2558258C2 (pt)
WO (1) WO2010131916A2 (pt)

Families Citing this family (45)

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KR101224828B1 (ko) 2009-05-14 2013-01-22 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법
KR101722948B1 (ko) * 2012-01-05 2017-04-04 (주)바이오니아 리간드가 결합된 이중나선 올리고 ｒｎａ 구조체 및 그 제조방법
JP5952423B2 (ja) * 2011-12-15 2016-07-13 バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ 新規オリゴヌクレオチド接合体およびその用途
KR101752812B1 (ko) 2012-01-05 2017-06-30 (주)바이오니아 고효율 나노입자형 이중나선 올리고 rna 구조체 및 그의 제조방법
JP5906327B2 (ja) * 2012-01-18 2016-04-20 バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ 磁性ナノ粒子−ＳＡＭｉＲＮＡ複合体およびその製造方法
IN2015DN02055A (pt) 2012-09-17 2015-08-14 Grace W R & Co
KR20150064065A (ko) * 2012-10-05 2015-06-10 (주)바이오니아 엠피레귤린 특이적 이중 나선 올리고 rna, 그러한 이중나선 올리고 rna 를 포함하는 이중나선 올리고 rna 구조체 및 이를 포함하는 호흡기 질환의 예방 또는 치료용 조성물
JP6446269B2 (ja) * 2012-12-06 2018-12-26 協和発酵バイオ株式会社 アジュバント用二重鎖リボ核酸
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KR20150006743A (ko) * 2013-07-09 2015-01-19 (주)바이오니아 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물
KR20150006742A (ko) * 2013-07-09 2015-01-19 (주)바이오니아 간암 연관 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 조성물
US10208309B2 (en) 2014-04-04 2019-02-19 Bioneer Corporation Double-stranded oligo RNA targeted to amphiregulin and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases
EP3137209B1 (en) 2014-05-02 2022-10-05 W.R. Grace & CO. - CONN. Functionalized support material and methods of making and using functionalized support material
JP6751084B2 (ja) * 2014-10-15 2020-09-02 ユニバーシティー オブ コネチカット 薬物送達のための生還元性（ｂｉｏ−ｒｅｄｕｃｉｂｌｅ）自己組織化液晶ブロックコポリマー
SG10201911134QA (en) 2015-06-05 2020-01-30 Grace W R & Co Adsorbent bioprocessing clarification agents and methods of making and using the same
WO2016204515A1 (ko) * 2015-06-15 2016-12-22 (주)바이오니아 STAT3 유전자 특이적 siRNA, 그러한 siRNA를 포함하는 이중나선 올리고 RNA 구조체, 이를 포함하는 조성물 및 이의 용도
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