BRPI1012367B8 - processo para a preparação de derivados aromáticos carboxílicos triiodados - Google Patents

processo para a preparação de derivados aromáticos carboxílicos triiodados

Info

Publication number
BRPI1012367B8
BRPI1012367B8 BRPI1012367A BRPI1012367A BRPI1012367B8 BR PI1012367 B8 BRPI1012367 B8 BR PI1012367B8 BR PI1012367 A BRPI1012367 A BR PI1012367A BR PI1012367 A BRPI1012367 A BR PI1012367A BR PI1012367 B8 BRPI1012367 B8 BR PI1012367B8
Authority
BR
Brazil
Prior art keywords
preparation
triiodinated
aromatic derivatives
carboxylic aromatic
derivatives
Prior art date
Application number
BRPI1012367A
Other languages
English (en)
Inventor
Mortillaro Armando
Lattuada Luciano
Brocchetta Marino
Lucio Anelli Pier
Fretta Roberta
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Publication of BRPI1012367A2 publication Critical patent/BRPI1012367A2/pt
Publication of BRPI1012367B1 publication Critical patent/BRPI1012367B1/pt
Publication of BRPI1012367B8 publication Critical patent/BRPI1012367B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/68—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

processo para a preparação de derivados aromáticos carboxílicos triiodados. a presente invenção se refere a um processo para a preparação de certos compostos de carboxamidos dado, em particular, de derivados do ácido 2, 4, 6-triiodoisoftálico, como intermediários úteis para a preparação dos meios de contraste de raios-x de contraste, dentre os quais se encontra o iopamidol. o referido processo compreende a reação de compostos intermediários adequados de n-sulfinil com um alfa-hidroxiácido comercialmente disponível ou um sal do mesmo.
BRPI1012367A 2009-03-20 2010-03-12 processo para a preparação de derivados aromáticos carboxílicos triiodados BRPI1012367B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09155695A EP2230227A1 (en) 2009-03-20 2009-03-20 Process for the preparation of triiodinated carboxylic aromatic derivatives
PCT/EP2010/053186 WO2010105983A1 (en) 2009-03-20 2010-03-12 Process for the preparation of triiodinated carboxylic aromatic derivatives

Publications (3)

Publication Number Publication Date
BRPI1012367A2 BRPI1012367A2 (pt) 2016-03-29
BRPI1012367B1 BRPI1012367B1 (pt) 2020-04-07
BRPI1012367B8 true BRPI1012367B8 (pt) 2021-05-25

Family

ID=40933154

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI1012367A BRPI1012367B8 (pt) 2009-03-20 2010-03-12 processo para a preparação de derivados aromáticos carboxílicos triiodados

Country Status (13)

Country Link
US (1) US9096495B2 (pt)
EP (2) EP2230227A1 (pt)
JP (1) JP5559302B2 (pt)
KR (1) KR101306033B1 (pt)
CN (1) CN102325748B (pt)
AU (1) AU2010224945B2 (pt)
BR (1) BRPI1012367B8 (pt)
CA (1) CA2755650C (pt)
ES (1) ES2426610T3 (pt)
IL (1) IL215209A (pt)
MX (1) MX2011009057A (pt)
RU (1) RU2512358C2 (pt)
WO (1) WO2010105983A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2496971A (en) * 2011-11-25 2013-05-29 Ge Healthcare As Preparation of X-ray contrast agents
CA2897700C (en) * 2012-12-11 2022-05-03 Bracco Imaging S.P.A. Continuous process for the preparation of (s)-2-acetyloxypropionic acid chloride
DK3154928T3 (da) 2014-06-10 2020-05-18 Bracco Imaging Spa Fremgangsmåde til fremstilling af (s)-2-acetyloxypropionsyre og derivater deraf
WO2018104228A1 (en) * 2016-12-05 2018-06-14 Bracco Imaging Spa Mechanochemical synthesis of radiographic agents intermediates
FR3062850B1 (fr) * 2017-02-10 2020-01-31 Guerbet Procede de preparation monotope de composes organo-iodes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1085648B (de) * 1958-08-06 1960-07-21 Lentia Gmbh Roentgenkontrastmittel
CH608189A5 (pt) * 1974-12-13 1978-12-29 Savac Ag
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Carboxamide non-ionic contrast media and method for the preparation thereof
US5698739A (en) 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
IT1256162B (it) 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1256248B (it) 1992-12-24 1995-11-29 Bracco Spa Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x
US5763650A (en) 1995-05-23 1998-06-09 Fructamine S.P.A. Process for the preparation of a halosubstituted aromatic acid
AU698623B2 (en) 1995-05-23 1998-11-05 Bracco Imaging S.P.A. Process for the preparation of a dicarboxylic acid dichloride
BR9606488A (pt) 1995-05-23 1997-11-25 Fructamine Spa Processo para a preparação de um dicloreto de ácido dicarboxílico
IT1288114B1 (it) 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio
IT1286522B1 (it) 1996-12-04 1998-07-15 Dibra Spa Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
IT1289520B1 (it) 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1299202B1 (it) 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
IT1319671B1 (it) * 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
EA200970848A1 (ru) * 2007-03-13 2010-02-26 Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. Амидосодержащие соединения и их применение в качестве противоопухолевых агентов

Also Published As

Publication number Publication date
EP2230227A1 (en) 2010-09-22
EP2408735A1 (en) 2012-01-25
CA2755650C (en) 2013-12-03
RU2011142308A (ru) 2013-04-27
EP2408735B1 (en) 2013-06-05
JP2012520844A (ja) 2012-09-10
WO2010105983A1 (en) 2010-09-23
CN102325748A (zh) 2012-01-18
BRPI1012367A2 (pt) 2016-03-29
US20110275850A1 (en) 2011-11-10
IL215209A (en) 2016-03-31
BRPI1012367B1 (pt) 2020-04-07
KR20110121620A (ko) 2011-11-07
AU2010224945A1 (en) 2011-09-01
US9096495B2 (en) 2015-08-04
CN102325748B (zh) 2015-05-20
IL215209A0 (en) 2011-12-29
RU2512358C2 (ru) 2014-04-10
KR101306033B1 (ko) 2013-09-12
AU2010224945B2 (en) 2014-07-03
MX2011009057A (es) 2011-09-21
JP5559302B2 (ja) 2014-07-23
ES2426610T3 (es) 2013-10-24
CA2755650A1 (en) 2010-09-23

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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
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